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    SUSPENSION COMPOSITION FOR HEMATOLOGY ANALYSIS CONTROL
    31.
    发明申请
    SUSPENSION COMPOSITION FOR HEMATOLOGY ANALYSIS CONTROL 审中-公开

    公开(公告)号：US20190178876A1

    公开(公告)日：2019-06-13

    申请号：US16321747

    申请日：2017-07-28

    Applicant: STRECK, INC.

    Inventor： Brad Hunsley ,  John W. Scholl

    IPC: G01N33/50 ,  C12N5/078

    Abstract: A suspension composition for a hematology analysis control particularly useful for preserving relevant detectable characteristics of blood cells for a prolong stability period. The suspension may include at least one polysaccharide, which may include or derive from chitosan and/or chitin, as a stabilizing agent.

    Preservation of cell-free nucleic acids
    32.
    发明授权
    Preservation of cell-free nucleic acids 有权

    公开(公告)号：US10253351B2

    公开(公告)日：2019-04-09

    申请号：US15937446

    申请日：2018-03-27

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/68 ,  C12Q1/6806 ,  C09K15/20

    Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    Compositions and Methods for Stabilizing Circulating Tumor Cells
    33.
    发明申请
    Compositions and Methods for Stabilizing Circulating Tumor Cells 审中-公开

    公开(公告)号：US20190075785A1

    公开(公告)日：2019-03-14

    申请号：US16153273

    申请日：2018-10-05

    Applicant: Streck, Inc.

    Inventor： Rohan M. Fernando ,  Wayne L. Ryan ,  Brad Hunsley

    IPC: A01N1/02 ,  G01N33/574

    Abstract: Compositions and Methods for Stabilizing Circulating Tumor Cells Methods and compositions for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, especially blood, the biological sample including at least one circulating tumor cell from the subject. The methods may include a step of contacting the biological sample with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.

    PRESERVATION OF CELL-FREE NUCLEIC ACIDS
    35.
    发明申请
    PRESERVATION OF CELL-FREE NUCLEIC ACIDS 有权

    公开(公告)号：US20170260569A1

    公开(公告)日：2017-09-14

    申请号：US15601682

    申请日：2017-05-22

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

    Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    Preservation of cell-free RNA in blood samples
    36.
    发明授权
    Preservation of cell-free RNA in blood samples 有权

    公开(公告)号：US09657227B2

    公开(公告)日：2017-05-23

    申请号：US14071969

    申请日：2013-11-05

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/68 ,  C09K15/20

    CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

    Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    METHOD AND DEVICE FOR COLLECTING AND PRESERVING CELLS FOR ANALYSIS
    37.
    发明申请
    METHOD AND DEVICE FOR COLLECTING AND PRESERVING CELLS FOR ANALYSIS 审中-公开
    用于收集和保存细胞用于分析的方法和装置

    公开(公告)号：US20160143268A1

    公开(公告)日：2016-05-26

    申请号：US15010549

    申请日：2016-01-29

    Applicant: Streck, Inc.

    Inventor： Wayne L. Ryan

    IPC: A01N1/02

    CPC classification number: A01N1/0226 ,  B01L1/52 ,  B01L3/5082 ,  B01L2200/16

    Abstract: The claimed subject matter comprises a device to collect and preserve cells comprising of: (1) a collection container comprised of a tube having an open end and a closed end, a closure in the open end of the tube, a vacuum drawn to a predetermined level inside the container; and (2) compounds including an anticoagulant agent and a fixative agent, wherein the compounds are in a sufficient amount to preserve said cells” original morphology and antigenic sites without significant dilution of said cells, and thereby allowing said cells to be directly analyzed by a flow cytometer without further treatment. The claimed subject matter further comprises of a method of making a collection device for cells comprising of: (1) providing a tube having an open end and a closed end; (2) preloading compounds including: an anticoagulant agent, and a fixative agent into the tube, wherein the compounds are in a sufficient amount to preserve the cells” original morphology and antigenic sites without significant dilution of the cells, and thereby allowing the cells to be directly analyzed by a flow cytometer without further treatment; (3) inserting a closure into the open end of the tube; and (4) drawing a vacuum inside the tube to a predetermined level to form the collection device.

    Abstract translation: 所要求保护的主题包括收集和保存细胞的装置，包括：（1）由具有开口端和封闭端的管构成的收集容器，管的开口端中的封闭件，抽吸到预定的 容器内的水平; 和（2）包括抗凝血剂和固定剂的化合物，其中所述化合物足够量以保持所述细胞“原始形态和抗原位点，而不显着稀释所述细胞，从而允许所述细胞通过 流式细胞仪无需进一步处理。 所要求保护的主题还包括制备用于电池的收集装置的方法，包括：（1）提供具有开口端和封闭端的管; （2）将包含抗凝血剂和固定剂的化合物预加载到管中，其中所述化合物足够量以保持细胞“原始形态和抗原位点而不显着稀释细胞，从而允许细胞 直接用流式细胞仪分析，无需进一步处理; （3）将封闭件插入管的开口端; 和（4）将管内的真空抽出到预定水平以形成收集装置。

    METHODS OF PREPARING SAMPLES FOR PROTEOMIC ANALYSIS
    39.
    发明公开
    METHODS OF PREPARING SAMPLES FOR PROTEOMIC ANALYSIS 审中-公开

    公开(公告)号：US20230314442A1

    公开(公告)日：2023-10-05

    申请号：US18012054

    申请日：2021-06-30

    Applicant: STRECK, INC.

    Inventor： Matthew R. Sobansky ,  Nicholas Michael George ,  Bradford A. Hunsley ,  Sean Salamifar ,  Agnes Alicia Lenagh

    IPC: G01N33/68

    CPC classification number: G01N33/6842 ,  G01N2570/00 ,  G01N33/6848

    Abstract: Provided herein are methods of preparing a protein sample for proteomic analysis. In exemplary embodiments, the method comprises (a) contacting a blood sample comprising proteins with a protective agent comprising an anticoagulant (AC) and an aldehyde releaser (AR), to obtain a mixture, optionally, wherein the blood sample is added to a blood collection tube (BCT) comprising the protective agent, and (b) isolating a fraction comprising proteins or a source of proteins from the mixture to yield a protein sample or a source of a protein sample, wherein steps of the method are carried out in the absence of exogenous proteolytic enzyme inhibitors, wherein the protein sample is suitable for proteomic and peptidomic analysis.

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