公开(公告)号：US10028692B2

公开(公告)日：2018-07-24

申请号：US14259940

申请日：2014-04-23

Applicant: OptiScan Biomedical Corporation

Inventor： Michael Butler ,  Eugene Lim ,  Craig Johnson

IPC: A61M39/10 ,  A61B5/15 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M39/26

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a sample from a source of fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample. The analyte monitoring system can be connected to the fluid source via a connector that is configured to improve fluid flow and reduce blood clotting risk. These goals can be accomplished, for example, by employing coatings in or on a connector, positioning a resilient substance at or near the junction, by reducing dead space volume, by using resiliency to improve fit, by extending a portion of one connector to better mate with a portion of another connector, etc.

公开(公告)号：US09907504B2

公开(公告)日：2018-03-06

申请号：US15225079

申请日：2016-08-01

Applicant: OptiScan Biomedical Corporation

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48 ,  A61B5/157 ,  G01N21/3577 ,  G01N21/03 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/15 ,  A61B5/151 ,  A61B5/00 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

公开(公告)号：US09883829B2

公开(公告)日：2018-02-06

申请号：US14598111

申请日：2015-01-15

Applicant: OptiScan Biomedical Corporation

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/157 ,  A61B5/15 ,  A61B5/155 ,  A61B5/145 ,  A61M5/172 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/3577 ,  A61B5/153 ,  A61B5/00 ,  A61M5/142 ,  A61M5/168 ,  A61M5/36 ,  A61M5/38 ,  G01N21/03 ,  G01N21/35

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

公开(公告)号：US20140228710A1

公开(公告)日：2014-08-14

申请号：US14257920

申请日：2014-04-21

Applicant: OptiScan Biomedical Corporation

Inventor： Michael Butler ,  Eugene Lim ,  Craig Johnson

IPC: A61B5/15 ,  A61M39/10

CPC classification number: A61B5/157 ,  A61B5/0059 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/412 ,  A61B5/6866 ,  A61B2560/0228 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M39/10 ,  A61M39/1011 ,  A61M2005/14208 ,  A61M2039/1033 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can be connected to the source of bodily fluid via a connector that is configured to maintain uniform velocity across the connector and reduce the dead space volume.

Abstract translation: 描述了用于测定来自样品如血液或血浆的一种或多种分析物的浓度的方法和系统。 本文描述的系统可以被配置为从体液源抽出一定体积的样品，将抽出的样品的第一部分引导到分析物监测系统，并将样品的第二部分返回给患者。 分析物监测系统可以经由连接器连接到体液源，该连接器被配置为保持穿过连接器的均匀速度并减少死空间体积。

公开(公告)号：US20140058228A1

公开(公告)日：2014-02-27

申请号：US13946967

申请日：2013-07-19

Applicant: OPTISCAN BIOMEDICAL CORPORATION

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/15 ,  A61B10/00 ,  A61B5/145 ,  A61B5/157 ,  A61B5/1455

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

Abstract translation: 提供了可移除地与体液分析器接合的流体处理模块。 模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。 流体处理元件可以具有至少一个控制元件接口。

公开(公告)号：US10568555B2

公开(公告)日：2020-02-25

申请号：US14670073

申请日：2015-03-26

Applicant: OptiScan Biomedical Corporation

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/15 ,  A61B5/155 ,  A61B5/145 ,  A61M5/172 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/3577 ,  A61B5/153 ,  A61M5/142 ,  A61M5/168 ,  A61M5/36 ,  A61M5/38 ,  G01N21/03 ,  G01N21/35

Abstract: A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

公开(公告)号：US20180344231A1

公开(公告)日：2018-12-06

申请号：US16042869

申请日：2018-07-23

Applicant: OptiScan Biomedical Corporation

Inventor： Michael Butler ,  Eugene Lim ,  Craig Johnson

IPC: A61B5/15 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61M39/26 ,  A61M39/10 ,  A61B5/00 ,  A61B5/157 ,  A61B5/153

CPC classification number: A61B5/150992 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B2560/0437 ,  A61M39/10 ,  A61M39/1011 ,  A61M39/26 ,  A61M2039/1027 ,  A61M2039/1033 ,  A61M2039/263 ,  A61M2205/0222 ,  A61M2205/0238

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a sample from a source of fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample. The analyte monitoring system can be connected to the fluid source via a connector that is configured to improve fluid flow and reduce blood clotting risk. These goals can be accomplished, for example, by employing coatings in or on a connector, positioning a resilient substance at or near the junction, by reducing dead space volume, by using resiliency to improve fit, by extending a portion of one connector to better mate with a portion of another connector, etc.

公开(公告)号：US20180317828A1

公开(公告)日：2018-11-08

申请号：US15909572

申请日：2018-03-01

Applicant: OptiScan Biomedical Corporation

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: A61B5/157 ,  G01N21/35 ,  A61B5/15 ,  A61B5/1455 ,  G01N21/03 ,  G01N33/66 ,  G01N33/49 ,  A61B5/01 ,  A61B10/00 ,  A61B5/00 ,  A61B5/151 ,  G01N21/3577 ,  A61B5/145 ,  G01N21/3581

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

公开(公告)号：US20180168497A1

公开(公告)日：2018-06-21

申请号：US15888918

申请日：2018-02-05

Applicant: OptiScan Biomedical Corporation

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/157 ,  A61B5/155 ,  A61B5/15 ,  A61B10/00 ,  A61M5/172 ,  G01N21/3577 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/153 ,  A61M5/142 ,  A61M5/168 ,  A61M5/36 ,  A61M5/38 ,  G01N21/03 ,  G01N21/35

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

公开(公告)号：US20180153456A1

公开(公告)日：2018-06-07

申请号：US15881109

申请日：2018-01-26

Applicant: OptiScan Biomedical Corporation

Inventor： James R. Braig ,  Peter Rule

IPC: A61B5/15 ,  A61B5/153 ,  A61B5/145 ,  A61B5/1455 ,  G16H10/40 ,  G01N21/27 ,  A61M5/172 ,  A61B5/00 ,  A61B5/157 ,  A61B5/155 ,  A61M5/142 ,  A61M5/168 ,  A61B5/1486 ,  A61M5/36 ,  G01N21/35 ,  A61M5/38

CPC classification number: A61B5/150992 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150854 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/274 ,  G01N21/35 ,  G01N2201/1293 ,  G06F19/3468 ,  G16H10/40 ,  G16H20/17

Abstract: In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.