公开(公告)号：US20160245776A1

公开(公告)日：2016-08-25

申请号：US15144024

申请日：2016-05-02

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar G. Iyengar

IPC: G01N27/403 ,  G01N27/327

CPC classification number: G01N27/403 ,  C12Q1/004 ,  G01N27/30 ,  G01N27/3272 ,  Y10T29/49002 ,  Y10T29/49114 ,  Y10T29/49117 ,  Y10T156/1052 ,  Y10T156/1062 ,  Y10T156/1074

Abstract: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.

Abstract translation: 通过将具有结合开口的电阻片粘附到第一导电片上，精确地和精确地制造电化学测试电池。 然后通过电阻片和第一导电片冲切开切口。 开槽开口与电阻薄片中的第一个开口相交，并将第一个结合开口转变成电阻薄片中的凹口。 第二导电片被冲压成具有与第一导电片相对应的开槽开口，并且其粘接到电阻片的另一侧，使得开槽开口对准。 这种结构从周围的材料上被切割成一个电化学电池，该电化学电池具有用于接收由第一和第二导电片和电阻片中的凹口限定的样品的样品空间。

公开(公告)号：US20160192871A1

公开(公告)日：2016-07-07

申请号：US15069071

申请日：2016-03-14

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding

IPC: A61B5/1486 ,  A61B5/00

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7225 ,  C12Q1/001 ,  C12Q1/006

Abstract: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.

公开(公告)号：US09234862B2

公开(公告)日：2016-01-12

申请号：US14278299

申请日：2014-05-15

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327 ,  G01N27/30 ,  C12Q1/00

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

公开(公告)号：US20140262778A1

公开(公告)日：2014-09-18

申请号：US14291990

申请日：2014-05-30

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar G. Iyengar

IPC: G01N27/403

CPC classification number: G01N27/403 ,  C12Q1/004 ,  G01N27/30 ,  G01N27/3272 ,  Y10T29/49002 ,  Y10T29/49114 ,  Y10T29/49117 ,  Y10T156/1052 ,  Y10T156/1062 ,  Y10T156/1074

Abstract: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.

Abstract translation: 通过将具有结合开口的电阻片粘附到第一导电片上，精确地和精确地制造电化学测试电池。 然后通过电阻片和第一导电片冲切开切口。 开槽开口与电阻薄片中的第一个开口相交，并将第一个结合开口转变成电阻薄片中的凹口。 第二导电片被冲压成具有与第一导电片相对应的开槽开口，并且其粘接到电阻片的另一侧，使得开槽开口对准。 这种结构从周围的材料上被切割成一个电化学电池，该电化学电池具有用于接收由第一和第二导电片和电阻片中的凹口限定的样品的样品空间。

公开(公告)号：US20140001045A1

公开(公告)日：2014-01-02

申请号：US14010792

申请日：2013-08-27

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding

IPC: G01N27/30

Abstract: An electrochemical test device is provided having a base layer with a first electrode thereon and a top layer with a second electrode thereon. The two electrodes are separated by a spacer layer having an opening therein, such that a sample-receiving space is defined with one electrode on the top surface, the other electrodes on the bottom surface and side walls formed from edges of the opening in the spacer. Reagents for performing the electrochemical reaction are deposited on one of the electrodes and on the side walls of the sample-receiving space.

Abstract translation: 提供一种电化学测试装置，其具有其上具有第一电极的基底层和其上具有第二电极的顶层。 两个电极由其中具有开口的间隔层隔开，使得样品接收空间被限定在顶表面上的一个电极，底表面上的另一电极和由间隔件中的开口的边缘形成的侧壁 。 用于进行电化学反应的试剂沉积在样品接收空间的一个电极和侧壁上。

公开(公告)号：US20130118921A1

公开(公告)日：2013-05-16

申请号：US13723713

申请日：2012-12-21

Applicant: AGAMATRIX, INC.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

Abstract translation: 在施加到使用还原介体的电化学测试条的样品中的氧或红细胞的存在通过作为样品的温度的函数确定的添加剂校正因子来校正，并且反映 样品的氧气承载能力。 测量的氧气承载能力也可用于确定血细胞比容并区分血液样本和应用于测试条的对照溶液。

公开(公告)号：US11719687B2

公开(公告)日：2023-08-08

申请号：US16222683

申请日：2018-12-17

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding ,  Richard Williams ,  Kevin Cai

IPC: G01N33/487 ,  G01N27/327

CPC classification number: G01N33/48771 ,  G01N27/3274

Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.

公开(公告)号：US11175256B2

公开(公告)日：2021-11-16

申请号：US14010792

申请日：2013-08-27

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding

IPC: G01N27/403 ,  C12Q1/00 ,  G01N27/327 ,  G01N27/30

Abstract: An electrochemical test device is provided having a base layer with a first electrode thereon and a top layer with a second electrode thereon. The two electrodes are separated by a spacer layer having an opening therein, such that a sample-receiving space is defined with one electrode on the top surface, the other electrodes on the bottom surface and side walls formed from edges of the opening in the spacer. Reagents for performing the electrochemical reaction are deposited on one of the electrodes and on the side walls of the sample-receiving space.

公开(公告)号：US10288577B2

公开(公告)日：2019-05-14

申请号：US15477485

申请日：2017-04-03

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding ,  Charles Boiteau ,  Colin Butters

IPC: G01N27/327 ,  G01N21/77 ,  G01N21/84 ,  G01N33/487 ,  G01N21/25 ,  G01J1/42

Abstract: A test strip with an incorporated optical waveguide and deflectors punched through the optical waveguide allows light to exit through a layer of the test strip and be detected by a photo detector. Using light and a photodetector, these uniquely coded strips are identified. The waveguide can be constructed by sandwiching two layers of the test strip around a light transmissible layer. This configuration allows light to be transmitted through the test strip and out the other end, as well as allowing some light to escape the deflector. This light is detected by a photodetector mounted in the analyte test meter. The deflectors may be placed in patterns such that detection of this light indicates certain characteristics of the strip, such as non-counterfeit, regional identification, type of analyte tested, and coding information.

公开(公告)号：US10285633B2

公开(公告)日：2019-05-14

申请号：US15910251

申请日：2018-03-02

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding

IPC: A61B5/00 ,  A61B5/1486 ,  C12Q1/00 ,  A61B5/145 ,  A61B5/1495

Abstract: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.