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公开(公告)号：US08367694B2
公开(公告)日：2013-02-05
申请号：US12506485
申请日：2009-07-21
Applicant: Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
Inventor： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
IPC: C07D487/14 , A61K31/437
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/5355 , A61K31/541 , A61K31/551 , C07D471/04
Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
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公开(公告)号：US08143257B2
公开(公告)日：2012-03-27
申请号：US11720061
申请日：2005-11-23
Applicant: Soongyu Choi , Young-Choon Moon , Nadarajan Tamilarasu
Inventor： Soongyu Choi , Young-Choon Moon , Nadarajan Tamilarasu
IPC: C07D401/02 , A61K31/44
CPC classification number: A61K31/403 , A61K31/343 , A61K31/4035 , A61K31/407 , A61K31/4162 , A61K31/4184 , A61K31/4188 , A61K31/424 , A61K31/4245 , A61K31/506 , A61K31/5377 , C07D209/08 , C07D209/90 , C07D471/04
Abstract: The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.
Abstract translation: 本发明涉及抑制血管发生的方法，化合物和组合物。 更具体地说，本发明涉及抑制VEGF产生的方法，化合物和组合物。
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33.发明授权Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 失效茚基乙酸衍生物及其作为药剂，中间体和制备方法的用途公开(公告)号：US07906653B2
公开(公告)日：2011-03-15
申请号：US12759328
申请日：2010-04-13
Applicant: Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens
Inventor： Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens
IPC: C07D277/20
CPC classification number: C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04
Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
Abstract translation: 本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体和制备方法。
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公开(公告)号：US20100179132A1
公开(公告)日：2010-07-15
申请号：US12715651
申请日：2010-03-02
Applicant: Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
Inventor： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
IPC: A61K31/551 , A61K31/497 , A61K31/437 , A61K31/506 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P35/00
CPC classification number: A61K31/337 , A61K31/4353 , A61K31/437 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/5513 , G01N2333/475 , G01N2333/515 , A61K2300/00
Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
Abstract translation: 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，治疗实体瘤癌症和降低血浆和/或肿瘤VEGF水平的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，治疗癌症以及降低血浆和/或肿瘤VEGF水平的方法。
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公开(公告)号：US20090298854A1
公开(公告)日：2009-12-03
申请号：US12508314
申请日：2009-07-23
Applicant: Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
Inventor： Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
IPC: A61K31/497 , C07D261/20 , A61K31/42 , C07D263/30 , A61K31/422 , C07D401/10 , A61P3/10
CPC classification number: C07D403/12 , C07D209/08 , C07D401/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
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Patent Agency Ranking
公开(公告)号：US07601840B2
公开(公告)日：2009-10-13
申请号：US11079420
申请日：2005-03-15
Applicant: Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
Inventor： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
IPC: C07D487/04 , A61K31/437
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/5355 , A61K31/541 , A61K31/551 , C07D471/04
Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
Abstract translation: 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的方法。
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公开(公告)号：US07592361B2
公开(公告)日：2009-09-22
申请号：US10555024
申请日：2004-04-28
Applicant: Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
Inventor： Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
IPC: A61K31/425 , A61K31/42 , C07D417/00 , C07D277/20 , C07D498/00 , C07D263/30
CPC classification number: C07D403/12 , C07D209/08 , C07D401/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
Abstract translation: 本发明涉及吲哚乙酸衍生物及其在药物组合物中用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的用途。 本发明还涉及可用于制备吲哚乙酸衍生物的中间体和制备方法。
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公开(公告)号：US20080261956A1
公开(公告)日：2008-10-23
申请号：US11720061
申请日：2005-11-23
Applicant: Soongyu Choi , Young-Choon Moon , Nadarajan Tamilarasu
Inventor： Soongyu Choi , Young-Choon Moon , Nadarajan Tamilarasu
IPC: A61K31/551 , C07D211/60 , A61K31/445 , C07D243/08 , A61P35/00 , C12N5/06 , A61K31/18 , C07C311/13
CPC classification number: A61K31/403 , A61K31/343 , A61K31/4035 , A61K31/407 , A61K31/4162 , A61K31/4184 , A61K31/4188 , A61K31/424 , A61K31/4245 , A61K31/506 , A61K31/5377 , C07D209/08 , C07D209/90 , C07D471/04
Abstract: The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.
Abstract translation: 本发明涉及抑制血管发生的方法，化合物和组合物。 更具体地说，本发明涉及抑制VEGF产生的方法，化合物和组合物。
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公开(公告)号：US20070281962A2
公开(公告)日：2007-12-06
申请号：US11079420
申请日：2005-03-15
Applicant: Young-Choon MOON , Liangxian CAO , Nadarajan TAMILARASU , Hongyan QI , Soongyu CHOI , William LENNOX , Donald CORSON , Seongwoo HWANG
Inventor： Young-Choon MOON , Liangxian CAO , Nadarajan TAMILARASU , Hongyan QI , Soongyu CHOI , William LENNOX , Donald CORSON , Seongwoo HWANG
IPC: A61K31/4745
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/5355 , A61K31/541 , A61K31/551 , C07D471/04
Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
Abstract translation: 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的方法。
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公开(公告)号：US20050272759A1
公开(公告)日：2005-12-08
申请号：US11079420
申请日：2005-03-15
Applicant: Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Lennox , Donald Corson , Seongwoo Hwang
Inventor： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Lennox , Donald Corson , Seongwoo Hwang
IPC: A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/506 , A61K31/5355 , A61K31/541 , A61K31/551 , A61K31/724 , C07D471/04
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/5355 , A61K31/541 , A61K31/551 , C07D471/04
Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
Abstract translation: 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的方法。
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