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公开(公告)号：US20090132031A1
公开(公告)日：2009-05-21
申请号：US11941591
申请日：2007-11-16
Applicant: Brian Cook , Mark Dolan
Inventor： Brian Cook , Mark Dolan
IPC: A61F2/82
CPC classification number: A61F2/88 , A61F2/86 , A61F2250/0035 , A61F2250/0068
Abstract: A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.
Abstract translation: 药物递送支架由金属或聚合物管状支柱形成，其形状为大致圆柱形的构造，管状支柱具有用于在其中容纳治疗物质或药物的中心腔。 管状支柱具有从支柱的内表面延伸到支柱的外表面的连续通道，所述支柱的外表面围绕螺旋状围绕或以开瓶器方式围绕管状支柱的圆周定位，用于将治疗物质或药物输送至狭窄病变。 螺旋或螺旋状通道宽度可以沿着支柱的长度变化以控制支架的洗脱速率和/或柔性。 螺旋或螺旋状通道的螺距也可以沿着支柱的长度变化以控制支架的柔性。 支架可以携带在球囊导管的球囊上，以移植支架的狭窄病变部位。
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公开(公告)号：US08016880B2
公开(公告)日：2011-09-13
申请号：US11941591
申请日：2007-11-16
Applicant: Brian Cook , Mark Dolan
Inventor： Brian Cook , Mark Dolan
IPC: A61F2/06
CPC classification number: A61F2/88 , A61F2/86 , A61F2250/0035 , A61F2250/0068
Abstract: A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.
Abstract translation: 药物递送支架由金属或聚合物管状支柱形成，其形状为大致圆柱形的构造，管状支柱具有用于在其中容纳治疗物质或药物的中心腔。 管状支柱具有从支柱的内表面延伸到支柱的外表面的连续通道，所述支柱的外表面围绕螺旋状围绕或以开瓶器方式围绕管状支柱的圆周定位，用于将治疗物质或药物输送至狭窄病变。 螺旋或螺旋状通道宽度可以沿着支柱的长度变化以控制支架的洗脱速率和/或柔性。 螺旋或螺旋状通道的螺距也可以沿着支柱的长度变化以控制支架的柔性。 支架可以携带在球囊导管的球囊上，以移植支架的狭窄病变部位。
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公开(公告)号：US08021420B2
公开(公告)日：2011-09-20
申请号：US12403114
申请日：2009-03-12
Applicant: Mark Dolan
Inventor： Mark Dolan
IPC: A61F2/24
CPC classification number: A61M25/1011 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2250/0048 , A61M29/02 , A61M2025/0039 , A61M2025/004
Abstract: A prosthetic valve delivery system for percutaneously delivering and deploying a prosthetic valve within an existing valve is disclosed. The delivery system includes a stented prosthetic valve having a balloon-expandable stent portion with a prosthetic valve disposed therein and at least one self-expanding stent portion. The delivery system further includes a dual balloon catheter having a first balloon on which the stented prosthetic valve is disposed during delivery and a second balloon. Upon delivery within the existing valve, the self-expanding stent portion contacts the existing valve and the first balloon expands the balloon-expandable stent portion to a first diameter such that the stented prosthetic valve is in a first stage deployment configuration. The second balloon then expands the balloon-expandable stent portion to a second diameter, greater than the first diameter, such that the stented prosthetic valve is in a second stage deployment configuration being fully deployed within the existing valve.
Abstract translation: 公开了一种用于在现有阀内经皮递送和展开假体瓣膜的假体瓣膜输送系统。 输送系统包括支架假体瓣膜，其具有球囊扩张支架部分，其中设置有人工瓣膜和至少一个自扩张支架部分。 输送系统还包括具有第一气囊的双气囊导管，其中支架假体瓣膜在输送期间设置在其上并具有第二气囊。 在现有阀门内传送后，自膨胀支架部分接触现有阀门，第一气囊将球囊扩张支架部分扩张至第一直径，使得支架假体瓣膜处于第一阶段展开构型。 然后，第二气囊将球囊扩张支架部分扩大到大于第一直径的第二直径，使得支架假体瓣膜处于完全展开在现有瓣膜内的第二阶段展开构型。
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公开(公告)号：US20090093871A1
公开(公告)日：2009-04-09
申请号：US11868742
申请日：2007-10-08
Applicant: Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
Inventor： Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
IPC: A61F2/06
CPC classification number: A61F2/90 , A61F2250/0068
Abstract: A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes tubing having a wall defining a central lumen and a plurality of holes. The system further includes a therapeutic agent disposed within the central lumen of the tubing. A method of manufacturing a therapeutic agent carrying stent includes inserting a therapeutic agent within a therapeutic agent delivery system into the central lumen of a hollow metal tube and forming a stent framework from the hollow tube.
Abstract translation: 用于治疗血管状态的系统包括导管和设置在导管上的支架。 支架包括具有限定中心腔和多个孔的壁的管。 该系统还包括设置在管的中心腔内的治疗剂。 制造治疗剂携带支架的方法包括将治疗剂递送系统内的治疗剂插入中空金属管的中心腔，并从中空管形成支架框架。
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公开(公告)号：US20070244544A1
公开(公告)日：2007-10-18
申请号：US11279769
申请日：2006-04-14
Applicant: Matthew Birdsall , Mark Dolan , Justin Goshgarian , Michael Krivoruchko , Joseph Lessar , Darrel Untereker , Peter Urbanski
Inventor： Matthew Birdsall , Mark Dolan , Justin Goshgarian , Michael Krivoruchko , Joseph Lessar , Darrel Untereker , Peter Urbanski
CPC classification number: A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2002/9528 , A61F2210/0061 , A61F2250/006 , A61F2250/0069 , A61L24/0031 , A61L24/08 , C08L5/08
Abstract: A valve replacement system that can be used for treating abnormalities of the right ventricular outflow tract includes a prosthetic valve device having a sealant contacting at least a portion of the outer surface of the valve device. The sealant may be breakable, and may be a hydrogel, an expandable hydrogel, or a solid. One embodiment of the invention includes a flowable sealant that is injected within the vascular system. Another embodiment of the invention includes a method for replacing a pulmonary valve that includes forming a seal around the exterior surface of a replacement valve and preventing blood flow around the replacement valve.
Abstract translation: 可用于治疗右心室流出道异常的瓣膜置换系统包括具有与阀装置的外表面的至少一部分接触的密封剂的人造瓣膜装置。 密封剂可以是可破裂的，并且可以是水凝胶，可膨胀水凝胶或固体。 本发明的一个实施方案包括注射在血管系统内的可流动的密封剂。 本发明的另一个实施例包括一种用于替换肺动脉瓣的方法，该方法包括在置换瓣膜的外表面周围形成密封并防止置换瓣膜周围的血液流动。
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Patent Agency Ranking
公开(公告)号：US20070239269A1
公开(公告)日：2007-10-11
申请号：US11278984
申请日：2006-04-07
Applicant: Mark Dolan , Jeffrey Allen
Inventor： Mark Dolan , Jeffrey Allen
CPC classification number: A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2250/006
Abstract: A system for replacing a pulmonary valve includes a conduit having a lumen, a delivery catheter and a replacement valve device disposed on the delivery catheter. The replacement valve device includes a prosthetic valve connected to a valve support region of an expandable support structure. The valve support region includes a plurality of protective struts disposed between a first stent region and a second stent region. A method for replacing a pulmonary valve includes implanting a conduit and delivering a replacement valve device to the conduit. The replacement valve device includes a valve connected to a valve support region that includes a plurality of protective struts. The method also includes deploying the prosthetic valve device from a delivery catheter into the lumen, positioning the prosthetic valve device within the conduit lumen and expanding the prosthetic valve device into contact with the inner wall of the conduit.
Abstract translation: 用于替换肺动脉瓣的系统包括具有内腔，输送导管和设置在输送导管上的置换瓣膜装置的导管。 替换阀装置包括连接到可扩张支撑结构的阀支撑区域的假体阀。 阀支撑区域包括设置在第一支架区域和第二支架区域之间的多个保护支柱。 用于替换肺动脉瓣膜的方法包括植入导管并将更换瓣膜装置输送到导管。 更换阀装置包括连接到包括多个保护支柱的阀支撑区域的阀。 该方法还包括将假体瓣膜装置从输送导管部署到内腔中，将人工瓣膜装置定位在导管管腔内并使人工瓣膜装置膨胀成与导管的内壁接触。
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公开(公告)号：US20050203605A1
公开(公告)日：2005-09-15
申请号：US11079956
申请日：2005-03-15
Applicant: Mark Dolan
Inventor： Mark Dolan
CPC classification number: A61F2/2418 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054 , A61F2250/0018
Abstract: A system for treating a vascular condition includes a catheter and a stent coupled to the catheter. The stent includes a stent framework having at least one stent segment with a plurality of interconnected struts and crowns and at least one stiffening ring having a plurality of ring segments connected between circumferentially adjacent crowns of the stent segment. The stiffening ring is oriented circumferentially about a longitudinal axis of the stent framework when the stent is deployed. A stent and a method of treating a vascular condition are also disclosed.
Abstract translation: 用于治疗血管病症的系统包括与导管联接的导管和支架。 所述支架包括支架框架，所述支架框架具有至少一个具有多个互连的支柱和冠部的支架段和至少一个加强环，所述至少一个加强环具有连接在所述支架段的周向相邻冠部之间的多个环段。 当支架展开时，加强环围绕支架框架的纵向轴向定向。 还公开了支架和治疗血管病症的方法。
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公开(公告)号：US08303639B2
公开(公告)日：2012-11-06
申请号：US11689733
申请日：2007-03-22
Applicant: Mark Dolan , Matthew J. Birdsall , Eugene Tedeschi , Joseph Berglund , Raffy Brown
Inventor： Mark Dolan , Matthew J. Birdsall , Eugene Tedeschi , Joseph Berglund , Raffy Brown
IPC: A61F2/06
CPC classification number: A61F2/958 , A61F2/91 , A61F2250/0067
Abstract: A method for treating a vascular condition is disclosed, the method comprising delivering a stent to a target region of a vessel, the stent including a drug polymer coating including an elution portion and a remaining portion, eluting the elution portion from the delivered stent for an elution period, heating the delivered stent after the elution period; and removing the remaining portion based on the heating.
Abstract translation: 公开了一种用于治疗血管病症的方法，所述方法包括将支架输送到血管的靶区域，所述支架包括药物聚合物涂层，其包括洗脱部分和剩余部分，从所述输送的支架洗脱洗脱部分， 洗脱期后，在洗脱期后加热输送的支架; 并且基于加热去除剩余部分。
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公开(公告)号：US20080234808A1
公开(公告)日：2008-09-25
申请号：US11689733
申请日：2007-03-22
Applicant: Mark Dolan , Matthew J. Birdsall , Eugene Tedeschi , Joseph Berglund , Raffy Brown
Inventor： Mark Dolan , Matthew J. Birdsall , Eugene Tedeschi , Joseph Berglund , Raffy Brown
IPC: A61F2/06
CPC classification number: A61F2/958 , A61F2/91 , A61F2250/0067
Abstract: A method for treating a vascular condition is disclosed, the method comprising delivering a stent to a target region of a vessel, the stent including a drug polymer coating including an elution portion and a remaining portion, eluting the elution portion from the delivered stent for an elution period, heating the delivered stent after the elution period; and removing the remaining portion based on the heating.
Abstract translation: 公开了一种用于治疗血管病症的方法，所述方法包括将支架输送到血管的靶区域，所述支架包括药物聚合物涂层，其包括洗脱部分和剩余部分，从所述输送的支架洗脱洗脱部分， 洗脱期后，在洗脱期后加热输送的支架; 并且基于加热去除剩余部分。
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公开(公告)号：US20060079951A1
公开(公告)日：2006-04-13
申请号：US10962316
申请日：2004-10-08
Applicant: Mark Dolan , Dwayne Yamasaki
Inventor： Mark Dolan , Dwayne Yamasaki
IPC: A61F2/06
CPC classification number: A61F2/966 , A61F2/95 , A61F2/958 , A61F2002/9583
Abstract: The invention provides a system and method for treating a vascular condition. The system comprises a guide catheter that includes a central lumen. A stent delivery device that includes a delivery catheter and a stent disposed on the delivery catheter is slidably received in the central lumen. A stop interface retains a portion of the delivery catheter within the central lumen while still allowing positioning of the stent beyond a distal end of the guide catheter. In use, the guide catheter with the retained stent delivery device is introduced into a vessel. The stent carried on the stent delivery device is expanded after being positioned at a location beyond a distal end of the guide catheter.
Abstract translation: 本发明提供了治疗血管病症的系统和方法。 该系统包括一个包括中央管腔的引导导管。 包括输送导管和设置在输送导管上的支架的支架输送装置可滑动地容纳在中央管腔中。 停止接口将输送导管的一部分保持在中央腔内，同时仍然允许支架定位在引导导管的远端之外。 在使用中，将具有保留的支架输送装置的引导导管引入血管。 承载在支架输送装置上的支架在定位在超过引导导管的远端的位置之后被扩张。
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