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    TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING CHEMICAL PERMEATION ENHANCERS
    2.
    发明申请
    TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING CHEMICAL PERMEATION ENHANCERS 审中-公开
    转运药物递送装置及包括化学渗透增强剂的方法

    公开(公告)号：US20150065997A1

    公开(公告)日：2015-03-05

    申请号：US14537585

    申请日：2014-11-10

    Applicant: PALO ALTO RESEARCH CENTER INCORPORATED

    Inventor： Scott Uhland ,  Eric Peeters ,  Hussain Fatakdawala

    IPC: A61M31/00

    CPC classification number: A61M31/002 ,  A61K9/0036

    Abstract: Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.

    Abstract translation: 提供了用于经粘膜药物递送的装置和方法。 透粘膜药物递送装置可以包括构造成用于腔内部署的壳体，例如阴道内部分入人或动物受试者; 药物分配部分，其包含至少一种药物，所述药物分配部分构造成通过正位移从所述壳体分配药物; 以及渗透性增强剂分配部分，被配置为释放或产生渗透性增强物质，以在选择的时间在脉管内部署在人或动物受试者中的同时破坏邻近所述壳体的粘膜屏障的至少一个区域。 该装置可操作以将药物从壳体分配到由渗透性增强物质破坏的粘膜屏障的区域。

    DEVICES AND METHODS FOR INTRALUMINAL RETENTION AND DRUG DELIVERY
    3.
    发明申请
    DEVICES AND METHODS FOR INTRALUMINAL RETENTION AND DRUG DELIVERY 有权
    用于内皮保留和药物递送的装置和方法

    公开(公告)号：US20140200553A1

    公开(公告)日：2014-07-17

    申请号：US13742203

    申请日：2013-01-15

    Applicant: PALO ALTO RESEARCH CENTER INCORPORATED

    Inventor： David Mathew Johnson ,  Martin Sheridan ,  Scott A. Uhland ,  Ramkumar Abhishek ,  Eric Peeters ,  Timothy J. Curley ,  Felicia Linn ,  Philipp H. Schmaelzle

    IPC: A61M31/00

    CPC classification number: A61M31/002 ,  A61D7/00 ,  A61M5/1452 ,  A61M2210/1433 ,  A61M2210/1475

    Abstract: Retention devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and at least one reservoir contained within the housing. The at least one reservoir may have an actuation end and a release end and contain at least one drug formulation. A plug may be contained within the at least one reservoir and be moveable from the actuation end toward the release end. The device may also include an actuation system operably connected to the actuation end of the at least one reservoir and configured to drive the at least one drug formulation from the reservoir. The device may also include at least one retention member affixed to the housing and movable between a non-stressed position, a deployment position, and a retention position for retaining the device in an intraluminal location in the subject.

    Abstract translation: 提供了用于药物递送的保留装置和方法。 该装置可以包括被配置用于腔内部署到人或动物受试者中的壳体和容纳在壳体内的至少一个储存器。 至少一个储存器可以具有致动端和释放端，并且包含至少一种药物制剂。 塞子可以容纳在至少一个储存器内并且可以从致动端朝向释放端移动。 该装置还可以包括可操作地连接到至少一个储存器的致动端并被构造成从贮存器驱动至少一种药物制剂的致动系统。 该装置还可以包括固定到壳体上的至少一个保持构件，并可在非应力位置，展开位置和保持位置之间移动，用于将装置保持在受试者的腔内位置。

    Multiple reservoir drug delivery device and methods
    7.
    发明授权
    Multiple reservoir drug delivery device and methods 有权
    多库药物输送装置及方法

    公开(公告)号：US09204895B2

    公开(公告)日：2015-12-08

    申请号：US14577252

    申请日：2014-12-19

    Applicant: PALO ALTO RESEARCH CENTER INCORPORATED

    Inventor： Scott A. Uhland ,  Ramkumar Abhishek ,  Eric Peeters ,  Timothy J. Curley ,  Felicia Linn

    IPC: A61B17/43 ,  A61M5/145 ,  A61M5/168 ,  A61M31/00 ,  A61K9/00 ,  A61D7/00 ,  A61M5/14 ,  A61M5/155 ,  A61M5/142

    CPC classification number: A61B17/43 ,  A61D7/00 ,  A61D19/024 ,  A61D19/027 ,  A61K9/0004 ,  A61K9/0034 ,  A61M5/1408 ,  A61M5/145 ,  A61M5/155 ,  A61M5/16827 ,  A61M31/00 ,  A61M2005/14204 ,  A61M2210/1042 ,  A61M2210/1085 ,  A61M2210/1433 ,  A61M2210/1475

    Abstract: Devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.

    Abstract translation: 提供了用于药物递送的装置和方法。 该装置可以包括构造成用于管腔内部署到人或动物受试者中的壳体，以及壳体内的第一和第二储存器，每个储存器具有致动端，相对的释放端和可从致动端向释放端移动的塞子。 第一和第二药物制剂可以分别包含在第一和第二储存器中。 该装置还可以包括配置成驱动第一和第二塞子以便从第一和第二储存器驱动第一和第二药物制剂的一个或多个致动系统。 壳体可以包括与第一和第二储存器的释放端流体连通的多孔膜侧壁，多孔膜侧壁被配置为分配从第一和第二储存器驱动的第一和第二药物制剂。

    System and method for detecting, tracking and estimating the speed of vehicles from a mobile platform
    8.
    发明授权
    System and method for detecting, tracking and estimating the speed of vehicles from a mobile platform 有权
    用于从移动平台检测，跟踪和估计车辆速度的系统和方法

    公开(公告)号：US09070289B2

    公开(公告)日：2015-06-30

    申请号：US13891765

    申请日：2013-05-10

    Applicant: Palo Alto Research Center Incorporated

    Inventor： Eric Saund ,  Christopher Paulson ,  Gregory Burton ,  Eric Peeters

    IPC: G08G1/054 ,  G08G1/017

    CPC classification number: G08G1/054 ,  B64C2201/127 ,  G05D1/0094 ,  G06K9/0063 ,  G06K9/00785 ,  G06K9/3241 ,  G06K2209/23 ,  G06T7/215 ,  G06T7/246 ,  G06T2207/10032 ,  G06T2207/30236 ,  G08G1/0175 ,  G08G5/00

    Abstract: A method and system for measurement of ground based vehicle speed includes a movable platform that includes an unmanned aerial vehicle (UAV) located in proximity to a roadway, the UAV operates under control and navigation of a UAV control unit, and the UAV also carries camera and monitoring equipment, the camera and monitoring equipment including an onboard computing system, and a camera with a wide angle lens and a camera with a telephoto lens, the cameras being mounted on a pan/tilt device. An algorithm operated by the on-board computing system is used to detect and track vehicles moving on a roadway. The algorithm is configured to detect and track the vehicles despite motion created by movement of the UAV. The cameras mounted on the pan/tilt device are moved under the direction of the computer vision algorithm to maintain a target vehicle of the detected moving vehicles in view, and the speed of the target vehicle is measured.

    Abstract translation: 一种用于测量地面车辆速度的方法和系统包括可移动平台，其包括位于巷道附近的无人驾驶飞行器（UAV），UAV在UAV控制单元的控制和导航下操作，并且UAV还携带摄像机 以及监视设备，摄像机和包括机载计算系统的监视设备，以及具有广角镜头的照相机和具有长焦镜头的照相机，照相机安装在平移/倾斜装置上。 使用由车载计算系统操作的算法来检测和跟踪在道路上行驶的车辆。 该算法被配置为检测和跟踪车辆，尽管由UAV的移动产生的运动。 安装在摇摄/倾斜装置上的摄像机在计算机视觉算法的方向下移动以保持检测到的移动车辆的目标车辆的视野，并且测量目标车辆的速度。

    Multiple reservoir drug delivery device and methods
    9.
    发明授权
    Multiple reservoir drug delivery device and methods 有权
    多库药物输送装置及方法

    公开(公告)号：US09005108B2

    公开(公告)日：2015-04-14

    申请号：US13629159

    申请日：2012-09-27

    Applicant: Palo Alto Research Center Incorporated

    Inventor： Scott A. Uhland ,  Ramkumar Abhishek ,  Eric Peeters ,  Timothy J. Curley ,  Felicia Linn

    IPC: A61M5/00 ,  A61B17/43 ,  A61K9/00 ,  A61D7/00 ,  A61M31/00

    CPC classification number: A61B17/43 ,  A61D7/00 ,  A61D19/024 ,  A61D19/027 ,  A61K9/0004 ,  A61K9/0034 ,  A61M5/1408 ,  A61M5/145 ,  A61M5/155 ,  A61M5/16827 ,  A61M31/00 ,  A61M2005/14204 ,  A61M2210/1042 ,  A61M2210/1085 ,  A61M2210/1433 ,  A61M2210/1475

    Abstract: Devices and methods are provided for drug delivery. The device may include a housing configured for intralumenal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.

    Abstract translation: 提供了用于药物递送的装置和方法。 该装置可以包括构造成用于腔内部署到人或动物受试者中的壳体，以及壳体内的第一和第二储存器，每个储存器具有致动端，相对的释放端和可从致动端向释放端移动的塞子。 第一和第二药物制剂可以分别包含在第一和第二储存器中。 该装置还可以包括配置成驱动第一和第二塞子以便从第一和第二储存器驱动第一和第二药物制剂的一个或多个致动系统。 壳体可以包括与第一和第二储存器的释放端流体连通的多孔膜侧壁，多孔膜侧壁被配置为分配从第一和第二储存器驱动的第一和第二药物制剂。

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