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21.发明申请GENTIC POLYMORPHISMS ASSOCIATED WITH STROKE, METHODS OF DETECTION AND USES THEREOF 审中-公开与STROKE相关的生物多样性，检测方法及其用途公开(公告)号：US20090221620A1
公开(公告)日：2009-09-03
申请号：US12389313
申请日：2009-02-19
Applicant: May Luke , James J. Devlin
Inventor： May Luke , James J. Devlin
IPC: A61K31/505 , C12Q1/68 , A61K31/22 , A61K31/40 , A61K31/35 , A61K31/435 , A61K31/404 , A61P25/00
CPC classification number: C12Q1/6883 , A61K31/22 , A61K31/35 , A61K31/40 , A61K31/404 , A61K31/435 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with vascular diseases such as stroke. In particular, the present invention relates to genetic polymorphisms that have utility for such uses as predicting disease risk or predicting an individual's response to a treatment such as statins, including groups of polymorphisms that may be used as a signature marker set for such uses, as well as nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明提供了与诸如中风等血管疾病相关的遗传多态性的组合物和方法。 特别地，本发明涉及对预测疾病风险或预测个体对治疗的反应（例如他汀类药物）的用途的遗传多态性，所述治疗包括可以用作为此类用途设定的签名标记的多形性组，如 以及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态性核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用试剂进行检测的方法。
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22.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH STROKE, METHODS OF DETECTION AND USES THEREOF 审中-公开与STROKE相关的遗传多态性，检测方法及其用途公开(公告)号：US20090170111A1
公开(公告)日：2009-07-02
申请号：US12341083
申请日：2008-12-22
Applicant: May M. LUKE , James J. DEVLIN , Michele CARGILL
Inventor： May M. LUKE , James J. DEVLIN , Michele CARGILL
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/156
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases, particularly stroke. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明基于与血管疾病特别是中风相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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公开(公告)号：US06747031B2
公开(公告)日：2004-06-08
申请号：US10121379
申请日：2002-04-12
Applicant: Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
Inventor： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
IPC: A61K31506
CPC classification number: C07D231/12 , C07D233/56 , C07D249/08
Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
Abstract translation: 式（I）的N-杂环衍生物：本文描述以及其它N-杂环作为一氧化氮合酶的抑制剂。 含有这些化合物的药物组合物，使用这些化合物作为一氧化氮合酶抑制剂的方法以及合成这些化合物的方法也在本文中描述。
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公开(公告)号：US06432947B1
公开(公告)日：2002-08-13
申请号：US09383813
申请日：1999-08-26
Applicant: Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
Inventor： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
IPC: A61K31506
CPC classification number: C07D231/12 , C07D233/56 , C07D249/08
Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
Abstract translation: 式（I）的N-杂环衍生物：本文描述以及其它N-杂环作为一氧化氮合酶的抑制剂。 含有这些化合物的药物组合物，使用这些化合物作为一氧化氮合酶抑制剂的方法以及合成这些化合物的方法也在本文中描述。
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25.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS, METHODS OF DETECTION AND USES THEREOF 审中-公开与VENOUS THROMBOSIS相关的遗传多态性，检测方法及其用途公开(公告)号：US20120264692A1
公开(公告)日：2012-10-18
申请号：US13270936
申请日：2011-10-11
Applicant: Lance BARE , James J. DEVLIN , Frits R. ROSENDAAL , Pieter H. REITSMA , Irene D. BEZEMER
Inventor： Lance BARE , James J. DEVLIN , Frits R. ROSENDAAL , Pieter H. REITSMA , Irene D. BEZEMER
IPC: C12Q1/68 , A61K31/616 , A61K31/4365 , A61K31/37 , A61K31/727 , G01N27/447 , A61K31/702 , A61K31/4709 , A61K38/55 , A61K31/4439 , A61P7/02 , G01N21/64 , A61K31/122
CPC classification number: C12Q1/6883 , A61K31/352 , A61K31/4365 , A61K31/4439 , A61K31/47 , A61K31/60 , A61K31/715 , A61K31/727 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N35/00
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with venous thrombosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明基于与静脉血栓形成相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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Patent Agency Ranking
26.发明授权Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof 有权与心血管疾病相关的遗传多态性，检测方法及其应用公开(公告)号：US08216786B2
公开(公告)日：2012-07-10
申请号：US12500378
申请日：2009-07-09
Applicant: Dov Shiffman , James J. Devlin , Judy Z. Louie , Eric Boerwinkle
Inventor： Dov Shiffman , James J. Devlin , Judy Z. Louie , Eric Boerwinkle
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明提供了与心血管疾病特别是冠心病（尤其是心肌梗死）或高血压有关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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27.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS, METHODS OF DETECTION AND USES THEREOF 有权与VENOUS THROMBOSIS相关的遗传多态性，检测方法及其用途公开(公告)号：US20120039864A1
公开(公告)日：2012-02-16
申请号：US13023295
申请日：2011-02-08
Applicant: Lance BARE , James J. DEVLIN , Frits R. ROSENDAAL , Pieter H. REITSMA , Irene D. BEZEMER
Inventor： Lance BARE , James J. DEVLIN , Frits R. ROSENDAAL , Pieter H. REITSMA , Irene D. BEZEMER
IPC: A61K39/395 , G01N33/566 , A61P7/02 , C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular VT and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明基于与冠心病相关的遗传多态性的发现，特别是VT和对药物治疗的反应。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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28.发明授权Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof 有权与静脉血栓形成相关的遗传多态性，检测方法及其用途公开(公告)号：US08071291B2
公开(公告)日：2011-12-06
申请号：US12403552
申请日：2009-03-13
Applicant: Lance Bare , James J. Devlin , Frits R. Rosendaal , Pieter H. Reitsma , Irene D. Bezemer
Inventor： Lance Bare , James J. Devlin , Frits R. Rosendaal , Pieter H. Reitsma , Irene D. Bezemer
CPC classification number: C12Q1/6883 , A61K31/352 , A61K31/4365 , A61K31/4439 , A61K31/47 , A61K31/60 , A61K31/715 , A61K31/727 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N35/00
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with venous thrombosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明基于与静脉血栓形成相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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29.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH STATIN RESPONSE AND CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF 审中-公开与STATIN反应和心血管疾病相关的遗传多态性，检测方法及其用途公开(公告)号：US20110269735A1
公开(公告)日：2011-11-03
申请号：US13085955
申请日：2011-04-13
Applicant: Dov SHIFFMAN , James J. DEVLIN , May LUKE , David A. ROSS
Inventor： Dov SHIFFMAN , James J. DEVLIN , May LUKE , David A. ROSS
IPC: C12Q1/68 , A61K31/397 , C07H21/04 , A61K31/366 , A61P9/10 , A61K31/505 , A61K31/22 , A61K31/405 , A61P9/00 , A61K31/455 , A61K31/40
CPC classification number: C12Q1/6883 , A61K31/22 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/405 , A61K31/455 , A61K31/505 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G06F19/18 , G06F19/20 , G16B20/00 , G16B25/00
Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection.
Abstract translation: 本发明提供了基于与他汀类药物治疗反应相关的遗传多态性的组合物和方法，特别是用于降低心血管疾病，特别是冠心病（例如心肌梗死）和中风的风险。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态核酸分子和变体蛋白的试剂和试剂盒，以及使用核酸分子和蛋白质的方法 作为使用试剂和试剂盒进行检测的方法。
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30.发明申请Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof 审中-公开与冠心病相关的遗传多态性，检测方法及其用途公开(公告)号：US20090312410A1
公开(公告)日：2009-12-17
申请号：US11788862
申请日：2007-04-20
Applicant: Dov Shiffman , James J. Devlin
Inventor： Dov Shiffman , James J. Devlin
CPC classification number: C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2500/04 , G01N2800/324
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, specifically MI and including early-onset MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明基于与冠心病相关的遗传多态性的发现，特别是MI并且包括早发性MI和对药物治疗的反应。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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