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    CARTRIDGES, CONTAINERS, AND/OR PROBES, AND SYSTEMS, DEVICES, AND METHODS FOR USING THEM IN TESTING
    2.
    发明申请
    CARTRIDGES, CONTAINERS, AND/OR PROBES, AND SYSTEMS, DEVICES, AND METHODS FOR USING THEM IN TESTING 有权

    公开(公告)号：US20230008204A1

    公开(公告)日：2023-01-12

    申请号：US17305504

    申请日：2021-07-08

    Applicant: Instrumentation Laboratory Company

    Inventor： Christopher FARREN ,  Joshua A. SHREVE ,  Hugh FOLSOM

    IPC: A61J1/14 ,  A61J1/06 ,  A61J1/20

    Abstract: The embodiments of the present disclosure provide a pierceable stopper, comprising a plug portion, and a disk portion disposed on top of the plug portion and comprising a flange extending radially beyond an outer diameter of the plug portion. The embodiments also provide a lyophilization stopper, comprising a body comprising an integral hinge means, and a flange extending radially beyond an outer diameter of the body. Additionally, the embodiments provide a probe assembly, comprising a first needle comprising a hollow cavity and a pointed tip, and a second needle disposed inside the hollow cavity and comprising a rounded tip. The embodiments further provide a cartridge assembly, comprising a first housing comprising a first set of cavities configured to accommodate one or more containers, and a second housing comprising a second set of cavities corresponding to the first set of cavities when the second housing is coupled to the first housing.

    DETERMINING A PLATELET AGGREGATION VALUE
    3.
    发明申请
    DETERMINING A PLATELET AGGREGATION VALUE 有权

    公开(公告)号：US20220400983A1

    公开(公告)日：2022-12-22

    申请号：US17352550

    申请日：2021-06-21

    Applicant: Instrumentation Laboratory Company

    Inventor： Cory Lee McCluskey ,  Robert S. Hillman

    IPC: A61B5/1459 ,  G01N21/49

    Abstract: An example system includes a chamber to hold a mixture that includes a whole blood sample from a patient, a light source to illuminate the mixture in the chamber, a detector to detect light from the light source transmitted through the mixture in the chamber, and one or more processing devices to determine, based on the light detected by the detector, a platelet aggregation value of the whole blood sample that is substantially independent of a hematocrit of the whole blood sample.

    Disposable hemolysis sensor
    4.
    发明授权
    Disposable hemolysis sensor 有权

    公开(公告)号：US11231409B2

    公开(公告)日：2022-01-25

    申请号：US16591413

    申请日：2019-10-02

    Applicant: Instrumentation Laboratory Company

    Inventor： Brian Joseph Bosy ,  Josef Kerimo

    IPC: G01N33/49 ,  G01N15/14

    Abstract: An apparatus for measuring hemolysis in a cartridge based automated blood analyzer is described. The apparatus allows hemolysis testing to be performed on a sample which is presented as a whole blood sample for other testing by the cartridge based automated blood analyzer. A disposable module is configured for optically analyzing one or more plasma analytes in a flow cell while red blood cells are acoustically separated from plasma in the flow cell.

    Methods and systems for point-of-care coagulation assays by optical detection
    5.
    发明授权
    Methods and systems for point-of-care coagulation assays by optical detection 有权

    公开(公告)号：US11079325B2

    公开(公告)日：2021-08-03

    申请号：US14696756

    申请日：2015-04-27

    Applicant: Instrumentation Laboratory Company

    Inventor： Josef Kerimo ,  Hansong Zeng ,  Ron Scharlack ,  Gert Blankenstein

    IPC: G01N21/53 ,  G01N21/64 ,  G01N21/65 ,  G01N33/49 ,  G01N21/59

    Abstract: This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.

    Total protein measurement using whole blood refractometry
    8.
    发明授权
    Total protein measurement using whole blood refractometry 有权

    公开(公告)号：US10648907B2

    公开(公告)日：2020-05-12

    申请号：US16403180

    申请日：2019-05-03

    Applicant: Instrumentation Laboratory Company

    Inventor： Ethan Schonbrun ,  Lara Adib ,  Gert Blankenstein

    IPC: G01N21/41 ,  G01N21/27 ,  G01N33/68 ,  G01N33/49

    Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.

    Cuvette-based apparatus for blood coagulation measurement and testing
    9.
    发明授权
    Cuvette-based apparatus for blood coagulation measurement and testing 有权

    公开(公告)号：US10578605B2

    公开(公告)日：2020-03-03

    申请号：US16210433

    申请日：2018-12-05

    Applicant: Instrumentation Laboratory Company

    Inventor： Gregory M. Colella ,  Henry D. Huang ,  Anthony F. Kuklo, Jr. ,  Dimitri Shishkin ,  Maria Figueroa ,  James A. Mawhirt

    IPC: G01N33/49 ,  B01L3/00

    Abstract: An apparatus for measuring blood clotting time includes a blood clot detection instrument and a cuvette for use with the blood clot detection instrument. The cuvette includes a blood sample receptor-inlet; a channel arrangement including at least one test channel for performing a blood clotting time measurement, a sampling channel having at least one surface portion that is hydrophilic, communicating with the blood sample receptor-inlet and the at least one test channel, and a waste channel having at least one surface portion that is hydrophilic, communicating with the sampling channel; and a vent opening communicating with the sampling channel. The sampling channel, the vent opening and the waste channel, coact to automatically draw a requisite volume of a blood sample deposited at the blood receptor-inlet, into the sampling channel. More specifically, air compressed within the blood clot detection instrument, the at least one test channel of the cuvette, and the section of the sampling channel extending beyond the vent opening of the cuvette, coacts with the waste channel to cause a leading edge of the blood sample drawn into the sampling channel from the blood receptor-inlet, to pull back within the sampling channel and uncover an optical sensor in of the blood clot detection instrument. The uncovering of the optical sensor activates a pump module of the blood clot detection instrument, which draws the requisite volume of the blood sample into the at least one test channel.

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