公开(公告)号：US5130009A

公开(公告)日：1992-07-14

申请号：US469214

申请日：1990-01-24

Applicant: Hermann Marsoner ,  Helmut List ,  Heinz Kontschieder ,  Falko Skrabal

Inventor： Hermann Marsoner ,  Helmut List ,  Heinz Kontschieder ,  Falko Skrabal

IPC: C12Q1/00 ,  G01N27/08 ,  G01N27/28 ,  G01N27/404 ,  G01N27/416

CPC classification number: C12Q1/006 ,  G01N27/3272 ,  Y10S435/817 ,  Y10S436/806

Abstract: In order to produce a small-volume flow measuring cell with good flow characteristics in a sensor device for determining the concentration of a substrate in a sample medium, comprising an enzyme electrode which is covered by a membrane and a reference electrode, both of which are in contact with the measuring cell, the proposal is put forward that the reference electrode be located outside of the membrane cover of the enzyme electrode and that the maximum extension of the flow measuring cell normal to the flow direction of the sample medium essentially be the same as the diameter of the sensitive layer of the enzyme electrode.

Abstract translation: 为了在用于确定样品介质中的基底浓度的传感器装置中产生具有良好流动特性的小体积流量测量单元，包括由膜和参比电极覆盖的酶电极，它们均为 提出了将参考电极定位在酶电极的膜覆盖层外侧的方案，并且流动测量元件的垂直于样品介质的流动方向的最大延伸基本上是相同的 作为酶电极敏感层的直径。

公开(公告)号：US5032361A

公开(公告)日：1991-07-16

申请号：US529705

申请日：1990-05-30

Applicant: Erich Kleinhappl ,  Hermann Marsoner ,  Fritz Fischer

Inventor： Erich Kleinhappl ,  Hermann Marsoner ,  Fritz Fischer

IPC: G01N1/00

CPC classification number: G01N35/1095

Abstract: A feeding device with a feeder element for liquid or gaseous samples includes an automatic sample exchanger having sample vessels for the liquid or gaseous samples and openings between the sample vessels through which the feeder element is automatically shifted from the feed position for serial samples to an initial position in contact with a feed opening for calibrating or cleansing media.

Abstract translation: 具有用于液体或气体样品的进料器元件的进料装置包括具有用于液体或气体样品的样品容器和样品容器之间的开口的自动样品交换器，进料元件通过该样品容器自动地从用于连续样品的进料位置移动到初始 与用于校准或清洁介质的进料口接触的位置。

公开(公告)号：US4927603A

公开(公告)日：1990-05-22

申请号：US213155

申请日：1988-06-29

Applicant: Fritz Fischer ,  Erich Kleinhappl ,  Hermann Marsoner

Inventor： Fritz Fischer ,  Erich Kleinhappl ,  Hermann Marsoner

IPC: G01N1/00 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N35/1095 ,  G01N2035/0484 ,  G01N35/1004

Abstract: A feeding device for introducing liquid or gaseous media into the analysis path of an analyzing apparatus includes a feeder element which cooperates in an initial position with a feed opening for calibrating or cleansing media and which may by brought into one or more sample feed positions. The feeder element is fastened by means of chain pins to a driven link chain which is guided by a guide pulley, the chain permitting the feeder element to be moved from the initial position and then tilted into a sample feed position upon contact of the feeder element with the guide pulley.

Abstract translation: 用于将液体或气体介质引入分析设备的分析路径的进料装置包括一个进料器元件，其在初始位置与一个用于校准或清洁介质的进料口配合，并且可以通过进入一个或多个样品进料位置。 馈线元件通过链销固定到由引导滑轮引导的从动连杆链上，链条允许馈送元件从初始位置移动，然后在馈线元件接触时倾斜到样品供给位置 带导轮。

公开(公告)号：US4705667A

公开(公告)日：1987-11-10

申请号：US695066

申请日：1985-01-25

Applicant: Hermann Marsoner ,  Erich Kleinhappl

Inventor： Hermann Marsoner ,  Erich Kleinhappl

IPC: G01N35/10 ,  G01N1/00 ,  G01N35/00 ,  G01N1/02 ,  B65B3/04 ,  B65B3/14 ,  G01N1/14

CPC classification number: G01N35/00594 ,  G01N35/00693

Abstract: In its initial position an input opening of a sample input device provides a seal against a funnel element which is directly connected to a feed pipe delivering standard media and to a valve-controlled air supply, and which has a feed opening cooperating with the input opening. Thus, in the initial position of the sample input device, the input opening and the feed opening at the funnel element together are part of a closed path for the additional media required for measurement and cleaning purposes, which will simplify the overall design of the apparatus.

Abstract translation: 在其初始位置，样品输入装置的输入开口提供与漏斗元件的密封，所述漏斗元件直接连接到输送标准介质的进料管和阀控空气源，并且具有与输入开口配合的进料口 。 因此，在样品输入装置的初始位置，漏斗元件处的输入开口和进料口一起是用于测量和清洁目的所需的附加介质的闭合路径的一部分，这将简化装置的总体设计 。

公开(公告)号：US4657736A

公开(公告)日：1987-04-14

申请号：US883430

申请日：1986-07-14

Applicant: Hermann Marsoner ,  Herbert Kroneis ,  Otto Wolfbeis

Inventor： Hermann Marsoner ,  Herbert Kroneis ,  Otto Wolfbeis

IPC: G01N21/76 ,  C08L83/04 ,  C09K11/02 ,  C09K11/06 ,  G01N21/64 ,  G01N21/78 ,  G01N31/00 ,  G01N31/22 ,  G01J3/30 ,  G01N21/26 ,  G01N21/48 ,  G01N33/16

CPC classification number: G01N21/643 ,  C09K11/02 ,  C09K11/025 ,  C09K11/06 ,  G01N21/648 ,  G01N2021/773 ,  G01N2021/7786 ,  G01N21/6428 ,  Y10T436/207497

Abstract: In an O.sub.2 sensor element which contains a fluorescent indicator substance, a polymerized silicone polymer is used as a carrier material in which the indicator substance is incorporated in solubilized form and in an at least approximately homogeneous distribution. Solubilization of the indicator substance may essentially be performed in analogy to Friedel-Crafts alkylation of aromatics, which will increase solubility of the indicator substance in the polymer carrier without affecting quenching behavior.

Abstract translation: 在含有荧光指示物质的O 2传感器元件中，使用聚合的硅氧烷聚合物作为载体材料，其中指示剂物质以溶解形式并入至少近似均匀的分布。 指示剂物质的溶解可以基本上类似于芳烃的Friedel-Crafts烷基化进行，这将增加指示剂物质在聚合物载体中的溶解度，而不影响猝灭行为。

公开(公告)号：US4632807A

公开(公告)日：1986-12-30

申请号：US563931

申请日：1983-12-21

Applicant: Hermann Marsoner

Inventor： Hermann Marsoner

IPC: G01N21/64 ,  G01N21/62

CPC classification number: G01N21/643 ,  G01N21/274 ,  G01N21/6428

Abstract: In an optical sensor used mainly for determining the partial pressure of O.sub.2 or CO.sub.2 in respiratory gas includes a sample measuring chamber through which sample medium to be analyzed flows or into which it is fed, a reference measuring chamber containing a reference gas or a reference liquid of constant composition, a light source, a unitary excitation filter positioned between the light source and first sides of both the sample measuring chamber and the reference measuring chamber, a single fluorescent sensor element on the second sides of both the sample measuring chamber and the reference measuring chamber, and first and second detectors for detecting the fluorescence radiation from the fluorescent sensor element respectively based on the light passing thereto from the sample measuring chamber and the reference measuring chamber.

Abstract translation: 在主要用于确定呼吸气体中的O 2或CO 2的分压的光学传感器中包括：样品测量室，待分析的样品介质通过该样品测量室流入或被供给到其中的参考测量室，其包含参考气体或参考液体 恒定组成的光源，位于光源和样品测量室和参考测量室的第一侧之间的单一激发滤光器，在样品测量室和参考测量室的第二侧上的单个荧光传感器元件 测量室，以及分别基于从样品测量室和参考测量室通过的光检测来自荧光传感器元件的荧光辐射的第一和第二检测器。

公开(公告)号：US4366040A

公开(公告)日：1982-12-28

申请号：US300557

申请日：1981-09-09

Applicant: Hermann Marsoner ,  Christoph Ritter

Inventor： Hermann Marsoner ,  Christoph Ritter

IPC: G01N27/28 ,  G01N27/30

CPC classification number: G01N27/28

Abstract: In a capillary reference electrode with a capillary body which comprises a measuring chamber connected through an electrolytic bridge to a test sample which is adapted to be introduced into a capillary bore, the inlet orifice for the electrolyte is arranged at a point of the measuring chamber which is in a low position when the element is installed and the outlet orifice is arranged at a high position of the measuring chamber. The electrolytic bridge is formed through a communicating passage which has a substantially conical narrow end adjacent to the capillary bore with a very fine communication bore leading to the capillary bore. The resulting economy in electrolyte-consumption and absence of sensitivity in respect of potentially occuring air bubbles are further improved by providing the said communication bore with a substantially annular cross section.

Abstract translation: 在具有毛细管体的毛细管参比电极中，包括通过电解桥连接到适于引入毛细管孔的测试样品的测量室，用于电解质的入口孔布置在测量室的一个点处， 当元件安装时处于低位置，并且出口孔布置在测量室的高位置。 电解桥通过连通通道形成，该连通通道具有与毛细管孔相邻的基本圆锥形的窄端，具有通向毛细管孔的非常精细的连通孔。 通过提供具有基本上环形的横截面的所述连通孔，进一步改善了所产生的电解质消耗的经济性和对潜在的发生气泡的敏感性的缺乏。

公开(公告)号：US5193545A

公开(公告)日：1993-03-16

申请号：US476360

申请日：1990-02-07

Applicant: Hermann Marsoner ,  Falko Skrabal ,  Helmut List

Inventor： Hermann Marsoner ,  Falko Skrabal ,  Helmut List

IPC: A61B5/00

CPC classification number: A61B5/14542 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/686 ,  Y10S128/13

Abstract: A device designed for determining one or more medical variables in living organisms, comprises a part to be inserted into the tissue of the organism, which has an exchange channel with openings into the tissue. The device comprising a delivery unit connected with the exchange channel for the delivery of a perfusion fluid and its drainage after partial equilibration with the medical variable or quantity to be measured, i.e., preferably glucose concentration, and comparatively constant endogenous or exogenous marker variables. The device further comprising an analyzing unit for measuring the medical variable and one marker variable, and an evaluation unit for determining the actual concentration of the medical variable with the use of the marker variables. The proposal is put forward that the part to be inserted into the tissue is configured as a flexible plastic cannula, and that this cannula is provided with a puncturing needle on one end, and that the two ends of the cannula are connected to feeder and drainage tubes of the delivery unit both on the pressure and suction side.

Abstract translation: 设计用于确定活生物体中的一个或多个医学变量的装置包括要插入生物体的组织的部分，其具有与组织中的开口的交换通道。 该装置包括与用于输送灌注流体的交换通道连接的递送单元，以及在与待测量的医学变量或待测量的部分平衡之后的排水，即优选葡萄糖浓度，以及相对恒定的内源或外源标记变量。 该装置还包括用于测量医疗变量和一个标记变量的分析单元，以及用于使用标记变量来确定医疗变量的实际浓度的评估单元。 提出的是，要插入组织的部分被配置为柔性塑料插管，并且该套管在一端设有穿刺针，套管的两端连接到给料器和排水管 输送单元的管在压力和吸力侧。

公开(公告)号：US5185263A

公开(公告)日：1993-02-09

申请号：US785878

申请日：1991-11-04

Applicant: Herbert Kroneis ,  Hermann Marsoner ,  Taghi Noormofidi

Inventor： Herbert Kroneis ,  Hermann Marsoner ,  Taghi Noormofidi

IPC: G01N27/416

CPC classification number: G01N27/4165 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/115831

Abstract: In order to calibrate a measurement apparatus used for determining at least the pH and pCO.sub.2 values in aqueous media, two aqueous base solutions A and B with good storage stability are mixed at a defined ratio immediately prior to calibration, the desired pH and pCO.sub.2 values being provided for calibration of the measuring electrodes of the measurement apparatus only after chemical reaction of the base solutions A and B has taken place.

Abstract translation: 为了校准用于确定水性介质中的至少pH和pCO 2值的测量装置，具有良好储存稳定性的两种碱性水溶液A和B在校准之前以确定的比例混合，所需的pH和pCO 2值为 仅在基础溶液A和B发生化学反应之后才提供测量装置的测量电极的校准。

公开(公告)号：US4755667A

公开(公告)日：1988-07-05

申请号：US40628

申请日：1987-04-17

Applicant: Hermann Marsoner ,  Hellfried Karpf ,  Alfred Leitner

Inventor： Hermann Marsoner ,  Hellfried Karpf ,  Alfred Leitner

IPC: G01N21/64 ,  G01N21/27 ,  G01N21/77 ,  G02B6/34 ,  G02B6/42 ,  G01N21/00

CPC classification number: G02B6/34 ,  G01N21/7703 ,  G02B6/42 ,  G01N2201/0622

Abstract: A sensor element for use in determining the concentrations of substances contained in gaseous and liquid samples includes a carrier layer and an indicator layer containing one or more indicator substances whose optical properties change depending on the concentration of the substances to be measured, the carrier layer being provided with at least one photosensitive element with electrical contacts in planar arrangement, the indicator layer acting as a waveguide for excitation radiation coupled therein by an optical element.

Abstract translation: 用于确定气态和液体样品中所含物质浓度的传感器元件包括载体层和含有一种或多种指示物质的指示剂层，其指示剂物质的光学性质根据待测物质的浓度而变化，载体层为 设置有至少一个具有平面布置的电触头的感光元件，所述指示器层用作通过光学元件耦合在其中的激发辐射的波导。