公开(公告)号：US20240240147A1

公开(公告)日：2024-07-18

申请号：US18561889

申请日：2022-05-19

Applicant: University of Southern California

Inventor： Qi-Long Ying ,  Shi Yue ,  Xueyuan Jing

IPC: C12N5/0787 ,  A61K39/00 ,  A61P35/02 ,  C07K14/705 ,  C12N5/0786 ,  C12N5/0789 ,  C12N15/86

CPC classification number: C12N5/0642 ,  A61K39/4614 ,  A61K39/4631 ,  A61P35/02 ,  C07K14/70503 ,  C12N5/0645 ,  C12N5/0647 ,  C12N15/86 ,  C07K2319/03 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/46 ,  C12N2501/125 ,  C12N2501/22 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2506/11 ,  C12N2510/00 ,  C12N2740/15041

Abstract: The disclosure provides methods to genetically engineer granulocyte-macrophage progenitors (GMPs) to express a chimeric antigen receptor (CAR), and uses thereof, including for cancer immunotherapy.