公开(公告)号：US12081657B2

公开(公告)日：2024-09-03

申请号：US17638705

申请日：2020-08-26

Applicant: Children's Hospital Los Angeles ,  University of Southern California

Inventor： Xiaowu Gai ,  Alex Ryutov ,  Tatyana Ryutov

IPC: H04L9/08 ,  H04L9/06

CPC classification number: H04L9/0869 ,  H04L9/0618 ,  H04L2209/608

Abstract: Examples are described for dynamically applying a digital watermark to a file, such as a dataset of genomic sequencing data. In one example, a method of dynamically applying a watermark to at least a portion of a file includes generating, using a secret key, a first random seed, generating, using the first random seed, an ordered pseudorandom set of integers, generating, using entity information and timing information, a second random seed, selecting, using the second random seed, a subset of the ordered pseudorandom set of integers, and modifying data at data locations in the file corresponding to at least a portion of the identifiers included in the subset to generate a watermarked file. The method may further include performing a check to determine whether the watermark is present in a file using a sequence of watermark elements that are generated based on the secret key.

公开(公告)号：US20240279608A1

公开(公告)日：2024-08-22

申请号：US18561253

申请日：2022-05-26

Applicant: University of Southern California

Inventor： Denis Evseenko

IPC: C12N5/077

CPC classification number: C12N5/0655 ,  C12N2500/92 ,  C12N2501/105 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2513/00 ,  C12N2533/52

Abstract: The disclosure provides for production processes for directed differentiation of stem cells into chondrocytes in fully defined animal free conditions, and uses thereof, including for focal repair of articular cartilage.

公开(公告)号：US20240275420A1

公开(公告)日：2024-08-15

申请号：US18568139

申请日：2022-06-09

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Manuel Alejandro MONGE ,  Nilan Udayanga GALABADA KANKANAMGE

IPC: H04B1/3827 ,  A61B5/00 ,  A61N1/372 ,  H04B1/00

CPC classification number: H04B1/385 ,  A61B5/0031 ,  A61N1/37223 ,  H04B1/005

Abstract: A dual-band implantable/wearable transceiver includes a first on-chip antenna and a second on-chip antenna that are mutually coupled. A receiver includes a dual receiver chain having a first receiver chain and a second receiver chain. The first receiver chain is in electrical communication with the first on-chip antenna and configured to operate within a first frequency band. Similarly, the second receiver chain is in electrical communication with the second on-chip antenna and configured to operate within a second frequency band. A dual-band dual-port LC oscillator-based transmitter is in electrical communication with the first on-chip antenna and the second on-chip antenna and configured transmit data within the first frequency band and/or the second frequency band. A power management unit is configured to supply power to the receiver and the dual-band dual-port LC oscillator-based transmitter.

公开(公告)号：US12058929B2

公开(公告)日：2024-08-06

申请号：US17012997

申请日：2020-09-04

Applicant: University of Southern California

Inventor： Mark E. Thompson ,  Matthew J. Jurow ,  Peter I. Djurovich ,  Tobias D. Schmidt

IPC: H10K85/30 ,  C09K11/02 ,  C09K11/06 ,  H10K50/11 ,  H10K101/10 ,  H10K101/30

CPC classification number: H10K85/342 ,  C09K11/025 ,  C09K11/06 ,  C09K2211/1044 ,  C09K2211/185 ,  H10K50/11 ,  H10K2101/10 ,  H10K2101/30

Abstract: Organic light emitting devices incorporating a film of metal complex emitters that are oriented with their transition dipole moment vectors oriented parallel to the device substrate enhances the outcoupling and eliminate the need for micro-lens arrays, gratings, or other physical extraneous outcoupling methods.

公开(公告)号：US12048679B2

公开(公告)日：2024-07-30

申请号：US17716645

申请日：2022-04-08

Applicant: University of Southern California

Inventor： Keigo Machida

IPC: A61K31/191 ,  C12Q1/6886 ,  G01N33/53

CPC classification number: A61K31/191 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: The molecular mechanism of the function of TBC1D15 in NOTCH activation and stabilization is associated with maintenance and expansion of tumor-initiating stem-like cells (TICs). We herein demonstrate that TBC1D15 preferentially binds an NUMB isoform and NOTCH1-PEST domain and stabilizes NOTCH1 protein. This interaction enhances phosphorylation of NUMB, taking it away from NUMB-mediated ubiquitin degradation of NOTCH. Thus, TBC1D15 acts as a switch to augment NOTCH signaling in TICs. We also have identified inhibitors of TBC1D15 such as latanoprost acid and a salt thereof, which blocks the NOTCH-TBC1D15 interaction and selectively kills CD133-positive TICs, resulting in a reduction in the tumor size in a patient-derived, hepatocellular carcinoma xenograft model.

公开(公告)号：US20240240147A1

公开(公告)日：2024-07-18

申请号：US18561889

申请日：2022-05-19

Applicant: University of Southern California

Inventor： Qi-Long Ying ,  Shi Yue ,  Xueyuan Jing

IPC: C12N5/0787 ,  A61K39/00 ,  A61P35/02 ,  C07K14/705 ,  C12N5/0786 ,  C12N5/0789 ,  C12N15/86

CPC classification number: C12N5/0642 ,  A61K39/4614 ,  A61K39/4631 ,  A61P35/02 ,  C07K14/70503 ,  C12N5/0645 ,  C12N5/0647 ,  C12N15/86 ,  C07K2319/03 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/46 ,  C12N2501/125 ,  C12N2501/22 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2506/11 ,  C12N2510/00 ,  C12N2740/15041

Abstract: The disclosure provides methods to genetically engineer granulocyte-macrophage progenitors (GMPs) to express a chimeric antigen receptor (CAR), and uses thereof, including for cancer immunotherapy.

公开(公告)号：US20240230646A9

公开(公告)日：2024-07-11

申请号：US18449154

申请日：2023-08-14

Applicant: University of Southern California

Inventor： Preet M. Chaudhary

IPC: G01N33/569 ,  C07K16/28 ,  G01N33/50 ,  G01N33/58

CPC classification number: G01N33/56972 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2866 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/2896 ,  G01N33/5023 ,  G01N33/5044 ,  G01N33/56966 ,  G01N33/581 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/43 ,  C07K2319/60 ,  G01N2333/70503 ,  G01N2333/72 ,  G01N2800/52

Abstract: Provided herein are methods for detecting an antigen or for detecting expression of a chimeric antigen receptor (CAR). The methods include obtaining a sample from a subject, contacting the sample with a fusion protein comprising a reporter fused to a single chain antibody specific to the antigen or fused to an extracellular domain of an antigen targeted by the CAR or fused to Protein L and assaying the activity of the reporter, wherein presence of reporter activity or increase in reporter activity relative to a reference value is indicative of presence of the antigen or presence of the expression of the chimeric antigen receptor in the sample.

公开(公告)号：US20240220840A1

公开(公告)日：2024-07-04

申请号：US18684145

申请日：2022-08-16

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Ajey Poovannummoottil JACOB ,  Akhilesh Ramlaut JAISWAL ,  Ramesh KUDALIPPALLIYALIL

IPC: G06N10/40

CPC classification number: G06N10/40

Abstract: A heterogeneous quantum device includes an interposer, a qubit sources disposed over the interposer, and an electro-optic quantum transducer disposed over the interposer. The electro-optic quantum transducer being a frequency converter that converts microwave frequency to optical frequency coupled to the qubit sources by superconducting capacitive or inductive coupling.

公开(公告)号：US20240194339A1

公开(公告)日：2024-06-13

申请号：US18286918

申请日：2022-05-27

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Nima Nassiri ,  Giovanni Cacciamani ,  Steven Cen ,  Vinay Duddalwar ,  Inderbir Gill ,  Darryl Hwang ,  Marissa Maas ,  Bino Varghese ,  Felix Yuh-Chern Yap

IPC: G16H50/20 ,  G06T7/00 ,  G06T7/40 ,  G06T7/62 ,  G16H30/40

CPC classification number: G16H50/20 ,  G06T7/0012 ,  G06T7/40 ,  G06T7/62 ,  G16H30/40 ,  G06T2207/10081 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/20081 ,  G06T2207/30084 ,  G06T2207/30096

Abstract: A system, computer readable medium, apparatus and/or method for non-invasive, non-surgical, digital biopsy. The system, computer readable medium, apparatus and/or method accurately predicts benign kidney lesions from cancers in a patient. A processor may receive patient clinical factors, texture analysis of computer-tomographic imaging, and an artificial intelligence learning model. By implementing artificial intelligence, the processor may then predict or determine a probability of kidney cancer in the patient using the patient clinical factors, the texture analysis of computer-tomographic imaging, and the artificial intelligence learning model. Notably, the prediction is performed without needing invasive biopsy surgery and subsequent pathology analysis to arrive at a diagnosis but relies on radiomics metrics.

公开(公告)号：US20240188886A1

公开(公告)日：2024-06-13

申请号：US18275108

申请日：2022-02-04

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Gary Rosen ,  Susan Luczak ,  Chunming Wang ,  Jay Bartroff ,  Larry Goldstein

IPC: A61B5/00 ,  G16H40/67 ,  G16H50/30

CPC classification number: A61B5/4845 ,  A61B5/6801 ,  A61B5/7264 ,  G16H40/67 ,  G16H50/30

Abstract: System, method and application that obtains, consolidates, and integrates multiple sources of data including Transdermal Alcohol Concentration (TAC) along with drinking diary, photo/video, breath analyzer, other biological data (e.g., heart rate, skin conductance. blood flow, person-level biometrics), and environmental data (e.g., ambient temperature, humidity, GPS) and uses models described herein to convert TAC obtained from a wearable biosensor into estimated Blood Alcohol Concentration (BAC) or Breath Alcohol Concentration (BrAC).