公开(公告)号：US20100021620A1

公开(公告)日：2010-01-28

申请号：US12179783

申请日：2008-07-25

Applicant: Paul Coates ,  Brian Cook

Inventor： Paul Coates ,  Brian Cook

IPC: B05D3/12

CPC classification number: C23C14/12 ,  A61F2/82 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/02 ,  C23C14/024

Abstract: A drug coating is formed by vaporizing a drug in a deposition chamber having an implantable medical device such as a stent loaded therein. A vacuum is utilized to lower the pressure within the deposition chamber, thereby reducing the temperature necessary to vaporize the drug. The drug is then deposited onto the implantable medical device while in a vapor phase to form the drug coating.

Abstract translation: 通过在具有植入式医疗装置（诸如其中装载的支架）的沉积室中蒸发药物来形成药物涂层。 利用真空来降低沉积室内的压力，从而降低蒸发药物所需的温度。 然后将药物在气相中沉积到可植入医疗装置上以形成药物涂层。

公开(公告)号：US20090132031A1

公开(公告)日：2009-05-21

申请号：US11941591

申请日：2007-11-16

Applicant: Brian Cook ,  Mark Dolan

Inventor： Brian Cook ,  Mark Dolan

IPC: A61F2/82

CPC classification number: A61F2/88 ,  A61F2/86 ,  A61F2250/0035 ,  A61F2250/0068

Abstract: A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.

Abstract translation: 药物递送支架由金属或聚合物管状支柱形成，其形状为大致圆柱形的构造，管状支柱具有用于在其中容纳治疗物质或药物的中心腔。 管状支柱具有从支柱的内表面延伸到支柱的外表面的连续通道，所述支柱的外表面围绕螺旋状围绕或以开瓶器方式围绕管状支柱的圆周定位，用于将治疗物质或药物输送至狭窄病变。 螺旋或螺旋状通道宽度可以沿着支柱的长度变化以控制支架的洗脱速率和/或柔性。 螺旋或螺旋状通道的螺距也可以沿着支柱的长度变化以控制支架的柔性。 支架可以携带在球囊导管的球囊上，以移植支架的狭窄病变部位。

公开(公告)号：US20080255658A1

公开(公告)日：2008-10-16

申请号：US11734388

申请日：2007-04-12

Applicant: Brian Cook ,  Joseph Berglund

Inventor： Brian Cook ,  Joseph Berglund

IPC: A61F2/06

CPC classification number: A61L31/10 ,  A61F2/95 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/44 ,  A61L2300/604

Abstract: A system for treating a vascular condition includes a stent having a biodegradable coating on the stent framework. The coating releases a therapeutically effective amount of therapeutic agent as a function of degradation of the coating. Also provided is a method of treating a vascular condition by placing a stent having a biodegradable coating at a treatment site and delivering a therapeutically effective amount of therapeutic agent at the treatment site as a function of degradation of the coating. Also provided is a method of improving the performance of a medical device by including a biodegradable coating on the surface of the device and releasing a therapeutically effective amount of a therapeutic agent at the treatment site as a function of degradation of the coating.

Abstract translation: 用于治疗血管病症的系统包括在支架框架上具有可生物降解的涂层的支架。 涂层释放作为涂层降解的功能的治疗有效量的治疗剂。 还提供了通过将具有可生物降解涂层的支架放置在治疗部位并在治疗部位递送治疗有效量的治疗剂作为涂层降解的功能来治疗血管病症的方法。 还提供了通过在装置的表面上包括可生物降解的涂层并在治疗部位释放治疗有效量的治疗剂作为涂层降解的功能来改善医疗装置的性能的方法。

公开(公告)号：US20080111191A1

公开(公告)日：2008-05-15

申请号：US11865921

申请日：2007-10-02

Applicant: Takashi MIYAZAWA ,  Brian Cook Cook ,  David Wayen Devore ,  Daniel Robert Gagnon ,  Kris Eren Kallenberger ,  David Kyle Murray

Inventor： Takashi MIYAZAWA ,  Brian Cook Cook ,  David Wayen Devore ,  Daniel Robert Gagnon ,  Kris Eren Kallenberger ,  David Kyle Murray

IPC: H01L23/62

CPC classification number: G09G3/3233 ,  G09G2300/0842 ,  G09G2300/0866 ,  G09G2310/0251 ,  G09G2310/06

Abstract: An electronic circuit that drives a driven element to which driving voltage or driving current is supplied. The electronic circuit includes a signal line, a unit circuit connected to the signal line, and a voltage supply line. The unit circuit includes a driving transistor, a switching element, and a capacitive element. The driving transistor includes a gate terminal, a first terminal, a second terminal connected to the voltage supply line, and a channel formed between the first terminal and the second terminal. The switching element controls electrical connection between the gate terminal of the driving transistor and one of the first terminal and the second terminal. The capacitive element includes a first electrode connected to the gate terminal of the driving transistor and a second electrode connected to the signal line. A conductive state between the first terminal and the second terminal is controlled by a gate voltage applied to the gate terminal. During a first period, which is at least part of a period during which the switching element is in an off state, a voltage level of the gate voltage changes from a first voltage level to a second voltage level by a first signal being supplied to the signal line. During a second period, which is at least part of a period during which a second signal is supplied to the signal line, the switching element is set to an on state.

Abstract translation: 驱动驱动电压或驱动电流的驱动元件的电子电路。 电子电路包括信号线，连接到信号线的单元电路和电压供给线。 单位电路包括驱动晶体管，开关元件和电容元件。 驱动晶体管包括栅极端子，第一端子，连接到电压供应线路的第二端子以及形成在第一端子和第二端子之间的通道。 开关元件控制驱动晶体管的栅极端子与第一端子和第二端子之一的电连接。 电容元件包括连接到驱动晶体管的栅极端子的第一电极和连接到信号线的第二电极。 第一端子和第二端子之间的导通状态由施加到栅极端子的栅极电压控制。 在开关元件处于截止状态的期间的至少一部分的第一时段期间，栅极电压的电压电平由第一电压电平变化到第二电压电平，第一信号被提供给 信号线。 在将第二信号提供给信号线的期间的至少一部分的第二期间，将开关元件设定为接通状态。

公开(公告)号：US20070157967A1

公开(公告)日：2007-07-12

申请号：US11639372

申请日：2006-12-14

Applicant: Andreas Mershin ,  Brian Cook ,  Shuguang Zhang

Inventor： Andreas Mershin ,  Brian Cook ,  Shuguang Zhang

IPC: H01L31/00

CPC classification number: H01G9/2027 ,  B82Y10/00 ,  B82Y30/00 ,  H01G9/204 ,  H01G9/2059 ,  H01L51/0093 ,  Y02E10/542 ,  Y02E10/549

Abstract: The present invention provides a wet or dry bio-sensitized photoelectric conversion device (photodetector or photovoltaic) comprising: a stabilized biologically-derived sensitizer, such as a stablilized photosystem I (PS-I), deposited on nanowires, semiconductor material, electrodes and a support. The nanowires provide a greater surface area of the light absorption layer for better energy conversion efficiency and are chosen such as to complement the absorption spectrum of the sensitizer and protect the sensitizer from photobleaching.

Abstract translation: 本发明提供一种湿或干生物敏化光电转换装置（光电检测器或光伏），其包括：稳定的生物衍生的敏化剂，例如沉积在纳米线，半导体材料，电极上的稳定的光系统I（PS-1） 支持。 纳米线提供更大的光吸收层的表面积以获得更好的能量转换效率，并且被选择为补充敏化剂的吸收光谱并保护敏化剂免受漂白。

公开(公告)号：US20060218467A1

公开(公告)日：2006-09-28

申请号：US11088562

申请日：2005-03-24

Applicant: James Sibigtroth ,  Brian Cook ,  George Espinor ,  Clay Merritt ,  Bruce Morton

Inventor： James Sibigtroth ,  Brian Cook ,  George Espinor ,  Clay Merritt ,  Bruce Morton

IPC: G11C29/00

CPC classification number: G11C7/1045 ,  G11C7/1006 ,  G11C29/028 ,  G11C29/52 ,  G11C2029/0409 ,  G11C2029/1804 ,  G11C2207/104

Abstract: A memory has an ECC-enabled mode and an ECC-disabled mode in which the portion of the memory dedicated to use as storing ECC in the ECC-enabled mode is used for storing general purpose information (data) in the ECC-disabled mode. This is achieved in a non-volatile memory (NVM) by having the data and the portion of the memory with the corresponding ECC on the same word line. This is particularly important in an NVM because of complication relating to erase. In the ECC-enabled mode the ECC and corresponding data should be erased, programmed, and read together in order to avoid a significant layout and performance penalty. This is best achieved by having the ECC and the data on the same word line.

Abstract translation: 存储器具有ECC使能模式和ECC禁用模式，其中专用于在ECC启用模式中存储ECC的存储器的部分用于存储ECC禁用模式中的通用信息（数据）。 这通过在同一字线上具有相应的ECC的数据和存储器的一部分而在非易失性存储器（NVM）中实现。 这在NVM中特别重要，因为与擦除相关的并发症。 在启用ECC的模式下，ECC和相应的数据应该被擦除，编程和一起读取，以避免重大的布局和性能损失。 这最好通过将ECC和数据放在同一个字线上来实现。

公开(公告)号：US20060127902A1

公开(公告)日：2006-06-15

申请号：US10524432

申请日：2003-08-15

Applicant: Stephen Madden ,  Clarence Cook ,  Brian Cook ,  John Laterra ,  Kevin Walter

Inventor： Stephen Madden ,  Clarence Cook ,  Brian Cook ,  John Laterra ,  Kevin Walter

IPC: C12Q1/68 ,  G01N33/567 ,  G01N33/53

CPC classification number: G01N33/57407 ,  C12N5/0693 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N2500/00

Abstract: To gain a better understanding of brain tumor angiogenesis, new techniques for isolating brain endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from brain ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed genes that were specifically elevated in tumor-associated brain endothelium. These results confirm that neoplastic and normal endothelium in human brains are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.

Abstract translation: 为了更好地了解脑肿瘤血管生成，开发了分离脑内皮细胞（ECs）和评估基因表达模式的新技术。 将来自正常和恶性结肠直肠组织的脑EC的转录物与来自非内皮细胞的转录物进行比较，鉴定出在内皮中主要表达的基因。 正常和肿瘤来源的内皮的比较显示在肿瘤相关脑内皮细胞中特异性升高的基因。 这些结果证实，人脑中的肿瘤和正常内皮在分子水平上是不同的，并且对未来抗血管生成疗法的发展具有重要的意义。

公开(公告)号：US06213174B1

公开(公告)日：2001-04-10

申请号：US09248954

申请日：1999-02-12

Applicant: Bernard Brian Cook ,  John McEwan ,  Lim Peng Keong ,  Werner Eugen Friedrich

Inventor： Bernard Brian Cook ,  John McEwan ,  Lim Peng Keong ,  Werner Eugen Friedrich

IPC: B65B130

CPC classification number: G01G13/06 ,  G01G13/2952

Abstract: This invention is directed to methods, procedures and apparatus for controlling the portioning of flowable materials, particularly soft serve frozen confections, though also including other flowable products. Such other products may include soups, beverages such as milk shakes, soft drinks, and alcoholic beverages such as beers, and so forth. Typically a method for controlling the delivery of a portion of a flowable substance includes the steps of: i) Delivering the flowable substance in a stream; and ii) Noting the time for the delivery of a portion of a targeted amount; and iii) Determining the weight of the portion, and iv) Using this information to influence the delivery of further substance to meet a pre-determined target value. A preferred method is characterized by both the weight of the flowable substance being delivered and the time for the delivery of same being repeatedly or continuously assessed to achieve delivery of a pre-determined target weight or volume.

Abstract translation: 本发明涉及用于控制可流动材料分段的方法，程序和装置，特别是软饮料冷冻甜食，尽管还包括其它可流动的产品。 这样的其他产品可以包括汤，诸如奶昔的饮料，软饮料和酒精饮料如啤酒等。通常，用于控制可流动物质的一部分的输送的方法包括以下步骤：i） 流中的可流动物质; 注意到交付一部分目标金额的时间; 和iii）确定该部分的重量，并且使用该信息来影响另外的物质的输送以满足预定的目标值。优选的方法的特征在于被输送的可流动物质的重量和 反复或连续评估相同的递送以实现预定目标重量或体积的输送。

公开(公告)号：US4177254A

公开(公告)日：1979-12-04

申请号：US923933

申请日：1978-07-13

Applicant: Karrar A. Khan ,  Brian Cook

Inventor： Karrar A. Khan ,  Brian Cook

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K31/43 ,  A61K9/36

CPC classification number: A61K9/1676 ,  A61K31/43

Abstract: Two, preferably three, layered orally administrable granules containing orally administrable penicillins have desirable properties such as elegance, freedom from dust and good reconstitution. They contain an inert core, preferably of sucrose, a penicillin/binder first layer and normally and preferably a final coating layer of conventional additives such as dyes, flavors etc..Preferably the penicillin is amoxycillin trihydrate and the binder sucrose. The granules may be prepared by fluid bed granulation.

Abstract translation: 两种，优选三种含有口服给药的青霉素的可分层口服颗粒具有优雅性，无灰尘和良好重构的所需性质。 它们含有惰性核心，优选蔗糖，青霉素/粘合剂第一层，通常且优选常规添加剂如染料，香料等的最终涂层。优选青霉素为阿莫西林三水合物和粘合剂蔗糖。 颗粒可以通过流化床造粒制备。