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    OLEFIN METATHESIS CATALYSTS AND RELATED METHODS
    31.
    发明申请
    OLEFIN METATHESIS CATALYSTS AND RELATED METHODS 有权
    OLEFIN METATHESIS催化剂及相关方法

    公开(公告)号：US20150065723A1

    公开(公告)日：2015-03-05

    申请号：US14479917

    申请日：2014-09-08

    Applicant: Massachusetts Institute of Technology

    Inventor： Adam S. Hock ,  Richard R. Schrock

    IPC: B01J31/22 ,  C07C6/04

    CPC classification number: B01J31/2295 ,  B01J31/122 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/2234 ,  B01J31/2265 ,  B01J31/2291 ,  B01J2231/482 ,  B01J2231/54 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07C6/04 ,  C07C2531/22

    Abstract: The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to generate a catalytically active species, often under mild conditions and in high yields. In some cases, a wide variety of catalysts may be synthesized from a single catalyst precursor. Methods of the invention may also include the preparation of catalysts which, under reaction conditions known in the art, may have been difficult or impossible to prepare and/or isolate due to, for example, steric crowding at the metal center. The present invention also provides catalyst compositions, and precursors thereof, which may be useful in various chemical reactions including olefin metathesis. In some cases, methods of the invention may reduce the number of synthetic and purification steps required to produce catalysts and/or other reaction products, as well as reducing time, cost, and waste production.

    Abstract translation: 本发明提供合成催化剂及其前体的方法。 本发明的方法可以包括将催化剂前体和至少一种配体结合以产生催化活性物质，通常在温和条件下和高产率下。 在一些情况下，可以从单一催化剂前体合成多种催化剂。 本发明的方法还可以包括催化剂的制备，其在本领域已知的反应条件下可能由于例如在金属中心的空间拥挤而难以或不可能制备和/或分离。 本发明还提供催化剂组合物及其前体，其可用于包括烯烃复分解的各种化学反应。 在一些情况下，本发明的方法可以减少制备催化剂和/或其它反应产物所需的合成和纯化步骤的数量，以及减少时间，成本和废物的产生。

    COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES
    32.
    发明申请
    COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES 有权
    铜和乙烯的铜催化剂

    公开(公告)号：US20150031895A1

    公开(公告)日：2015-01-29

    申请号：US14508552

    申请日：2014-10-07

    Applicant: THE SCRIPPS RESEARCH INSTITUTE

    Inventor： K. Barry SHARPLESS ,  Valery FOKIN ,  Vsevold A. ROSTOVTSEV ,  Luke GREEN ,  Fahmi HIMO

    IPC: C07D249/04

    CPC classification number: C07D249/04 ,  B01J31/1805 ,  B01J2231/327 ,  B01J2531/16 ,  B01J2531/96 ,  C07D249/06 ,  C07D403/06

    Abstract: A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion in human blood plasma to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt, Cu(II) ion in the presence of a reducing agent, or copper metal.

    Abstract translation: 使用铜催化的点击化学连接方法结合叠氮化物和末端炔烃以提供1,4-二取代的1,2,3-三唑三唑。 该方法包括使有机叠氮化物和末端炔与人血浆中的反应性Cu（I）离子源接触以通过环加成1,4-二取代的1,2,3-三唑接触。 反应性Cu（I）离子的来源可以是例如在还原剂存在下的Cu（I）盐，Cu（II）离子或铜金属。

    Platinum complex, manufacturing method thereof and platinum catalyst constructed thereby
    38.
    发明授权
    Platinum complex, manufacturing method thereof and platinum catalyst constructed thereby 有权
    铂络合物，其制造方法和由此构成的铂催化剂

    公开(公告)号：US08809564B2

    公开(公告)日：2014-08-19

    申请号：US12688374

    申请日：2010-01-15

    Applicant: Weng-Sing Hwang ,  Shyh-Jiun Liu ,  Chia-Hung Huang ,  Chun-Kai Huang

    Inventor： Weng-Sing Hwang ,  Shyh-Jiun Liu ,  Chia-Hung Huang ,  Chun-Kai Huang

    IPC: C07F15/00 ,  B01J31/18

    CPC classification number: B01J31/1815 ,  B01J31/1805 ,  B01J31/183 ,  C07F15/0053

    Abstract: A manufacturing method of a platinum complex is mixing chloroplatinic acid and a chelating agent with a solvent, wherein [PtCl6]2− ions of the chloroplatinic acid is reacted with the chelating agent to form a platinum complex Pt[R]2+, wherein the chelating agent(R) is selected from ethylenediamine, 1,10-phenanthroline, 2,2′-Bipyridine, diethylenetriamine, triethylenetetraamine, phenanthroline, or bipyridine. Moreover, a method for producing a platinum catalyst on supports is mixing the chloroplatinic acid, a chelating agent and supports with a solvent to form a platinum complex, which is incorporated onto the supports. Following, a reduction step and a drying step are processed to get the platinum catalyst on the supports.

    Abstract translation: 铂络合物的制造方法是将氯铂酸和螯合剂与溶剂混合，其中氯铂酸的[PtCl 6] 2 - 离子与螯合剂反应形成铂络合物Pt [R 2+]，其中 螯合剂（R）选自乙二胺，1,10-菲咯啉，2,2'-联吡啶，二亚乙基三胺，三亚乙基四胺，菲咯啉或联吡啶。 此外，在载体上制备铂催化剂的方法是将氯铂酸，螯合剂和载体与溶剂混合以形成铂配合物，其被并入载体上。 接下来，处理还原步骤和干燥步骤以在载体上获得铂催化剂。

    Chelating carbene ligand precursors and their use in the synthesis of metathesis catalysts
    39.
    发明授权
    Chelating carbene ligand precursors and their use in the synthesis of metathesis catalysts 有权
    螯合卡宾配体前体及其在复分解催化剂合成中的应用

    公开(公告)号：US08754249B2

    公开(公告)日：2014-06-17

    申请号：US13542607

    申请日：2012-07-05

    Applicant: Richard L. Pederson ,  Jason K. Woertink ,  Christopher M. Haar ,  David E. Gindelberger ,  Yann Schrodi

    Inventor： Richard L. Pederson ,  Jason K. Woertink ,  Christopher M. Haar ,  David E. Gindelberger ,  Yann Schrodi

    IPC: C07F15/00 ,  B01J31/00

    CPC classification number: B01J31/2414 ,  B01J31/1805 ,  B01J31/2204 ,  B01J31/2208 ,  B01J31/2265 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2404 ,  B01J2231/50 ,  B01J2231/54 ,  B01J2231/543 ,  B01J2531/821 ,  B01J2531/825 ,  C07F15/002 ,  C07F15/0046

    Abstract: Chelating ligand precursors for the preparation of olefin methathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various methathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene methathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type methathesis catalysts. The invention provides an efficient method for preparing chelating-carbene metathesis catalysts by reacting a suitable ruthenium complex in high concentrations of the ligand precursors followed by crystallization from an organic solvent.

    Abstract translation: 公开了用于制备烯烃复合催化剂的螯合配体前体。 得到的催化剂是能够有效促进各种复合反应的空气稳定的单体物质，其可以从反应混合物中回收并重复使用。 使用内部烯烃化合物，特别是β-取代的苯乙烯作为配体前体。 与末端烯烃化合物如未取代的苯乙烯相比，β-取代的苯乙烯更容易制备成本更低，更稳定，因为它们不易于自发聚合。 公开了不使用CuCl制备螯合 - 卡宾络合催化剂的方法。 这通过用有机酸，无机酸，温和氧化剂甚至水代替它来消除对CuCl的需要，导致Hoveyda型复分解催化剂的高产率。 本发明提供了一种制备螯合碳烯复分解催化剂的有效方法，该方法是通过在高浓度配体前体中合适的钌络合物，然后从有机溶剂中结晶而制备。

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