公开(公告)号：US5039490A

公开(公告)日：1991-08-13

申请号：US40163

申请日：1987-04-17

Applicant: Hermann Marsoner ,  Herbert Kroneis ,  Hellfried Karpf ,  Otto S. Wolfbeis ,  Helmut List ,  Alfred Leitner

Inventor： Hermann Marsoner ,  Herbert Kroneis ,  Hellfried Karpf ,  Otto S. Wolfbeis ,  Helmut List ,  Alfred Leitner

IPC: G01N21/64 ,  G01N21/25 ,  G01N21/27 ,  G01N21/77 ,  G01N21/81

CPC classification number: G01N21/77 ,  G01N21/255 ,  G01N2021/174 ,  G01N2021/7786 ,  G01N21/6428 ,  G01N21/81 ,  G01N2201/0621 ,  G01N2201/0622

Abstract: Due to the size of the devices used for the excitation and measuring of light, conventional sensor elements for optically determining the concentrations of substances contained in gaseous and liquid samples, featuring an indicator layer with one or more indicator substances, are not well suited for use with microanalysis equipment, nor are they easy to mass-produce. These disadvantages are eliminated by using a unitary sensor element having a carrier layer, at least one photosensitive element with electric contact leads in contact with the carrier layer, and an indicator layer containing an indicator substance.

Abstract translation: 由于用于激发和测量光的装置的尺寸，用于光学确定气态和液体样品中所含物质浓度的常规传感器元件，其特征在于具有一个或多个指示剂物质的指示剂层，不太适用于 使用微量分析设备，也不易于批量生产。 这些缺点通过使用具有载体层的单一传感器元件，至少一个具有电接触引线与载体层接触的感光元件以及含有指示物质的指示剂层来消除。

公开(公告)号：US4587101A

公开(公告)日：1986-05-06

申请号：US553386

申请日：1983-11-18

Applicant: Hermann Marsoner ,  Herbert Kroneis

Inventor： Hermann Marsoner ,  Herbert Kroneis

IPC: G01N21/76 ,  C09K11/02 ,  C09K11/06 ,  G01N21/64 ,  G01N21/78 ,  G01N31/00 ,  G01N31/22

CPC classification number: G01N21/643 ,  C09K11/02 ,  C09K11/025 ,  C09K11/06 ,  G01N21/6428

Abstract: In a sensor element for determining the O.sub.2 content of a sample, comprising a fluorescent indicator substance which is embedded in a polymer carrier and with which the sample may be brought into contact, a fluorescence extinction sufficiently high for yielding useful measurement results is achieved by the use of plasticizer-compatible polymers as carrier materials which contain plasticizers in addition to the indicator molecules.

Abstract translation: 在用于确定样品的O 2含量的传感器元件中，包括嵌入在聚合物载体中并与样品接触的荧光指示物质，足够高的荧光消光以产生有用的测量结果，由 使用与增塑剂相容的聚合物作为载体材料，除了指示剂分子之外还含有增塑剂。

公开(公告)号：US4529495A

公开(公告)日：1985-07-16

申请号：US577835

申请日：1984-02-07

Applicant: Hermann Marsoner

Inventor： Hermann Marsoner

IPC: G01N21/77 ,  G01N25/00 ,  G01N27/28 ,  G01N27/40 ,  G01N27/404

CPC classification number: G01N27/40

Abstract: Between a substance to be analyzed and a sensor there is placed at least one membrane, forming part of a sample vessel containing a sample to be analyzed and being permeable for a species depending on the substance to be analyzed. This membrane constitutes at least one wall of the sample vessel, through which the active sensor surface may be brought into contact with the substance to be analyzed. The sensor is designed as a separate unit which is movable relative to the sample vessel, with which its membrane may be brought into contact. For the purpose of measurement the sensor is contacted by the membrane stretching over the active sensor surface which in itself does not carry a membrane.In this way the sensor cannot be contaminated by the sample, and the device may be successfully used for series measurements.

Abstract translation: 在要分析的物质和传感器之间放置至少一个膜，形成包含待分析样品的一部分样品容器，并且根据待分析的物质对物质是可渗透的。 该膜构成样品容器的至少一个壁，主动传感器表面可以与被分析物质接触。 传感器被设计成可以相对于样品容器移动的单独的单元，其膜可以与其接触。 为了测量的目的，传感器通过在主动传感器表面上伸展的膜接触，该传感器本身不携带膜。 以这种方式，传感器不能被样品污染，并且该装置可以成功地用于串联测量。

公开(公告)号：US5193545A

公开(公告)日：1993-03-16

申请号：US476360

申请日：1990-02-07

Applicant: Hermann Marsoner ,  Falko Skrabal ,  Helmut List

Inventor： Hermann Marsoner ,  Falko Skrabal ,  Helmut List

IPC: A61B5/00

CPC classification number: A61B5/14542 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/686 ,  Y10S128/13

Abstract: A device designed for determining one or more medical variables in living organisms, comprises a part to be inserted into the tissue of the organism, which has an exchange channel with openings into the tissue. The device comprising a delivery unit connected with the exchange channel for the delivery of a perfusion fluid and its drainage after partial equilibration with the medical variable or quantity to be measured, i.e., preferably glucose concentration, and comparatively constant endogenous or exogenous marker variables. The device further comprising an analyzing unit for measuring the medical variable and one marker variable, and an evaluation unit for determining the actual concentration of the medical variable with the use of the marker variables. The proposal is put forward that the part to be inserted into the tissue is configured as a flexible plastic cannula, and that this cannula is provided with a puncturing needle on one end, and that the two ends of the cannula are connected to feeder and drainage tubes of the delivery unit both on the pressure and suction side.

Abstract translation: 设计用于确定活生物体中的一个或多个医学变量的装置包括要插入生物体的组织的部分，其具有与组织中的开口的交换通道。 该装置包括与用于输送灌注流体的交换通道连接的递送单元，以及在与待测量的医学变量或待测量的部分平衡之后的排水，即优选葡萄糖浓度，以及相对恒定的内源或外源标记变量。 该装置还包括用于测量医疗变量和一个标记变量的分析单元，以及用于使用标记变量来确定医疗变量的实际浓度的评估单元。 提出的是，要插入组织的部分被配置为柔性塑料插管，并且该套管在一端设有穿刺针，套管的两端连接到给料器和排水管 输送单元的管在压力和吸力侧。

公开(公告)号：US5185263A

公开(公告)日：1993-02-09

申请号：US785878

申请日：1991-11-04

Applicant: Herbert Kroneis ,  Hermann Marsoner ,  Taghi Noormofidi

Inventor： Herbert Kroneis ,  Hermann Marsoner ,  Taghi Noormofidi

IPC: G01N27/416

CPC classification number: G01N27/4165 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/115831

Abstract: In order to calibrate a measurement apparatus used for determining at least the pH and pCO.sub.2 values in aqueous media, two aqueous base solutions A and B with good storage stability are mixed at a defined ratio immediately prior to calibration, the desired pH and pCO.sub.2 values being provided for calibration of the measuring electrodes of the measurement apparatus only after chemical reaction of the base solutions A and B has taken place.

Abstract translation: 为了校准用于确定水性介质中的至少pH和pCO 2值的测量装置，具有良好储存稳定性的两种碱性水溶液A和B在校准之前以确定的比例混合，所需的pH和pCO 2值为 仅在基础溶液A和B发生化学反应之后才提供测量装置的测量电极的校准。

公开(公告)号：US4755667A

公开(公告)日：1988-07-05

申请号：US40628

申请日：1987-04-17

Applicant: Hermann Marsoner ,  Hellfried Karpf ,  Alfred Leitner

Inventor： Hermann Marsoner ,  Hellfried Karpf ,  Alfred Leitner

IPC: G01N21/64 ,  G01N21/27 ,  G01N21/77 ,  G02B6/34 ,  G02B6/42 ,  G01N21/00

CPC classification number: G02B6/34 ,  G01N21/7703 ,  G02B6/42 ,  G01N2201/0622

Abstract: A sensor element for use in determining the concentrations of substances contained in gaseous and liquid samples includes a carrier layer and an indicator layer containing one or more indicator substances whose optical properties change depending on the concentration of the substances to be measured, the carrier layer being provided with at least one photosensitive element with electrical contacts in planar arrangement, the indicator layer acting as a waveguide for excitation radiation coupled therein by an optical element.

Abstract translation: 用于确定气态和液体样品中所含物质浓度的传感器元件包括载体层和含有一种或多种指示物质的指示剂层，其指示剂物质的光学性质根据待测物质的浓度而变化，载体层为 设置有至少一个具有平面布置的电触头的感光元件，所述指示器层用作通过光学元件耦合在其中的激发辐射的波导。

公开(公告)号：US4704893A

公开(公告)日：1987-11-10

申请号：US903199

申请日：1986-09-03

Applicant: Hermann Marsoner ,  Gerald Kirchmayer ,  Helmut List

Inventor： Hermann Marsoner ,  Gerald Kirchmayer ,  Helmut List

IPC: G01N33/483 ,  G01N1/22

CPC classification number: G01N33/4925 ,  Y10T436/25

Abstract: A device for equilibrating small quantities of a liquid reagent or a test solution with a gas-containing liquid or a gas in which at least part of the passage of the reagent leads through a hollow space that is separated by a permeable wall from a gas chamber which is closed, except for an inlet and an outlet opening, and which may be charged with the gas or gas-containing liquid. In order to ensure good mixing of the test liquid during equilibration, the hollow space carrying the liquid is configured as a tube or hose with one or more helical sections inside the gas chamber whose walls are permeable to the gas.

Abstract translation: 一种用于使含有气体的液体或气体平衡少量液体试剂或测试溶液的装置，其中试剂的至少一部分通道穿过由透气壁与气室隔开的中空空间 除了入口和出口之外，其是封闭的，并且可以装入气体或含气体的液体。 为了在平衡期间确保测试液体的良好混合，承载液体的中空空间被配置为具有一个或多个螺旋部分的管或软管，其内部的气体可渗透气体室内。

公开(公告)号：US4670127A

公开(公告)日：1987-06-02

申请号：US798959

申请日：1985-11-18

Applicant: Christoph Ritter ,  Massoud Ghahramani ,  Hermann Marsoner

Inventor： Christoph Ritter ,  Massoud Ghahramani ,  Hermann Marsoner

IPC: G01N27/333 ,  G01N27/30

CPC classification number: G01N27/3335

Abstract: In order to produce a sensitive membrane electrode with high selectivity with respect to other anions and lipophilic ions or interfering substances, the membrane is based on an unplasticized polymer matrix whose content of electroactive component is between 50 and 90 percent by weight.

Abstract translation: 为了产生相对于其它阴离子和亲脂性离子或干扰物质具有高选择性的敏感膜电极，膜基于未增塑的聚合物基质，其电活性组分的含量为50-90重量％。

公开(公告)号：US4512953A

公开(公告)日：1985-04-23

申请号：US380874

申请日：1982-05-21

Applicant: Hermann Marsoner ,  Christoph Ritter ,  Erich Kleinhappl ,  Winfried Strutz

Inventor： Hermann Marsoner ,  Christoph Ritter ,  Erich Kleinhappl ,  Winfried Strutz

IPC: G01N35/02 ,  G01N35/08 ,  G01N35/10 ,  G01N35/00

CPC classification number: G01N35/10 ,  Y10T436/115831 ,  Y10T436/117497 ,  Y10T436/118339

Abstract: An analyzing apparatus for the analysis of liquid samples is provided with a single sample input unit and a serial sample input unit which may alternatively be connected to a joint evaluation unit by means of a change-over switch. This will permit the measurement of single samples during a serial sample run by interrupting the automated process, additional provisions ensuring an automatic return to the serial sample mode.

Abstract translation: 用于分析液体样品的分析装置设置有单个样本输入单元和串行样本输入单元，其可以通过转换开关替代地连接到联合评估单元。 这将允许在串行采样运行期间通过中断自动化过程来测量单个样本，另外的条件确保自动返回到串行采样模式。

公开(公告)号：US5160420A

公开(公告)日：1992-11-03

申请号：US692695

申请日：1991-04-29

Applicant: Hermann Marsoner ,  Horst Ruther

Inventor： Hermann Marsoner ,  Horst Ruther

IPC: G01N35/08

CPC classification number: G01N35/08

Abstract: An analyzing apparatus for the purpose of analyzing samples of body fluids, comprising a sample feeding device and a measuring channel in which measuring probes are contained. In order to attain good reproducibility and uniform conditions of treatment of the samples the measuring channel is separated by means of a valve from a storage tank communicating with the sample feeding device.

Abstract translation: 用于分析体液样本的分析装置，包括样本供给装置和测量通道，其中包含测量探针。 为了获得良好的再现性和均匀的样品处理条件，通过阀与来自与样品供给装置连通的储存罐分离测量通道。