公开(公告)号：US20160327514A1

公开(公告)日：2016-11-10

申请号：US15148924

申请日：2016-05-06

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet ,  Klaus Witt

IPC: G01N27/447

CPC classification number: G01N30/32 ,  G01N2030/324 ,  G01N2030/326

Abstract: A sample separation apparatus includes a metering device for metering a predefined amount of fluidic sample to be separated by a sample separation apparatus, a metering path for fluidically coupling the metering device and a sample source providing fluidic sample to be metered, and a control device. The control device is configured for controlling operation of the metering device for at least partially compensating for a deviation between a target value to be metered and an actual value of an amount of fluidic sample that is metered, the deviation resulting from a thermally induced volume change in the sample separation apparatus.

Abstract translation: 样品分离装置包括计量装置，用于计量由样品分离装置分离的预定量的流体样品，用于流体耦合计量装置的计量路径和提供要计量的流体样品的样品源以及控制装置。 控制装置被配置为控制计量装置的操作，用于至少部分地补偿要计量的目标值与计量的流体样品量的实际值之间的偏差，由热诱导的体积变化导致的偏差 在样品分离装置中。

公开(公告)号：US20160138577A1

公开(公告)日：2016-05-19

申请号：US14901580

申请日：2013-06-28

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Konstantin Shoykhet ,  Klaus Witt ,  Hans Georg Weissgerber

IPC: F04B19/22

CPC classification number: F04B19/22 ,  F04B13/02 ,  F04B15/02 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/326

Abstract: Disclosed is a pumping apparatus (200) configured for delivering a fluid. The pumping apparatus (200) comprises a pumping chamber (220) configured for receiving one or more fluids (310, 320) in defined proportions and for further delivering the received fluids, an outlet (240), fluidically coupling to a first position (350) in the pumping chamber (220), for outleting the fluid to be delivered, and a channel (410). The channel (410) fluidically couples on one side to a second position (340) in the pumping chamber (220) and on the other side to the outlet (240), so that—in operation—a first portion of the delivered fluid as outlet at the outlet (240) is received from the first position (350) in the pumping chamber (220), and a second portion of the delivered fluid as outlet at the outlet (240) is received from the second position (340) in the pumping chamber (220). One of the first (350) and second (340) positions is a spatial position within the pumping chamber (220) where fluid components having a first property would tend to accumulate during operation of the pumping apparatus (200) if such position were not coupled to the outlet (240), with such accumulation resulting from variations in the first property.

Abstract translation: 公开了一种被配置为输送流体的泵送装置（200）。 泵送装置（200）包括泵送室（220），其构造成用于以一定比例接收一个或多个流体（310,320）并且用于进一步输送所接收的流体;流体耦合到第一位置（350）的出口（240） ）在泵送室（220）中，用于输送待输送的流体和通道（410）。 通道（410）在一侧流体耦合到泵送室（220）中的第二位置（340），而在另一侧与出口（240）流体耦合，使得在运行中 - 输送流体的第一部分作为 在出口（240）处的出口从泵送室（220）中的第一位置（350）接收，并且作为出口（240）处的出口的输送流体的第二部分从第二位置（340）被接收在 泵送室（220）。 第一（350）和第二（340）位置中的一个位置是泵送室（220）内的空间位置，其中具有第一特性的流体部件将在泵送装置（200）的操作期间倾向于积聚，如果该位置未耦合 到出口（240），由于第一性质的变化而产生这种累积。

公开(公告)号：US20150285239A1

公开(公告)日：2015-10-08

申请号：US14677558

申请日：2015-04-02

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Konstantin Shoykhet ,  Klaus Witt

IPC: F04B49/00 ,  F04B51/00

CPC classification number: F04B51/00 ,  F04B23/06 ,  F04B49/08 ,  F04B49/20 ,  G01N30/32 ,  G01N30/36 ,  G01N2030/326

Abstract: A device for determining a leakage of fluid in a piston pump, wherein the piston pump comprises a piston arranged in such a manner that it can reciprocate in a piston chamber for delivering fluid, wherein the device comprises a control unit for controlling the piston in such a manner that the piston executes two piston chamber evacuation processes with different evacuation times, in each case for at least partial evacuating of fluid located in the piston chamber, and a determination unit for determining the leakage based on a comparison of fluid quantities evacuated from the piston chamber in the two piston chamber evacuation processes.

Abstract translation: 一种用于确定活塞泵中的流体泄漏的装置，其中所述活塞泵包括以能够在用于输送流体的活塞室中往复运动的方式布置的活塞，其中所述装置包括用于控制活塞的控制单元 活塞执行具有不同排气时间的两个活塞室排空过程的方式，在每种情况下至少部分抽空位于活塞室中的流体;以及确定单元，用于基于从所述活塞室排出的流体量的比较来确定泄漏 活塞室在两个活塞室排空过程中。

公开(公告)号：US12174160B2

公开(公告)日：2024-12-24

申请号：US17631924

申请日：2020-07-30

Applicant: Agilent Technologies, Inc.

Inventor： Dwight Robert Stoll ,  Konstantin Shoykhet ,  Thomas Ortmann ,  Stephan Buckenmaier ,  Sascha Lege

IPC: G01N30/46 ,  G01N30/02 ,  G01N30/34

Abstract: A fluid processing apparatus includes a first fluid processing unit and a second fluid processing unit. A fluid unit is fluidically coupled to the first fluid processing unit and includes a first buffering unit configured for buffering fluid, and/or a mask flow source configured for providing a mask fluid or a flow thereof. A first coupling point is fluidically coupled between the first fluid processing unit and the fluid unit. A modulation unit is configured, selectively, for withdrawing fluid from the first coupling point, or for transferring withdrawn fluid into the second fluid processing unit. The apparatus may be utilized for chromatography.

公开(公告)号：US20240230455A1

公开(公告)日：2024-07-11

申请号：US18562113

申请日：2022-05-16

Applicant: Agilent Technologies, Inc.

Inventor： Timo Witte ,  Konstantin Shoykhet ,  Sascha Lege ,  Clemens Plachetka

IPC: G01M3/26 ,  G01N30/32

CPC classification number: G01M3/26 ,  G01N30/32 ,  G01N2030/326

Abstract: A restriction in a liquid network containing a liquid is determined by generating a vacuum bubble within the liquid network, the vacuum bubble representing a volume in which the liquid has been substantially removed. A period of time between generating the vacuum bubble and until the volume has been substantially filled with the liquid is determined. A conclusion regarding the restriction is made based on the determined period of time.

公开(公告)号：US12005376B2

公开(公告)日：2024-06-11

申请号：US17279354

申请日：2019-09-17

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet ,  Dwight Robert Stoll

IPC: B01D15/18 ,  B01D15/16 ,  G01N27/447 ,  G01N30/02 ,  G01N30/06 ,  G01N30/16 ,  G01N30/32 ,  G01N30/46

CPC classification number: B01D15/1878 ,  B01D15/163 ,  G01N27/44773 ,  G01N30/06 ,  G01N30/16 ,  G01N30/32 ,  G01N30/463 ,  G01N2030/326

Abstract: A sample separation apparatus includes a first-dimension separation unit for separating the fluidic sample, having a first-dimension outlet for outputting the fluidic sample or fractions thereof, and a second-dimension separation unit for further separating the fluidic sample or fractions thereof. The second-dimension separation unit has a second-dimension inlet fluidically coupled to the first-dimension outlet. A modulation unit, coupled between the first-dimension outlet and the second-dimension inlet at a first coupling point, is configured for withdrawing fluid from the first coupling point and for ejecting fluid into the first coupling point. A second-dimension fluid drive is coupled to a second coupling point located between the first-dimension outlet and the second-dimension inlet and downstream from the first coupling point. The second-dimension fluid drive is configured for generating a fluid flow for driving at least part of the fluidic sample after treatment by the first-dimension separation unit through the second-dimension separation unit.

公开(公告)号：US20240027407A1

公开(公告)日：2024-01-25

申请号：US18265923

申请日：2021-12-07

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet ,  Thomas Ortmann

IPC: G01N30/20 ,  B01D15/14

CPC classification number: G01N30/20 ,  B01D15/14 ,  G01N2030/027

Abstract: A fluid valve, for a sample separation device such as for liquid chromatography, includes a rotor, a stator, and external terminals for fluidically connecting one or more components. By rotating the rotor, different fluidic coupling and/or decoupling states between components are adjustable. Ports are connectable with one or more external terminals. A first channel is formed along a first circular path. A second channel includes a first coupling point located on the first circular path and a second coupling point located on a second circular path. By rotating the rotor, a fluidic coupling between a first port and a second port can be established, by the first channel being connected with the first port and at least the first coupling point with the second channel, and by the second channel being connected at least via the second coupling point with the second port.

公开(公告)号：US11635412B2

公开(公告)日：2023-04-25

申请号：US17045751

申请日：2018-04-06

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet

IPC: G01N30/20 ,  G01N30/32 ,  G01N30/46 ,  G01N30/02

Abstract: An apparatus for separating a fluidic sample includes a fluid drive arrangement including fluid drive units for driving a mobile phase along a flow path to a sample separation unit, a sample accommodation volume for accommodating the fluidic sample and selectively fluidically coupleable with or decoupleable from the flow path, and a control unit. The control unit is configured to control pressure decoupling of at least part of at least one of the fluid drive units from the flow path, and enable the partially pressure-decoupled fluid drive unit(s) to pressurize the sample accommodation volume before fluidically coupling the sample accommodation volume with the flow path and/or to de-pressurize the sample accommodation volume after fluidically coupling the sample accommodation volume with the flow path for preparing a subsequent intake of fluidic sample in the sample accommodation volume.

公开(公告)号：US20210394082A1

公开(公告)日：2021-12-23

申请号：US17279354

申请日：2019-09-17

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet ,  Dwight Robert Stoll

IPC: B01D15/18 ,  B01D15/16 ,  G01N27/447 ,  G01N30/06 ,  G01N30/32 ,  G01N30/16 ,  G01N30/46

Abstract: A sample separation apparatus includes a first-dimension separation unit for separating the fluidic sample, having a first-dimension outlet for outputting the fluidic sample or fractions thereof, and a second-dimension separation unit for further separating the fluidic sample or fractions thereof. The second-dimension separation unit has a second-dimension inlet fluidically coupled to the first-dimension outlet. A modulation unit, coupled between the first-dimension outlet and the second-dimension inlet at a first coupling point, is configured for withdrawing fluid from the first coupling point and for ejecting fluid into the first coupling point. A second-dimension fluid drive is coupled to a second coupling point located between the first-dimension outlet and the second-dimension inlet and downstream from the first coupling point. The second-dimension fluid drive is configured for generating a fluid flow for driving at least part of the fluidic sample after treatment by the first-dimension separation unit through the second-dimension separation unit.

公开(公告)号：US20210055268A1

公开(公告)日：2021-02-25

申请号：US17045756

申请日：2019-04-05

Applicant: Agilent Technologies, Inc.

Inventor： Stephan Buckenmaier ,  Konstantin Shoykhet

IPC: G01N30/20 ,  G01N30/46 ,  G01N30/82

Abstract: A sampling unit for handling a sample fluid includes a sample container having a length and being configured for receiving and storing the sample fluid, and a sample segment dispatching unit configured for providing a plurality of individual sample packages of the fluidic sample, each contained in a respective volume segment along the length of the sample container, and for individually dispatching each of the plurality of individual sample packages for further processing in a fluid processing unit.