公开(公告)号：US11583299B1

公开(公告)日：2023-02-21

申请号：US16295607

申请日：2019-03-07

Applicant: University of Washington through its Center for Commercialization

Inventor： Adam D. Maxwell ,  Bryan W. Cunitz ,  Wayne Kreider ,  Oleg A. Sapozhnikov ,  Ryan S. Hsi ,  Michael R. Bailey

IPC: A61B17/22

Abstract: A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm).

公开(公告)号：US20230038081A1

公开(公告)日：2023-02-09

申请号：US17881026

申请日：2022-08-04

Applicant: University of Washington

Inventor： Michael R. Bailey ,  Mohamed Abdalla Ghanem ,  Adam D. Maxwell

IPC: A61N7/00 ,  G02B5/32 ,  B29D11/00

Abstract: Non-planar holographic beam shaping lenses for acoustics are disclosed herein. In one embodiment, an ultrasonic therapy system that is configured to apply ultrasound to a target in a body includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable holographic lens configured to focus the ultrasound onto a focal area of a target that is an object or a portion of the object in the body. The customizable holographic lens is designed and produced based on the target. Furthermore, the customizable holographic lens is curved to mate with a front surface of the ultrasonic transducer.

公开(公告)号：US20210325280A1

公开(公告)日：2021-10-21

申请号：US17239387

申请日：2021-04-23

Applicant: University of Washington

Inventor： Thomas J. Matula ,  Karol Bomsztyk ,  Brian MacConaghy ,  Justin Reed ,  Adam D. Maxwell

IPC: G01N1/28 ,  B06B1/02 ,  B06B1/06 ,  G10K11/30 ,  C12M1/00 ,  B01L3/00

Abstract: A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.

公开(公告)号：US10251657B1

公开(公告)日：2019-04-09

申请号：US14268414

申请日：2014-05-02

Applicant: University of Washington through its Center for Commercialization

Inventor： Adam D. Maxwell ,  Bryan W. Cunitz ,  Wayne Kreider ,  Oleg A. Sapozhnikov ,  Ryan S. Hsi ,  Michael R. Bailey

IPC: A61B17/22

Abstract: Methods, computing devices, and a computer-readable medium are described herein related to fragmenting or comminuting an object in a subject using a burst wave lithotripsy (BWL) waveform. A computing device, such a computing device coupled to a transducer, may carry out functions for producing a BWL waveform. The computing device may determine a burst frequency for a number of bursts in the BWL waveform, where the number of bursts includes a number of cycles. Further, the computing device may determine a cycle frequency for the number of cycles. Yet further, the computing device may determine a pressure amplitude for the BWL waveform, where the pressure amplitude is less than or equal to 8 MPa. In addition, the computing device may determine a time period for producing the BWL waveform.

公开(公告)号：US20170205318A1

公开(公告)日：2017-07-20

申请号：US15326892

申请日：2015-07-14

Applicant: University of Washington

Inventor： Thomas J. Matula ,  Karol Bomsztyk ,  Brian MacConaghy ,  Justin Reed ,  Adam D. Maxwell

IPC: G01N1/28 ,  B01L3/00 ,  B06B1/02 ,  G10K11/30 ,  B06B1/06

CPC classification number: G01N1/286 ,  B01L3/5085 ,  B06B1/0215 ,  B06B1/0629 ,  B06B2201/55 ,  B06B2201/70 ,  C12M47/06 ,  G10K11/30

Abstract: A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.