公开(公告)号：US10729673B2

公开(公告)日：2020-08-04

申请号：US16776919

申请日：2020-01-30

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams ,  Gary E. Clapp

IPC: A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/51 ,  A61J3/02 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20200060969A1

公开(公告)日：2020-02-27

申请号：US16669692

申请日：2019-10-31

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Matthew McClorey ,  William Johnston ,  Gere S. diZerega ,  James Verco

IPC: A61K9/00 ,  A61K31/337 ,  A61K9/16 ,  A61K9/10 ,  A61P35/00 ,  A61P11/00 ,  A61K47/26 ,  A61K47/02 ,  A61K9/14

Abstract: Disclosed herein are compositions and methods for treating lung disorders including lung tumors by pulmonary administration of compositions comprising taxane particles such as docetaxel or paclitaxel particles.

公开(公告)号：US12128131B2

公开(公告)日：2024-10-29

申请号：US18351711

申请日：2023-07-13

Applicant: CRITITECH, INC.

Inventor： Gere S. diZerega ,  Michael Baltezor ,  Charles J. Decedue ,  Sam Campbell ,  Matthew McClorey ,  Marc Iacobucci ,  Holly Maulhardt

IPC: A61K9/10 ,  A61B8/08 ,  A61B8/12 ,  A61K9/00 ,  A61K9/107 ,  A61K9/14 ,  A61K31/337 ,  A61K47/26 ,  A61P1/18 ,  A61P35/00 ,  A61K9/16

CPC classification number: A61K9/0019 ,  A61B8/0841 ,  A61B8/12 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K31/337 ,  A61K47/26 ,  A61P1/18 ,  A61P35/00 ,  A61K9/1688

Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.

公开(公告)号：US12029818B2

公开(公告)日：2024-07-09

申请号：US17812479

申请日：2022-07-14

Applicant: CRITITECH, INC.

Inventor： Jacob Sittenauer ,  Joseph Farthing ,  Mark Williams ,  Michael Baltezor ,  Gere Dizerega ,  Aranza Barreda Abarca ,  Shelby Clark

IPC: A61K9/14 ,  A61K31/5365 ,  A61K47/26

CPC classification number: A61K9/14 ,  A61K31/5365 ,  A61K47/26

Abstract: The disclosure provides particles of at least 95% by weight of lapatinib, or a pharmaceutically acceptable salt thereof, wherein the particles have a specific surface area (SSA) of at least 10 m2/g and have a mean particle size by volume distribution of between about 0.7 μm and about 8 μm.

公开(公告)号：US11160754B2

公开(公告)日：2021-11-02

申请号：US16669692

申请日：2019-10-31

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Matthew McClorey ,  William Johnston ,  Gere S. diZerega ,  James Verco

IPC: A61K9/00 ,  A61P11/00 ,  A61P35/00 ,  A61K9/16 ,  A61K9/10 ,  A61K31/337 ,  A61K9/14 ,  A61K47/02 ,  A61K47/26

Abstract: Disclosed herein are compositions and methods for treating lung disorders including lung tumors by pulmonary administration of compositions comprising taxane particles such as docetaxel or paclitaxel particles.

公开(公告)号：US11058639B2

公开(公告)日：2021-07-13

申请号：US16834155

申请日：2020-03-30

Applicant: CRITITECH, INC.

Inventor： Gere S. Dizerega ,  Michael Baltezor ,  Sam Campbell ,  Charles J. Decedue ,  Matthew McClorey

IPC: A61K9/16 ,  A61K31/337 ,  C07K16/28 ,  A61K9/00 ,  A61K39/00

Abstract: Disclosed are combination therapy methods useful for the therapeutic treatment of cancer by combining local administration of compositions containing antineoplastic particles, such as taxane particles, with systemic administration of compositions containing immunotherapeutic agents. Local administration methods include topical application, pulmonary administration, intratumoral injection, intraperitoneal injection, and intracystic injection.

公开(公告)号：US20190314277A1

公开(公告)日：2019-10-17

申请号：US16444299

申请日：2019-06-18

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Matthew McClorey ,  William Johnston ,  Gere S. diZerega ,  James Verco

IPC: A61K9/00 ,  A61K31/337 ,  A61K9/10 ,  A61P35/00 ,  A61P11/00 ,  A61K47/02 ,  A61K9/16 ,  A61K9/14 ,  A61K47/26

Abstract: Disclosed herein are compositions and methods for treating lung disorders including lung tumors by pulmonary administration of compositions comprising taxane particles such as docetaxel or paclitaxel particles.

公开(公告)号：US10398646B2

公开(公告)日：2019-09-03

申请号：US16007095

申请日：2018-06-13

Applicant: CRITITECH, INC.

Inventor： Michael Baltezor ,  Matthew McClorey ,  William Johnston ,  Gere S. diZerega ,  James Verco

IPC: A61K9/00 ,  A61P11/00 ,  A61P35/00 ,  A61K9/16 ,  A61K9/10 ,  A61K31/337 ,  A61K47/02 ,  A61K47/26 ,  A61K9/14

Abstract: Disclosed herein are compositions and methods for treating lung disorders including lung tumors by pulmonary administration of compositions comprising taxane particles such as docetaxel or paclitaxel particles.

公开(公告)号：US20190254957A1

公开(公告)日：2019-08-22

申请号：US16382446

申请日：2019-04-12

Applicant: CRITITECH, INC.

Inventor： Gere S. diZerega ,  Michael Baltezor ,  Charles J. Decedue ,  Sam Campbell ,  Matthew McClorey ,  Marc Iacobucci ,  Holly Maulhardt

IPC: A61K9/00 ,  A61B8/08 ,  A61B8/12 ,  A61K9/107 ,  A61K47/26 ,  A61K9/14 ,  A61K31/337 ,  A61P35/00

Abstract: Disclosed herein are methods for treating epithelial cysts including pancreatic cysts in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.