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公开(公告)号：US10596358B2
公开(公告)日：2020-03-24
申请号：US15658172
申请日：2017-07-24
Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
Inventor： David Mathew Johnson , Martin Sheridan , Scott A. Uhland , Ramkumar Abhishek , Eric Peeters , Timothy J. Curley , Felicia Linn , Philipp H. Schmaelzle
Abstract: Retention devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and at least one reservoir contained within the housing. The at least one reservoir may have an actuation end and a release end and contain at least one drug formulation. A plug may be contained within the at least one reservoir and be moveable from the actuation end toward the release end. The device may also include an actuation system operably connected to the actuation end of the at least one reservoir and configured to drive the at least one drug formulation from the reservoir. The device may also include at least one retention member affixed to the housing and movable between a non-stressed position, a deployment position, and a retention position for retaining the device in an intraluminal location in the subject.
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公开(公告)号：US10278675B2
公开(公告)日：2019-05-07
申请号：US14448074
申请日：2014-07-31
Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
Inventor： David Mathew Johnson , Scott A. Uhland , Ramkumar Abhishek , Robert Thomas Krivacic , Martin Sheridan
IPC: A61B10/00 , A61D19/02 , A61D19/04 , A61B5/0205 , A61B5/07 , A61D17/00 , A61B5/1459 , A61B5/1455 , A61B5/11 , A61B5/03 , A61B5/00 , A61B5/024 , A61B5/103
Abstract: Devices, systems, and methods for detecting estrus in subjects are provided. Devices include a housing configured for intravaginal/intrauterine deployment and retention and a sensor disposed in or on the housing, and are configured to use condition information sensed by the sensor to determine an estrus condition of the subject. Methods include deploying a device in the subject, sensing the condition information, and determining an estrus condition using the condition information. Systems include a device configured to communicate with a base station and/or with other implanted devices, which are located within a reception radius thereof, regarding the determined estrus condition.
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公开(公告)号：US10006617B2
公开(公告)日：2018-06-26
申请号：US15818296
申请日：2017-11-20
Applicant: Palo Alto Research Center Incorporated
Inventor： Ashish Pattekar , Christopher Paulson , Ramkumar Abhishek , Patrick Yasuo Maeda
IPC: F21V29/00 , F21V29/83 , F21K9/232 , F21Y115/10
CPC classification number: F21V29/00 , F21K9/232 , F21V29/83 , F21Y2115/10
Abstract: A light emitting diode (LED) light bulb includes a thermally conductive base and at least one LED assembly disposed on and thermally coupled to a surface of the base. The LED assembly includes at least one LED configured to generate light. A thermal optical diffuser defines an interior volume and the LED is arranged to emit light into the interior volume and through the thermal optical diffuser. The thermal optical diffuser is disposed on the surface of the base and extends from the base to a terminus on the light emitting side. The thermal optical diffuser is configured to include one or more openings that allow convective air flow between the interior volume of the thermal optical diffuser and ambient environment.
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公开(公告)号：US09801660B2
公开(公告)日：2017-10-31
申请号：US14448087
申请日：2014-07-31
Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
Inventor： David Mathew Johnson , Scott A. Uhland , Ramkumar Abhishek , Robert Thomas Krivacic , Martin Sheridan
IPC: A61B17/43 , A61M31/00 , A61D7/00 , A61B17/435
CPC classification number: A61B17/43 , A61B17/435 , A61D7/00 , A61M31/002
Abstract: Devices, systems, and methods for delivering fluid are provided. Devices include a housing configured for intravaginal deployment and retention, at least one reservoir configured to contain a fluid, and a fluid dispensing mechanism configured to dispense the fluid past the cervix and to the uterus of the subject. Methods include intravaginally deploying and retaining a device in the subject, and dispensing the fluid from the device such that the fluid is driven past the cervix to the uterus of the subject.
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公开(公告)号：US20170097612A1
公开(公告)日：2017-04-06
申请号：US15380449
申请日：2016-12-15
Applicant: Palo Alto Research Center Incorporated
Inventor： Ramkumar Abhishek , Sourobh Raychaudhuri , Ashish Pattekar
CPC classification number: G04F1/00 , A61J7/0409 , A61J7/0427 , A61J2200/70 , A61M5/31 , A61M2205/584 , B65D1/02 , B65D25/205 , B65D75/367 , B65D75/54 , G01N31/229 , G04F7/00
Abstract: An elapsed timer device includes a timer element comprising a timer chamber, a timer chamber conditioning material disposed within the timer chamber, and a sensor arranged to sense a timer chemical within the timer chamber. The sensor indicates elapsed time in response to a threshold level of the chemical being present within the timer chamber. The timer chamber, timer chemical adsorption/desorption characteristics of the timer chamber conditioning material, and the sensor are configured so that an amount of the timer chemical within the timer chamber reaches the threshold level within a predetermined time after initialization of the timer element.
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Patent Agency Ranking
公开(公告)号：US20170038282A1
公开(公告)日：2017-02-09
申请号：US14816849
申请日：2015-08-03
Applicant: Palo Alto Research Center Incorporated
Inventor： Mandana Veiseh , JengPing Lu , Eugene M. Chow , David K. Biegelsen , Ramkumar Abhishek , Felicia Linn
CPC classification number: G01N1/10 , G01N21/253 , G01N29/02
Abstract: An electronic test plate includes a test plate comprising plurality of wells, each well configured to contain a substance to be analyzed. Sensors are arranged to sense characteristics of the substance and to generate sensor signals based on the sensed characteristics over time. The sensors are arranged so that multiple sensors are associated with each well. At least one sensor of the multiple sensors senses a characteristic of the substance that is different from a characteristic sensed by another sensor of the multiple sensors. Sensor select circuitry is arranged on a backplane disposed along the test plate. The sensor select circuitry is coupled to the sensors and enable the sensor signals of selected sensors to be accessed at a data output of the backplane.
Abstract translation: 电子测试板包括包含多个孔的测试板，每个井配置成容纳待分析的物质。 传感器被布置成感测物质的特性并基于随时间感测的特征产生传感器信号。 传感器布置成使得多个传感器与每个孔相关联。 多个传感器的至少一个传感器感测与多个传感器的另一个传感器感测到的特性不同的物质的特性。 传感器选择电路布置在沿着测试板设置的背板上。 传感器选择电路耦合到传感器，并使所选传感器的传感器信号能够在背板的数据输出端被访问。
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公开(公告)号：US09204895B2
公开(公告)日：2015-12-08
申请号：US14577252
申请日：2014-12-19
Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
Inventor： Scott A. Uhland , Ramkumar Abhishek , Eric Peeters , Timothy J. Curley , Felicia Linn
IPC: A61B17/43 , A61M5/145 , A61M5/168 , A61M31/00 , A61K9/00 , A61D7/00 , A61M5/14 , A61M5/155 , A61M5/142
CPC classification number: A61B17/43 , A61D7/00 , A61D19/024 , A61D19/027 , A61K9/0004 , A61K9/0034 , A61M5/1408 , A61M5/145 , A61M5/155 , A61M5/16827 , A61M31/00 , A61M2005/14204 , A61M2210/1042 , A61M2210/1085 , A61M2210/1433 , A61M2210/1475
Abstract: Devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.
Abstract translation: 提供了用于药物递送的装置和方法。 该装置可以包括构造成用于管腔内部署到人或动物受试者中的壳体，以及壳体内的第一和第二储存器，每个储存器具有致动端，相对的释放端和可从致动端向释放端移动的塞子。 第一和第二药物制剂可以分别包含在第一和第二储存器中。 该装置还可以包括配置成驱动第一和第二塞子以便从第一和第二储存器驱动第一和第二药物制剂的一个或多个致动系统。 壳体可以包括与第一和第二储存器的释放端流体连通的多孔膜侧壁，多孔膜侧壁被配置为分配从第一和第二储存器驱动的第一和第二药物制剂。
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公开(公告)号：US20150167184A1
公开(公告)日：2015-06-18
申请号：US14107367
申请日：2013-12-16
Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
Inventor： Ramkumar Abhishek , Frederick Joseph Endicott
CPC classification number: C25B9/063 , C25B1/04 , C25B9/06 , F03G7/005 , Y02E60/366
Abstract: Devices and methods are provided for generating gas(es). A device includes a first layer having a conductive region and an electrode, a sealing layer adjacent the first layer and having a conductive region and a multi-electrode assembly including an ionic layer with a cathode side and an opposed anode side, and a second layer adjacent the sealing layer and having a conductive region and an electrode operably associated with an isolated electrical connector, wherein the device is configured to generate the gas(es) upon application of a voltage to the electrical connector and to the conductive regions of the layers.
Abstract translation: 提供了用于产生气体的装置和方法。 一种器件包括具有导电区域和电极的第一层，与第一层相邻并具有导电区域的密封层和包括具有阴极侧和相对阳极侧的离子层的多电极组件，以及第二层 邻近所述密封层并且具有与隔离的电连接器可操作地相关联的导电区域和电极，其中所述装置被配置为在对所述电连接器施加电压并且对所述层的所述导电区域施加电压时产生所述气体。
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公开(公告)号：US09005108B2
公开(公告)日：2015-04-14
申请号：US13629159
申请日：2012-09-27
Applicant: Palo Alto Research Center Incorporated
Inventor： Scott A. Uhland , Ramkumar Abhishek , Eric Peeters , Timothy J. Curley , Felicia Linn
CPC classification number: A61B17/43 , A61D7/00 , A61D19/024 , A61D19/027 , A61K9/0004 , A61K9/0034 , A61M5/1408 , A61M5/145 , A61M5/155 , A61M5/16827 , A61M31/00 , A61M2005/14204 , A61M2210/1042 , A61M2210/1085 , A61M2210/1433 , A61M2210/1475
Abstract: Devices and methods are provided for drug delivery. The device may include a housing configured for intralumenal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.
Abstract translation: 提供了用于药物递送的装置和方法。 该装置可以包括构造成用于腔内部署到人或动物受试者中的壳体，以及壳体内的第一和第二储存器，每个储存器具有致动端，相对的释放端和可从致动端向释放端移动的塞子。 第一和第二药物制剂可以分别包含在第一和第二储存器中。 该装置还可以包括配置成驱动第一和第二塞子以便从第一和第二储存器驱动第一和第二药物制剂的一个或多个致动系统。 壳体可以包括与第一和第二储存器的释放端流体连通的多孔膜侧壁，多孔膜侧壁被配置为分配从第一和第二储存器驱动的第一和第二药物制剂。
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公开(公告)号：US20140126213A1
公开(公告)日：2014-05-08
申请号：US13671372
申请日：2012-11-07
Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
Inventor： Ashish Pattekar , Christopher Paulson , Ramkumar Abhishek , Patrick Yasuo Maeda
IPC: F21V29/02
CPC classification number: F21V29/00 , F21K9/232 , F21V29/83 , F21Y2115/10
Abstract: A light emitting diode (LED) light bulb includes a thermally conductive base and at least one LED assembly disposed on and thermally coupled to a surface of the base. The LED assembly includes at least one LED configured to generate light. A thermal optical diffuser defines an interior volume and the LED is arranged to emit light into the interior volume and through the thermal optical diffuser. The thermal optical diffuser is disposed on the surface of the base and extends from the base to a terminus on the light emitting side. The thermal optical diffuser is configured to include one or more openings that allow convective air flow between the interior volume of the thermal optical diffuser and ambient environment.
Abstract translation: 发光二极管（LED）灯泡包括导热基座和至少一个LED组件，其布置在基座的表面上并热耦合到基座的表面。 LED组件包括至少一个配置成产生光的LED。 热光漫射器限定内部体积，并且LED布置成将光发射到内部空间中并通过热光漫射器。 热光漫射器设置在基底的表面上并且从基底延伸到发光侧的终点。 热光漫射器被配置为包括一个或多个允许对流空气在热光漫射器的内部空间与周围环境之间流动的开口。
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