公开(公告)号：US20170020387A1

公开(公告)日：2017-01-26

申请号：US15106910

申请日：2015-02-04

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Jeffrey P. Fingler ,  Scott E. Fraser

IPC: A61B3/10 ,  G01B9/02 ,  F21V8/00 ,  A61B3/12 ,  A61B3/00

CPC classification number: A61B3/102 ,  A61B3/0025 ,  A61B3/10 ,  A61B3/1233 ,  G01B9/02091 ,  G01N21/4795 ,  G02B6/0005

Abstract: This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system having a configuration that uses a phase sensitive B-scan registration method. In this disclosure, an OCT system may have a configuration that scans a physical object, acquires OCT signals to form B-scans, uses these B-scans to determine an optimal shift in an axial direction by using total phase error between B-scans, and align B-scans, thereby minimizing effects of motion that may occur during scanning of the physical object.

Abstract translation: 本公开涉及光学相干断层扫描（OCT）领域。 本公开特别涉及具有使用相敏B扫描注册方法的配置的OCT系统。 在本公开中，OCT系统可以具有扫描物理对象的结构，获取OCT信号以形成B扫描，使用这些B扫描来通过使用B扫描之间的总相位误差来确定轴向上的最佳偏移， 并对齐B扫描，从而最小化在物理对象的扫描期间可能发生的运动的影响。

公开(公告)号：US12196679B2

公开(公告)日：2025-01-14

申请号：US17911006

申请日：2021-03-12

Applicant: University of Southern California

Inventor： Francesco Cutrale ,  Pu Wang ,  Scott E. Fraser

IPC: G01N21/64 ,  G02B21/16 ,  G02B21/36

Abstract: Systems and methods are provided for multi-spectral or hyper-spectral fluorescence imaging. In one example, a spectral encoding device may be positioned in a detection light path between a detection objective and an imaging sensor of a microscope. In one example, the spectral encoding device includes a first dichroic mirror having a sine transmittance profile and a second dichroic mirror having a cosine transmittance profile. In addition to collecting transmitted light, reflected light from each dichroic mirror is collected and used for total intensity normalization and image analysis.

公开(公告)号：US20230092749A1

公开(公告)日：2023-03-23

申请号：US17911006

申请日：2021-03-12

Applicant: University of Southern California

Inventor： Francesco Cutrale ,  Pu Wang ,  Scott E. Fraser

IPC: G01N21/64 ,  G02B21/36 ,  G02B21/16

Abstract: Systems and methods are provided for multi-spectral or hyper-spectral fluorescence imaging. In one example, a spectral encoding device may be positioned in a detection light path between a detection objective and an imaging sensor of a microscope. In one example, the spectral encoding device includes a first dichroic mirror having a sine transmittance profile and a second dichroic mirror having a cosine transmittance profile. In addition to collecting transmitted light, reflected light from each dichroic mirror is collected and used for total intensity normalization and image analysis.

公开(公告)号：US09913603B2

公开(公告)日：2018-03-13

申请号：US14621286

申请日：2015-02-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Sameer Walavalkar ,  Chieh-feng Chang ,  Axel Scherer ,  Brandon Marin ,  Scott E. Fraser ,  Andrea R. Tao

IPC: G01N21/65 ,  G01N33/18 ,  G01N33/483 ,  G01N33/00 ,  A61B5/1459 ,  H01L27/146 ,  A61B5/1473 ,  A61B5/07 ,  A61B5/00 ,  B82Y40/00 ,  B82Y30/00

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/076 ,  A61B5/14735 ,  A61B5/6848 ,  A61B5/686 ,  A61B2562/0233 ,  A61B2562/0285 ,  A61B2562/12 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/658 ,  H01L27/14698

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

公开(公告)号：US20160331227A1

公开(公告)日：2016-11-17

申请号：US15106949

申请日：2015-03-04

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Jeffrey P. Fingler ,  Scott E. Fraser

IPC: A61B3/10 ,  A61B3/113 ,  A61B3/12 ,  A61B3/00

CPC classification number: A61B3/102 ,  A61B3/0025 ,  A61B3/0083 ,  A61B3/0091 ,  A61B3/113 ,  A61B3/1241

Abstract: This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to methods and systems for providing larger field of view OCT images. This disclosure also particularly relates to methods and systems for OCT angiography. These systems may allow OCT scanning for an extended duration and generation of large field OCT images suitable for the OCT angiography.

Abstract translation: 本公开涉及光学相干断层扫描（OCT）领域。 本公开特别涉及用于提供更大视场OCT图像的方法和系统。 本公开还特别涉及用于OCT血管造影术的方法和系统。 这些系统可以允许OCT扫描延长的持续时间并产生适合于OCT血管造影术的大场OCT图像。