公开(公告)号：US20180067019A1

公开(公告)日：2018-03-08

申请号：US15490232

申请日：2017-04-18

Applicant: OptiScan Biomedical Corporation

Inventor： Gil Rivas ,  Michael Butler ,  Jeffrey T. Chiou ,  Eugene Lim

IPC: G01N1/10 ,  A61M39/10 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1455 ,  G06F19/10 ,  A61B5/157 ,  A61B5/153 ,  A61M39/02 ,  A61M5/14 ,  A61M5/172

CPC classification number: G01N1/10 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150267 ,  A61B5/150305 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150824 ,  A61B5/150854 ,  A61B5/153 ,  A61B5/157 ,  A61M5/1415 ,  A61M5/1723 ,  A61M39/02 ,  A61M39/10 ,  A61M2039/1077 ,  A61M2039/1094 ,  A61M2230/201 ,  G16B99/00 ,  Y10T436/11 ,  Y10T436/144444

Abstract: Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.

公开(公告)号：US20170296112A1

公开(公告)日：2017-10-19

申请号：US15418485

申请日：2017-01-27

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/15 ,  A61B5/153 ,  A61B5/155 ,  G01N33/49 ,  G01N21/07 ,  G01N21/03 ,  A61M5/172 ,  G06F19/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  G01N21/35

CPC classification number: A61B5/157 ,  A61B5/0059 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/412 ,  A61B5/6866 ,  A61B2560/0228 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M39/10 ,  A61M39/1011 ,  A61M2005/14208 ,  A61M2039/1033 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

公开(公告)号：US20170188943A1

公开(公告)日：2017-07-06

申请号：US15236831

申请日：2016-08-15

Applicant: OptiScan Biomedical Corporation

Inventor： James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/1495 ,  G06F19/00 ,  A61B5/155 ,  A61B5/157 ,  A61M5/168 ,  A61B5/145 ,  A61B5/15

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

公开(公告)号：US09326717B2

公开(公告)日：2016-05-03

申请号：US14257920

申请日：2014-04-21

Applicant: OptiScan Biomedical Corporation

Inventor： Michael Butler ,  Eugene Lim ,  Craig Johnson

IPC: A61B5/05 ,  A61B5/15 ,  A61B5/00 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/157 ,  A61M39/10 ,  A61B5/153

CPC classification number: A61B5/157 ,  A61B5/0059 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/412 ,  A61B5/6866 ,  A61B2560/0228 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M39/10 ,  A61M39/1011 ,  A61M2005/14208 ,  A61M2039/1033 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can be connected to the source of bodily fluid via a connector that is configured to maintain uniform velocity across the connector and reduce the dead space volume.

Abstract translation: 描述了用于测定来自样品如血液或血浆的一种或多种分析物的浓度的方法和系统。 本文描述的系统可以被配置为从体液源抽出一定体积的样品，将抽出的样品的第一部分引导到分析物监测系统，并将样品的第二部分返回给患者。 分析物监测系统可以经由连接器连接到体液源，该连接器被配置为保持穿过连接器的均匀速度并减少死空间体积。

公开(公告)号：US20150366495A1

公开(公告)日：2015-12-24

申请号：US14670073

申请日：2015-03-26

Applicant: OptiScan Biomedical Corporation

Inventor： Jennifer H. Gable, III ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/157 ,  A61B5/15 ,  A61B5/00

Abstract: A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

Abstract translation: 提供了可移除地与体液分析器接合的流体处理模块。 模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。 流体处理元件可以具有至少一个控制元件接口。

公开(公告)号：US20150119663A1

公开(公告)日：2015-04-30

申请号：US14589867

申请日：2015-01-05

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/15 ,  A61B5/1455

CPC classification number: A61B5/157 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/6866 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

Abstract translation: 公开了用于确定流体（例如血液）中分析物浓度的系统和方法。 该系统可以从患者抽取血液并将血液输送到样品池。 流体（例如，等离子体）的特定组分可以被分离和/或定位，使得在流体的特定组分（例如，等离子体）中测量分析物的浓度。 样品池可以包括具有两个窗件的样品容器。 该系统可以具有流体通道，其具有构造成与多腔导管配合而不泄漏的顶端。 多腔导管可以具有近端和远端端口。 流体压力系统可以被配置成周期性地从脉管系统中抽取流体通过近端血管内开口和近端口，同时保持低压和/或流速，从而降低反转容器中的流体流动的风险，并将输注物上游到另一个 血管内开放。

公开(公告)号：US10677688B2

公开(公告)日：2020-06-09

申请号：US15490232

申请日：2017-04-18

Applicant: OptiScan Biomedical Corporation

Inventor： Gil Rivas ,  Michael Butler ,  Jeffrey T. Chiou ,  Eugene Lim

IPC: A61B5/145 ,  A61B5/1455 ,  A61M39/02 ,  A61M39/10 ,  A61B5/15 ,  A61B5/153 ,  A61B5/157 ,  A61M5/14 ,  A61M5/172 ,  G01N1/10 ,  G16B99/00

Abstract: Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.

公开(公告)号：US10660557B2

公开(公告)日：2020-05-26

申请号：US16271653

申请日：2019-02-08

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/153 ,  A61B5/155 ,  A61M39/10 ,  A61B5/15 ,  A61B5/1459 ,  A61M5/172 ,  G01N21/03 ,  G01N21/07 ,  G01N33/49 ,  G06F19/00 ,  G16H20/17 ,  A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  G01N21/35

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

公开(公告)号：US20190336678A1

公开(公告)日：2019-11-07

申请号：US16270471

申请日：2019-02-07

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule

IPC: A61M5/142 ,  A61B5/157 ,  A61M5/172 ,  A61B5/15 ,  A61B5/1468 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145

Abstract: Systems for rapid and accurate analyte measurement are described. For example, periodic glucose measurements can be achieved with high accuracy in a critical care environment by drawing blood into a device more than once per hour, analyzing blood (for example using infrared radiation through plasma). Safety and accuracy can be achieved by improved fluid control and avoidance of clotting. Data can be conveyed (e.g., displayed) to a user. A user can be allowed to annotate the data. For example, a touchscreen or other interface can allow addition of notes on a running graph of data, indicating events or other items of interest that may correspond to data readings or to particular times.

公开(公告)号：US10201303B2

公开(公告)日：2019-02-12

申请号：US15418485

申请日：2017-01-27

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/153 ,  A61M39/10 ,  A61B5/15 ,  A61B5/1459 ,  A61M5/172 ,  G01N21/03 ,  G01N21/07 ,  G01N33/49 ,  G06F19/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  G01N21/35

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.