公开(公告)号：US20220354993A1

公开(公告)日：2022-11-10

申请号：US17787318

申请日：2020-12-18

Applicant: Paul GATENHOLM

Inventor： Paul GATENHOLM

IPC: A61L27/38 ,  A61L27/48 ,  A61L27/52 ,  A61L27/56 ,  C12N5/00 ,  B33Y80/00 ,  A61L27/20

Abstract: A cell delivery device and a method of producing a three dimensional device which is vascularized when implanted or topologically applied to human or animal body. Cell laden hydrogel (cells mixed with hydrogel) is casted or injected or 3D bioprinted in a leaf-like form, which contains removable parts (templates). After crosslinking, the templates are removed and the channel for vascularization is created. The device is ready for use in vitro or in vivo.

公开(公告)号：US20100297239A1

公开(公告)日：2010-11-25

申请号：US12645453

申请日：2009-12-22

Applicant: Paul GATENHOLM

Inventor： Paul GATENHOLM

IPC: A61K9/14 ,  C12P19/04 ,  A61P19/04

CPC classification number: C12P19/04 ,  A61L27/48 ,  A61L27/52 ,  A61L2430/06 ,  C08L1/00

Abstract: The present invention provides engineered composite materials for use in medical treatment of injured or degenerated menisci, cartilage, and bone. The composite materials include a cellulosic layer substantially or completely consisting of β-1→4-glucan units, and a hydrogel layer substantially or completely consisting of copolymers of β-1→2-glucan, β-1→3-glucan, and/or β-1→4-glucan, or mixtures of two or all three of these units. Production of the composite materials is achieved in a single culture milieu, using regulation of oxygen availability to control production of the various units and deposition of the layers by Acetobacter xylinum or other microorganisms that produce extracellular cellulosic material.

Abstract translation: 本发明提供了用于医疗治疗受伤或退化的半月板，软骨和骨骼的工程复合材料。 复合材料包括基本上或完全由β-葡聚糖单元组成的纤维素层，以及基本上或完全由＆lt; b→1→2-葡聚糖，1→3-葡聚糖的共聚物组成的水凝胶层 ，和/或＆bgr; -1→4-葡聚糖，或这些单元中的两种或全部三种的混合物。 复合材料的生产在单一培养环境中实现，使用调节氧气可用性来控制各种单元的生产并且由木醋杆菌或产生细胞外纤维素材料的其它微生物沉积层。