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1.发明授权公开(公告)号：US09816930B2
公开(公告)日：2017-11-14
申请号：US14868369
申请日：2015-09-28
Applicant: NOVADAQ TECHNOLOGIES INC.
Inventor： Eduardo Hiroyuki Moriyama , Chun Ho Sze
CPC classification number: G01N21/6456 , A61B1/043 , A61B1/0638 , A61B5/0071 , A61B5/7203 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N2021/6419 , G01N2021/6439 , G06T5/50 , G06T7/0016 , G06T2207/10064 , G06T2207/10152 , G06T2207/20224 , G06T2207/30024
Abstract: Methods and systems are disclosed for extracting an image of a target fluorophore in a biological material, which involve inducing both autofluorescence of the biological material and fluorescence of the fluorophore, acquiring an image arising from both the autofluorescence of the biological material and the fluorophore, and an image arising only from the autofluorescence, subtracting the two images to produce an image representing only the fluorophore, wherein relative intensities of the excitation light used to induce the autofluorescence and the fluorescence are modulated prior to acquiring the images.
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2.发明申请公开(公告)号：US20170245766A1
公开(公告)日：2017-08-31
申请号：US15433502
申请日：2017-02-15
Applicant: Novadaq Technologies Inc.
Inventor： Robert W. FLOWER , Robert Anthony STEAD , Arthur E. BAILEY
CPC classification number: A61B5/0261 , A61B5/0071 , A61B5/02416 , A61B5/0275 , A61B5/029 , A61B5/6826
Abstract: Methods and systems for facilitating assessment of blood flow in a tissue volume of a subject are disclosed. In some variations, the method may include: after a predetermined amount of a fluorescence agent has been administered to the subject, exciting the fluorescence agent in the tissue volume such that the excited fluorescence agent emits fluorescent light, acquiring fluorescence data based on the fluorescent light emitted during blood flow through the tissue volume, estimating a molar concentration of the fluorescence agent in the blood flowing through the tissue volume, and generating an assessment of blood flow in the tissue volume based at least in part on the fluorescence data and the estimated molar concentration of the fluorescence agent. The estimated molar concentration may be based on the predetermined amount of the fluorescence agent and an estimated circulating blood volume of the subject.
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公开(公告)号：US20170124768A1
公开(公告)日：2017-05-04
申请号：US15337986
申请日：2016-10-28
Applicant: Novadaq Technologies Inc.
Inventor： Jorgen WALLE-JENSEN , Lina GUREVICH , Gregory Vincent BROWNE
CPC classification number: G06T19/006 , A61B5/0071 , A61K49/0034 , G06T7/33 , G06T2207/10016 , G06T2207/10064 , G06T2207/30048 , G06T2207/30104 , G06T2207/30196 , G06T2207/30204 , G06T2210/41
Abstract: Methods and systems for alignment of a subject for medical imaging are disclosed, and involve providing a reference image of an anatomical region of the subject, the anatomical region comprising a target tissue, processing the reference image to generate an alignment reference image, displaying the alignment reference image concurrently with real-time video of the anatomical region, and aligning the real-time video with the alignment reference image to overlay the real-time video with the alignment reference image. Following such alignment, the subject may be imaged using, for example, fluorescence imaging, wherein the fluorescence imaging may be performed by an image acquisition assembly aligned in accordance with the alignment.
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4.发明申请SPATIAL AND SPECTRAL FILTERING APERTURES AND OPTICAL IMAGING SYSTEMS INCLUDING THE SAME 审中-公开空间和频谱滤波器和包括其中的光学成像系统公开(公告)号：US20150309225A1
公开(公告)日：2015-10-29
申请号：US14636658
申请日：2015-03-03
Applicant: NOVADAQ TECHNOLOGIES INC.
Inventor： Frederick Allen MOORE
CPC classification number: G02B5/22 , A61B1/00186 , A61B1/0638 , G02B5/005 , G02B5/201 , G02B23/2446 , G02B27/0025 , G02B27/0068 , G02B27/1013 , G03B11/00
Abstract: A filter includes a central filter region, the central filter region to transmit a first wavelength range, a peripheral filter region, the peripheral filter region to block a second wavelength range, and a transition filter region between the central and peripheral filter regions, the transition filter region to transmit or block the second wavelength range differently than the second wavelength range is to be transmitted or blocked in the central and peripheral filter regions. More generally, there may be “N” regions and up to N-1 transition regions.
Abstract translation: 滤波器包括中心滤波器区域，用于传输第一波长范围的中心滤波器区域，外围滤波器区域，外围滤波器区域以阻挡第二波长范围，以及中心滤波器区域与周边滤波器区域之间的过渡区域， 在第二波长范围内发射或阻挡第二波长范围的滤波器区域将在中央和外围滤波器区域中传输或阻挡。 更一般地，可能存在“N”个区域和直到N-1个过渡区域。
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公开(公告)号：US20150230698A1
公开(公告)日：2015-08-20
申请号：US14629473
申请日：2015-02-23
Applicant: Novadaq Technologies Inc.
Inventor： Richard W. Cline , John J.P. Fengler , Joachim W. Boehm
CPC classification number: A61B5/0071 , A61B1/00009 , A61B1/00057 , A61B1/00186 , A61B1/041 , A61B1/043 , A61B1/045 , A61B1/051 , A61B1/06 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/2676 , A61B5/0084 , G01N21/6458 , G06F19/00
Abstract: A fluorescence endoscopy video system includes a multimode light source for producing white light, fluorescence excitation light, or fluorescence excitation light with a reference reflectance light. An endoscope directs light to illuminate a tissue sample and collects reflected light or fluorescence light produced by the tissue. A camera includes a high sensitivity color image sensor having a plurality of pixel elements. Each of the pixel elements has an integrated filter configured to block reflected excitation light from reaching the pixel elements and allow fluorescence and reflectance light to reach the pixel elements. A processor receives image signals from the image sensor, combines image signals from a first group of pixel elements to form a first image formed by fluorescence light, and combines image signals from a second group of pixel elements to form a second image formed by reflectance light. A video monitor simultaneously superimposes the first and second images.
Abstract translation: 荧光内窥镜视频系统包括用于产生具有参考反射光的白光，荧光激发光或荧光激发光的多模光源。 内窥镜引导光照射组织样品并收集由组织产生的反射光或荧光。 相机包括具有多个像素元件的高灵敏度彩色图像传感器。 每个像素元件具有集成滤波器，其被配置为阻挡反射的激发光到达像素元件，并允许荧光和反射光到达像素元件。 处理器从图像传感器接收图像信号，组合来自第一组像素元件的图像信号以形成由荧光形成的第一图像，并且组合来自第二组像素元件的图像信号以形成由反射光形成的第二图像 。 视频监视器同时叠加第一和第二图像。
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Patent Agency Ranking
6.发明申请QUANTIFICATION OF ABSOLUTE BLOOD FLOW IN TISSUE USING FLUORESCENCE-MEDIATED PHOTOPLETHYSMOGRAPHY 审中-公开使用荧光介质光电子显微镜对组织中绝对血液流量的定量公开(公告)号：US20150182137A1
公开(公告)日：2015-07-02
申请号：US14510848
申请日：2014-10-09
Applicant: NOVADAQ TECHNOLOGIES INC.
Inventor： Robert W. FLOWER , Robert Anthony Stead , Arthur E. Bailey
IPC: A61B5/0275 , A61B5/00
CPC classification number: A61B5/0275 , A61B5/0071 , A61B5/0295 , A61B5/6826
Abstract: A method and an apparatus for measuring a time-varying change in an amount of blood in a tissue include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain the measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent.
Abstract translation: 用于测量组织中血液的时变变化的方法和装置包括激发血液中的荧光剂，在通过组织体积的血液的脉动流动期间获取时变光强度信号， 具有类似于常规光谱体积图的收缩期和舒张期的脉动流，并且通过应用修改的Beer-Lambert定律来处理所获取的信号，以获得组织体积中血液量的时变变化的测量。 通过利用荧光剂的荧光发射光谱中的浓度介导的变化来确定荧光剂的瞬时摩尔浓度。
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公开(公告)号：US20140343362A1
公开(公告)日：2014-11-20
申请号：US14278833
申请日：2014-05-15
Applicant: NOVADAQ TECHNOLOGIES INC.
Inventor： John TESAR
IPC: A61B1/002
CPC classification number: A61B1/002 , G02B23/2446
Abstract: A highly corrected relay system for medical endoscopes or the like is provided. The system includes a plurality of bonded lenses that are selected to provide color correction from the blue region of the spectrum through to the near infrared region of the spectrum. The system allows co-located visible and near infrared images to be resolved on a single detector.
Abstract translation: 提供了用于医用内窥镜等的高度校正的继电器系统。 该系统包括多个粘合透镜，其被选择用于从光谱的蓝色区域到光谱的近红外区域提供颜色校正。 该系统允许在单个检测器上解决共定位的可见光和近红外图像。
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公开(公告)号：US20180234603A1
公开(公告)日：2018-08-16
申请号：US15591909
申请日：2017-05-10
Applicant: Novadaq Technologies Inc.
Inventor： Frederick Allen MOORE , Anton Walter LAMPRECHT , Lesley Myron OTSIG , Paul Roald WESTWICK , Muhammad Nasir al-Din bin ZULKAFLY , Gavin Michael MURRAY , Adam John TYNAN , James Elliott CAMERON , Gregory Vincent BROWNE , Isabelle FONTAINE , Bernard HARRIS
CPC classification number: H04N5/2259 , A61B1/043 , A61B1/06 , A61B5/0071 , A61B5/0075 , G01N21/6456 , H04N5/2251 , H04N5/2254 , H04N5/2256 , H04N5/23245 , H04N5/2351 , H04N5/2352 , H04N5/2354 , H04N5/332 , H04N9/04551
Abstract: An imaging device having an imaging field of view, the imaging device including at least one illumination port configured to output light for illuminating a target; an imaging sensor to detect light traveling along an optical path to the imaging sensor; and a first movable window positioned upstream of the sensor with respect to a direction of travel of light along the optical path, wherein the first movable window is configured to move into the optical path in a deployed position for modifying light received from the target.
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9.发明申请公开(公告)号：US20170303800A1
公开(公告)日：2017-10-26
申请号：US15517895
申请日：2014-10-09
Applicant: Novadaq Technologies Inc.
Inventor： Robert W. FLOWER , Robert Anthony STEAD , Arthur E. BAILEY
IPC: A61B5/026 , A61B5/0275 , A61B5/00 , A61B5/0295
CPC classification number: A61B5/0261 , A61B5/00 , A61B5/0071 , A61B5/0275 , A61B5/0295 , A61B5/6826
Abstract: A method, an apparatus, and a kit including the apparatus and a fluorescence agent are provided for measuring a time-varying change in an amount of blood in a tissue volume, and include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain a measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent. There is further provided a fluorescence agent for use in the method.
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公开(公告)号：US20170266398A1
公开(公告)日：2017-09-21
申请号：US15073259
申请日：2016-03-17
Applicant: Novadaq Technologies Inc.
Inventor： Gavin Michael MURRAY , Gregory Vincent BROWNE
IPC: A61M13/00
CPC classification number: A61M13/00 , A61M1/0058 , A61M13/003 , A61M2202/02 , A61M2202/0225 , A61M2202/0233 , A61M2205/33 , A61M2205/582 , A61M2205/584 , A61M2202/0007
Abstract: Described herein are introducer devices and methods for using an introducer device to facilitate passing an endoluminal instrument to a target region of a body cavity. An introducer device may include a tubular member having an inner wall that defines a channel configured to receive the endoluminal instrument and a plurality of projections disposed in the channel at perimetrically spaced apart locations around the inner wall, where the projections extend inward and are configured to offset the endoluminal instrument from the inner wall, thereby creating a space between the endoluminal instrument and the inner wall. A method for using an introducer device may include passing the endoluminal instrument to a first instrument insertion depth within the introducer device, advancing the introducer device in the body cavity, and advancing the endoluminal instrument to a second instrument insertion depth within the introducer device.
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