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    CHANNEL-LESS PUMP, METHODS, AND APPLICATIONS THEREOF
    1.
    发明申请
    CHANNEL-LESS PUMP, METHODS, AND APPLICATIONS THEREOF 审中-公开

    公开(公告)号：US20190085838A1

    公开(公告)日：2019-03-21

    申请号：US16193050

    申请日：2018-11-16

    Applicant: Rheonix, Inc.

    Inventor： Lincoln C. Young ,  Peng Zhou

    IPC: F04B43/04 ,  F04B43/06 ,  F04B43/02 ,  F04B43/00 ,  F04B43/12 ,  B01L3/00

    Abstract: A channel-less microfluidic pump includes a cartridge including a substrate and an actuatable film layer disposed on the substrate, and a manifold having at least three actuatable void volumes separated by a plurality of wall sections and an actuatable flexible layer disposed on the manifold interfacing the actuatable film layer. In operation, the pump can be in an unactuated state wherein the actuatable film layer is disposed against the surface of the substrate or an actuated state wherein at least a portion of the flexible layer and a corresponding portion of the actuatable film layer are deflected into a corresponding void volume thus forming a fluidic volume between the deflected portion of the actuatable film layer and the surface of the substrate. In the actuated state, there is a fluidic gap between immediately adjacent void volumes formed by a thinned region of the flexible layer at a point of contact with a top surface of a wall section. A method of transporting fluid using the channel-less microfluidic pump is described.

    MICROFLUIDIC APPARATUS, METHOD, AND APPLICATIONS
    2.
    发明申请
    MICROFLUIDIC APPARATUS, METHOD, AND APPLICATIONS 审中-公开
    微流体装置，方法和应用

    公开(公告)号：US20150056650A1

    公开(公告)日：2015-02-26

    申请号：US14478049

    申请日：2014-09-05

    Applicant: RHEONIX, INC.

    Inventor： Peng Zhou

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  B01L3/502715 ,  B01L2200/0631 ,  C07H1/08 ,  C12N15/1003 ,  C12Q2527/101 ,  C12Q2565/629

    Abstract: A microfluidic apparatus, method, and associated applications utilize and apply to a formalin-fixed paraffin-embedded (FFPE) tissue sample and performing a liquid-liquid extraction to remove the paraffin from the tissue sample prior to a nucleic acid purification step. A microfluidic device includes a dedicated liquid-liquid extraction process vessel, a nucleic acid purification process component, and a nucleic acid amplification reactor. A liquid-liquid extraction and nucleic acid purification kit includes a microfluidic device capable of performing both a liquid-liquid extraction process and a nucleic acid purification process, including a dedicated liquid-liquid extraction process vessel, an immiscible liquid or a precursor phase thereof disposed in the vessel, a nucleic acid purification process component, a nucleic acid amplification reactor fluidically, and a supply of reagents suitable to enable the liquid-liquid extraction process and the nucleic acid purification process.

    Abstract translation: 微流体装置，方法和相关应用利用并应用于福尔马林固定的石蜡包埋（FFPE）组织样品，并且在核酸纯化步骤之前进行液 - 液萃取从组织样品中除去石蜡。 微流体装置包括专用液 - 液提取处理容器，核酸纯化工艺组分和核酸扩增反应器。 液 - 液萃取和核酸纯化试剂盒包括能够进行液 - 液萃取方法和核酸纯化方法的微流体装置，包括专用液 - 液萃取处理容器，不混溶液体或前体相 在容器中，核酸纯化方法组分，流式的核酸扩增反应器和适于实现液 - 液萃取方法和核酸纯化方法的试剂供应。

    Channel-less pump, methods, and applications thereof
    4.
    发明授权
    Channel-less pump, methods, and applications thereof 有权

    公开(公告)号：US10180133B2

    公开(公告)日：2019-01-15

    申请号：US14548474

    申请日：2014-11-20

    Applicant: Rheonix, Inc.

    Inventor： Lincoln C. Young ,  Peng Zhou

    IPC: F04B43/12 ,  F04B43/04 ,  F04B43/06 ,  B01L3/00 ,  F04B43/00 ,  F04B43/02

    Abstract: A channel-less microfluidic pump includes a cartridge including a substrate and an actuatable film layer disposed on the substrate, and a manifold having at least three actuatable void volumes separated by a plurality of wall sections and an actuatable flexible layer disposed on the manifold interfacing the actuatable film layer. In operation, the pump can be in an unactuated state wherein the actuatable film layer is disposed against the surface of the substrate or an actuated state wherein at least a portion of the flexible layer and a corresponding portion of the actuatable film layer are deflected into a corresponding void volume thus forming a fluidic volume between the deflected portion of the actuatable film layer and the surface of the substrate. In the actuated state, there is a fluidic gap between immediately adjacent void volumes formed by a thinned region of the flexible layer at a point of contact with a top surface of a wall section. A method of transporting fluid using the channel-less microfluidic pump is described.

    MICROFLUIDIC APPARATUS, METHOD, AND APPLICATIONS
    10.
    发明申请
    MICROFLUIDIC APPARATUS, METHOD, AND APPLICATIONS 有权

    公开(公告)号：US20130164826A1

    公开(公告)日：2013-06-27

    申请号：US13678732

    申请日：2012-11-16

    Applicant: RHEONIX, INC.

    Inventor： Peng Zhou

    IPC: C07H1/08

    CPC classification number: C12Q1/6806 ,  B01L3/502715 ,  B01L2200/0631 ,  C07H1/08 ,  C12N15/1003 ,  C12Q2527/101 ,  C12Q2565/629

    Abstract: A microfluidic apparatus, method, and associated applications utilize and apply to a formalin-fixed paraffin-embedded (FFPE) tissue sample and performing a liquid-liquid extraction to remove the paraffin from the tissue sample prior to a nucleic acid purification step. A microfluidic device includes a dedicated liquid-liquid extraction process vessel, a nucleic acid purification process component, and a nucleic acid amplification reactor. A liquid-liquid extraction and nucleic acid purification kit includes a microfluidic device capable of performing both a liquid-liquid extraction process and a nucleic acid purification process, including a dedicated liquid-liquid extraction process vessel, an immiscible liquid or a precursor phase thereof disposed in the vessel, a nucleic acid purification process component, a nucleic acid amplification reactor fluidically, and a supply of reagents suitable to enable the liquid-liquid extraction process and the nucleic acid purification process.

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