公开(公告)号：US06849739B2

公开(公告)日：2005-02-01

申请号：US10121212

申请日：2002-04-12

Applicant: Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

Inventor： Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

IPC: C07D403/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/547 ,  A61P1/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/02 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07D213/00 ,  C07D233/00 ,  C07D239/00 ,  C07D241/02 ,  C07D265/00 ,  C07D279/00 ,  C07D317/44 ,  C07D319/00 ,  C07D333/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D521/00 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

公开(公告)号：US06372751B1

公开(公告)日：2002-04-16

申请号：US09539812

申请日：2000-03-30

Applicant: David D. Davey ,  Gary B. Phillips

Inventor： David D. Davey ,  Gary B. Phillips

IPC: C07D23952

CPC classification number: C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: wherein Z1, Z2, R1, R2, R3, R4, R5 and R6 are defined herein. These compounds are useful as anti-coagulants.

Abstract translation: 本发明涉及选自下式的芳基和杂环基取代的嘧啶衍生物：其中Z 1，Z 2，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 这些化合物可用作抗凝剂。

公开(公告)号：US5171858A

公开(公告)日：1992-12-15

申请号：US687143

申请日：1991-04-18

Applicant: David D. Davey

Inventor： David D. Davey

IPC: C07D213/38 ,  C07D471/04 ,  C07D521/00

CPC classification number: C07D231/12 ,  C07D213/38 ,  C07D233/56 ,  C07D249/08 ,  C07D471/04

Abstract: This invention relates to novel substituted imidazo-[1,5-a]pyridines, most especially novel 8-phenylimidazo-[1,5-a]pyridines. It also relates to novel intermediates and to a novel process for the preparation of certain of these compounds. The compounds of the invention have been found to have significant cardiotonic, antiarrhythmic, hypotensive, CNS stimulant, and other pharmacological effects.

Abstract translation: 本发明涉及新的取代的咪唑并[1,5-a]吡啶，最特别的是新的8-苯基咪唑并〔1,5-a〕吡啶。 它还涉及新型中间体和用于制备某些这些化合物的新方法。 已经发现本发明的化合物具有显着的强心剂，抗心律失常药，降血压药，CNS兴奋剂等药理作用。

公开(公告)号：US5055465A

公开(公告)日：1991-10-08

申请号：US359182

申请日：1989-05-31

Applicant: David D. Davey

Inventor： David D. Davey

IPC: C07D471/14 ,  C07D487/04

CPC classification number: C07D471/14 ,  C07D487/04

Abstract: This invention relates to novel imidazoquinoxalinones and their aza analogs and to a process for their preparation. The compounds of this invention have been found to have inodilatory, vasodilatory, venodilatory and other pharmacologic effects.

公开(公告)号：US06841673B2

公开(公告)日：2005-01-11

申请号：US10121886

申请日：2002-04-12

Applicant: Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

Inventor： Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

IPC: C07D403/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/547 ,  A61P1/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/02 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07D213/00 ,  C07D233/00 ,  C07D239/00 ,  C07D241/02 ,  C07D265/00 ,  C07D279/00 ,  C07D317/44 ,  C07D319/00 ,  C07D333/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D521/00 ,  C07D239/70

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

Abstract translation: 式（I）的N-杂环衍生物：本文描述以及其它N-杂环作为一氧化氮合酶的抑制剂。 含有这些化合物的药物组合物，使用这些化合物作为一氧化氮合酶抑制剂的方法以及合成这些化合物的方法也在本文中描述。

公开(公告)号：US06670473B2

公开(公告)日：2003-12-30

申请号：US10121808

申请日：2002-04-12

Applicant: Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

Inventor： Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

IPC: C07D47316

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

公开(公告)号：US6127376A

公开(公告)日：2000-10-03

申请号：US205498

申请日：1998-12-04

Applicant: David D. Davey ,  Gary B. Phillips

Inventor： David D. Davey ,  Gary B. Phillips

IPC: A61K31/495 ,  A61K31/506 ,  A61P3/10 ,  A61P7/02 ,  A61P9/10 ,  A61P11/00 ,  A61P31/04 ,  A61P35/02 ,  A61P43/00 ,  C07D239/24 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  A61K31/505 ,  C07D239/52

CPC classification number: C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: ##STR1## wherein Z.sup.1, Z.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein. These compounds are useful as anti-coagulants.

Abstract translation: 本发明涉及选自下式的芳基和杂环基取代的嘧啶衍生物：其中Z 1，Z 2，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 这些化合物可用作抗凝剂。

公开(公告)号：US6034103A

公开(公告)日：2000-03-07

申请号：US910609

申请日：1997-08-13

Applicant: Brad O. Buckman ,  David D. Davey ,  William J. Guilford ,  Michael M. Morrissey ,  Howard P. Ng ,  Gary B. Phillips ,  Shung C. Wu ,  Wei Xu

Inventor： Brad O. Buckman ,  David D. Davey ,  William J. Guilford ,  Michael M. Morrissey ,  Howard P. Ng ,  Gary B. Phillips ,  Shung C. Wu ,  Wei Xu

IPC: A61P7/02 ,  C07C257/18 ,  C07C275/42 ,  C07D213/69 ,  C07D213/74 ,  C07D213/79 ,  C07D213/81 ,  C07D213/82 ,  C07D239/52 ,  C07D241/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D521/00 ,  A61K31/43 ,  A61K31/44

CPC classification number: C07D213/69 ,  C07C257/18 ,  C07C275/42 ,  C07D213/74 ,  C07D213/79 ,  C07D213/81 ,  C07D213/82 ,  C07D231/12 ,  C07D233/56 ,  C07D239/52 ,  C07D241/18 ,  C07D249/08 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14

Abstract: This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

公开(公告)号：US6004981A

公开(公告)日：1999-12-21

申请号：US913241

申请日：1997-12-08

Applicant: Brad O. Buckman ,  David D. Davey ,  William J. Guilford ,  Michael M. Morrissey ,  Howard P. Ng ,  Gary B. Phillips ,  Shung C. Wu ,  Wei Xu

Inventor： Brad O. Buckman ,  David D. Davey ,  William J. Guilford ,  Michael M. Morrissey ,  Howard P. Ng ,  Gary B. Phillips ,  Shung C. Wu ,  Wei Xu

IPC: C07D213/69 ,  A61K31/44 ,  C07D213/79 ,  C07D401/04 ,  C07D401/12

CPC classification number: C07D213/69

Abstract: This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

Abstract translation: PCT No.PCT / US96 / 02641 Sec。 371 1997年12月8日第 102（e）日期1997年12月8日PCT 1996年3月8日PCT公布。 WO96 / 28427 PCT出版物 日期1996年9月19日本发明涉及可用作抗凝剂的苯甲脒衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。

公开(公告)号：US5877181A

公开(公告)日：1999-03-02

申请号：US910774

申请日：1997-08-13

Applicant: Brad O. Buckman ,  David D. Davey ,  William J. Guilford ,  Michael M. Morrissey ,  Howard P. Ng ,  Gary B. Phillips ,  Shung C. Wu ,  Wei Xu

Inventor： Brad O. Buckman ,  David D. Davey ,  William J. Guilford ,  Michael M. Morrissey ,  Howard P. Ng ,  Gary B. Phillips ,  Shung C. Wu ,  Wei Xu

IPC: A61P7/02 ,  C07C257/18 ,  C07C275/42 ,  C07D213/69 ,  C07D213/74 ,  C07D213/79 ,  C07D213/81 ,  C07D213/82 ,  C07D239/52 ,  C07D241/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D521/00 ,  A61K31/505 ,  C07D239/02 ,  C07D239/10

CPC classification number: C07D213/69 ,  C07C257/18 ,  C07C275/42 ,  C07D213/74 ,  C07D213/79 ,  C07D213/81 ,  C07D213/82 ,  C07D231/12 ,  C07D233/56 ,  C07D239/52 ,  C07D241/18 ,  C07D249/08 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14

Abstract: This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.