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1.发明授权Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 有权与心肌梗死相关的遗传多态性，检测方法及其用途公开(公告)号：US07781168B2
公开(公告)日：2010-08-24
申请号：US12287505
申请日：2008-10-08
Applicant: Olga Iakoubova , James J. Devlin
Inventor： Olga Iakoubova , James J. Devlin
CPC classification number: C12Q1/6883 , C12Q2600/156
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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2.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF 审中-公开与心血管疾病相关的遗传多态性与药物反应，检测方法及其用途公开(公告)号：US20100190172A1
公开(公告)日：2010-07-29
申请号：US12683099
申请日：2010-01-06
Applicant: Michele CARGILL , Olga IAKOUBOVA , James J. DEVLIN , Zenta TSUCHIHASHI , Peter SHAW , Lynn Marie PLOUGHMAN , Kim E. ZERBA , Koustubh RANADE , Todd KIRCHGESSNER
Inventor： Michele CARGILL , Olga IAKOUBOVA , James J. DEVLIN , Zenta TSUCHIHASHI , Peter SHAW , Lynn Marie PLOUGHMAN , Kim E. ZERBA , Koustubh RANADE , Todd KIRCHGESSNER
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , A61K31/22 , A61K31/225 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2800/32 , G01N2800/324
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明基于与心血管疾病特别是急性冠状动脉事件如心肌梗塞和中风相关的遗传多态性的发现，以及与个体对用他汀类药物治疗心血管疾病的反应性相关的遗传多态性。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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3.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH CORONARY EVENTS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF 有权与冠状动脉和药物反应相关的遗传多态性，检测方法及其用途公开(公告)号：US20100120040A1
公开(公告)日：2010-05-13
申请号：US12569475
申请日：2009-09-29
Applicant: Olga IAKOUBOVA , James J. DEVLIN , Charles ROWLAND , Carmen TONG
Inventor： Olga IAKOUBOVA , James J. DEVLIN , Charles ROWLAND , Carmen TONG
CPC classification number: C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32 , G01N2800/324 , G01N2800/329 , Y10T436/143333
Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明提供了与冠心病（特别是心肌梗塞），动脉瘤/解剖和/或对药物治疗，特别是他汀类药物治疗的反应相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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4.发明授权公开(公告)号：US07482117B2
公开(公告)日：2009-01-27
申请号：US10741600
申请日：2003-12-22
Applicant: Michele Cargill , James J. Devlin , Olga Iakoubova
Inventor： Michele Cargill , James J. Devlin , Olga Iakoubova
CPC classification number: C12Q1/6883 , C12Q2600/156
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
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公开(公告)号：US06864368B2
公开(公告)日：2005-03-08
申请号：US10122006
申请日：2002-04-12
Applicant: Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
Inventor： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
IPC: C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/547 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D213/00 , C07D233/00 , C07D239/00 , C07D241/02 , C07D265/00 , C07D279/00 , C07D317/44 , C07D319/00 , C07D333/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D521/00
CPC classification number: C07D231/12 , C07D233/56 , C07D249/08
Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
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Patent Agency Ranking
公开(公告)号：US06864263B2
公开(公告)日：2005-03-08
申请号：US10121659
申请日：2002-04-12
Applicant: Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
Inventor： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
IPC: C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/547 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D213/00 , C07D233/00 , C07D239/00 , C07D241/02 , C07D265/00 , C07D279/00 , C07D317/44 , C07D319/00 , C07D333/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D521/00
CPC classification number: C07D231/12 , C07D233/56 , C07D249/08
Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
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7.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF 审中-公开与心血管疾病相关的遗传多态性，检测方法及其用途公开(公告)号：US20130030051A1
公开(公告)日：2013-01-31
申请号：US13486424
申请日：2012-06-01
Applicant: Dov SHIFFMAN , James J. DEVLIN , Judy Z. LOUIE , Eric BOERWINKLE
Inventor： Dov SHIFFMAN , James J. DEVLIN , Judy Z. LOUIE , Eric BOERWINKLE
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明提供了与心血管疾病特别是冠心病（特别是心肌梗塞）或高血压相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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8.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF 有权与心血管疾病相关的遗传多态性，检测方法及其用途公开(公告)号：US20100035983A1
公开(公告)日：2010-02-11
申请号：US12500378
申请日：2009-07-09
Applicant: Dov SHIFFMAN , James J. DEVLIN , Judy Z. LOUIE , Eric BOERWINKLE
Inventor： Dov SHIFFMAN , James J. DEVLIN , Judy Z. LOUIE , Eric BOERWINKLE
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明提供了与心血管疾病特别是冠心病（尤其是心肌梗死）或高血压有关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。
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9.发明授权Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof 有权与冠状动脉狭窄相关的遗传多态性，检测方法及其用途公开(公告)号：US07625699B2
公开(公告)日：2009-12-01
申请号：US10796280
申请日：2004-03-10
Applicant: James J. Devlin , May M. Luke
Inventor： James J. Devlin , May M. Luke
CPC classification number: C12Q1/6883 , C12Q2600/156
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary stenosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明基于与冠状动脉狭窄相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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10.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH CORONARY HEART DISEASE, METHODS OF DETECTION AND USES THEREOF 审中-公开与冠状动脉疾病相关的遗传多态性，检测方法及其用途公开(公告)号：US20090264453A1
公开(公告)日：2009-10-22
申请号：US12430627
申请日：2009-04-27
Applicant: Dov SHIFFMAN , Michele CARGILL , James J. DEVLIN
Inventor： Dov SHIFFMAN , Michele CARGILL , James J. DEVLIN
CPC classification number: C12Q1/6883 , C12Q2600/156
Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, and in particular MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
Abstract translation: 本发明基于与冠心病相关的遗传多态性的发现，特别是MI和对药物治疗的反应。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。
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