公开(公告)号：US11906812B2

公开(公告)日：2024-02-20

申请号：US17167724

申请日：2021-02-04

Applicant: University of Rochester

Inventor： Erik P. Power ,  Jake Bromage ,  Jonathan D. Zuegel

IPC: G02B7/18

CPC classification number: G02B7/1815

Abstract: Integrated active cooling of high-power reflective or diffractive optics uses substrates manufactured from low-expansion ceramics to flow coolant between the back surface of the substrate and chambers behind but adjacent a reflective front surface, in a direction transverse to the front surface, to thereby achieve much greater average power handling than known cooling techniques.

公开(公告)号：US11904179B2

公开(公告)日：2024-02-20

申请号：US17487863

申请日：2021-09-28

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Michael J. Hasselberg ,  David John Mitten ,  Kostantinos Vasalos ,  Wendy Cross

IPC: A61N5/06 ,  G06F3/01 ,  G09B19/00 ,  G06F3/16

CPC classification number: A61N5/0618 ,  G06F3/012 ,  G06F3/165 ,  G09B19/00 ,  A61N2005/0626 ,  A61N2005/0648

Abstract: An individualized therapy session can be delivered to a patient using a virtual reality headset and system. In one example, the system can include an accelerometer and a processor. The processor can receive data detected by the accelerometer. The data can include head position data and head movement data. The processor can then determine a view direction of a user of the VR device using the head position data, determine a heart rate of the user by using the view direction of the user to process the head movement data, and output the heart rate of the user to a remote device. The processor can receive, from the remote device, a command to adjust a VR session presented by the VR device to the user. Based on the command, the processor can adjust one or more parameters of the VR session presented by the VR device.

公开(公告)号：US11899141B2

公开(公告)日：2024-02-13

申请号：US17305421

申请日：2021-07-07

Applicant: University of Rochester

Inventor： Zeljko Ignjatovic ,  Michael Huang ,  Swetha George

IPC: A61B8/08 ,  A61B8/00 ,  A61B8/14 ,  G01S7/52 ,  G01S15/89 ,  G01S7/00

CPC classification number: G01S7/52047 ,  A61B8/14 ,  A61B8/4472 ,  A61B8/4483 ,  A61B8/5207 ,  A61B8/565 ,  G01S15/8915 ,  G01S15/8918 ,  G01S15/8959 ,  G01S7/003 ,  G01S7/52096 ,  G01S15/8925 ,  G01S15/8993

Abstract: An ultrasound imaging system includes an array of ultrasound transducer elements chat send ultrasound energy into an object when energized for respective transmission time periods and provide responses to ultrasound energy emitted from the object for respective reception time periods, a reception modulation circuit modulating the responses with irregular sequences of modulation coefficients, a combiner circuit combining the modulated responses, and an image reconstruction processor configured to computer-process the combined modulated responses into one or more images of the object.

公开(公告)号：US20240029587A1

公开(公告)日：2024-01-25

申请号：US18480280

申请日：2023-10-03

Applicant: University of Rochester

Inventor： Jonathan STONE ,  Ahmed E. GHAZI

IPC: G09B23/30 ,  G09B23/34

CPC classification number: G09B23/303 ,  G09B23/34

Abstract: The invention provides systems and methods for improved simulation of surgical procedures, using models of anatomical organs. The models comprise models of internal components present in the anatomical organ. The models of the internal components are registered to the position which the internal component occupies in the anatomical organ, and in some embodiments the models of the anatomical organ can lose simulated physiological fluids during simulated surgery.

公开(公告)号：US11866702B2

公开(公告)日：2024-01-09

申请号：US17041148

申请日：2019-03-27

Applicant: University of Rochester ,  ProQR Therapeutics II B.V.

Inventor： Bart Klein ,  Janne Juha Turunen ,  Lenka Van Sint Fiet ,  Pedro Duarte Morais Fernandes Arantes Da Silva ,  Julien Auguste Germain Boudet ,  Yi-Tao Yu ,  Hironori Adachi ,  Meemanage De Zoysa

IPC: C07H21/04 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/335

Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.

公开(公告)号：US20240001358A1

公开(公告)日：2024-01-04

申请号：US17585914

申请日：2022-01-27

Applicant: Ortho-Clinical Diagnostics, Inc. ,  The Research Foundation for the State University of New York ,  University of Rochester

Inventor： Raymond F. Jakubowicz ,  Harold Warren ,  Benjamin Miller ,  Michael Bryan ,  Daniel Steiner ,  John Cognetti ,  Nathaniel Cady ,  Minhaz Abedin ,  Natalya Tokranova

IPC: B01L3/00 ,  G02B6/42 ,  G02B6/293

CPC classification number: B01L3/502715 ,  G02B6/4215 ,  G02B6/29305 ,  G02B6/4262 ,  B01L2300/0654 ,  B01L2300/0816

Abstract: An apparatus, methods, and a system for a photonic biosensor are disclosed. The photonic biosensor includes a substrate having a sample addition zone in fluid communication with a wicking zone and a sample detection zone. The substrate also includes an optical input port configured to optically couple to a light source and an optical output port configured to optically couple to a light detector. The photonic biosensor also includes a photonic integrated circuit (“PIC”) connected to the substrate. The PIC includes a first grating coupler aligned with the optical input port, a second grating coupler aligned with the optical output port, at least one waveguide between the first grating coupler and the second grating coupler, and at least one detection element disposed within the at least one waveguide.

公开(公告)号：US11860100B2

公开(公告)日：2024-01-02

申请号：US16964831

申请日：2019-01-25

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Stavros G. Demos ,  Chi Huang

IPC: G01N21/64 ,  G01N1/30

CPC classification number: G01N21/6458 ,  G01N1/30 ,  G01N2001/302

Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limtiation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments. Although just the tissue auto fluorescence maybe used, image quality is enhanced with brief application of nontoxic fluorescent dyes to selectively highlight cellular compartments. Sample preparation is safe, efficient and familiar to students with basic chemistry or biology lab experience. Mixed-dye powders may be used to simplify translation of this method for educational, medical, research, low resource, and other settings.

公开(公告)号：US11845143B2

公开(公告)日：2023-12-19

申请号：US16629199

申请日：2018-07-06

Applicant: University of Rochester

Inventor： Daniel R. Brooks ,  Jonathan D. Ellis

IPC: B23K26/082 ,  B23K26/0622 ,  B23K26/06 ,  G02B13/00 ,  G02B26/10 ,  G02B27/00

CPC classification number: B23K26/082 ,  B23K26/0624 ,  B23K26/0648 ,  G02B13/0005 ,  G02B13/0095 ,  G02B26/101 ,  G02B26/105 ,  G02B27/0031

Abstract: A pre-objective two-degree-of-freedom galvanometer scanning system including two galvo mirrors (111,112) with an optical relay (120) between the mirrors (111,112) and a microscope objective (130) with a curved image plane (140) is presented. The second galvo mirror (112) is located in the aperture stop before the objective. The optical system enables scanning in both directions over the full, curved field for creating custom refractive structures across the 6.5 mm optical zone of contact lenses using femtosecond micro-modification.

公开(公告)号：US11808774B2

公开(公告)日：2023-11-07

申请号：US17157932

申请日：2021-01-25

Applicant: Georgetown University ,  University of Rochester

Inventor： Howard J. Federoff ,  Massimo S. Fiandaca ,  Amrita K. Cheema ,  Mark E. Mapstone

IPC: G01N33/92 ,  G01N33/68

CPC classification number: G01N33/92 ,  G01N33/6896 ,  G01N2405/04 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/60

Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

公开(公告)号：US11789207B2

公开(公告)日：2023-10-17

申请号：US17016768

申请日：2020-09-10

Applicant: University of Rochester

Inventor： Jaime Cardenas ,  Juniyali Nauriyal

IPC: G02B6/30

CPC classification number: G02B6/305

Abstract: A device for attaching at least one optical fiber to a chip includes at least one nanowaveguide disposed on a substrate of a chip to be attached to an at least one off-chip fiber respectively. At least one oxide taper mode converter is disposed around a nanowaveguide end and in optical communication with and modally coupled to each of the at least one nanowaveguide respectively, and adapted such that each corresponding fiber of at least one off-chip fiber corresponds to a cleaved fiber end each cleaved fiber end to be fused to each oxide taper mode converter respectively to optically couple and mode match each cleaved fiber end to each of the nanowaveguide ends of each of the at least one nanowaveguide via the oxide taper mode converter by a modal coupling. A method for attaching at least one optical fiber to a chip is also described.