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    METHOD AND SYSTEM FOR OPTICAL OR ELECTRICAL MEASUREMENTS IN DISPERSE FLUIDS
    23.
    发明申请
    METHOD AND SYSTEM FOR OPTICAL OR ELECTRICAL MEASUREMENTS IN DISPERSE FLUIDS 有权

    公开(公告)号：US20210283607A1

    公开(公告)日：2021-09-16

    申请号：US16336832

    申请日：2017-10-09

    Applicant: ACOUSORT AB ,  INSTRUMENTATION LABORATORY COMPANY

    Inventor： Per AUGUSTSSON ,  Pelle Daniel OHLSSON ,  Ola JAKOBSSON ,  Klara ANDERSSON ,  Gert BLANKENSTEIN ,  Josef KERIMO ,  Ethan SCHONBRUN

    IPC: B01L3/00 ,  G01N33/49 ,  G01N1/40

    Abstract: The invention relates to a method of performing an optical or electrical measurement in a sample of a disperse fluid, the sample comprising particles and a fluid. The method comprises the steps of: a) positioning the sample in a microfluidic cavity having a resonance frequency, b) subjecting the sample, in the cavity, to an acoustic standing wave configured for causing the particles to congregate in at least one first region of the cavity, thereby causing the fluid to occupy at least one second region of the cavity, wherein the frequency of the acoustic standing wave is varied between a frequency below the resonance frequency and a frequency above the resonance frequency, and c) performing an optical or electrical measurement in the fluid in at least one of the at least one second region of the cavity. Varying the frequency ensures reproducible results. The invention also relates to a system therefore and a method and system for measuring hematocrit.

    Hematocrit Level Detection Using IR Laser Refraction
    25.
    发明申请
    Hematocrit Level Detection Using IR Laser Refraction 审中-公开

    公开(公告)号：US20200237273A1

    公开(公告)日：2020-07-30

    申请号：US16774903

    申请日：2020-01-28

    Applicant: Instrumentation Laboratory Company

    Inventor： Paul McCormack ,  Stephanie Annessi ,  Alberto Gomes

    IPC: A61B5/145 ,  G01N33/48 ,  G01F23/292 ,  A61M1/36

    Abstract: Principals of refraction of a light ray are used to identify the location of an interface between two materials having different refractive indices. The interface may be an interface between a plasma layer and a red blood cell layer of a centrifuged container, for example. An array of light detector elements are arranged to receive light that has been refracted through different layers in a centrifuged sample. Elements of the light detector array are arranged at known locations relative to an emitter of the light so detection of light by one or more particular detector elements is indicative of the angle of refraction of the light. Vertical position of the sample is tracked and correlated with corresponding angles of refraction to determine the vertical position of the sample when a change in the angle of diffraction is detected.

    Optical flow cell and test head apparatus
    27.
    发明授权
    Optical flow cell and test head apparatus 有权

    公开(公告)号：US10324025B2

    公开(公告)日：2019-06-18

    申请号：US15971061

    申请日：2018-05-04

    Applicant: Instrumentation Laboratory Company

    Inventor： Brian Joseph Bosy ,  Josef Kerimo

    IPC: G01N21/01 ,  G01N21/05 ,  G01N21/03 ,  G01N21/27 ,  G01N33/49 ,  B01L3/00 ,  G01N21/11

    Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member made from an optically clear material and a second plate member made from an optically clear material and opposing the first plate member. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal. The floating seal surrounds a fluid chamber that retains a sample of body fluid for optical measurement. The fluid chamber may be opened for flushing by separating the first plate member from the second plate member. During measurements the fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member.

    Optical flow cell apparatus and method for reducing deflection of sample chamber
    28.
    发明授权
    Optical flow cell apparatus and method for reducing deflection of sample chamber 有权

    公开(公告)号：US10288556B2

    公开(公告)日：2019-05-14

    申请号：US15694083

    申请日：2017-09-01

    Applicant: Instrumentation Laboratory Company

    Inventor： Brian Joseph Bosy ,  Josef Kerimo

    IPC: G01N21/31 ,  G01N21/05 ,  B01L3/00 ,  G01N21/03 ,  G01N33/49 ,  G01N21/11

    Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member and a second plate member made from an optically clear material. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal, which surrounds a fluid sample chamber. The fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member. The seal channel is vented to prevent fluid pressure from flexing the first plate member or the second plate member. An actuator having an extended foot portion extends over the fluid chamber to help prevent flexing of the first plate member or the second plate member.

    Cuvette-based apparatus for blood coagulation measurement and testing
    29.
    发明授权
    Cuvette-based apparatus for blood coagulation measurement and testing 有权

    公开(公告)号：US10180419B2

    公开(公告)日：2019-01-15

    申请号：US13959007

    申请日：2013-08-05

    Applicant: Instrumentation Laboratory Company

    Inventor： Gregory M. Colella ,  Henry D. Huang ,  Anthony F. Kuklo, Jr. ,  Dimitri Shishkin ,  Maria Figueroa ,  James A. Mawhirt

    IPC: G01N33/49 ,  B01L3/00

    Abstract: An apparatus for measuring blood clotting time includes a blood clot detection instrument and a cuvette for use with the blood clot detection instrument. The cuvette includes a blood sample receptor-inlet; a channel arrangement including at least one test channel for performing a blood clotting time measurement, a sampling channel having at least one surface portion that is hydrophilic, communicating with the blood sample receptor-inlet and the at least one test channel, and a waste channel having at least one surface portion that is hydrophilic, communicating with the sampling channel; and a vent opening communicating with the sampling channel. The sampling channel, the vent opening and the waste channel, coact to automatically draw a requisite volume of a blood sample deposited at the blood receptor-inlet, into the sampling channel.

    Method and Apparatus For Linear and Rotational Container Agitation
    30.
    发明申请
    Method and Apparatus For Linear and Rotational Container Agitation 审中-公开

    公开(公告)号：US20180345235A1

    公开(公告)日：2018-12-06

    申请号：US15981179

    申请日：2018-05-16

    Applicant: Instrumentation Laboratory Company

    Inventor： Renen Bassik

    IPC: B01F11/00 ,  G01N1/38 ,  B01F15/00

    CPC classification number: B01F11/0062 ,  B01F11/0025 ,  F16H25/122

    Abstract: A linear actuator member applies a vertical force to a vessel or to a holding apparatus in which a vessel is contained. A linear to angular motion constraining member such as a cage structure having a helical track translates linearly directed force and motion applied by the linear actuator member into a combined linear and rotational motion of the vessel. The combined vertical and rotational motion of the vessel in response to the vertical force is repeatable according to a predefined agitation pattern for mixing components in the vessel.

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