公开(公告)号：US20230233876A1

公开(公告)日：2023-07-27

申请号：US18001297

申请日：2021-06-14

Applicant: RAYSEARCH LABORATORIES AB

Inventor： Rasmus BOKRANTZ ,  Lars GLIMELIUS

IPC: A61N5/10 ,  G16H50/30

CPC classification number: A61N5/103 ,  G16H50/30 ,  A61N2005/1087

Abstract: A method for dynamically estimating a biological effect of a variable combination of non-photon radiation in accordance with a relative biological effectiveness, RBE, model including at least one biological effect multiplier δ(T, E) which depends on particle type T and/or particle energy E, the method comprising:

obtaining one or more non-photon radiation contributions D(i)(T, E), 1 ≤ i ≤ N, at least one of said contributions including multiple particle types and/or multiple particle energies;
storing per-contribution dose-weighted averages δ̅(i), 1 ≤ i ≤ N, of said at least one biological effect multiplier with respect to each of the one or more contributions; and
in response to obtaining an assignment Π of the combination, the assignment being in terms of non-negative coefficients k1, k2, ..., kN ≥ 0 to be applied to the one or more contributions, determining a biological effect of the combination, including computing a combined dose-weighted average δ̅Π of said at least one biological effect multiplier on the basis of the stored per-contribution dose-weighted averages.

公开(公告)号：US20230191156A1

公开(公告)日：2023-06-22

申请号：US17999708

申请日：2021-05-19

Applicant: RAYSEARCH LABORATORIES AB

Inventor： Tianfang ZHANG

IPC: A61N5/10 ,  G16H20/40

CPC classification number: A61N5/1039 ,  A61N5/1031 ,  A61N5/1038 ,  G16H20/40 ,  A61N2005/1034

Abstract: A computer-implemented method for generating a radiation therapy treatment plan for a volume of a patient, the method comprising: receiving an image of the volume; receiving at least one dose-distribution-derived function configured to provide a value as an output based on, as input, at least part of a dose distribution defined relative to said image; receiving a first probability distribution and at least a second, different, probability distribution, the first and at least second probability distributions; defining a multi-criteria optimization problem comprising at least a first objective function based on the at least one dose-distribution-derived function, the first probability distribution and a loss function; and a second objective function based on the at least one dose-distribution-derived function, the second probability distribution and the loss function; and performing a multi-criteria optimization process based on said at least two objective functions to generate at least two output treatment plans.

公开(公告)号：US20230117544A1

公开(公告)日：2023-04-20

申请号：US17906201

申请日：2021-03-31

Applicant: RaySearch Laboratories AB (Publ)

Inventor： Tianfang ZHANG

IPC: A61N5/10

Abstract: A method and apparatus for generating a radiation treatment plan for a volume comprising: receiving a first treatment plan upon which to base a second treatment plan, the first treatment plan indicative of a dose distribution; receiving at least one dose-distribution-derived function configured to provide a value based on at least part of the dose distribution; receiving a target for the respective value of each dose-distribution-derived function comprising receiving a probability distribution; determining an optimization problem, wherein the or each objective function is a function of the dose-distribution-derived function, the respective probability distribution and a respective loss function; performing the optimization process based on said optimization problem; and determining said second treatment plan.

公开(公告)号：US20230032956A1

公开(公告)日：2023-02-02

申请号：US17786420

申请日：2020-12-09

Applicant: RaySearch Laboratories AB

Inventor： Rickard HOLMBERG

IPC: A61N5/10

Abstract: It is provided a method for checking quality of a treatment plan, wherein a treatment plan specifies a distribution of radiation to thereby provide radiation to a planning target volume. The method is performed by a quality assurance device and comprises the steps of: obtaining a treatment plan and a corresponding first dose, the treatment plan having been calculated in a treatment planning system, the first dose being a predicted dose to be deposited in the patient using the treatment plan; initiating a calculation of a secondary dose, being a dose deposited by the treatment plan, using a secondary dose calculation algorithm; repeatedly calculating a confidence interval of a comparative statistical measurement by comparing the first dose and the secondary dose over a defined geometric volume; and interrupting the calculation of the secondary dose when the confidence interval is better than at least one predefined criterion.

公开(公告)号：US20230019727A1

公开(公告)日：2023-01-19

申请号：US17783205

申请日：2020-11-30

Applicant: RaySearch Laboratories AB

Inventor： Rickard HOLMBERG

IPC: A61N5/10

Abstract: It is provided a method for providing a treatment plan for radiotherapy when the delivery is interrupted, the method being performed by a treatment planning system. The method comprises the steps of: detecting that delivery of a first treatment plan has been interrupted; obtaining an indication of delivery of a partial dose, representing the part of the first treatment plan that was delivered prior to the interruption; generating a second treatment plan, wherein the partial dose delivery forms an input to the second treatment plan generation as a background dose; and optimizing the second treatment plan while considering a plurality of scenarios.

公开(公告)号：US11413474B2

公开(公告)日：2022-08-16

申请号：US16500419

申请日：2018-04-03

Applicant: RaySearch Laboratories AB

Inventor： Albin Fredriksson

IPC: A61N5/10 ,  G16H20/40

Abstract: A method is proposed for evaluating the robustness of a radiotherapy treatment plan. The method comprises, defining a number of scenarios, each comprising one or more errors for each fraction of the plan, including interfractional and/or intrafractional errors, and calculating a dose distribution resulting from the scenario;
The robustness of the plan is then evaluated based at least one of the following i. the probability of fulfilling a set of clinical goals estimated as the clinical goal fulfilment over the scenarios ii. the range of DVH values over the scenarios iii. dose statistics for dose distributions defined as voxel-wise aggregates over the scenario doses.

公开(公告)号：US20220143424A1

公开(公告)日：2022-05-12

申请号：US17594307

申请日：2020-03-30

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz ,  Martin Janson

IPC: A61N5/10

Abstract: It is provided a method for generating a plurality of treatment plans for radiation therapy, each treatment plan specifying weights for a plurality of geometrically defined fluence elements. Each weight defines an amount of radiation fluence, to thereby provide radiation dose to a target volume. The method is performed in a treatment planning system and comprises the steps of: generating a first set of treatment plans; determining a subset of the fluence elements, based on the first set of treatment plans; and generating a second set of at least two treatment plans, wherein the treatment plans only contain weights for the subset of fluence elements.

公开(公告)号：US11291856B2

公开(公告)日：2022-04-05

申请号：US15580472

申请日：2016-06-10

Applicant: RaySearch Laboratories AB

Inventor： Kjell Eriksson

IPC: A61N5/10 ,  G16H20/40 ,  G16H50/30

Abstract: A method of optimizing a radiotherapy treatment plan is disclosed, comprising the steps of: a. obtaining a deliverable input treatment plan; b. optimizing the deliverable input treatment plan to obtain an optimized treatment plan, using an objective function and at least one constraint, wherein i. the objective function is related to reducing the plan complexity in terms of minimizing the machine output (MU) and/or minimizing the time required to deliver the plan and/or maximizing the segment area, and/or minimizing jaggedness of the MLC shapes, ii. to ensure that the quality is maintained, the at least one constraint is based on the dose distribution of the input plan, related to maintaining an acceptable dose distribution.

公开(公告)号：US11213696B2

公开(公告)日：2022-01-04

申请号：US16599546

申请日：2019-10-11

Applicant: RaySearch Laboratories AB

Inventor： Erik Traneus

IPC: A61N5/10

Abstract: A method of performing dose calculations for ion radiotherapy compensating for tissue in which the density within a voxel may be inhomogeneous by approximating a portion of the voxel as an air cavity. For each dose voxel, the voxel is inscribed in a three-dimensional grid comprising a number of cells and the propagation of ions through the voxel is calculated based on the cell pattern in the at least one cell overlapping the voxel. Preferably, the voxel is inscribed in the three-dimensional grid in such a way that it overlaps at least one cell fully. Each cell comprises a first portion representing a first density corresponding to a density of a tissue and a second portion representing a second density corresponding to the density of air, the first and second portions forming a cell pattern.

公开(公告)号：US20210228906A1

公开(公告)日：2021-07-29

申请号：US17053876

申请日：2019-05-14

Applicant: RaySearch Laboratories AB

Inventor： Erik TRANEUS

IPC: A61N5/10 ,  G16H20/40

Abstract: Accumulated path length for ions that reach a particular area of a patient is used in dose planning as an indicator of plan robustness. Also, the magnitude of the variations of the accumulated path lengths is determined for a number of beam directions, allowing beam directions to be selected for maximum robustness in treatment planning.