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公开(公告)号：US20170084024A1
公开(公告)日：2017-03-23
申请号：US15224088
申请日：2016-07-29
Applicant: Novadaq Technologies Inc.
Inventor： Lina GUREVICH
IPC: G06T7/00
CPC classification number: A61B5/0071 , A61B5/0261 , A61B5/0275 , A61B5/445 , A61B2576/02
Abstract: Methods and systems for assessing tissue of a subject include receiving a time series of signal intensity data capturing the transit of an imaging agent through tissue over a period of time, wherein the tissue comprises a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to the calculation region; determining, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region; and converting the coefficient values across the plurality of calculation regions into a coefficient-derived image map.
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公开(公告)号：US20170084012A1
公开(公告)日：2017-03-23
申请号：US15224342
申请日：2016-07-29
Applicant: Novadaq Technologies Inc.
Inventor： Jorgen WALLE-JENSEN , Gregory Vincent BROWNE
CPC classification number: G06T5/009 , G06T5/50 , G06T7/0012 , G06T11/206 , G06T2200/24 , G06T2207/10064 , G06T2207/20208 , G06T2210/12
Abstract: Systems and methods for storing data for a first time series of fluorescence images of the subject acquired during a first imaging session, storing data for a second time series of fluorescence images of the subject acquired during a second imaging session, receiving a request to view attributes of the subject, and in response to receiving the request, displaying a user interface on the display, the user interface comprising a first image showing a visually enhanced attribute of the subject, wherein the first image is generated from the data for the first time series of fluorescence images, and a second image showing the visually enhanced attribute of the subject, wherein the second image is generated from the data for the second time series of fluorescence images.
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23.发明申请公开(公告)号：US20170064257A1
公开(公告)日：2017-03-02
申请号：US15343034
申请日：2016-11-03
Applicant: Novadaq Technologies Inc.
Inventor： Paul R. WESTWICK , David POTKINS , John FENGLER
Abstract: An endoscopic video system and method using a camera with a single color image sensor, for example a CCD color image sensor, for fluorescence and color imaging and for simultaneously displaying the images acquired in these imaging modes at video rates in real time is disclosed. The tissue under investigation is illuminated continuously with fluorescence excitation light and is further illuminated periodically using visible light outside of the fluorescence excitation wavelength range. The illumination sources may be conventional lamps using filters and shutters, or may include light-emitting diodes mounted at the distal tip of the endoscope.
Abstract translation: 公开了一种使用具有用于荧光和彩色成像的单色彩色图像传感器（例如CCD彩色图像传感器）的相机和用于以视频速率实时显示在这些成像模式中获取的图像的内窥镜视频系统和方法。 用荧光激发光连续照射被研究的组织，并使用荧光激发波长范围外的可见光进一步周期性地照射。 照明源可以是使用过滤器和百叶窗的常规灯，或者可以包括安装在内窥镜的远端的发光二极管。
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24.发明申请METHODS AND SYSTEMS FOR LASER SPECKLE IMAGING OF TISSUE USING A COLOR IMAGE SENSOR 审中-公开使用彩色图像传感器组织激光成像的方法和系统公开(公告)号：US20160328848A1
公开(公告)日：2016-11-10
申请号：US15148959
申请日：2016-05-06
Applicant: Novadaq Technologies Inc.
Inventor： Marc ANDRÉ , Arthur E. BAILEY , Paul Roald WESTWICK
CPC classification number: G06T7/0012 , A61B5/0059 , A61B5/0062 , A61B5/0075 , A61B5/0261 , A61B5/445 , G01N2021/479 , G06T7/90 , G06T2207/10004 , G06T2207/10024 , G06T2207/30104 , H04N1/482 , H04N1/603 , H04N1/6086
Abstract: Methods and systems for imaging tissue of a subject are disclosed, and involve illuminating the tissue with a coherent light having a coherent wavelength, acquiring image data of the tissue using a color image sensor, and processing the image data using laser speckle contrast analysis while correcting for differences in sensitivity of color pixels at the coherent wavelength to generate a perfusion image of the tissue. The perfusion image is then displayed to the user. Also disclosed are methods and systems for correcting for ambient light and for acquiring white light images along with laser speckle images.
Abstract translation: 公开了用于成像对象的组织的方法和系统，并且涉及用具有相干波长的相干光来照射组织，使用彩色图像传感器获取组织的图像数据，以及使用激光散斑对比分析来处理图像数据，同时校正 对于在相干波长处的彩色像素的灵敏度的差异来产生组织的灌注图像。 然后将灌注图像显示给用户。 还公开了用于校正环境光并用于获取白光图像以及激光散斑图像的方法和系统。
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公开(公告)号：US20160253800A1
公开(公告)日：2016-09-01
申请号：US15013945
申请日：2016-02-02
Applicant: Novadaq Technologies Inc.
Inventor： Lina GUREVICH , Jorgen WALLE-JENSEN
IPC: G06T7/00
CPC classification number: G06T7/0016 , A61B5/0071 , A61B5/445 , A61B6/486 , A61B6/507 , A61B6/5217 , A61B2576/02 , G06T2207/10064 , G06T2207/30088 , G06T2207/30096 , G06T2207/30104 , G06T2210/41 , G06T2211/404 , G16H50/50
Abstract: Methods and systems for characterizing tissue of a subject are disclosed. The method includes receiving a time series of fluorescence images of the tissue of the subject wherein the images define a plurality of calculation regions, generating a plurality of time-intensity curves for the plurality of calculation regions, creating a set of parameter values for each calculation region, generating a total rank value for each calculation region by comparing the sets of parameter values, and converting the total rank value into a ranking map image. Also disclosed are methods and systems for characterizing a wound in tissue by generating a wound index value.
Abstract translation: 公开了用于表征受试者组织的方法和系统。 该方法包括接收对象的组织的荧光图像的时间序列，其中图像限定多个计算区域，为多个计算区域生成多个时间 - 强度曲线，为每个计算创建一组参数值 区域，通过比较参数值的集合，并将总秩值转换为排名图图像来生成每个计算区域的总秩值。 还公开了通过产生伤口指数值来表征组织中伤口的方法和系统。
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Patent Agency Ranking
26.发明申请Compositions Comprising Fluorescent Dyes Associated With Viral Components For Nerve Imaging 审中-公开包含与用于神经成像的病毒组分相关的荧光染料的组合物公开(公告)号：US20160199515A1
公开(公告)日：2016-07-14
申请号：US15077677
申请日：2016-03-22
Applicant: NOVADAQ TECHNOLOGIES INC.
Inventor： Robert W. FLOWER
IPC: A61K49/00
CPC classification number: A61K49/0056 , A61K35/76 , A61K35/763 , A61K47/6901 , A61K49/0021 , A61K49/0034 , A61K49/0041 , A61K49/0043 , A61K49/0045 , A61K49/0097
Abstract: Disclosed herein is a composition for imaging nerve cells. The composition includes a fluorescent dye; and a viral component including a neurotropic herpes varicellae unable to replicate in nerve cells, a viral protein of a neurotropic herpes varicellae unable to replicate in nerve cells, a capsid of a neurotropic herpes varicellae unable to replicate in nerve cells, or a combination thereof. The fluorescent dye is bound to the viral component to form a dye/viral component complex that is capable of penetrating nerve cells.
Abstract translation: 本文公开了用于成像神经细胞的组合物。 该组合物包括荧光染料; 以及包含不能在神经细胞中复制的神经营养性疱疹性水痘的病毒成分，不能在神经细胞中复制的神经营养性疱疹性水痘病毒的病毒蛋白质，不能在神经细胞中复制的神经营养性疱疹性水痘的衣壳，或其组合。 荧光染料与病毒组分结合形成能够穿透神经细胞的染料/病毒组分复合物。
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27.发明申请IMAGING SYSTEM FOR COMBINED FULL-COLOR REFLECTANCE AND NEAR-INFRARED IMAGING 有权用于组合全彩色反射和近红外成像的成像系统公开(公告)号：US20160100763A1
公开(公告)日：2016-04-14
申请号：US14873842
申请日：2015-10-02
Applicant: NOVADAQ TECHNOLOGIES INC.
Inventor： John FENGLER , Paul R. WESTWICK , Aurther E. BAILEY , Paul COTTLE
CPC classification number: A61B5/0086 , A61B1/00009 , A61B1/00043 , A61B1/00045 , A61B1/0005 , A61B1/00163 , A61B1/00186 , A61B1/04 , A61B1/042 , A61B1/043 , A61B1/045 , A61B1/06 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0062 , A61B5/0071 , A61B5/0075 , A61B5/418 , A61B5/7425 , G06T2207/10048 , H04N5/33 , H04N5/332
Abstract: An imaging system for acquisition of NIR and full-color images includes a light source providing visible light and NIR light to an area under observation, such as living tissue, a camera having one or more image sensors configured to separately detect blue reflectance light, green reflectance light, and combined red reflectance light/detected NIR light returned from the area under observation. A controller in signal communication with the light source and the camera is configured to control the light source to continuously illuminate area under observation with temporally continuous blue/green illumination light and with red illumination light and NIR excitation light. At least one of the red illumination light and NIR excitation light are switched on and off periodically in synchronism with the acquisition of red and NIR light images in the camera.
Abstract translation: 用于获取NIR和全色图像的成像系统包括向可观察的区域提供可见光和NIR光的光源，例如活组织，具有一个或多个图像传感器的相机，其被配置为分别检测蓝色反射光，绿色 反射光和从观察区域返回的红外反射光/检测到的NIR光。 与光源和摄像机进行信号通信的控制器被配置为控制光源，以连续地照亮在时间上连续的蓝/绿照明光和红色照明光和NIR激发光下的观察区域。 与摄像机中的红色和NIR光图像的获取同步，周期性地打开和关闭红外照明光和NIR激发光中的至少一个。
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公开(公告)号：US20150256721A1
公开(公告)日：2015-09-10
申请号：US14636448
申请日：2015-03-03
Applicant: NOVADAQ TECHNOLOGIES INC.
Inventor： Frederick Allen MOORE
CPC classification number: A61B1/002 , A61B1/055 , G02B13/0095 , G02B23/2446 , G02B27/0062 , H04N2005/2255
Abstract: An optical system includes a first relay rod of a first material, a second relay rod of a second material, different from the first material, and a lens between the first and second relay rods.
Abstract translation: 光学系统包括第一材料的第一继电器杆，与第一材料不同的第二材料的第二继电器棒，以及在第一和第二继电器棒之间的透镜。
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29.发明申请METHODS FOR PRODUCTION AND USE OF SUBSTANCE-LOADED ERYTHROCYTES (S-IEs) FOR OBSERVATION AND TREATMENT OF MICROVASCULAR HEMODYNAMICS 审中-公开用于生产和使用物质负载型心脏病（S-IE）的观察和治疗微血管动力学的方法公开(公告)号：US20140308656A1
公开(公告)日：2014-10-16
申请号：US14177050
申请日：2014-02-10
Applicant: Novadaq Technologies, Inc.
Inventor： Robert W. Flower
IPC: C12N5/078
CPC classification number: C12N5/0641 , A61K9/5063 , A61K49/0034 , A61K49/0097
Abstract: Disclosed herein are methods, kits, and compositions for medical imaging relating to fluorescent dyes entrapped in erythrocytes. Also disclosed therein are methods, and compositions further comprising erythrocytes entrapping at least one therapeutically active agent, as well as methods for releasing the entrapped therapeutically active agent(s). Disclosed herein also are methods for preparation of the cells entrapping dye and therapeutically active agent(s) in a freeze-dried form that makes them readily available and easy to use in a clinical environment.
Abstract translation: 本文公开了与包含在红细胞中的荧光染料相关的医学成像的方法，试剂盒和组合物。 其中还公开了方法和进一步包含截留至少一种治疗活性剂的红细胞的组合物，以及释放包埋的治疗活性剂的方法。 本文还公开了以冻干形式捕获染料和治疗活性剂的细胞的制备方法，使得它们易于获得并且易于在临床环境中使用。
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公开(公告)号：US20140308210A1
公开(公告)日：2014-10-16
申请号：US14177045
申请日：2014-02-10
Applicant: Novadaq Technologies Inc.
Inventor： Gurpreet Mangat , Lukasz Brzozowski , Richard L. Croft
IPC: A61K49/00
CPC classification number: A61K49/0045 , A61K49/0019 , A61K49/0032 , A61K49/0034 , A61K49/0041 , A61K49/0043
Abstract: A method of determining the patency of a donor organ or at least one vessel to a donor organ in a donor subject includes administering a fluorescent dye to the donor subject, applying a sufficient amount of energy to the vessel such that the fluorescent dye fluoresces, obtaining a fluorescent image of the donor organ or the vessel attached to a donor organ, and observing the image to determine if a fluorescent signal is continuous through the vessel. A continuous fluorescent signal in the donor organ or vessel indicates the respective donor organ or vessel is patent
Abstract translation: 确定给供体器官或至少一个血管对给体受体中供体器官的通畅性的方法包括向供体受试者施用荧光染料，向容器施加足够量的能量使得荧光染料发荧光，获得 供体器官或附着于供体器官的血管的荧光图像，观察图像以确定荧光信号是否连续通过血管。 供体器官或血管中的连续荧光信号指示相应的供体器官或血管是专利的
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