公开(公告)号：US20130309295A1

公开(公告)日：2013-11-21

申请号：US13983709

申请日：2012-02-06

Applicant: Paul Gatenholm

Inventor： Paul Gatenholm

IPC: C12P19/04 ,  A61L27/20 ,  A61L17/10

CPC classification number: C12P19/04 ,  A61B17/06166 ,  A61L17/005 ,  A61L17/06 ,  A61L17/10 ,  A61L27/20 ,  A61L27/38 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2400/12 ,  C08L1/02

Abstract: Embodiments of the invention are based on the fermentation of bacteria to produce nano-cellulose in oxygen permeable tubular bioreactors. The resulting hydrogel non-hollow fiber can be stretched and dewatered to form strong, stiff yet flexible fiber. The fiber can be dehydrated by freeze drying or solvent exchange to form macroporous material and then optionally soaked with a solution of growth factors, anti-inflammatory drugs, and/or anitibacterial agents to provide a slow release drug delivery device in fiber form. The surface of the fiber is composed of nano-structured cellulose which promotes cell migration, tissue integration, and the healing process. BC fibers are not degraded in the human body and thus are well suited as reinforcement of implants and growing tissue. Uses for the BC fibers include surgical sutures, and reinforcing and promoting regeneration of damaged tissue or implants.

Abstract translation: 本发明的实施方案是基于在透氧管状生物反应器中产生纳米纤维素的细菌的发酵。 所得到的水凝胶非中空纤维可以被拉伸和脱水以形成强而硬的柔性纤维。 纤维可以通过冷冻干燥或溶剂交换脱水以形成大孔材料，然后任选地用生长因子，抗炎药物和/或抗菌剂的溶液浸泡以提供纤维形式的缓释药物递送装置。 纤维表面由促进细胞迁移，组织整合和愈合过程的纳米结构纤维素组成。 BC纤维在人体内不会降解，因此非常适合作为植入物和生长组织的增强。 BC纤维的用途包括手术缝线，以及加强和促进受损组织或植入物的再生。

公开(公告)号：US20100278893A1

公开(公告)日：2010-11-04

申请号：US12528800

申请日：2008-02-26

Applicant: Aase Bodin ,  Paul Gatenholm ,  Helen Fink ,  Bo Risberg ,  Harry Brumer ,  Nils Lage Ahrenstedt

Inventor： Aase Bodin ,  Paul Gatenholm ,  Helen Fink ,  Bo Risberg ,  Harry Brumer ,  Nils Lage Ahrenstedt

IPC: A61K9/00 ,  C12N9/10 ,  C12N5/071 ,  A01N1/00 ,  A61K35/12 ,  A61P9/00

CPC classification number: A61L27/507 ,  A61L27/34 ,  A61L27/54 ,  A61L33/08 ,  A61L2300/25 ,  A61L2300/414 ,  C08L1/00

Abstract: Implantable materials for medical or surgical applications comprising specific chemical groups on their surface to alter the physico-chemical properties of said material rendering it suitable implantation or biocompatible properties.

Abstract translation: 用于医疗或外科应用的植入材料包括其表面上的特定化学基团，以改变所述材料的物理化学性质，使其具有合适的植入或生物相容性质。

公开(公告)号：US20100129642A1

公开(公告)日：2010-05-27

申请号：US12527070

申请日：2008-02-19

Applicant: Maria Gröndahl ,  Lisa Bindgard ,  Paul Gatenholm ,  Thomas Hjertberg

Inventor： Maria Gröndahl ,  Lisa Bindgard ,  Paul Gatenholm ,  Thomas Hjertberg

IPC: C09D105/14 ,  B05D3/02 ,  B32B19/02 ,  C09D101/02

CPC classification number: C08L5/14 ,  B05D3/0254 ,  C08J5/18 ,  C08J2305/14 ,  C08K3/346 ,  C08K3/36 ,  C08K5/053 ,  C08L1/02 ,  C08L29/04 ,  C08L2201/06 ,  C09D101/02 ,  C09D105/14 ,  D21H21/16 ,  Y10T428/251 ,  Y10T428/277 ,  C08L2666/26 ,  C08L2666/04

Abstract: A film forming composition and a polymeric film or coating comprising hemicellulose and at least one component selected from the group consisting of plasticizers, cellulose, and an oligomer or polymer, is disclosed, said polymeric film or coating further comprising at least one additive/reactant increasing the liquid/moisture resistance and mixed with and/or reacting with the hemicellulose and said at least one component before or in conjunction with the forming of the film or coating. The use of said film or coating is also disclosed. Further, a method for the manufacture of said polymeric film or coating is disclosed, as well as a method for improving the liquid/moisture resistance of hemicellulose. Said at least one additive/reactant increasing the liquid/moisture resistance is either a cross-linking agent or a hydrophobizing agent. In another preferred embodiment the additive is a 2:1 layered phyllosilicate. The additive forms a nanocomposite with the hemicellulose as a matrix. The hemicellulose/phyllosilicate nanocomposite reinforced material provides excellent liquid/moisture resistance. Heat treatment of all of the films increases their liquid/moisture resistance and reduces their oxygen permeability.

Abstract translation: 公开了一种成膜组合物和包含半纤维素和至少一种选自增塑剂，纤维素和低聚物或聚合物的组分的聚合物膜或涂层，所述聚合物膜或涂层还包含至少一种添加剂/反应物增加 液体/耐湿性，并与半纤维素和所述至少一种组分在形成薄膜或涂层之前或结合之后混合和/或与半纤维素和所述至少一种组分反应。 还公开了所述膜或涂层的使用。 此外，公开了制造所述聚合物膜或涂层的方法，以及用于改善半纤维素的液体/耐湿性的方法。 所述至少一种增加液体/耐湿性的添加剂/反应物是交联剂或疏水剂。 在另一个优选的实施方案中，添加剂是2:1层状页硅酸盐。 添加剂形成与半纤维素作为基质的纳米复合材料。 半纤维素/页硅酸盐纳米复合材料增强材料提供优异的液体/防潮性。 所有这些膜的热处理增加了它们的液体/耐湿性并降低了它们的透氧性。

公开(公告)号：US07427643B2

公开(公告)日：2008-09-23

申请号：US10548799

申请日：2004-03-18

Applicant: Paul Gatenholm ,  Aase Bodin ,  Maria Gröndahl ,  Sofia Dammstrom ,  Lisa Eriksson

Inventor： Paul Gatenholm ,  Aase Bodin ,  Maria Gröndahl ,  Sofia Dammstrom ,  Lisa Eriksson

IPC: C08L3/00 ,  C08L89/00 ,  D21H19/54

CPC classification number: C08J5/18 ,  C08J2305/14 ,  C09D105/14

Abstract: A film-forming composition and a polymeric film or coating comprising hemicellulose, having a molecular weight of less than 50 000 g/mol, and at least one component selected from the group consisting of plasticizers, cellulose and a synthetic oligomer or polymer is disclosed. The use of said film or coating as an oxygen barrier is also disclosed. Further, a method for the manufacture of said polymeric film or coating is disclosed, as well as a method for improving the film-forming properties of hemicellulose having a molecular weight of less than 50 000 g/mol.

Abstract translation: 公开了一种成膜组合物和包含分子量小于50 000g / mol的半纤维素和至少一种选自增塑剂，纤维素和合成低聚物或聚合物的组分的聚合物膜或涂层。 还公开了所述膜或涂层作为氧阻挡层的用途。 此外，公开了制造所述聚合物膜或涂层的方法，以及改进分子量小于50 000g / mol的半纤维素的成膜性能的方法。

公开(公告)号：US20210108098A1

公开(公告)日：2021-04-15

申请号：US16608714

申请日：2018-04-25

Applicant: Paul Gatenholm ,  Erdem Karabulut

Inventor： Paul Gatenholm ,  Erdem Karabulut

IPC: C09D11/14 ,  A61L27/08 ,  A61L27/20 ,  A61L27/36 ,  A61L27/38 ,  A61L27/44 ,  A61L27/50 ,  C09D11/037

Abstract: The present invention relates to preparation and use of nanocellulose fibrils or crystals such as disintegrated bacterial nanocellulose, tunicate-derived nanocellulose, or plant-derived nanocellulose, together with carbon nanotubes, as a biocompatible and conductive ink for 3D printing of electrically conductive patterns. Biocompatible conductive bioinks described in this invention were printed in the form of connected lines onto wet or dried nanocellulose films, bacterial cellulose membrane, or tunicate decellularized tissue. The devices were biocompatible and showed excellent mechanical properties and good electrical conductivity through printed lines (3.8·10−1 S cm−1). Such scaffolds were used to culture neural cells. Neural cells attached selectively on the printed pattern and formed connective networks. The devices prepared by this invention are suited as bioassays to screen drugs against neurodegenerative diseases such as Alzheimer's and Parkinson's, study brain function, and/or be used to link the human brain with electronic and/or communication devices. They can also be implanted to replace neural tissue or stimulate guiding of neural cells. They can also be used to stimulate the heart by using electrical signaling or to repair myocardial infarction and/or damage related thereto.

公开(公告)号：US08557033B2

公开(公告)日：2013-10-15

申请号：US12527070

申请日：2008-02-19

Applicant: Maria Gröndahl ,  Lisa Bindgard ,  Paul Gatenholm ,  Thomas Hjertberg

Inventor： Maria Gröndahl ,  Lisa Bindgard ,  Paul Gatenholm ,  Thomas Hjertberg

IPC: C08L1/00 ,  C08L3/00 ,  C08L5/00 ,  C09D101/00 ,  C09D103/00 ,  C09D105/00 ,  C09J101/00 ,  C09J103/00 ,  C09J105/00 ,  C08K3/34 ,  C08K9/04 ,  D21H19/58 ,  C09C1/42

CPC classification number: C08L5/14 ,  B05D3/0254 ,  C08J5/18 ,  C08J2305/14 ,  C08K3/346 ,  C08K3/36 ,  C08K5/053 ,  C08L1/02 ,  C08L29/04 ,  C08L2201/06 ,  C09D101/02 ,  C09D105/14 ,  D21H21/16 ,  Y10T428/251 ,  Y10T428/277 ,  C08L2666/26 ,  C08L2666/04

Abstract: A film forming composition and a polymeric film or coating comprising hemicellulose and at least one component selected from the group consisting of plasticizers, cellulose, and an oligomer or polymer, is disclosed, said polymeric film or coating further comprising at least one additive/reactant increasing the liquid/moisture resistance and mixed with and/or reacting with the hemicellulose and said at least one component before or in conjunction with the forming of the film or coating. The use of said film or coating is also disclosed. Further, a method for the manufacture of said polymeric film or coating is disclosed, as well as a method for improving the liquid/moisture resistance of hemicellulose. Said at least one additive/reactant increasing the liquid/moisture resistance is either a cross-linking agent or a hydrophobizing agent. In another preferred embodiment the additive is a 2:1 layered phyllosilicate. The additive forms a nanocomposite with the hemicellulose as a matrix. The hemicellulose/phyllosilicate nanocomposite reinforced material provides excellent liquid/moisture resistance. Heat treatment of all of the films increases their liquid/moisture resistance and reduces their oxygen permeability.

Abstract translation: 公开了一种成膜组合物和包含半纤维素和至少一种选自增塑剂，纤维素和低聚物或聚合物的组分的聚合物膜或涂层，所述聚合物膜或涂层还包含至少一种添加剂/反应物增加 液体/耐湿性，并与半纤维素和所述至少一种组分在形成薄膜或涂层之前或结合之后混合和/或与半纤维素和所述至少一种组分反应。 还公开了所述膜或涂层的使用。 此外，公开了制造所述聚合物膜或涂层的方法，以及用于改善半纤维素的液体/耐湿性的方法。 所述至少一种增加液体/耐湿性的添加剂/反应物是交联剂或疏水剂。 在另一个优选的实施方案中，添加剂是2:1层状页硅酸盐。 添加剂形成与半纤维素作为基质的纳米复合材料。 半纤维素/页硅酸盐纳米复合材料增强材料提供优异的液体/防潮性。 所有这些膜的热处理增加了它们的液体/耐湿性并降低了它们的透氧性。

公开(公告)号：US20060173104A1

公开(公告)日：2006-08-03

申请号：US10548799

申请日：2004-03-18

Applicant: Paul Gatenholm ,  Aase Bodin ,  Maria Grondahl ,  Sofia Dammstrom ,  Lisa Eriksson

Inventor： Paul Gatenholm ,  Aase Bodin ,  Maria Grondahl ,  Sofia Dammstrom ,  Lisa Eriksson

IPC: C08G18/38 ,  C09D101/00

CPC classification number: C08J5/18 ,  C08J2305/14 ,  C09D105/14

Abstract: A film-forming composition and a polymeric film or coating comprising hemicellulose, having a molecular weight of less than 50 000 g/mol, and at least one component selected from the group consisting of plasticizers, cellulose and a synthetic oligomer or polymer is disclosed. The use of said film or coating as an oxygen barrier is also disclosed. Further, a method for the manufacture of said polymeric film or coating is disclosed, as well as a method for improving the film-forming properties of hemicellulose having a molecular weight of less than 50 000 g/mol.

Abstract translation: 公开了一种成膜组合物和包含分子量小于50 000g / mol的半纤维素和至少一种选自增塑剂，纤维素和合成低聚物或聚合物的组分的聚合物膜或涂层。 还公开了所述膜或涂层作为氧阻挡层的用途。 此外，公开了制造所述聚合物膜或涂层的方法，以及改进分子量小于50 000g / mol的半纤维素的成膜性能的方法。

公开(公告)号：US20180326665A1

公开(公告)日：2018-11-15

申请号：US15755767

申请日：2016-08-31

Applicant: Erik Gatenholm ,  Ivan Tournier ,  Paul Gatenholm ,  Cellink AB

Inventor： Erik Gatenholm ,  Ivan Tournier ,  Paul Gatenholm

IPC: B29C64/364 ,  C12M3/00 ,  B33Y30/00 ,  B29C64/264 ,  B29C64/245 ,  B33Y50/02 ,  B29C64/393 ,  B29C64/25

CPC classification number: B29C64/364 ,  B01L1/02 ,  B01L3/0241 ,  B01L2200/0636 ,  B01L2300/0681 ,  B29C64/245 ,  B29C64/25 ,  B29C64/264 ,  B29C64/393 ,  B29L2031/40 ,  B33Y30/00 ,  B33Y40/00 ,  B33Y50/02 ,  B33Y70/00 ,  B33Y80/00 ,  C12M21/08 ,  F24F3/161 ,  F24F13/28 ,  F24F2011/0004

Abstract: Clean chamber technology for 3D printers and bioprinters is described. An airtight chamber or enclosure is provided so that positive pressure can be created inside the chamber. Unfiltered air is sucked in from outside into the chamber through a high efficiency filter such as a HEPA filter, using an electrically powered fan or blower, filtering out at least about 99% of particles and contaminants. The filtered air is then pushed into a 3D printing area inside the chamber and out through vents within the frame of the chamber. The technology provides a clean environment for 3D bioprinting of human tissue models and organs and 3D cell culturing without requiring clean room facilities.

公开(公告)号：US20180305569A1

公开(公告)日：2018-10-25

申请号：US15963076

申请日：2018-04-25

Applicant: Paul Gatenholm

Inventor： Paul Gatenholm

IPC: C09D11/14 ,  C09D11/52 ,  C09D11/03 ,  C09D11/38 ,  C09D11/30 ,  A61L27/08 ,  A61L27/20 ,  A61L27/50 ,  C12N5/09 ,  C12N5/071 ,  A61L27/38 ,  A61L27/36 ,  A61N1/05 ,  A61N1/36 ,  A61N1/362 ,  B33Y70/00 ,  B33Y80/00

Abstract: The present invention relates to preparation and use of nanocellulose fibrils or crystals such as disintegrated bacterial nanocellulose, tunicate-derived nanocellulose, or plant-derived nanocellulose, together with carbon nanotubes, as a biocompatible and conductive ink for 3D printing of electrically conductive patterns. Biocompatible conductive bioinks described in this invention were printed in the form of connected lines onto wet or dried nanocellulose films, bacterial cellulose membrane, or tunicate decellularized tissue. The devices were biocompatible and showed excellent mechanical properties and good electrical conductivity through printed lines (3.8·10−1 S cm−1). Such scaffolds were used to culture neural cells. Neural cells attached selectively on the printed pattern and formed connective networks. The devices prepared by this invention are suited as bioassays to screen drugs against neurodegenerative diseases such as Alzheimer's and Parkinson's, study brain function, and/or be used to link the human brain with electronic and/or communication devices. They can also be implanted to replace neural tissue or stimulate guiding of neural cells. They can also be used to stimulate the heart by using electrical signaling or to repair myocardial infarction and/or damage related thereto.

公开(公告)号：US20140093724A1

公开(公告)日：2014-04-03

申请号：US14034586

申请日：2013-09-24

Applicant: Maria Grondahl ,  Lisa Bindgard ,  Paul Gatenholm ,  Thomas Hjertberg

Inventor： Maria Grondahl ,  Lisa Bindgard ,  Paul Gatenholm ,  Thomas Hjertberg

IPC: C08L5/14 ,  C09D105/14 ,  C08L1/02 ,  B05D3/02 ,  C08L29/04

CPC classification number: C08L5/14 ,  B05D3/0254 ,  C08J5/18 ,  C08J2305/14 ,  C08K3/346 ,  C08K3/36 ,  C08K5/053 ,  C08L1/02 ,  C08L29/04 ,  C08L2201/06 ,  C09D101/02 ,  C09D105/14 ,  D21H21/16 ,  Y10T428/251 ,  Y10T428/277 ,  C08L2666/26 ,  C08L2666/04

Abstract: A film forming composition and a polymeric film or coating comprising hemicellulose is disclosed, said polymeric film or coating further comprising at least one additive/reactant increasing the liquid/moisture resistance. The use of said film or coating is also disclosed. Further, a method for the manufacture of said polymeric film or coating is disclosed, as well as a method for improving the liquid/moisture resistance of hemicellulose. The hemicellulose/phyllosilicate nanocomposite reinforced material provides excellent liquid/moisture resistance.

Abstract translation: 公开了一种成膜组合物和包含半纤维素的聚合物膜或涂层，所述聚合物膜或涂层还包含增加液体/耐湿性的至少一种添加剂/反应物。 还公开了所述膜或涂层的使用。 此外，公开了制造所述聚合物膜或涂层的方法，以及用于改善半纤维素的液体/耐湿性的方法。 半纤维素/页硅酸盐纳米复合材料增强材料提供优异的液体/防潮性。