公开(公告)号：US20200333282A1

公开(公告)日：2020-10-22

申请号：US16840990

申请日：2020-04-06

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327 ,  C12Q1/00 ,  G01N27/30

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

公开(公告)号：US20190113498A1

公开(公告)日：2019-04-18

申请号：US16222683

申请日：2018-12-17

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding ,  Richard Williams ,  Kevin Cai

IPC: G01N33/487

Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.

公开(公告)号：US10168313B2

公开(公告)日：2019-01-01

申请号：US13835672

申请日：2013-03-15

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding ,  Richard Williams ,  Kevin Cai

IPC: G01N33/487 ,  G01N27/327

Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.

公开(公告)号：US20180231552A1

公开(公告)日：2018-08-16

申请号：US15944148

申请日：2018-04-03

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar Iyengar ,  Richard Williams

IPC: G01N33/573 ,  C12Q1/00 ,  G01N33/543 ,  G01N27/416

CPC classification number: G01N33/573 ,  C12Q1/001 ,  G01N27/4166 ,  G01N33/5438 ,  G01N2333/90 ,  G01N2333/902

Abstract: A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes.

公开(公告)号：US20140262828A1

公开(公告)日：2014-09-18

申请号：US13835672

申请日：2013-03-15

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding ,  Richard Williams ,  Kevin Cai

IPC: G01N27/327

CPC classification number: G01N33/48771 ,  G01N27/3274

Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.

Abstract translation: 提供了一种用于获得编码在电化学测试条上的信息的方法。 测试条具有设置在样品空间内的两个电极，并且在引入液体样品之前将该信息编码在测试条上。 该方法包括将样品引入样品空间以使样品与样品空间内的两个电极接触的步骤。 在另一步骤中，确定代表测试条的双层电容和/或测试条的等效电容的值。 然后将确定的值转换为在引入样品之前反映测试条的特性的信息。

公开(公告)号：US09234862B2

公开(公告)日：2016-01-12

申请号：US14278299

申请日：2014-05-15

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327 ,  G01N27/30 ,  C12Q1/00

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

公开(公告)号：US20130118921A1

公开(公告)日：2013-05-16

申请号：US13723713

申请日：2012-12-21

Applicant: AGAMATRIX, INC.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

Abstract translation: 在施加到使用还原介体的电化学测试条的样品中的氧或红细胞的存在通过作为样品的温度的函数确定的添加剂校正因子来校正，并且反映 样品的氧气承载能力。 测量的氧气承载能力也可用于确定血细胞比容并区分血液样本和应用于测试条的对照溶液。

公开(公告)号：US20180080895A1

公开(公告)日：2018-03-22

申请号：US15825598

申请日：2017-11-29

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327 ,  C12Q1/00 ,  G01N27/30

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

公开(公告)号：US11408849B2

公开(公告)日：2022-08-09

申请号：US16840990

申请日：2020-04-06

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327 ,  C12Q1/00 ,  G01N27/30

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

公开(公告)号：US09939440B2

公开(公告)日：2018-04-10

申请号：US15017787

申请日：2016-02-08

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar Iyengar ,  Richard Williams

IPC: G01N27/416 ,  G01N33/573 ,  C12Q1/00 ,  G01N33/543

CPC classification number: G01N33/573 ,  C12Q1/001 ,  G01N27/4166 ,  G01N33/5438 ,  G01N2333/90 ,  G01N2333/902

Abstract: A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes.