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公开(公告)号：US10119619B2
公开(公告)日：2018-11-06
申请号：US15429706
申请日：2017-02-10
Applicant: RHEONIX, INC.
Inventor： Peng Zhou , Lincoln C. Young
IPC: F15C3/04 , F16K7/12 , B01F5/06 , B01F11/00 , B01F13/00 , B01L3/00 , B29C65/48 , B29C65/00 , B81C1/00 , F04B43/04 , F04B43/06 , F16K99/00 , F15C1/08 , B81B3/00 , F04B43/02 , B29K25/00 , B29K33/00 , B29K69/00 , B29K101/12 , B29L31/00
Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.
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公开(公告)号：US09638338B2
公开(公告)日：2017-05-02
申请号：US14274698
申请日：2014-05-10
Applicant: RHEONIX, INC.
Inventor： Peng Zhou , Lincoln C. Young
IPC: F15C3/04 , F16K7/12 , B01F5/06 , B01F11/00 , B01F13/00 , B01L3/00 , B29C65/48 , B29C65/00 , B81C1/00 , F04B43/04 , F04B43/06 , F16K99/00 , F15C1/08 , B29K25/00 , B29K33/00 , B29K69/00 , B29K101/12 , B29L31/00
CPC classification number: F16K7/12 , B01F5/0683 , B01F5/0688 , B01F11/0071 , B01F13/0059 , B01F2215/0034 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , B01L2400/0638 , B01L2400/0655 , B01L2400/084 , B29C65/4895 , B29C66/004 , B29C66/54 , B29C66/5412 , B29C66/71 , B29K2025/00 , B29K2025/04 , B29K2033/08 , B29K2069/00 , B29K2101/12 , B29L2031/7496 , B29L2031/7506 , B29L2031/756 , B81B3/0021 , B81B2201/036 , B81B2201/054 , B81B2203/0127 , B81C1/00103 , B81C1/00158 , F04B43/028 , F04B43/043 , F04B43/06 , F15C1/08 , F16K99/0001 , F16K99/0015 , F16K99/0021 , F16K99/0034 , F16K99/0055 , F16K99/0057 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T29/49405 , Y10T137/212 , Y10T137/2202 , Y10T137/2218 , Y10T137/8593 , Y10T137/85978 , Y10T156/1002 , Y10T156/1043 , B29K2033/12 , B29K2025/06
Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.
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公开(公告)号：US09096890B2
公开(公告)日：2015-08-04
申请号：US13770521
申请日：2013-02-19
Applicant: RHEONIX, INC.
Inventor： Peng Zhou , Lincoln C. Young , Benjamin Thomas , Zongyuan Chen , Greg Mouchka , Todd Roswech , Gwendolyn Spizz , Rubina Yasmin
CPC classification number: C12Q1/6806 , B01L3/022 , B01L3/5027 , B01L3/502753 , B01L7/52 , B01L2200/0647 , B01L2200/0689 , B01L2200/141 , B01L2200/142 , B01L2300/044 , B01L2300/0681 , B01L2300/0829 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2400/043 , B01L2400/0481 , B01L2400/0666 , C12Q1/6846 , C12Q1/686 , C12Q1/6883 , C12Q1/708 , G01N35/1002 , C12Q2565/629
Abstract: A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.
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公开(公告)号：US08986614B2
公开(公告)日：2015-03-24
申请号：US13836032
申请日：2013-03-15
Applicant: Rheonix, Inc.
Inventor： Peng Zhou , Lincoln C. Young , Benjamin Thomas , Zongyuan Chen , Todd Roswech , Gwendolyn Spizz , Rubina Yasmin , Greg Mouchka
CPC classification number: C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/523 , B01L3/527 , B01L7/52 , B01L2200/0668 , B01L2200/10 , B01L2200/14 , B01L2200/147 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/18 , B01L2300/1827 , B01L2400/043 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6809 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/6846 , C12Q1/6876 , C12Q1/708 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N35/10 , G01N35/1002 , G01N2035/00346 , C12Q2565/629
Abstract: A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.
Abstract translation: 独立的，完全自动化的生物测定执行装置包括壳体; 包括设置在所述壳体中的可控制的试剂分配系统的分配平台; 设置在所述壳体中的试剂供应部件; 气动歧管，其可移除地设置在所述壳体中的由所述分配平台共享的空间中，可拆卸地联接到流体输送层和多个储存器，其中所述流体输送层，所述储存器以及待引入其中的待测样品设置在 空间中的壳体与分配平台分离; 气动供给系统，其可拆卸地联接到与分配平台分离的空间中的壳体中的气动歧管; 以及耦合到所述分配平台和所述气动供应系统中的至少一个的控制系统，所述控制系统设置在所述壳体中。
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公开(公告)号：US08926782B2
公开(公告)日：2015-01-06
申请号：US14268194
申请日：2014-05-02
Applicant: Rheonix, Inc.
Inventor： Peng Zhou , Lincoln C. Young
IPC: B32B38/04 , B32B37/00 , B01F5/06 , B01F11/00 , B01F13/00 , B01L3/00 , B29C65/48 , B29C65/00 , F04B43/04 , F04B43/06 , F16K99/00 , B29L31/00
CPC classification number: B32B37/0038 , B01F5/0683 , B01F5/0688 , B01F11/0071 , B01F13/0059 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , B01L2400/084 , B29C65/4895 , B29C66/1122 , B29C66/54 , B29C66/543 , B29C66/71 , B29C66/83411 , B29C66/8362 , B29L2031/756 , F04B43/043 , F04B43/06 , F16K99/0001 , F16K99/0015 , F16K99/0021 , F16K99/0034 , F16K99/0055 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , F16K2099/0094 , Y10T156/1002 , B29K2069/00 , B29K2033/08 , B29K2025/06
Abstract: A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.
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Patent Agency Ranking
公开(公告)号：US08778280B2
公开(公告)日：2014-07-15
申请号：US13759131
申请日：2013-02-05
Applicant: Rheonix, Inc.
Inventor： Peng Zhou , Lincoln C. Young
IPC: B01L3/00
CPC classification number: G01N1/28 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0655 , B01L2400/0666 , B01L2400/084 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0084 , F16K2099/0094 , Y10T137/0324 , Y10T436/117497 , Y10T436/2575
Abstract: The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.
Abstract translation: 本文所述的系统和方法包括具有互连以提供用于处理至少一种试剂的可配置流体输送系统的多个微特征的微流体芯片。 提供插入件可移除地与芯片的一个或多个微特征相配合，其中插入物包括与试剂相互作用的位点。 从以下描述可以看出，微流体芯片和插入物提供用于进行平行测定的有效和准确的方法。
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公开(公告)号：US20130209327A1
公开(公告)日：2013-08-15
申请号：US13759131
申请日：2013-02-05
Applicant: Rheonix, Inc.
Inventor： Peng Zhou , Lincoln C. Young
IPC: B01L3/00
CPC classification number: G01N1/28 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0655 , B01L2400/0666 , B01L2400/084 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0084 , F16K2099/0094 , Y10T137/0324 , Y10T436/117497 , Y10T436/2575
Abstract: The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.
Abstract translation: 本文所述的系统和方法包括具有互连以提供用于处理至少一种试剂的可配置流体输送系统的多个微特征的微流体芯片。 提供插入件可移除地与芯片的一个或多个微特征相配合，其中插入物包括与试剂相互作用的位点。 从以下描述可以看出，微流体芯片和插入物提供用于进行平行测定的有效和准确的方法。
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公开(公告)号：US20130105017A1
公开(公告)日：2013-05-02
申请号：US13662824
申请日：2012-10-29
Applicant: Rheonix, Inc.
Inventor： Peng Zhou , Lincoln C. Young
IPC: F15C1/08
CPC classification number: F16K7/12 , B01F5/0683 , B01F5/0688 , B01F11/0071 , B01F13/0059 , B01F2215/0034 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , B01L2400/0638 , B01L2400/0655 , B01L2400/084 , B29C65/4895 , B29C66/004 , B29C66/54 , B29C66/5412 , B29C66/71 , B29K2025/00 , B29K2025/04 , B29K2033/08 , B29K2069/00 , B29K2101/12 , B29L2031/7496 , B29L2031/7506 , B29L2031/756 , B81B3/0021 , B81B2201/036 , B81B2201/054 , B81B2203/0127 , B81C1/00103 , B81C1/00158 , F04B43/028 , F04B43/043 , F04B43/06 , F15C1/08 , F16K99/0001 , F16K99/0015 , F16K99/0021 , F16K99/0034 , F16K99/0055 , F16K99/0057 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T29/49405 , Y10T137/212 , Y10T137/2202 , Y10T137/2218 , Y10T137/8593 , Y10T137/85978 , Y10T156/1002 , Y10T156/1043 , B29K2033/12 , B29K2025/06
Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.
Abstract translation: 塑料微流体结构具有基本上刚性的膜片，其在松弛状态之间起作用，其中隔膜抵靠衬底的表面，以及致动状态，其中隔膜移动离开衬底。 从以下描述可以看出，用这种隔膜形成的微流体结构提供易于制造和坚固的系统，以及易于制造的部件，例如阀和泵。
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公开(公告)号：US11248596B2
公开(公告)日：2022-02-15
申请号：US16193050
申请日：2018-11-16
Applicant: Rheonix, Inc.
Inventor： Lincoln C. Young , Peng Zhou
Abstract: A channel-less microfluidic pump includes a cartridge including a substrate and an actuatable film layer disposed on the substrate, and a manifold having at least three actuatable void volumes separated by a plurality of wall sections and an actuatable flexible layer disposed on the manifold interfacing the actuatable film layer. In operation, the pump can be in an unactuated state wherein the actuatable film layer is disposed against the surface of the substrate or an actuated state wherein at least a portion of the flexible layer and a corresponding portion of the actuatable film layer are deflected into a corresponding void volume thus forming a fluidic volume between the deflected portion of the actuatable film layer and the surface of the substrate. In the actuated state, there is a fluidic gap between immediately adjacent void volumes formed by a thinned region of the flexible layer at a point of contact with a top surface of a wall section. A method of transporting fluid using the channel-less microfluidic pump is described.
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公开(公告)号：US20210054440A1
公开(公告)日：2021-02-25
申请号：US17092379
申请日：2020-11-09
Applicant: RHEONIX, INC.
Inventor： Peng Zhou
IPC: C12Q1/6806 , C12N15/10 , C07H1/08 , B01L3/00
Abstract: A microfluidic apparatus, method, and associated applications utilize and apply to a formalin-fixed paraffin-embedded (FFPE) tissue sample and performing a liquid-liquid extraction to remove the paraffin from the tissue sample prior to a nucleic acid purification step. A microfluidic device includes a dedicated liquid-liquid extraction process vessel, a nucleic acid purification process component, and a nucleic acid amplification reactor. A liquid-liquid extraction and nucleic acid purification kit includes a microfluidic device capable of performing both a liquid-liquid extraction process and a nucleic acid purification process, including a dedicated liquid-liquid extraction process vessel, an immiscible liquid or a precursor phase thereof disposed in the vessel, a nucleic acid purification process component, a nucleic acid amplification reactor fluidically, and a supply of reagents suitable to enable the liquid-liquid extraction process and the nucleic acid purification process.
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