公开(公告)号：US20110076665A1

公开(公告)日：2011-03-31

申请号：US12996412

申请日：2009-06-05

Applicant: Paul Gatenholm ,  Rafael V. Davalos ,  Michael B. Sano

Inventor： Paul Gatenholm ,  Rafael V. Davalos ,  Michael B. Sano

IPC: A01N1/00 ,  C40B50/06 ,  C12M1/00 ,  C08B1/00 ,  C12N5/00 ,  B32B23/00

CPC classification number: A01N1/00 ,  A61F2/00 ,  C08B1/00 ,  C12N1/066 ,  C12N5/0068 ,  C12N13/00 ,  C12N2529/00 ,  C12N2533/78 ,  C12N2535/10 ,  C12P1/04 ,  Y10T428/31986

Abstract: The precise application of an electromagnetic field controls cell motion to guide extrusion and deposition of biopolymers produced by the cells. This controlled biofabrication process is used to fabricate two- and three-dimensional networks of biocompatible nanofibrils (such as cellulose) for use as biomaterials, tissue scaffolds to be used in regenerative medicine, coatings for biomedical devices, and other health care products.

Abstract translation: 电磁场的精确应用控制细胞运动以引导由细胞产生的生物聚合物的挤出和沉积。 这种受控的生物制造过程用于制造用作生物材料的生物相容纳米原纤维（例如纤维素）的二维和三维网络，用于再生医学的组织支架，用于生物医学装置的涂层和其他保健产品。

公开(公告)号：US20100297239A1

公开(公告)日：2010-11-25

申请号：US12645453

申请日：2009-12-22

Applicant: Paul GATENHOLM

Inventor： Paul GATENHOLM

IPC: A61K9/14 ,  C12P19/04 ,  A61P19/04

CPC classification number: C12P19/04 ,  A61L27/48 ,  A61L27/52 ,  A61L2430/06 ,  C08L1/00

Abstract: The present invention provides engineered composite materials for use in medical treatment of injured or degenerated menisci, cartilage, and bone. The composite materials include a cellulosic layer substantially or completely consisting of β-1→4-glucan units, and a hydrogel layer substantially or completely consisting of copolymers of β-1→2-glucan, β-1→3-glucan, and/or β-1→4-glucan, or mixtures of two or all three of these units. Production of the composite materials is achieved in a single culture milieu, using regulation of oxygen availability to control production of the various units and deposition of the layers by Acetobacter xylinum or other microorganisms that produce extracellular cellulosic material.

Abstract translation: 本发明提供了用于医疗治疗受伤或退化的半月板，软骨和骨骼的工程复合材料。 复合材料包括基本上或完全由β-葡聚糖单元组成的纤维素层，以及基本上或完全由＆lt; b→1→2-葡聚糖，1→3-葡聚糖的共聚物组成的水凝胶层 ，和/或＆bgr; -1→4-葡聚糖，或这些单元中的两种或全部三种的混合物。 复合材料的生产在单一培养环境中实现，使用调节氧气可用性来控制各种单元的生产并且由木醋杆菌或产生细胞外纤维素材料的其它微生物沉积层。