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    Direct compression formulation and process
    31.
    发明申请
    Direct compression formulation and process 审中-公开
    直接压缩配方和工艺

    公开(公告)号：US20060210627A1

    公开(公告)日：2006-09-21

    申请号：US11333582

    申请日：2006-01-17

    Applicant: Sabine Pfeffer ,  Frank Schaefer ,  Ricardo Schneeberger ,  Paul Sutton ,  Martin Trueby ,  Wolfgang Wirth

    Inventor： Sabine Pfeffer ,  Frank Schaefer ,  Ricardo Schneeberger ,  Paul Sutton ,  Martin Trueby ,  Wolfgang Wirth

    IPC: A61K38/04 ,  A61K9/20

    CPC classification number: A61K9/2018 ,  A61K9/2054 ,  A61K31/195 ,  A61K31/40 ,  A61K31/4439 ,  Y10T428/2982

    Abstract: This invention relates to tablets especially tablets formed by direct compression of a dipeptidylpeptidase IV (DPP-IV) inhibitor compound, a process for the preparation thereof, to new pharmaceutical formulations, and new tableting powders comprising DPP-IV inhibitor formulations capable of being directly compressed into tablets. The invention relates further to a process for preparing the tablets by blending the active ingredient and specific excipients into the new formulations and then directly compressing the formulations into the direct compression tablets. The invention also relates to vildagliptin particle size distribution and a new crystal form of vildagliptin particularly adapted for the preparation of improved tablets and other pharmaceutical compositions.

    Abstract translation: 本发明涉及片剂，特别是通过直接压制二肽基肽酶IV（DPP-IV）抑制剂化合物，其制备方法，新药物制剂和包含能直接压制的DPP-IV抑制剂制剂的新型压片粉末形成的片剂 成片。 本发明还涉及通过将活性成分和特定赋形剂混合到新制剂中然后将制剂直接压制成直接压制片剂来制备片剂的方法。 本发明还涉及维格列汀的粒度分布和新型晶体形式的维格列汀，特别适用于制备改进的片剂和其它药物组合物。

    Apparatus and method for measuring a tire pressure from the tire footprint
    33.
    发明授权
    Apparatus and method for measuring a tire pressure from the tire footprint 有权
    用于从轮胎足迹测量轮胎压力的装置和方法

    公开(公告)号：US08833152B2

    公开(公告)日：2014-09-16

    申请号：US13809063

    申请日：2011-07-11

    Applicant: Frank Schaefer

    Inventor： Frank Schaefer

    IPC: B60C23/02 ,  G01L17/00 ,  G01M17/02 ,  G01B11/22 ,  B60C23/04

    CPC classification number: B60C23/04 ,  G01B11/22 ,  G01L17/005 ,  G01M17/02 ,  G01M17/027

    Abstract: An apparatus for measuring the pressure of a tire on a moving vehicle, comprising measuring device (14, 18, 24) which is provided on or inside a floor or ground so as to interact with the tire and which generates an electronically analyzable measurement signal in reaction to the tire driving over the measuring device, and analysis unit (22, 40) which output a tire pressure signal corresponding to the tire pressure in reaction to the measurement signal. The measuring device includes an optical unit (18) for acquiring a tire width as the width of a tire footprint forming when the tire drives over the floor/ground. The analysis unit is designed to determine a footprint length from a series of tire width data generated by the optical unit and/or from a pattern of a pressure measurement signal generated by the measuring device and to determine the tire pressure from a footprint area calculated as a function of the length and width of the footprint and from a force applied to the footprint area by the tire.

    Abstract translation: 一种用于测量移动车辆上的轮胎的压力的装置，包括测量装置（14,18,24），其设置在地板或地面上或内部，以便与轮胎相互作用并且产生电子可分析的测量信号 响应于测量装置上的轮胎的反应，以及响应于测量信号而输出与轮胎压力相对应的轮胎压力信号的分析单元（22,40）。 测量装置包括用于获取轮胎宽度作为轮胎在地板/地面上行驶时形成的轮胎足迹的宽度的光学单元（18）。 分析单元被设计成根据由光学单元生成的一系列轮胎宽度数据和/或从测量装置产生的压力测量信号的图案确定足迹长度，并且从根据以下计算的占地区域确定轮胎压力： 由足迹的长度和宽度以及由轮胎施加到覆盖区域的力的函数。

    Thermoplastic polyurethanes
    34.
    发明授权
    Thermoplastic polyurethanes 有权
    热塑性聚氨酯

    公开(公告)号：US08507633B2

    公开(公告)日：2013-08-13

    申请号：US12293103

    申请日：2007-04-11

    Applicant: Oliver Steffen Henze ,  Ruediger Krech ,  Frank Prissok ,  Karin Scheffer ,  Frank Schaefer ,  Heinrich Niermann

    Inventor： Oliver Steffen Henze ,  Ruediger Krech ,  Frank Prissok ,  Karin Scheffer ,  Frank Schaefer ,  Heinrich Niermann

    IPC: C08G18/00

    CPC classification number: A43B1/14 ,  A43B5/04 ,  C08G18/4854 ,  C08G18/6674 ,  C08G2120/00

    Abstract: A process for the preparation of thermoplastic polyurethane by reacting (a) isocyanates with (b) compounds reactive toward isocyanates and having a molecular weight (Mw) of from 500 to 10 000 g/mol and (c) chain extenders having a molecular weight of from 50 to 499 g/mol, if appropriate in the presence of (d) catalysts and/or (e) conventional additives, wherein the chain extender mixture consisting of a main chain extender (c1) and one or more co-chain extenders (c2) is used and the thermoplastic polyurethane prepared has a rigid phase fraction of greater than 0.40, the rigid phase fraction being defined by the following formula: rigid ⁢ ⁢ phase ⁢ ⁢ fraction = { ∑ x = 1 k ⁢ [ ( m KVx / M KVx ) * M Iso + m KVx ] } / m ges with the following meanings: MKVx: molar mass of the chain extender x in g/mol mKVx: mass of the chain extender x in g MIso: molar mass of the isocyanate used in g/mol mges: total mass of all starting materials in g k: number of chain extenders.

    Abstract translation: 一种通过使（a）异氰酸酯与（b）对异氰酸酯具有反应性并且分子量（Mw）为500至10000g / mol的化合物和（c）分子量为 在（d）催化剂和/或（e）常规添加剂的存在下，如果合适，其为50至499g / mol，其中由主链延长剂（c1）和一种或多种共扩链剂（ c2），所制备的热塑性聚氨酯具有大于0.40的刚性相分数，刚性相分数由下式定义：刚性相凝固分数= {Σx = 1 k [（m KVx / M KVx）* M Iso + m KVx]} / m ges，具有以下含义：MKVx：扩链剂的摩尔质量x（g / mol）mKVx：扩链剂的质量（以g计）MIso：所用异氰酸酯的摩尔质量 以g / mol mges为单位：所有原料的总质量（gk）：增链剂数量。

    APPARATUS AND METHOD FOR MEASURING A TIRE PRESSURE FROM THE TIRE FOOTPRINT
    35.
    发明申请
    APPARATUS AND METHOD FOR MEASURING A TIRE PRESSURE FROM THE TIRE FOOTPRINT 有权
    用于测量轮胎胎面压力的装置和方法

    公开(公告)号：US20130186194A1

    公开(公告)日：2013-07-25

    申请号：US13809063

    申请日：2011-07-11

    Applicant: Frank Schaefer

    Inventor： Frank Schaefer

    IPC: B60C23/04

    CPC classification number: B60C23/04 ,  G01B11/22 ,  G01L17/005 ,  G01M17/02 ,  G01M17/027

    Abstract: An apparatus for measuring the pressure of a tire on a moving vehicle, comprising measuring device (14, 18, 24) which is provided on or inside a floor or ground so as to interact with the tire and which generates an electronically analyzable measurement signal in reaction to the tire driving over the measuring device, and analysis unit (22, 40) which output a tire pressure signal corresponding to the tire pressure in reaction to the measurement signal. The measuring device includes an optical unit (18) for acquiring a tire width as the width of a tire footprint forming when the tire drives over the floor/ground. The analysis unit is designed to determine a footprint length from a series of tire width data generated by the optical unit and/or from a pattern of a pressure measurement signal generated by the measuring device and to determine the tire pressure from a footprint area calculated as a function of the length and width of the footprint and from a force applied to the footprint area by the tire.

    Abstract translation: 一种用于测量移动车辆上的轮胎的压力的装置，包括设置在地板或地面上或内部的测量装置（14,18,24），以便与轮胎相互作用并且产生电子可分析的测量信号 响应于测量装置上的轮胎的反应，以及响应于测量信号而输出与轮胎压力相对应的轮胎压力信号的分析单元（22,40）。 测量装置包括用于获取轮胎宽度作为轮胎在地板/地面上行驶时形成的轮胎足迹的宽度的光学单元（18）。 分析单元被设计成根据由光学单元生成的一系列轮胎宽度数据和/或从测量装置产生的压力测量信号的图案确定足迹长度，并且从根据以下计算的占地区域确定轮胎压力： 由足迹的长度和宽度以及由轮胎施加到覆盖区域的力的函数。

    Composite part as well as a method for manufacturing a composite part
    36.
    发明申请
    Composite part as well as a method for manufacturing a composite part 有权
    复合部件以及复合部件的制造方法

    公开(公告)号：US20120100342A1

    公开(公告)日：2012-04-26

    申请号：US13232726

    申请日：2011-09-14

    Applicant: Frank Schaefer

    Inventor： Frank Schaefer

    IPC: B32B3/00

    CPC classification number: B60N2/5816 ,  B60N2/5825 ,  B60N2/5883 ,  B60R13/02 ,  B60R13/0206 ,  B60R2013/0293 ,  Y10T428/19 ,  Y10T428/198 ,  Y10T428/24479

    Abstract: The invention relates to a composite part (1; 24) with a first skin (11), with a second skin (12), with a seam connecting the first and the second skin (12), with a holding profile (2) and with a sub-material (19; 22) with a recess (18), wherein the holding profile (2) comprises a groove (3) which is delimited by side walls (4, 6) and a base (5) and which extends in a first direction, wherein an end section (13) of the first skin, an end section of the second skin (14) and the seam (15) which is designed as a first seam preferably having at least one yarn, are arranged in the groove (3), wherein the holding profile (2) comprises at least one, preferably two wings (9, 10) and wherein the holding profile (2) is introduced into the recess (18). Soft haptics of the composite part are achieved by way of the fact that the sub-material (19; 22) has a compression hardness of at the most 50 kPa at a compression of 40%.

    Abstract translation: 本发明涉及一种具有第一皮肤（11）的复合部件（1; 24），具有第二皮肤（12），连接第一和第二皮肤（12）的接缝与保持轮廓（2）和 具有凹部（18）的子材料（19; 22），其中所述保持轮廓（2）包括由侧壁（4,6）和基部（5）限定的凹槽（3） 在第一方向上，其中第一皮肤的端部（13），第二皮肤（14）的端部部分和被设计为优选地具有至少一根纱线的第一接缝的接缝（15）布置在 所述槽（3），其中所述保持轮廓（2）包括至少一个，优选地两个翼（9,10），并且其中所述保持轮廓（2）被引入到所述凹部（18）中。 通过以下事实来实现复合部件的柔软触觉：副材料（19; 22）在40％的压缩下具有最多50kPa的压缩硬度。

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