公开(公告)号：US20170304828A1

公开(公告)日：2017-10-26

申请号：US15643860

申请日：2017-07-07

Applicant: Streck, Inc.

Inventor： Joel R. TerMaat ,  Scott E. Whitney ,  Hendrik J. Viljoen ,  Matthew Robert Kreifels

IPC: B01L7/00 ,  C12Q1/68 ,  G01N35/00

CPC classification number: B01L7/52 ,  B01L2200/14 ,  B01L2300/0627 ,  B01L2300/0858 ,  B01L2300/1805 ,  B01L2300/1822 ,  C12Q1/6844 ,  G01N2035/00366

Abstract: A thermocycling device and method of operating a thermocycler instrument the instrument including a sample holder, at least one thermal cycling element, and at least one first and second temperature sensors, for causing the sample holder containing the at least one sample to undergo polymerase chain reaction amplification by repeated cycling between at least a denaturation heating stage and an annealing cooling stage. The first temperature corresponding with the temperature of the sample holder is monitored using the at least one first temperature sensor, and a second temperature corresponding with the temperature external of the sample holder is monitored using the at least one second temperature sensor. Based upon the first temperature and the second temperature, the power that is delivered to the at least one thermal cycling element of the instrument is dynamically controlled.

公开(公告)号：US20180223335A1

公开(公告)日：2018-08-09

申请号：US15941383

申请日：2018-03-30

Applicant: Streck, Inc.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Joel R. TerMaat

IPC: C12Q1/686 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.

公开(公告)号：US09932632B2

公开(公告)日：2018-04-03

申请号：US13833349

申请日：2013-03-15

Applicant: Streck, Inc.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Joel R. TerMaat

IPC: G01N21/00 ,  C12Q1/68 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.

公开(公告)号：US20150238968A1

公开(公告)日：2015-08-27

申请号：US14708848

申请日：2015-05-11

Applicant: Streck, Inc.

Inventor： Joel R. TerMaat ,  Hendrik J. Viljoen ,  Scott E. Whitney

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L3/505 ,  B01L2300/043 ,  B01L2300/0627 ,  B01L2300/0838 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1844

Abstract: A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present between opposing modules. One or more multiple sample vessels are placed in between the module such that the vessels are subjected to temperature cycling by the modules. The sample vessels have a minimal internal dimensional that is substantially perpendicular to the modules that facilitates rapid temperature cycling. In embodiments of the invention the sample vessels may be deformable between: a) a shape having a wide mouth to facilitate filling and removing of sample fluids from the vessel, and b) a shape which is thinner for conforming to the sample cavity or interior space between the thermoelectric modules of the thermocycler for more rapid heat transfer.

Abstract translation: 用于快速执行PCR过程的热循环仪装置和方法采用至少两个热电模块，其与存在于相对模块之间的内部空间实质上空间相对。 将一个或多个多个样品容器放置在模块之间，使得容器经过模块的温度循环。 样品容器具有基本垂直于促进快速温度循环的模块的最小内部尺寸。 在本发明的实施例中，样品容器可以在以下之间变形：a）具有宽口的形状，以便于从容器中填充和去除样品流体，以及b）更薄的形状，以符合样品腔或内部空间 在热循环器的热电模块之间用于更快速的热传递。

公开(公告)号：US20140045250A1

公开(公告)日：2014-02-13

申请号：US13833349

申请日：2013-03-15

Applicant: STRECK, INC.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Joel R. TerMaat

IPC: C12Q1/68

CPC classification number: C12Q1/686 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.

Abstract translation: 一种用于促进聚合酶链反应的改进的装置和系统，包括占据最小空间的光源，检测器，波导和滤波器，并且有助于减少样品读取时间和快速读取多个光波长。