公开(公告)号：US20120192416A1

公开(公告)日：2012-08-02

申请号：US13422892

申请日：2012-03-16

Applicant: Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  James Singleton Little ,  Brian V. Mech ,  Robert J. Greenberg ,  Qingfang Yao ,  Dao Min Zhou

Inventor： Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  James Singleton Little ,  Brian V. Mech ,  Robert J. Greenberg ,  Qingfang Yao ,  Dao Min Zhou

IPC: H05K3/46 ,  H05K3/42 ,  H05K3/02

CPC classification number: A61N1/0543 ,  A61N1/0541 ,  A61N1/36046 ,  H05K1/028 ,  H05K1/0353 ,  H05K1/09 ,  H05K1/111 ,  H05K1/115 ,  H05K1/118 ,  H05K3/0014 ,  H05K3/0017 ,  H05K3/0041 ,  H05K3/06 ,  H05K3/188 ,  H05K3/22 ,  H05K3/388 ,  H05K3/4644 ,  H05K2201/0129 ,  H05K2201/0133 ,  H05K2201/0141 ,  H05K2201/0154 ,  Y10T29/49156 ,  Y10T29/49158

Abstract: A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.

Abstract translation: 一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。 聚合物材料可用作神经刺激的电极阵列体。 它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。

公开(公告)号：US08209023B2

公开(公告)日：2012-06-26

申请号：US12163658

申请日：2008-06-27

Applicant: David Daomin Zhou ,  Robert J. Greenberg ,  Jordan Matthew Neysmith ,  Boon-Khai Ng ,  James Singleton Little ,  Neil Hamilton Talbot ,  Satinderpall Singh Pannu ,  James Courtney Davidson ,  Phillipe John Tabada ,  Melody Tabada, legal representative

Inventor： David Daomin Zhou ,  Robert J. Greenberg ,  Jordan Matthew Neysmith ,  Boon-Khai Ng ,  James Singleton Little ,  Neil Hamilton Talbot ,  Satinderpall Singh Pannu ,  James Courtney Davidson ,  Phillipe John Tabada

IPC: A61N1/04 ,  A61N1/00

CPC classification number: A61N1/0543 ,  A61N1/0541 ,  H05K1/036 ,  H05K1/0393 ,  H05K1/118 ,  H05K3/28 ,  H05K2201/0133 ,  H05K2201/0195 ,  Y10T156/1002

Abstract: A flexible circuit electrode array and method of fabrication having a polymer base layer; metal traces deposited on the polymer base layer, including electrodes to stimulate tissue; a polymer top layer deposited on the polymer base layer and metal traces; and a coating of the base and top layer by a soft polymer. A method of preparing a flexible circuit electrode array, comprising: providing a first soft polymer layer; depositing a first a base layer on the first soft polymer layer; providing a metal thin film on the base layer; depositing a top polymer layer on the metal thin film; providing holes in the top polymer layer; depositing a second soft polymer layer on the top polymer layer; providing holes in the second soft polymer layer for bond pads and electrodes; and preparing electrodes in the provided holes.

Abstract translation: 柔性电路电极阵列和具有聚合物基底层的制造方法; 沉积在聚合物基层上的金属痕迹，包括刺激组织的电极; 沉积在聚合物基底层上的聚合物顶层和金属痕迹; 以及通过软聚合物涂覆基体和顶层。 一种制备柔性电路电极阵列的方法，包括：提供第一软聚合物层; 在第一软质聚合物层上沉积第一基底层; 在基层上提供金属薄膜; 在金属薄膜上沉积顶部聚合物层; 在顶部聚合物层中提供孔; 在顶部聚合物层上沉积第二软聚合物层; 在第二软聚合物层中提供用于接合焊盘和电极的孔; 并在所提供的孔中制备电极。

公开(公告)号：US07873419B2

公开(公告)日：2011-01-18

申请号：US11927315

申请日：2007-10-29

Applicant: Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

Inventor： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

IPC: A61N1/18

CPC classification number: A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

Abstract: An improved package and configuration for an implantable retinal prosthesis includes an electrode array suitable to be mounted in close proximity to a retina, an electronics package, and an inductive receiving coil mounted next to each other on a strap surrounding the sclera so that the height above the sclera of the prosthesis is minimized.

Abstract translation: 用于植入式视网膜假体的改进的包装和构造包括适于安装在靠近视网膜的电极阵列，电子封装和在包围巩膜的带上彼此相邻安装的感应接收线圈，使得高于 假体的巩膜最小化。

公开(公告)号：US20100197082A1

公开(公告)日：2010-08-05

申请号：US12726274

申请日：2010-03-17

Applicant: Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Honggang Jiang

Inventor： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Honggang Jiang

IPC: H01L21/56

CPC classification number: A61N1/375 ,  A61N1/3754 ,  H01L23/291 ,  H01L23/3107 ,  H01L24/03 ,  H01L24/05 ,  H01L24/12 ,  H01L24/85 ,  H01L2224/0345 ,  H01L2224/0347 ,  H01L2224/0401 ,  H01L2224/05083 ,  H01L2224/05124 ,  H01L2224/05147 ,  H01L2224/05164 ,  H01L2224/05166 ,  H01L2224/05187 ,  H01L2224/05624 ,  H01L2224/05647 ,  H01L2224/13099 ,  H01L2224/13164 ,  H01L2224/13169 ,  H01L2224/85 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01015 ,  H01L2924/01018 ,  H01L2924/01019 ,  H01L2924/01022 ,  H01L2924/01024 ,  H01L2924/01027 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01041 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/04941 ,  H01L2924/10253 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1433 ,  H01L2924/351 ,  H01L2924/04953 ,  H01L2924/00 ,  H01L2224/48 ,  H01L2224/45015 ,  H01L2924/207 ,  H01L2224/45099

Abstract: An implantable hermetically sealed microelectronic device and method of manufacture are disclosed. The microelectronic device of the present invention is hermetically encased in a insulator, such as alumina formed by ion bean assisted deposition (“IBAD”), with a stack of biocompatible conductive layers extending from a contact pad on the device to an aperture in the hermetic layer. In a preferred embodiment, one or more patterned titanium layers are formed over the device contact pad, and one or more platinum layers are formed over the titanium layers, such that the top surface of the upper platinum layer defines an external, biocompatible electrical contact for the device. Preferably, the bottom conductive layer is larger than the contact pad on the device, and a layer in the stack defines a shoulder.

Abstract translation: 公开了可植入气密微电子器件及其制造方法。 本发明的微电子器件气密地封装在诸如由离子豆辅助沉积（“IBAD”）形成的氧化铝之类的绝缘体中，一堆生物相容的导电层从器件上的接触垫延伸到密封的孔 层。 在优选实施例中，在器件接触焊盘上形成一个或多个图案化的钛层，并且在钛层上形成一个或多个铂层，使得上铂层的顶表面限定外部的生物相容的电接触， 装置。 优选地，底部导电层大于器件上的接触焊盘，并且堆叠中的层限定了肩部。

公开(公告)号：US20090270958A1

公开(公告)日：2009-10-29

申请号：US12429890

申请日：2009-04-24

Applicant: Robert J. Greenberg ,  Mohamed Khaldi ,  James Singleton Little ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot

Inventor： Robert J. Greenberg ,  Mohamed Khaldi ,  James Singleton Little ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot

IPC: A61N1/05

CPC classification number: A61N1/0543 ,  A61N1/36046

Abstract: The present invention is an electrode array for neural stimulation suitable to be attached to neural tissue such that the attachment point acts as a fulcrum like point and contact with an end of the array body presses the other end of the array body into the neural tissue to be stimulated. This invention is particularly useful in a retinal electrode array for a visual prosthesis. By curving an electrode portion of an array body to approximate but not exceed (never more tightly curved) the curvature of the retina and applying force to the array by external means at the fulcrum like point, approximately even pressure across all electrodes is achieved.

Abstract translation: 本发明是一种用于神经刺激的电极阵列，其适用于附着于神经组织，使得附着点作为支点，并且与阵列体的端部接触将阵列体的另一端压入神经组织， 被刺激。 本发明在用于视觉假体的视网膜电极阵列中特别有用。 通过将阵列体的电极部分弯曲成近似但不超过（从不更紧密地弯曲）视网膜的曲率并且通过外部装置在支点点处向阵列施加力，实现了跨所有电极的大致均匀的压力。

公开(公告)号：US20080221653A1

公开(公告)日：2008-09-11

申请号：US12044830

申请日：2008-03-07

Applicant: Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

Inventor： Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

IPC: A61N1/00

CPC classification number: A61N1/05 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36046

Abstract: A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.

Abstract translation: 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。

公开(公告)号：US10188853B2

公开(公告)日：2019-01-29

申请号：US12044830

申请日：2008-03-07

Applicant: Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

Inventor： Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

IPC: A61N1/05 ,  A61N1/36

Abstract: The present invention is a flexible circuit electrode array with a polymer base layer, metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue, a polymer top layer deposited on the polymer base layer and the metal traces, and a soft polymer filling a void through both the polymer base layer and polymer top layer, the soft polymer forming drum stress relief around an attachment point.

公开(公告)号：US09131863B2

公开(公告)日：2015-09-15

申请号：US11441993

申请日：2006-05-26

Applicant: Robert Greenberg ,  Neil Hamilton Talbot ,  Jerry Ok ,  Jordan Matthew Neysmith

Inventor： Robert Greenberg ,  Neil Hamilton Talbot ,  Jerry Ok ,  Jordan Matthew Neysmith

IPC: A61N1/05 ,  A61B5/04 ,  H05K1/03 ,  H05K3/00 ,  C23C16/01 ,  C23C16/56 ,  H05K3/04 ,  H05K3/06 ,  H05K3/28 ,  H05K3/46

CPC classification number: A61B5/04001 ,  A61B2562/125 ,  A61N1/0529 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/0553 ,  C23C16/01 ,  C23C16/56 ,  H05K1/032 ,  H05K3/007 ,  H05K3/048 ,  H05K3/06 ,  H05K3/28 ,  H05K3/4676 ,  H05K2201/0179 ,  H05K2203/016 ,  H05K2203/0502 ,  H05K2203/176 ,  Y10T29/49124 ,  Y10T29/49155

Abstract: The invention is directed to an implantable insulated electrical circuit that utilizes polyparaxylylene, preferably as Parylene, a known polymer that has excellent living tissue implant characteristics, to provide for chronic implantation of conductive electrical devices, such as stimulators and sensors. The device is thin, flexible, electrically insulated, and stable after long exposure to living tissue. Layers of Parylene may be combined with layers of a polymer, such as polyimide, to yield greater design flexibility in the circuit. Multiple electrical conduction layers may be stacked in the circuit to increase packing density.

Abstract translation: 本发明涉及一种可植入绝缘电路，其利用聚对二甲苯，优选作为聚对二甲苯（parylene），已知具有极好活体组织植入特征的聚合物，以提供诸如刺激剂和传感器的导电电气装置的慢性植入。 该设备在长时间暴露于生物体组织之后，薄，柔性，电绝缘和稳定。 聚对二甲苯层可以与诸如聚酰亚胺的聚合物层结合，以在电路中产生更大的设计灵活性。 多个导电层可以堆叠在电路中以增加堆积密度。

公开(公告)号：US08527057B2

公开(公告)日：2013-09-03

申请号：US12976650

申请日：2010-12-22

Applicant: Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkins ,  Neil Hamilton Talbot ,  Da-Yu Chang

Inventor： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkins ,  Neil Hamilton Talbot ,  Da-Yu Chang

IPC: A61N1/18

CPC classification number: A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

Abstract: The present invention is an improved package and configuration for an implantable retinal prosthesis. The retinal prosthesis of the present invention includes an electrode array suitable to be mounted in close proximity to a retina, an electronics package and inductive receiving coil mounted next to each other on a strap surrounding the sclera so that the height above the sclera of the prosthesis is minimized.

Abstract translation: 本发明是用于植入式视网膜假体的改进的包装和构造。 本发明的视网膜假体包括适于安装在视网膜附近的电极阵列，电子封装和感应接收线圈，其彼此相邻地安置在围绕巩膜的带上，使得假体巩膜上方的高度 被最小化。

公开(公告)号：US08524311B1

公开(公告)日：2013-09-03

申请号：US11926459

申请日：2007-10-29

Applicant: Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Brian V. Mech

Inventor： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Brian V. Mech

IPC: A61N1/04

CPC classification number: H05K3/0011 ,  A61N1/0543 ,  H05K3/0035 ,  H05K3/064 ,  H05K2203/0736 ,  H05K2203/095

Abstract: Polymer materials make useful materials as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision. Regardless of which polymer is used, the basic construction method is the same. A layer of polymer is laid down. A layer of metal is applied to the polymer and patterned to create electrodes and leads for those electrodes. A second layer of polymer is applied over the metal layer and patterned to leave openings for the electrodes, or openings are created later by means such as laser ablation. Hence the array and its supply cable are formed of a single body. A method for manufacturing a flexible circuit electrode array, comprises: a) depositing a metal trace layer on an insulator polymer base layer; b) applying a layer of photoresist on said metal trace layer and patterning said metal trace layer and forming metal traces on said insulator polymer base layer; and c) activating said insulator polymer base layer and depositing a top insulator polymer layer and forming one single insulating polymer layer with said base insulator polymer layer; wherein the insulator polymer layers were treated at a temperature from 80-150° C. and then at a temperature from 230-350° C.

Abstract translation: 聚合物材料作为电极阵列体用于神经刺激。 它们对视网膜刺激特别有用，以产生人造视力。 不管使用哪种聚合物，基本的施工方法是一样的。 放置一层聚合物。 将一层金属施加到聚合物上并图案化以产生用于那些电极的电极和引线。 将第二层聚合物施加在金属层上并图案化以留下电极的开口，或稍后通过诸如激光烧蚀的手段产生开口。 因此阵列及其供电电缆由单体形成。 一种制造柔性电路电极阵列的方法，包括：a）在绝缘体聚合物基层上沉积金属迹线层; b）在所述金属迹线层上施加一层光致抗蚀剂，并图案化所述金属迹线层并在所述绝缘体聚合物基底层上形成金属迹线; 以及c）激活所述绝缘体聚合物基层并沉积顶绝缘体聚合物层并与所述基础绝缘体聚合物层形成一个单一绝缘聚合物层; 其中绝缘体聚合物层在80-150℃的温度下然后在230-350℃的温度下进行处理