公开(公告)号：US20170333253A1

公开(公告)日：2017-11-23

申请号：US15591498

申请日：2017-05-10

Applicant: Novartis AG

Inventor： Tammo Heeren ,  Andrew David Johnson

IPC: A61F9/007 ,  A61M5/172 ,  A61B3/16 ,  A61F9/00

CPC classification number: A61F9/00781 ,  A61B3/16 ,  A61F9/0017 ,  A61F9/00736 ,  A61M5/142 ,  A61M5/16877 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/3344 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2210/0612

Abstract: Ophthalmic surgical devices, systems, and methods for automatically controlling the injection or extraction of viscous fluids from a patient's eye are provided. A syringe pump connected with an actuation line and a powered syringe provides pressures for viscous fluid injection or extraction in a vitreous chamber of the eye. A sensor disposed adjacent to or inside the eye determines sensor data relating to an intraocular pressure (IOP). The controller receives the sensor data and regulates the injection or extraction of the viscous fluid in response to the detected IOP, such as by controlling the syringe pump. The controller may determine whether the IOP is above an upper threshold or below a lower threshold and may control the syringe pump to regulate the injection or extraction of viscous fluid to maintain the IOP between the upper and the lower thresholds.

公开(公告)号：US20170326000A1

公开(公告)日：2017-11-16

申请号：US15590084

申请日：2017-05-09

Applicant: Novartis AG

Inventor： Tammo Heeren ,  Andrew David Johnson

IPC: A61F9/007 ,  A61M1/00 ,  A61M3/02

Abstract: Ophthalmic surgical devices, systems, and methods for regulating aspiration from a patient's eye are provided. A vacuum pump in fluid communication with an aspiration line provides fluid aspiration from a vitreous chamber of the eye through the aspiration line. A sensor disposed adjacent to or inside the eye determines sensor data relating to an intraocular pressure (IOP). The controller receives the sensor data and regulates the aspiration in response to changes in the TOP, such as by controlling the vacuum pump. The controller may determine whether a fluid infusion to the vitreous chamber through an infusion line is below a maximum infusion level, regulate the infusion in response to the TOP being below a threshold value and the infusion being below the maximum infusion level, and regulate the aspiration in response to the TOP being below the threshold value and the infusion being at or above the maximum infusion level.

公开(公告)号：US09492321B2

公开(公告)日：2016-11-15

申请号：US14618102

申请日：2015-02-10

Applicant: NOVARTIS AG

Inventor： Nicholas Max Gunn ,  Andrew David Johnson

IPC: A61F9/007 ,  F16K99/00 ,  A61F9/00

CPC classification number: A61F9/00781 ,  A61F9/0017 ,  A61F2250/0003 ,  A61M2205/0244 ,  A61M2210/0612 ,  B81B2201/054 ,  B81B2203/0127 ,  F16K99/0015 ,  F16K99/0057 ,  F16K2099/0088 ,  Y10T137/7895

Abstract: A microfluidic valve for implantation in an eye of a patient is disclosed. The valve may include a chamber formed between a substrate and a flexible membrane. The valve may also include a boss disposed in the chamber and having a top edge in selective contact with the flexible membrane. The top edge includes a relief portion and a non-relief portion, with the relief portion being structurally arranged so that a pressure required to separate the membrane from the relief portion is less than a pressure required to separate the membrane from the non-relief portion. The valve also may include an inlet extending through the boss and the substrate through which fluid enters the chamber and an outlet configured to allow fluid to exit the chamber. Methods for priming a microfluidic valve are also disclosed.

Abstract translation: 公开了一种用于植入患者眼睛的微流体阀。 阀可以包括形成在基底和柔性膜之间的腔室。 阀还可以包括设置在腔室中并具有与柔性膜选择性接触的顶边缘的凸台。 顶部边缘包括一个浮雕部分和一个非浮雕部分，其中该浮雕部分在结构上被布置成使得隔离该浮雕部分所需的压力小于将膜与该非浮雕部分分开所需的压力 。 阀还可以包括延伸穿过凸台和基底的入口，流体通过该基底进入腔室，以及出口，其构造成允许流体离开腔室。 还公开了引发微流控阀的方法。