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    THERMOCYCLER AND SAMPLE VESSEL FOR RAPID AMPLIFICATION OF DNA
    23.
    发明申请
    THERMOCYCLER AND SAMPLE VESSEL FOR RAPID AMPLIFICATION OF DNA 审中-公开
    热释放器和样品容器用于快速扩增DNA

    公开(公告)号：US20150238968A1

    公开(公告)日：2015-08-27

    申请号：US14708848

    申请日：2015-05-11

    Applicant: Streck, Inc.

    Inventor： Joel R. TerMaat ,  Hendrik J. Viljoen ,  Scott E. Whitney

    IPC: B01L7/00

    CPC classification number: B01L7/52 ,  B01L3/505 ,  B01L2300/043 ,  B01L2300/0627 ,  B01L2300/0838 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1844

    Abstract: A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present between opposing modules. One or more multiple sample vessels are placed in between the module such that the vessels are subjected to temperature cycling by the modules. The sample vessels have a minimal internal dimensional that is substantially perpendicular to the modules that facilitates rapid temperature cycling. In embodiments of the invention the sample vessels may be deformable between: a) a shape having a wide mouth to facilitate filling and removing of sample fluids from the vessel, and b) a shape which is thinner for conforming to the sample cavity or interior space between the thermoelectric modules of the thermocycler for more rapid heat transfer.

    Abstract translation: 用于快速执行PCR过程的热循环仪装置和方法采用至少两个热电模块，其与存在于相对模块之间的内部空间实质上空间相对。 将一个或多个多个样品容器放置在模块之间，使得容器经过模块的温度循环。 样品容器具有基本垂直于促进快速温度循环的模块的最小内部尺寸。 在本发明的实施例中，样品容器可以在以下之间变形：a）具有宽口的形状，以便于从容器中填充和去除样品流体，以及b）更薄的形状，以符合样品腔或内部空间 在热循环器的热电模块之间用于更快速的热传递。

    BLOOD COLLECTION DEVICE FOR IMPROVED NUCLEIC ACID REGULATION
    24.
    发明申请
    BLOOD COLLECTION DEVICE FOR IMPROVED NUCLEIC ACID REGULATION 审中-公开
    用于改善核酸调节的血液收集装置

    公开(公告)号：US20140080112A1

    公开(公告)日：2014-03-20

    申请号：US13766207

    申请日：2013-02-13

    Applicant: STRECK, INC.

    Inventor： Wayne L. Ryan ,  M. Rohan Fernando ,  Kausik Das

    IPC: C12N15/10

    CPC classification number: C12N15/1003 ,  C12Q1/6806 ,  C12Q2527/125

    Abstract: Methods and devices for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, the biological sample including at least one circulating cell-free first nucleic acid from the subject. The methods may include a step of contacting the biological sample while within the sample collection device with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.

    Abstract translation: 用于稳定用于分析的生物样品的方法和装置，包括以下步骤：在样品收集装置中获得来自受试者的生物样品，所述生物样品包括来自受试者的至少一种循环的无细胞的第一核酸。 所述方法可以包括使样品收集装置内的生物样品与保护剂组合物接触的步骤，所述保护剂组合物包括防腐剂，任选的抗凝剂和猝灭剂，以形成包含保护剂组合物和样品的混合物。

    Preservation of cell-free RNA in blood samples
    26.
    发明授权
    Preservation of cell-free RNA in blood samples 有权
    保存血液样品中的无细胞RNA

    公开(公告)号：US08586306B2

    公开(公告)日：2013-11-19

    申请号：US13648415

    申请日：2012-10-10

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

    Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    Abstract translation: 公开了一种用于保存和处理位于血液样品内的无细胞核酸的方法，其中处理含有无细胞核酸的血液样品以降低血液样品中的血细胞裂解和核酸酶活性。 样品的处理有助于增加可以鉴定和测试的无细胞核酸的量，同时保持核酸的结构和完整性。

    PRESERVATION OF CELL-FREE RNA IN BLOOD SAMPLES
    27.
    发明申请
    PRESERVATION OF CELL-FREE RNA IN BLOOD SAMPLES 有权
    在血液样品中保存无细胞RNA

    公开(公告)号：US20130034860A1

    公开(公告)日：2013-02-07

    申请号：US13648415

    申请日：2012-10-10

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/68 ,  C09K15/32 ,  C09K15/20 ,  C09K15/08 ,  C12Q1/70 ,  C09K15/00

    CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

    Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    Abstract translation: 公开了一种用于保存和处理位于血液样品内的无细胞核酸的方法，其中处理含有无细胞核酸的血液样品以降低血液样品中的血细胞裂解和核酸酶活性。 样品的处理有助于增加可以鉴定和测试的无细胞核酸的量，同时保持核酸的结构和完整性。

    PRESERVATION OF CELL-FREE NUCLEIC ACIDS
    29.
    发明申请
    PRESERVATION OF CELL-FREE NUCLEIC ACIDS 审中-公开

    公开(公告)号：US20200318161A1

    公开(公告)日：2020-10-08

    申请号：US16908233

    申请日：2020-06-22

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/6806 ,  C09K15/20

    Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    PRESERVATION OF CELL-FREE NUCLEIC ACIDS
    30.
    发明申请
    PRESERVATION OF CELL-FREE NUCLEIC ACIDS 审中-公开

    公开(公告)号：US20190233879A1

    公开(公告)日：2019-08-01

    申请号：US16377344

    申请日：2019-04-08

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/6806 ,  C09K15/20

    CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

    Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

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