公开(公告)号：US07420672B2

公开(公告)日：2008-09-02

申请号：US11820706

申请日：2007-06-20

Applicant: Peidong Wang ,  Daryoosh Vakhshoori ,  Yu Shen ,  Kevin J. Knopp ,  Masud Azimi

Inventor： Peidong Wang ,  Daryoosh Vakhshoori ,  Yu Shen ,  Kevin J. Knopp ,  Masud Azimi

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/44 ,  G01J2003/1213 ,  G01N2021/656

Abstract: Disclosed herein are Raman probes that include: (a) a first optical fiber for receiving laser excitation light from a light source and transmitting the same; (b) a first filter for receiving light from the first optical fiber and adapted to pass the laser excitation light and to block spurious signals associated with the light; (c) a second filter for receiving light from the first filter and adapted to direct the light toward a specimen; and (d) focusing apparatus for receiving the light from the second filter, focusing the light on the specimen so as to generate the Raman signal, and returning the Raman signal to the second filter. The second filter is further configured so that when the second filter receives the Raman signal from the focusing apparatus, the second filter filters out unwanted laser excitation light before directing the Raman signal to a second optical fiber.

Abstract translation: 本文公开了拉曼探针，其包括：（a）第一光纤，用于从光源接收激发激发光并将其传输; （b）第一滤光器，用于接收来自第一光纤的光，并适于通过激光激发光并阻止与光相关联的寄生信号; （c）第二过滤器，用于接收来自第一过滤器的光，并适于将光引向样本; 和（d）用于接收来自第二滤光器的光的聚焦装置，将光聚焦在样本上以产生拉曼信号，并将拉曼信号返回到第二滤光器。 第二滤波器进一步配置成使得当第二滤波器从聚焦装置接收拉曼信号时，第二滤波器在将拉曼信号引导到第二光纤之前滤除不期望的激光激发光。

公开(公告)号：US07062133B2

公开(公告)日：2006-06-13

申请号：US10832059

申请日：2004-04-26

Applicant: Masud Azimi ,  Andrew Vote ,  Daryoosh Vakhshoori

Inventor： Masud Azimi ,  Andrew Vote ,  Daryoosh Vakhshoori

IPC: G02B6/32 ,  G02B6/42

CPC classification number: G02B6/4226

Abstract: Apparatus is disclosed for precision alignment and assembly of opto-electronic components relative to one another, the apparatus comprising a selected optical component having a periphery forming at least one flat surface; a holding block having at least one attachment region corresponding to the at least one flat surface of the selected optical component; a positioning mechanism having a first portion and a second portion, the first portion configured to position the selected optical component relative to another opto-electronic component, and the second portion configured to position the holding block relative to the selected optical component and in contact with a platform in attachment with the another opto-electronic component; and an attachment component disposed between the selected optical component and the holding block, and the attachment component disposed between the holding block and the platform so as to fix the selected optical component in position relative to the another opto-electronic component. A method of precision alignment and assembly of opto-electronic components relative to one another is disclosed, the method comprising: positioning the selected optical component relative to the another optical component using the first portion of the positioning mechanism; positioning the holding block relative to the selected optical component and in contact with the platform; and securing the selected optical component and the holding block, and the holding block and the platform, with the attachment component.

Abstract translation: 公开了用于相对于彼此的光电子部件的精确对准和组装的装置，该装置包括具有形成至少一个平坦表面的周边的所选择的光学部件; 保持块，其具有至少一个对应于所选择的光学部件的至少一个平坦表面的附接区域; 具有第一部分和第二部分的定位机构，所述第一部分被配置为相对于另一个光电子部件定位所选择的光学部件，并且所述第二部分被配置为相对于所选择的光学部件定位所述保持块并与 与另一个光电组件相连的平台; 以及设置在所选择的光学部件和保持块之间的附接部件以及设置在保持块和平台之间的附接部件，以便将所选择的光学部件相对于另一光电部件固定就位。 公开了一种相对于彼此的光电子部件的精确对准和组装的方法，所述方法包括：使用所述定位机构的第一部分相对于所述另一光学部件定位所选择的光学部件; 将所述保持块相对于所选择的光学部件定位并与所述平台接触; 并且用所述附接部件固定所选择的光学部件和所述保持块以及所述保持块和所述平台。

公开(公告)号：US20050036535A1

公开(公告)日：2005-02-17

申请号：US10799304

申请日：2004-03-12

Applicant: Kevin Knopp ,  Daryoosh Vakhshoori ,  Masud Azimi ,  Peidong Wang

Inventor： Kevin Knopp ,  Daryoosh Vakhshoori ,  Masud Azimi ,  Peidong Wang

IPC: H01S3/04 ,  H01S3/08 ,  H01S5/00 ,  H01S5/02 ,  H01S5/022 ,  H01S5/024 ,  H01S5/0683 ,  H01S5/183 ,  H01S5/40

CPC classification number: H01S5/02284 ,  H01S5/0064 ,  H01S5/0078 ,  H01S5/02216 ,  H01S5/02248 ,  H01S5/024 ,  H01S5/0683 ,  H01S5/183 ,  H01S5/4006 ,  H01S5/50 ,  H01S2301/02 ,  H01S2301/163

Abstract: A laser source for generating amplified and filtered optical output, comprising a VCSEL, a power optical amplifier, and a filter. A laser source for generating amplified and filtered optical output, comprising a first mirror and a second mirror forming a cavity, an optical amplifier disposed in the cavity, and filter means for filtering ASE generated and amplified by the optical amplifier. A system for generating amplified and filtered optical output, comprising an optical platform having electrical connections and a fiber optic connection, a VCSEL configured to generate seed light, an optical amplifier configured to receive and amplify seed light to generate power boosted ASE and a filter configured to reduce background noise from the power boosted ASE. A method of generating optical output having high optical power with high spectral fidelity, comprising generating seed light, amplifying seed light, and filtering the amplified optical output to reduce background noise.

Abstract translation: 一种用于产生放大和滤波的光输出的激光源，包括VCSEL，功率光放大器和滤波器。 一种用于产生放大和滤波的光输出的激光源，包括第一反射镜和形成空腔的第二反射镜，设置在空腔中的光放大器和用于滤光由光放大器生成和放大的ASE的滤波器装置。 一种用于产生放大和滤波的光输出的系统，包括具有电连接和光纤连接的光学平台，被配置为产生种子光的VCSEL，配置成接收和放大种子光以产生增强功率的ASE的光放大器和配置的滤波器 以降低功率提升的ASE背景噪声。 一种产生具有高光谱保真度的高光功率的光输出的方法，包括产生种子光，放大种子光，并对放大的光输出进行滤波以降低背景噪声。

公开(公告)号：US08449842B2

公开(公告)日：2013-05-28

申请号：US12722211

申请日：2010-03-11

Applicant: Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang ,  Masud Azimi ,  Scott E. Miller ,  Jason Goldstein ,  Stephen McLaughlin

Inventor： Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang ,  Masud Azimi ,  Scott E. Miller ,  Jason Goldstein ,  Stephen McLaughlin

IPC: A61B10/00

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  Y10T436/2575

Abstract: Systems and methods disclosed include: a support apparatus configured to detachably receive a chip; movable pins extendible from a first position to a second position, where, in the first position, the movable pins do not contact a chip positioned on the support apparatus, and in the second position, the movable pins contact electrical terminals of a heating element within a chip positioned on the support apparatus; a radiation source configured to direct radiation to be incident on a chip positioned on the support apparatus; a detector; and an electronic processor, the electronic processor being configured to detect molecules in a sample positioned within the chip, and to determine a temperature of the chip by measuring an electrical resistance between two of the multiple pins connected to the electrical terminals.

Abstract translation: 所公开的系统和方法包括：配置成可拆卸地接收芯片的支撑装置; 可动销可从第一位置延伸到第二位置，其中在第一位置，可动销不接触位于支撑装置上的芯片，并且在第二位置，可动销接触加热元件内部的电气端子 位于所述支撑装置上的芯片; 辐射源，被配置为引导辐射入射到位于所述支撑装置上的芯片上; 检测器 以及电子处理器，所述电子处理器被配置为检测位于所述芯片内的样本中的分子，并且通过测量连接到所述电端子的多个引脚中的两个引脚之间的电阻来确定所述芯片的温度。

公开(公告)号：US08248588B2

公开(公告)日：2012-08-21

申请号：US13087753

申请日：2011-04-15

Applicant: Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

Inventor： Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

IPC: G01N21/25

CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4535 ,  G01N2021/3595

Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.

Abstract translation: 我们公开了包括以下设备：（a）包括孔的外壳; （b）安装在外壳中的棱镜，使得棱镜的表面通过该孔露出; （c）包含在所述外壳内的光学组件，所述光学组件包括辐射源和辐射探测器，所述源被配置成将辐射引向所述棱镜，并且所述检测器被配置为检测来自所述源的反射的源的辐射， 棱镜; 以及（d）包含在所述外壳内的电子处理器，所述电子处理器与所述检测器通信。 该装置可以被配置为使得在操作期间，电子处理器在与样品接触的同时基于从暴露的棱镜表面反射的辐射来确定关于与棱镜的暴露表面接触的样品的信息。

公开(公告)号：US20110309247A1

公开(公告)日：2011-12-22

申请号：US13087753

申请日：2011-04-15

Applicant: Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

Inventor： Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

IPC: G01J5/02

CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4535 ,  G01N2021/3595

Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.

Abstract translation: 我们公开了包括以下设备：（a）包括孔的外壳; （b）安装在外壳中的棱镜，使得棱镜的表面通过该孔露出; （c）包含在所述外壳内的光学组件，所述光学组件包括辐射源和辐射探测器，所述源被配置成将辐射引向所述棱镜，并且所述检测器被配置为检测来自所述源的反射的来自所述源的辐射， 棱镜; 以及（d）包含在所述外壳内的电子处理器，所述电子处理器与所述检测器通信。 该装置可以被配置为使得在操作期间，电子处理器在与样品接触的同时基于从暴露的棱镜表面反射的辐射来确定关于与棱镜的暴露表面接触的样品的信息。

公开(公告)号：US20110022324A1

公开(公告)日：2011-01-27

申请号：US12722211

申请日：2010-03-11

Applicant: Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang ,  Masud Azimi ,  Scott E. Miller ,  Jason Goldstein ,  Stephen McLaughlin

Inventor： Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang ,  Masud Azimi ,  Scott E. Miller ,  Jason Goldstein ,  Stephen McLaughlin

IPC: G06F19/00 ,  G01N31/00 ,  G01N33/48 ,  G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  Y10T436/2575

Abstract: Systems and methods disclosed include: a support apparatus configured to detachably receive a chip; movable pins extendible from a first position to a second position, where, in the first position, the movable pins do not contact a chip positioned on the support apparatus, and in the second position, the movable pins contact electrical terminals of a heating element within a chip positioned on the support apparatus; a radiation source configured to direct radiation to be incident on a chip positioned on the support apparatus; a detector; and an electronic processor, the electronic processor being configured to detect molecules in a sample positioned within the chip, and to determine a temperature of the chip by measuring an electrical resistance between two of the multiple pins connected to the electrical terminals.

Abstract translation: 所公开的系统和方法包括：配置成可拆卸地接收芯片的支撑装置; 可动销可从第一位置延伸到第二位置，其中在第一位置，可动销不接触位于支撑装置上的芯片，并且在第二位置，可动销接触加热元件内部的电气端子 位于所述支撑装置上的芯片; 辐射源，被配置为引导辐射入射到位于所述支撑装置上的芯片上; 检测器 以及电子处理器，所述电子处理器被配置为检测位于所述芯片内的样本中的分子，并且通过测量连接到所述电端子的多个引脚中的两个引脚之间的电阻来确定所述芯片的温度。

公开(公告)号：US07773645B2

公开(公告)日：2010-08-10

申请号：US11593966

申请日：2006-11-07

Applicant: Peidong Wang ,  Daryoosh Vakhshoori ,  Masud Azimi ,  Kevin J. Knopp

Inventor： Peidong Wang ,  Daryoosh Vakhshoori ,  Masud Azimi ,  Kevin J. Knopp

IPC: H01S3/04

CPC classification number: H01S5/141 ,  H01S5/02248 ,  H01S5/02453 ,  H01S5/0612

Abstract: A laser package comprising a semiconductor laser having an operating temperature range and a heater, wherein the heater is configured to heat the laser when the laser package is positioned in an environment having an ambient temperature which lies outside of the operating temperature range of the laser, so that the laser will remain within the operating temperature range.

Abstract translation: 一种激光器封装，包括具有工作温度范围的半导体激光器和加热器，其中所述加热器构造成当所述激光器封装位于具有位于所述激光器的工作温度范围之外的环境温度的环境中时加热所述激光器， 使激光器保持在工作温度范围内。

公开(公告)号：US20090237647A1

公开(公告)日：2009-09-24

申请号：US12414111

申请日：2009-03-30

Applicant: Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang ,  Stephen McLaughlin

Inventor： Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang ,  Stephen McLaughlin

IPC: G01N21/00 ,  G01J3/44

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4535 ,  G01N21/552

Abstract: We disclose an apparatus comprising: a hand-portable optical analysis unit including an optical interface; and a device configured to receive and releasably engage the hand-portable optical analysis unit. The device comprises: a housing; a sample unit in the housing; and a resilient member configured to bias the sample unit and the hand-portable analysis unit towards each other when the hand-portable optical analysis unit is received in the device to compress a sample disposed between the sample unit and the optical interface of the optical analysis unit. Methods of analyzing samples are also disclosed.

Abstract translation: 我们公开了一种装置，包括：手持式光学分析单元，包括光学接口; 以及被配置为接收和可释放地接合手持式光学分析单元的设备。 该装置包括：壳体; 壳体中的样品单元; 以及弹性构件，其构造成当所述手持式光学分析单元被接收在所述装置中时，将所述样本单元和所述手持式分析单元朝向彼此偏置，以压缩设置在所述样本单元和所述光学分析的所述光学界面之间的样本 单元。 还公开了分析样品的方法。

公开(公告)号：US07548673B2

公开(公告)日：2009-06-16

申请号：US12185357

申请日：2008-08-04

Applicant: Masud Azimi ,  Andrew Vote ,  Daryoosh Vakhshoori

Inventor： Masud Azimi ,  Andrew Vote ,  Daryoosh Vakhshoori

IPC: G02B6/32 ,  G02B6/42

CPC classification number: G02B6/4226

Abstract: Apparatus and methods are disclosed for precision alignment and assembly of opto-electronic components relative to one another.

Abstract translation: 公开了用于相对于彼此的光电子部件的精确对准和组装的装置和方法。