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公开(公告)号：US20230071935A1
公开(公告)日：2023-03-09
申请号：US17884705
申请日：2022-08-10
Applicant: Matchstick Technologies, Inc. , University of Washington
Inventor： Karol Bomsztyk , Gregory P. Darlington , Daniel S. Mar , Thomas J. Matula , Gregory T. Wing
Abstract: A sonicator assembly, including: a microplate defining a plurality of wells; a manifold for containing a transducer fluid that is thermally coupled to the plurality of wells of the microplate; an ultrasonic generator operable for applying an ultrasonic excitation to the wells of the microplate; one or more of a heating module thermally coupled to and operable for selectively heating the transducer fluid and a cooling module thermally coupled to and operable for selectively cooling the transducer fluid; and a controller operable for controlling operation of the ultrasonic generator and the one or more of the heating module and the cooling module. The controller is further operable for monitoring a temperature and a pressure within the manifold. A temperature of the plurality of wells is controllable over a temperature range from 4° C. to 95° C. Optionally, the plurality of wells include a plurality of heat-resistant round-bottom hydrophilic wells.
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公开(公告)号：US20140347669A1
公开(公告)日：2014-11-27
申请号：US14138616
申请日：2013-12-23
Applicant: University of Washington
Inventor： Thomas J. Matula , Jarred Swalwell
CPC classification number: G01N21/49 , A61B5/0059 , A61B8/481 , G01N15/1459 , G01N21/01 , G01N21/70 , G01N33/15 , G01N2015/1493 , G01N2021/0193
Abstract: Flow cytometry concepts are modified to enable dynamic characterizations of particles to be obtained using optical scattering data. Particles in flow will be introduced into a sample volume. Light scattered by a particle in the sample volume is collected and analyzed. What differentiates the concepts disclosed herein from conventional flow cytometry is the use of an acoustic source that is disposed to direct acoustic energy into the sample volume. As the particle passes through the sample volume, it responds to the acoustic energy, causing changes in the light scattered by the particle. Those changes, which are not measured during conventional flow cytometry, can be analyzed to determine additional physical properties of the particle.
Abstract translation: 流式细胞术概念被修改以使得能够使用光学散射数据获得的粒子的动态表征。 流入的颗粒将被引入样品体积。 收集并分析由样品体积中的颗粒散射的光。 将本文公开的概念与常规流式细胞术区分开来的是使用声源，其被设置为将声能引导到样本体积中。 当颗粒通过样品体积时，其响应于声能，引起颗粒散射的光的变化。 可以分析在常规流式细胞术中不测量的那些变化，以确定颗粒的附加物理性质。
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公开(公告)号：US12066362B2
公开(公告)日：2024-08-20
申请号：US17239387
申请日：2021-04-23
Applicant: University of Washington
Inventor： Thomas J. Matula , Karol Bomsztyk , Brian MacConaghy , Justin Reed , Adam D. Maxwell
CPC classification number: G01N1/286 , B01L3/5085 , B06B1/0215 , B06B1/0629 , C12M47/06 , G10K11/30 , B06B2201/55 , B06B2201/70
Abstract: A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.
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公开(公告)号：US20170100145A1
公开(公告)日：2017-04-13
申请号：US15288372
申请日：2016-10-07
Applicant: University of Washington
Inventor： Tatiana D. Khoklova , Thomas J. Matula , Wayne L. Monsky , Yak-Nam Wang
CPC classification number: A61N7/02 , A61B2017/22008 , A61B2017/22079 , A61B2217/005
Abstract: Methods for treating an extravascular hematoma in a patient can include liquefying a first portion of the extravascular hematoma by applying a first series of focused acoustic pulses to the extravascular hematoma at a first frequency; and liquefying a second portion of the extravascular hematoma by applying a second series of focused acoustic pulses to the extravascular hematoma at a second frequency. Liquefied remains of the extravascular hematoma can be aspirated from the patient following liquefaction and disruption.
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公开(公告)号：US11698364B2
公开(公告)日：2023-07-11
申请号：US16455550
申请日：2019-06-27
Applicant: University of Washington
Inventor： Thomas J. Matula , Masaoki Kawasumi , Oleg Sapozhnikov
CPC classification number: G01N33/4915 , B01L3/50273 , B01L3/502761 , G01N15/1056 , G01N33/5014 , G01N33/585 , B01L2200/0647 , B01L2400/0436 , G01N2015/142 , G01N2510/00
Abstract: Cell-separation systems and methods utilizing cell-specific microbubble tags and ultrasound-based separation are described. The methods are useful for simplification of time-consuming and costly cell purification procedures and real time apoptosis detection.
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Patent Agency Ranking
公开(公告)号：US10702719B2
公开(公告)日：2020-07-07
申请号：US15288372
申请日：2016-10-07
Applicant: University of Washington
Inventor： Tatiana Khokhlova , Thomas J. Matula , Wayne L. Monsky , Yak-Nam Wang
Abstract: Methods for treating an extravascular hematoma in a patient can include liquefying a first portion of the extravascular hematoma by applying a first series of focused acoustic pulses to the extravascular hematoma at a first frequency; and liquefying a second portion of the extravascular hematoma by applying a second series of focused acoustic pulses to the extravascular hematoma at a second frequency. Liquefied remains of the extravascular hematoma can be aspirated from the patient following liquefaction and disruption.
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公开(公告)号：US20200001293A1
公开(公告)日：2020-01-02
申请号：US16455550
申请日：2019-06-27
Applicant: University of Washington
Inventor： Thomas J. Matula , Masaoki Kawasumi , Oleg Sapozhnikov
Abstract: Cell-separation systems and methods utilizing cell-specific microbubble tags and ultrasound-based separation are described. The methods are useful for simplification of time-consuming and costly cell purification procedures and real time apoptosis detection.
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公开(公告)号：US20210325280A1
公开(公告)日：2021-10-21
申请号：US17239387
申请日：2021-04-23
Applicant: University of Washington
Inventor： Thomas J. Matula , Karol Bomsztyk , Brian MacConaghy , Justin Reed , Adam D. Maxwell
Abstract: A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.
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公开(公告)号：US20170205318A1
公开(公告)日：2017-07-20
申请号：US15326892
申请日：2015-07-14
Applicant: University of Washington
Inventor： Thomas J. Matula , Karol Bomsztyk , Brian MacConaghy , Justin Reed , Adam D. Maxwell
CPC classification number: G01N1/286 , B01L3/5085 , B06B1/0215 , B06B1/0629 , B06B2201/55 , B06B2201/70 , C12M47/06 , G10K11/30
Abstract: A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.
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10.发明申请SYSTEMS AND METHODS FOR TREATING ABSCESSES AND INFECTED FLUID COLLECTIONS 审中-公开用于治疗感染和感染的液体收集的系统和方法公开(公告)号：US20160184614A1
公开(公告)日：2016-06-30
申请号：US14907443
申请日：2014-08-27
Inventor： Thomas J. Matula , Keith Chan
CPC classification number: A61N7/00 , A61B8/085 , A61B8/4494 , A61B8/461 , A61B2017/320069 , A61B2018/00577 , A61B2090/374 , A61B2090/3762 , A61B2090/378 , A61N7/02 , A61N2007/0052
Abstract: The present disclosure provides systems and methods for treating (e.g., reducing and/or eliminating) abscesses by applying acoustic energy, for example high intensity focused ultrasound (“HIFU”).
Abstract translation: 本公开提供了通过施加声能来治疗（例如，减少和/或消除）脓肿的系统和方法，例如高强度聚焦超声（“HIFU”）。
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