公开(公告)号：US20220104876A1

公开(公告)日：2022-04-07

申请号：US17426553

申请日：2020-01-29

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Kidd ,  Shailesh Joshi

IPC: A61B18/18

Abstract: A microwave antenna apparatus comprises a radiating element configured to perform a treatment, the treatment comprising heating a volume of tissue using microwave radiation emitted from the radiating element; a cooling structure arranged for flowing a coolant through at least one lumen of the cooling structure during the treatment; and a controller configured to control the flow of coolant such as to provide a first flow rate of coolant through the at least one lumen during a first period of the treatment and to provide a second, different flow rate of coolant through the at least one lumen during a second, later period of the treatment.

公开(公告)号：US20240173561A1

公开(公告)日：2024-05-30

申请号：US18562654

申请日：2022-05-20

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Shailesh Joshi ,  Matthew Kidd

IPC: A61N5/02 ,  C12N13/00

CPC classification number: A61N5/025 ,  C12N13/00

Abstract: The disclosure is based on the finding that microwave energy may be used to modulate, for example up- or down-regulate the expression of certain genes. For example, where a disease or condition is associated with the aberrant expression of a particular gene or genes, microwave energy may be used to modulate the expression of those genes, thereby resolving and/or improving one or more of the symptoms of the disease or condition. Disclosed is a microwave system or microwave-generating apparatus, for use in a method of modulating the expression of one or more genes. Also disclosed are uses of microwave energy for modulating the expression of one or more genes in tissues, tissue samples and biopsies.

公开(公告)号：US20220219007A1

公开(公告)日：2022-07-14

申请号：US17557602

申请日：2021-12-21

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Kidd ,  Shailesh Joshi

IPC: A61N5/02 ,  A61P31/10

Abstract: The present disclosure provides compositions, medicaments and methods for treating or preventing disorders, conditions and/or diseases affecting keratinised structures or tissues such as, for example, nails.

公开(公告)号：US20210244469A1

公开(公告)日：2021-08-12

申请号：US17273554

申请日：2019-08-30

Applicant: Emblation Limited

Inventor： Eamon McErlean ,  Gary Beale ,  Matthew Kidd ,  Shailesh Joshi

IPC: A61B18/18

Abstract: A microwave system comprises: a microwave generator; and a microwave cable apparatus comprising a coaxial cable, wherein an exposed distal portion of an inner conductor of the coaxial cable is longer than an outer conductor of the coaxial cable, and wherein at least part of the exposed distal portion of the inner conductor is bent with respect to a longitudinal axis of the coaxial cable, thereby to provide a directional radiating element; wherein the microwave generator is configured to provide microwave energy to the cable apparatus at a frequency that provides directional radiation of microwave energy having a desired directionality from the radiating element.

公开(公告)号：US20220160427A1

公开(公告)日：2022-05-26

申请号：US17601013

申请日：2020-03-31

Applicant: Emblation Limited

Inventor： Eamon McErlean ,  Matthew Kidd ,  Gary Beale ,  Shailesh Joshi

IPC: A61B18/18

Abstract: A microwave system, comprises: a microwave generator; a microwave applicator for delivering microwave radiation generated by the microwave generator to a surface, wherein the microwave applicator is moveable relative to the surface; one or more sensors for sensing at least one of a position, an orientation, an acceleration, a speed and/or a velocity of the microwave applicator, and a controller configured to monitor sensor output from the one or more sensors and further configured to control one or more operational parameters of the microwave system based at least on the monitored sensor output.

公开(公告)号：US20190255348A1

公开(公告)日：2019-08-22

申请号：US16277171

申请日：2019-02-15

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Kidd

IPC: A61N5/02 ,  C07K16/28 ,  A61K31/655 ,  A61K31/495 ,  A61K47/64 ,  A61K31/337 ,  A61K33/243 ,  A61K31/282 ,  A61K31/475 ,  A61B18/18 ,  A61N5/04

Abstract: Described herein are methods and apparatus for the treatment of melanoma skin cancer.

公开(公告)号：US20220266048A1

公开(公告)日：2022-08-25

申请号：US17629030

申请日：2020-07-23

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Kidd ,  Shailesh Joshi

IPC: A61N5/02 ,  A61B18/18

Abstract: A microwave system comprises: a microwave generator; a controller configured to control the microwave generator to generate microwave energy having a selected operational frequency or range of frequencies; a microwave cable configured to deliver the microwave energy to a microwave antenna extending from or coupled to a distal end of the microwave cable; and the microwave antenna, the microwave antenna comprising a plurality of slots distributed along a portion of the microwave antenna, wherein a width of the slots varies with distance along the portion of the microwave antenna.

公开(公告)号：US20190274758A1

公开(公告)日：2019-09-12

申请号：US16277146

申请日：2019-02-15

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Kidd

IPC: A61B18/18 ,  A61K9/00

Abstract: Described herein are methods and apparatus for treating or preventing epidermal dysplasias, including, for example, dysplastic epidermal lesions and dermatological pre-cancerous disease.