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    Method for controlling fouling during a spinning membrane filtration procedure
    33.
    发明授权
    Method for controlling fouling during a spinning membrane filtration procedure 有权

    公开(公告)号：US10046278B2

    公开(公告)日：2018-08-14

    申请号：US15482248

    申请日：2017-04-07

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Kyungyoon Min

    IPC: A61M1/34 ,  B01D63/16 ,  B01D65/08 ,  C12N5/078

    Abstract: Methods for controlling a spinning membrane separator so as to limit fouling of the membrane by changing the rotation rate of the spinning membrane in response to the fouling rate, while maintaining a constant outlet cellular concentration. Increasing the spinner rotation rate will increase the strength of the Taylor vortices generated within the separator by the spinning of the membrane, which should reduce fouling of the membrane. The goal of the method is to rotate the spinning membrane at the slowest rate possible without unacceptable fouling. Two specific methods to control fouling are disclosed. In a first, unidirectional method, the spin rate of the membrane is only increased in response to undesirable fouling in order to prevent the fouling from continuing. In a second, bidirectional method, the spin rate of the membrane may be either increased or decreased in response to the measured fouling rate in order to maintain the fouling rate within a desired range.

    Fluid Separation Chambers For Fluid Processing Systems
    34.
    发明申请
    Fluid Separation Chambers For Fluid Processing Systems 审中-公开

    公开(公告)号：US20180221891A1

    公开(公告)日：2018-08-09

    申请号：US15943877

    申请日：2018-04-03

    Applicant: Fenwal, Inc.

    Inventor： Gregory G. Pieper ,  Salvatore Manzella, JR. ,  Brian C. Case ,  Steven R. Katz ,  Kyungyoon Min

    IPC: B04B7/08 ,  B04B5/04

    CPC classification number: B04B7/08 ,  B04B5/0442 ,  B04B2005/045

    Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

    AUTOMATED METHODS AND SYSTEMS FOR WASHING PLATELET CONCENTRATES
    40.
    发明申请
    AUTOMATED METHODS AND SYSTEMS FOR WASHING PLATELET CONCENTRATES 审中-公开
    用于洗涤板浓度的自动化方法和系统

    公开(公告)号：US20160333315A1

    公开(公告)日：2016-11-17

    申请号：US15193397

    申请日：2016-06-27

    Applicant: Fenwal, Inc.

    Inventor： Katherine Radwanski ,  Kyungyoon Min

    IPC: C12N5/078 ,  A01N1/02

    CPC classification number: C12N5/0644 ,  A01N1/0226 ,  A61K35/19 ,  A61M1/0209 ,  A61M1/0272 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427

    Abstract: Automated systems and methods for providing platelet concentrates and synthetic storage media with reduced residual plasma volumes are disclosed. The disclosed systems and methods reduce the residual volume of plasma in platelet concentrate to obtain a platelet product having a volume of plasma that is approximately 5% or less of the total platelet product volume. The disclosed systems and methods also reduce the residual volume of plasma in platelet concentrate to obtain a washed platelet product, wherein the volume of plasma in the washed platelet product is approximately 1% or less of the total washed platelet product volume. Storage media for platelets including less than approximately 10% plasma are also disclosed.

    Abstract translation: 公开了用于提供具有降低的残留血浆体积的血小板浓缩物和合成储存介质的自动化系统和方法。 所公开的系统和方法减少血小板浓缩物中的血浆的剩余体积，以获得血小板体积大约为总血小板产品体积的约5％或更小的血小板产品。 所公开的系统和方法还减少血小板浓缩物中的血浆的剩余体积以获得洗涤的血小板产物，其中洗涤的血小板产物中的血浆体积为总洗涤的血小板产物体积的约1％或更少。 还公开了包含小于约10％血浆的血小板的储存介质。

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