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    SAMPLE COLLECTION CONTAINERS, PROCESSES AND COLLECTED SAMPLES
    1.
    发明公开
    SAMPLE COLLECTION CONTAINERS, PROCESSES AND COLLECTED SAMPLES 审中-公开

    公开(公告)号：US20230302454A1

    公开(公告)日：2023-09-28

    申请号：US18020893

    申请日：2021-08-13

    Applicant: STRECK, INC.

    Inventor： Sean Salamifar ,  Nick George ,  Brad Hunsley

    IPC: B01L3/00

    CPC classification number: B01L3/5082 ,  B01L2200/16 ,  B01L2300/16

    Abstract: The present teachings relate to a method of making a biological sample collection container, an internally coated biological sample collection container, and uses of the same, particularly for omic analysis. A reagent (or a reagent precursor) is deposited in a liquid state at least partially along at least one side wall of the container. The reagent precursor is dried to form a dried coating having a predefined pattern and topology along at least a portion of the at least one side wall. A container thus results having a coating that includes, in a dried state, a stabilizer agent, or reaction product of a stabilizer agent and an anticoagulant, and upon collection of a sample enables stabilization of any present white blood cells, cell-free nucleic acids, extracellular vesicles, circulating tumor cells, proteins, metabolites, lipids, or any combination thereof, and preserving them in sufficient quantity and quality for omic analysis.

    PRESERVATION OF CELL-FREE NUCLEIC ACIDS
    3.
    发明申请
    PRESERVATION OF CELL-FREE NUCLEIC ACIDS 审中-公开

    公开(公告)号：US20180163256A1

    公开(公告)日：2018-06-14

    申请号：US15894077

    申请日：2018-02-12

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/6806

    CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

    Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    Devices and compositions for preservation of cell-free nucleic acids
    4.
    发明授权
    Devices and compositions for preservation of cell-free nucleic acids 有权

    公开(公告)号：US09926590B2

    公开(公告)日：2018-03-27

    申请号：US15601682

    申请日：2017-05-22

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

    Abstract: Devices including a composition for preserving and processing cell-free nucleic acids located within a blood sample and methods of using the same are disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The device may include a direct blood draw tube comprising a composition formulated for stabilizing cell-free nucleic acids within a blood sample including one or more formaldehyde releaser preservative agents, ethylenediaminetetraacetic acid (EDTA), one or more solvents, and formaldehyde. The composition is free of separately added formaldehyde but contains the formaldehyde as a result of the one or more formaldehyde releaser preservative agents. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    METHODS OF PREPARING SAMPLES FOR PROTEOMIC ANALYSIS
    7.
    发明申请
    METHODS OF PREPARING SAMPLES FOR PROTEOMIC ANALYSIS 有权

    公开(公告)号：US20220074949A1

    公开(公告)日：2022-03-10

    申请号：US17417234

    申请日：2019-12-27

    Applicant: STRECK, INC.

    Inventor： Matthew R. Sobansky

    IPC: G01N33/68 ,  G01N1/40 ,  G01N30/72 ,  G01N30/88 ,  G01N30/86

    Abstract: Provided herein are methods of preparing a protein sample for proteomic analysis. In exemplary embodiments, the method comprises (a) contacting a blood sample comprising proteins with a protective agent comprising an anticoagulant (AC) and an aldehyde releaser (AR), to obtain a mixture, optionally, wherein the blood sample is added to a blood collection tube (BCT) comprising the protective agent, and (b) isolating a fraction comprising proteins or a source of proteins from the mixture to yield a protein sample or a source of a protein sample, wherein steps of the method are carried out in the absence of exogenous proteolytic enzyme inhibitors, wherein the protein sample is suitable for proteomic analysis. Preferably, the protective agent consists of essentially (i) about 300 g/l to about 700 g/l imidazolidinyl urea; (ii) about 20 g/l to about 60 g/l glycine; and (iii) about 60 g/l to about 100 g/l EDTA; and the protein sample is analysed via mass spectrometry-based proteomic methods.

    METHOD AND DEVICE FOR COLLECTING AND PRESERVING CELLS FOR ANALYSIS
    8.
    发明申请
    METHOD AND DEVICE FOR COLLECTING AND PRESERVING CELLS FOR ANALYSIS 有权

    公开(公告)号：US20210267191A1

    公开(公告)日：2021-09-02

    申请号：US17182145

    申请日：2021-02-22

    Applicant: Streck, Inc.

    Inventor： Wayne L. Ryan

    IPC: A01N1/02 ,  B01L3/00

    Abstract: The claimed subject matter comprises a device to collect and preserve cells comprising of: (1) a collection container comprised of a tube having an open end and a closed end, a closure in the open end of the tube, a vacuum drawn to a predetermined level inside the container; and (2) compounds including an anticoagulant agent and a fixative agent, wherein the compounds are in a sufficient amount to preserve said cells” original morphology and antigenic sites without significant dilution of said cells, and thereby allowing said cells to be directly analyzed by a flow cytometer without further treatment. The claimed subject matter further comprises of a method of making a collection device for cells comprising of: (1) providing a tube having an open end and a closed end; (2) preloading compounds including: an anticoagulant agent, and a fixative agent into the tube, wherein the compounds are in a sufficient amount to preserve the cells” original morphology and antigenic sites without significant dilution of the cells, and thereby allowing the cells to be directly analyzed by a flow cytometer without further treatment; (3) inserting a closure into the open end of the tube; and (4) drawing a vacuum inside the tube to a predetermined level to form the collection device.

    BLOOD COLLECTION DEVICE FOR IMPROVED NUCLEIC ACID REGULATION
    9.
    发明申请
    BLOOD COLLECTION DEVICE FOR IMPROVED NUCLEIC ACID REGULATION 审中-公开

    公开(公告)号：US20200255819A1

    公开(公告)日：2020-08-13

    申请号：US16861150

    申请日：2020-04-28

    Applicant: Streck, Inc.

    Inventor： Wayne L. Ryan ,  M. Rohan Fernando ,  Kausik Das

    IPC: C12N15/10 ,  C12Q1/6806

    Abstract: Methods and devices for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, the biological sample including at least one circulating cell-free first nucleic acid from the subject. The methods may include a step of contacting the biological sample while within the sample collection device with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.

    MOLECULAR REFERENCE CONTROLS
    10.
    发明申请
    MOLECULAR REFERENCE CONTROLS 审中-公开

    公开(公告)号：US20190177774A1

    公开(公告)日：2019-06-13

    申请号：US16324411

    申请日：2017-08-11

    Applicant: STRECK, INC.

    Inventor： Christopher Connelly ,  Matthew R. Kreifels ,  Matthew Sobansky

    IPC: C12Q1/689

    Abstract: Reference controls for use in downstream molecular technologies comprising a control composition including a sample base matrix, such as at least one biological fluid or biological fluid component, at least one condition component processed to be indicative of a condition, and at least one cross-linking agent.

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