公开(公告)号：US08973910B2

公开(公告)日：2015-03-10

申请号：US13216424

申请日：2011-08-24

Applicant: Qing-Song Wen ,  Wei-Feng Pan ,  Jian-Xin Ma ,  Yu Lu

Inventor： Qing-Song Wen ,  Wei-Feng Pan ,  Jian-Xin Ma ,  Yu Lu

IPC: B23Q1/64 ,  B25B1/22 ,  B23Q3/00 ,  B23Q3/18 ,  B23K31/02 ,  B23K37/04 ,  B23Q1/48 ,  B23Q1/52

CPC classification number: B23Q3/18 ,  B23K31/02 ,  B23K37/04 ,  B23K37/0435 ,  B23Q1/4852 ,  B23Q1/525

Abstract: A positioning apparatus includes a base plate and a deflection mechanism mounted upon the base plate. The deflection mechanism includes a stationary platform, a rocker assembly and a deflection platform. The stationary platform is mounted over the base plate for placing and positioning a workpiece. The deflection platform is tiltably mounted over the stationary platform via the rocker assembly and the height of the stationary platform itself is adjustable. The rocker assembly comprises a first rocker and a second rocker of different lengths.

Abstract translation: 定位装置包括安装在基板上的基板和偏转机构。 偏转机构包括固定平台，摇杆组件和偏转平台。 固定平台安装在基板上，用于放置和定位工件。 偏转平台通过摇杆组件可倾斜地安装在固定平台上，固定平台本身的高度是可调节的。 摇臂组件包括不同长度的第一摇臂和第二摇臂。

公开(公告)号：US08541618B2

公开(公告)日：2013-09-24

申请号：US13035625

申请日：2011-02-25

Applicant: Derek B. Lowe ,  Philip L. Wickens ,  Xin Ma ,  Mingbao Zhang ,  William H. Bullock ,  Philip D. G. Coish ,  Ingo A. Mugge ,  Andreas Stolle ,  Ming Wang ,  Yamin Wang ,  Chengzhi Zhang ,  Hai-Jun Zhang ,  Lei Zhu ,  Manami Tsutsumi ,  James N. Livingston

Inventor： Derek B. Lowe ,  Philip L. Wickens ,  Xin Ma ,  Mingbao Zhang ,  William H. Bullock ,  Philip D. G. Coish ,  Ingo A. Mugge ,  Andreas Stolle ,  Ming Wang ,  Yamin Wang ,  Chengzhi Zhang ,  Hai-Jun Zhang ,  Lei Zhu ,  Manami Tsutsumi ,  James N. Livingston

IPC: C07C59/00 ,  C07C62/36 ,  C07C62/38 ,  C07C65/30 ,  C07C65/34 ,  A01N43/76 ,  A61K31/42

CPC classification number: C07D277/32 ,  C07B2200/07 ,  C07C51/412 ,  C07C51/44 ,  C07C59/72 ,  C07C69/732 ,  C07C69/734 ,  C07C69/738 ,  C07C2602/08 ,  C07D263/32 ,  C07D277/24 ,  C07D277/40 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12

Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

公开(公告)号：US08476280B2

公开(公告)日：2013-07-02

申请号：US10434004

申请日：2003-05-08

Applicant: Kwen-Jen Chang ,  Peter J. Gengo ,  Kestutis P. Biciunas ,  Xin Ma ,  William Pendergast ,  Shyi-Tai Jan

Inventor： Kwen-Jen Chang ,  Peter J. Gengo ,  Kestutis P. Biciunas ,  Xin Ma ,  William Pendergast ,  Shyi-Tai Jan

IPC: A61K31/4965 ,  A61K31/497

CPC classification number: A61K31/496 ,  A61K31/495 ,  A61K45/06

Abstract: Compositions and methods for treatment of a urinary tract dysfunction by administering to a subject in need of such treatment a pharmaceutical composition including a delta opioid receptor agonist in an amount effective to reduce the effects of the urinary tract dysfunction. The compositions may further include an additional active agent that is used to treat urinary tract dysfunctions, e.g., alpha-adrenergic agonists, anticholinergics, alpha-adrenergic antagonists and tricyclic antidepressants.

Abstract translation: 用于治疗尿道功能障碍的组合物和方法，其通过向需要这种治疗的受试者施用包含δ阿片受体激动剂的药物组合物，其量有效降低尿路功能障碍的作用。 组合物还可以包括用于治疗尿道功能障碍的另外的活性剂，例如α-肾上腺素能激动剂，抗胆碱能药，α-肾上腺素能拮抗剂和三环抗抑郁药。

公开(公告)号：US08431695B2

公开(公告)日：2013-04-30

申请号：US12084411

申请日：2006-11-02

Applicant: Stephen O'Connor ,  Jacques Dumas ,  Wendy Lee ,  Julie Dixon ,  David Cantin ,  David Gunn ,  Jennifer Burke ,  Barton Phillips ,  Derek Lowe ,  Tatiana Shelekhin ,  Gan Wang ,  Xin Ma ,  Shihong Ying ,  Andrea McClure ,  Furahi Achebe ,  Mario Lobell ,  Frederick Ehrgott ,  Christiana Iwuagwu ,  Kyle Parcella

Inventor： Stephen O'Connor ,  Jacques Dumas ,  Wendy Lee ,  Julie Dixon ,  David Cantin ,  David Gunn ,  Jennifer Burke ,  Barton Phillips ,  Derek Lowe ,  Tatiana Shelekhin ,  Gan Wang ,  Xin Ma ,  Shihong Ying ,  Andrea McClure ,  Furahi Achebe ,  Mario Lobell ,  Frederick Ehrgott ,  Christiana Iwuagwu ,  Kyle Parcella

IPC: C07D487/04 ,  C07D413/02 ,  C07D417/02 ,  A61K31/53 ,  A61P35/00

CPC classification number: C07D487/04

Abstract: This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.

Abstract translation: 本发明涉及新的式（I）化合物。 式（I）其中可变基团如说明书和权利要求中所定义，含有它们的药物组合物，以及使用它们治疗癌症的方法。

公开(公告)号：US20120161378A1

公开(公告)日：2012-06-28

申请号：US13216424

申请日：2011-08-24

Applicant: QING-SONG WEN ,  WEI-FENG PAN ,  JIAN-XIN MA ,  YU LU

Inventor： QING-SONG WEN ,  WEI-FENG PAN ,  JIAN-XIN MA ,  YU LU

IPC: B23Q1/64

CPC classification number: B23Q3/18 ,  B23K31/02 ,  B23K37/04 ,  B23K37/0435 ,  B23Q1/4852 ,  B23Q1/525

Abstract: A positioning apparatus includes a base plate and a deflection mechanism mounted upon the base plate. The deflection mechanism includes a stationary platform, a rocker assembly and a deflection platform. The stationary platform is mounted over the base plate for placing and positioning a workpiece. The deflection platform is tiltably mounted over the stationary platform via the rocker assembly and the height of the stationary platform itself is adjustable. The rocker assembly comprises a first rocker and a second rocker of different lengths.

Abstract translation: 定位装置包括安装在基板上的基板和偏转机构。 偏转机构包括固定平台，摇杆组件和偏转平台。 固定平台安装在基板上，用于放置和定位工件。 偏转平台通过摇杆组件可倾斜地安装在固定平台上，固定平台本身的高度是可调节的。 摇臂组件包括不同长度的第一摇臂和第二摇臂。

公开(公告)号：US07964622B2

公开(公告)日：2011-06-21

申请号：US12508314

申请日：2009-07-23

Applicant: Xin Ma ,  Louis-David Cantin ,  Soongyu Choi ,  Roger Clark ,  Martin Hentemann ,  Joachim Rudolph ,  Rico Lavoie ,  Zhonghua Zhang

Inventor： Xin Ma ,  Louis-David Cantin ,  Soongyu Choi ,  Roger Clark ,  Martin Hentemann ,  Joachim Rudolph ,  Rico Lavoie ,  Zhonghua Zhang

IPC: A61K31/425 ,  A61K31/42 ,  C07D417/00 ,  C07D277/20 ,  C07D498/00 ,  C07D263/30

CPC classification number: C07D403/12 ,  C07D209/08 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.

Abstract translation: 本发明涉及吲哚乙酸衍生物及其在药物组合物中用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的用途。 本发明还涉及可用于制备吲哚乙酸衍生物的中间体和制备方法。

公开(公告)号：US20100273800A1

公开(公告)日：2010-10-28

申请号：US12679787

申请日：2008-09-22

Applicant: Steven Magnuson ,  Philip Wickens ,  Zhonghua Zhang ,  Ning Qi ,  Xin Ma

Inventor： Steven Magnuson ,  Philip Wickens ,  Zhonghua Zhang ,  Ning Qi ,  Xin Ma

IPC: A61K31/53 ,  C07D253/10 ,  C12N9/99 ,  A61P35/00 ,  A61J1/05

CPC classification number: C07D487/04

Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.

Abstract translation: 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。

公开(公告)号：US20100217753A1

公开(公告)日：2010-08-26

申请号：US12772190

申请日：2010-05-01

Applicant: Eyal Shlomot ,  Jinliang Dai ,  Fuliang Yin ,  Xin Ma ,  Jun Zhang

Inventor： Eyal Shlomot ,  Jinliang Dai ,  Fuliang Yin ,  Xin Ma ,  Jun Zhang

IPC: G06F17/30

CPC classification number: G10L19/06 ,  G10L19/07 ,  G10L2019/0005 ,  G10L2019/0007 ,  H03M7/3082

Abstract: The invention discloses a multi-stage quantization method, which includes the following steps: obtaining a reference codebook according to a previous stage codebook; obtaining a current stage codebook according to the reference codebook and a scaling factor; and quantizing an input vector by using the current stage codebook. The invention also discloses a multi-stage quantization device. With the invention, the current stage codebook may be obtained according to the previous stage codebook, by using the correlation between the current stage codebook and the previous stage codebook. As a result, it does not require an independent codebook space for the current stage codebook, which saves the storage space and improves the resource usage efficiency.

Abstract translation: 本发明公开了一种多级量化方法，包括以下步骤：获得根据前一级码本的参考码本; 根据参考码本和缩放因子获得当前阶段码本; 并通过使用当前阶段码本量化输入向量。 本发明还公开了一种多级量化装置。 利用本发明，可以通过使用当前阶段码本和前一级码本之间的相关性，根据前一级码本获得当前级码本。 因此，不需要当前级码本的独立码本空间，可以节省存储空间，提高资源使用效率。

公开(公告)号：US20100204472A1

公开(公告)日：2010-08-12

申请号：US12759328

申请日：2010-04-13

Applicant: Louis-David Cantin ,  Soongyu Choi ,  Roger B. Clark ,  Martin F. Hentemann ,  Xin Ma ,  Joachim Rudolph ,  Sidney X. Liang ,  Christiana Akuche ,  Rico C. Lavoie ,  Libing Chen ,  Dyuti Majumdar ,  Philip L. Wickens

Inventor： Louis-David Cantin ,  Soongyu Choi ,  Roger B. Clark ,  Martin F. Hentemann ,  Xin Ma ,  Joachim Rudolph ,  Sidney X. Liang ,  Christiana Akuche ,  Rico C. Lavoie ,  Libing Chen ,  Dyuti Majumdar ,  Philip L. Wickens

IPC: C07D239/34 ,  C07D401/04 ,  C07D405/10 ,  C07D213/85 ,  C07D213/72 ,  C07D213/55 ,  C07D513/04 ,  C07D277/30 ,  C07D239/42

CPC classification number: C07D213/30 ,  C07C59/72 ,  C07C59/90 ,  C07C69/734 ,  C07C211/48 ,  C07C217/24 ,  C07C255/54 ,  C07C327/48 ,  C07C333/04 ,  C07C2602/08 ,  C07D209/08 ,  C07D213/63 ,  C07D213/83 ,  C07D213/84 ,  C07D215/20 ,  C07D231/12 ,  C07D239/26 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/52 ,  C07D249/06 ,  C07D249/08 ,  C07D261/20 ,  C07D263/32 ,  C07D263/56 ,  C07D277/24 ,  C07D277/34 ,  C07D277/56 ,  C07D277/64 ,  C07D277/66 ,  C07D285/08 ,  C07D307/42 ,  C07D307/79 ,  C07D333/16 ,  C07D405/04 ,  C07D417/04 ,  C07D513/04

Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

Abstract translation: 本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。

公开(公告)号：US07683168B2

公开(公告)日：2010-03-23

申请号：US11404632

申请日：2006-04-14

Applicant: Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis P. Biciunas ,  Xin Ma

Inventor： Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis P. Biciunas ,  Xin Ma

IPC: C07D245/02

CPC classification number: C07D405/12 ,  C07D241/04 ,  C07D401/10 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D491/10

Abstract: Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.

Abstract translation: 描述了二芳基甲基哌嗪化合物，其可用作mu和/或δ受体阿片样物质，没有中枢副作用。 包含这些化合物的药物组合物可用于外周或非中枢介导的适应症，包括周围介导的和神经性疼痛，泌尿生殖道疾病，膀胱过度活动症，尿失禁，性功能障碍，早泄，咳嗽，肺水肿，心脏病，心脏保护， 胃肠道疾病，腹泻，肠易激综合征，功能扩张，免疫调节和抗肿瘤活性。