公开(公告)号：US20140296780A1

公开(公告)日：2014-10-02

申请号：US14231267

申请日：2014-03-31

Applicant: Bradley Lyon ,  Adrianus I. Aria ,  Masoud Beizai ,  Morteza Gharib

Inventor： Bradley Lyon ,  Adrianus I. Aria ,  Masoud Beizai ,  Morteza Gharib

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C1/00031

Abstract: Composite CNT microneedle fabrication and finally-constructed delivery device embodiments are described. The microneedles can provide a self-administered, painless alternative to standard hypodermic injection.

Abstract translation: 描述了复合CNT微针制造和最终构造的输送装置实施例。 微针可以为标准皮下注射提供自我施用，无痛的替代方案。

公开(公告)号：US08137736B2

公开(公告)日：2012-03-20

申请号：US12348589

申请日：2009-01-05

Applicant: Mingwei Zhu ,  Yanfeng Chen ,  Zhenlin Wang ,  Yanqing Lu ,  Haixiong Ge ,  Yuefeng Tang

Inventor： Mingwei Zhu ,  Yanfeng Chen ,  Zhenlin Wang ,  Yanqing Lu ,  Haixiong Ge ,  Yuefeng Tang

IPC: B05D3/12

CPC classification number: B81C1/00476 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0338 ,  B81B2203/0361 ,  B81C2201/0108

Abstract: A novel method suitable for commercially mass production of hollow microneedle with high quality for delivery of drugs across or into biological tissue is provided. It typically includes the following processes: (1) coating an elongated template of a first material with a second material to form a cover; (2) removing tips of the template and cover to form an opening in the cover; and (3) removing the template of the first material to obtain hollow microneedles of the second material. This simple, efficient and cost-effective fabrication method can mass produce hollow microneedle arrays involving no complicated and expensive equipments or techniques, which can be used in commercial fabrication of hollow needles for delivering drugs or genes across or into skin or other tissue barriers with advantages of minimal damage, painless, long-term and continuous usages.

Abstract translation: 提供了一种适用于商业上大规模生产用于将药物跨越或进入生物组织的高品质的中空微针的新方法。 它通常包括以下过程：（1）用第二材料涂覆第一材料的细长模板以形成盖子; （2）去除模板和盖子的尖端以在盖子上形成开口; 和（3）去除第一材料的模板以获得第二材料的中空微针。 这种简单，高效和成本有效的制造方法可以大规模生产中空微针阵列，其不涉及复杂而昂贵的设备或技术，其可用于商业制造用于将药物或基因跨越或进入皮肤或其它组织屏障的中空针 最小的伤害，无痛，长期和持续的使用。

公开(公告)号：US07981346B2

公开(公告)日：2011-07-19

申请号：US11661113

申请日：2005-08-30

Applicant: Patrick Griss ,  Göran Stemme

Inventor： Patrick Griss ,  Göran Stemme

IPC: B28B1/14 ,  B28B1/48 ,  A61M35/00

CPC classification number: B29C45/2628 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C2045/0094 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034

Abstract: Method of hollow micro-projections having side walls and at least one opening in a side wall, by a molding technique. The hollow micro-projections are defined by a first, negative mold defining the exterior shape of the micro-projections and a second, positive mold defining the hollow interior shape of the micro-projections. The method includes injecting a moldable material into the space between the two molds, in a state where they have been brought together. The positive and negative molds each have an essentially cylindrical geometry. In the process of bringing the molds together, the mold halves are laterally off-set with respect to each other, such that the distance between an inner wall of the negative mold and the positive mold in the area, ranges from zero to a finite distance. Micro-projections and arrays of micro-projections are also disclosed.

Abstract translation: 通过成型技术的具有侧壁和侧壁中的至少一个开口的中空微型突起的方法。 中空微突起由限定微突起的外部形状的第一负模具和限定微突起的中空内部形状的第二正模定义。 该方法包括将可模塑材料注入到两个模具之间的空间中，并将它们合并在一起。 正负模具各自具有基本上圆柱形的几何形状。 在将模具合在一起的过程中，半模相对于彼此横向偏移，使得阴模的内壁和该区域中的正模之间的距离从零到有限距离 。 还公开了微突起和微突起的阵列。

公开(公告)号：US20110011827A1

公开(公告)日：2011-01-20

申请号：US12621594

申请日：2009-11-19

Applicant: Dae Sik LEE ,  Hyun Woo SONG ,  Moon Youn JUNG ,  Seon Hee PARK

Inventor： Dae Sik LEE ,  Hyun Woo SONG ,  Moon Youn JUNG ,  Seon Hee PARK

IPC: B44C1/22

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/3842 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111

Abstract: Provided is a method of manufacturing a hollow microneedle structure. The method includes forming an injection mold having a through hole, filling the injection mold with a photoresist formed of a viscous material, and extruding the photoresist from the injection mold through the through hole, solidifying the extruded photoresist to form a needle-type photoresist structure, forming a seed layer on the surface of the photoresist structure, forming a metal plated layer on the seed layer, inclining an end tip of the photoresist structure having the metal plated layer, and removing the photoresist from the metal plated layer to form a hollow. Thus, the hollow microneedle structure can be manufactured to have such diameter, length, hardness, and inclination angle as to minimize pain. The hollow microneedle structure can be combined with an apparatus for detecting a biomaterial or injecting cosmetic substances or medicines, and variously applied.

Abstract translation: 提供一种制造中空微针结构的方法。 该方法包括形成具有通孔的注射模具，用由粘性材料形成的光致抗蚀剂填充注射模具，并且通过通孔从注射模具中挤出光致抗蚀剂，固化挤出的光致抗蚀剂以形成针型光致抗蚀剂结构 在光致抗蚀剂结构的表面上形成种子层，在种子层上形成金属镀层，使具有金属镀层的光致抗蚀剂结构的末端倾斜，从金属镀层除去光致抗蚀剂，形成中空 。 因此，可以制造中空微针结构以具有使疼痛最小化的直径，长度，硬度和倾斜角度。 中空微针结构可以与用于检测生物材料或注射化妆品物质或药物的装置组合，并进行各种应用。

公开(公告)号：US20100312191A1

公开(公告)日：2010-12-09

申请号：US12853082

申请日：2010-08-09

Applicant: Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

Inventor： Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

IPC: A61M5/00

CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B17/205 ,  A61B2010/008 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61N1/303 ,  B33Y80/00 ,  B81B2201/055

Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

Abstract translation: 提供微针装置用于将组织屏障上的治疗和生物分子转运并用作微火焰保持器。 在用于跨组织输送的优选实施方案中，微针由可生物降解的聚合物形成。 还提供制造这些装置的方法，其可以包括中空和/或多孔微针。 用于制造微针的优选方法包括形成具有限定微针的外表面的侧壁的显微镜，电镀侧壁以形成中空微针，然后从微针中去除微镜。 在优选的使用方法中，微针装置用于将流体材料输送到生物屏障中，或者与一个或多个腔室中的至少一个微针流体连接。 该装置优选地还包括用于控制通过微针的材料流动的装置。 这些方法的代表性实例包括使用可渗透膜，可破裂的不渗透膜，阀和泵。

公开(公告)号：US20100305516A1

公开(公告)日：2010-12-02

申请号：US10592559

申请日：2004-03-12

Applicant: Yuan Xu ,  Minghua Wang ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

Inventor： Yuan Xu ,  Minghua Wang ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

IPC: A61M5/00 ,  B22C9/22 ,  B29C33/42 ,  C25D1/00

CPC classification number: B29C33/0061 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C33/301 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/424 ,  B29C33/56 ,  B29C59/026 ,  B29C2791/001 ,  B29C2793/0009 ,  B29L2031/756 ,  B29L2031/759 ,  B81B2201/055 ,  B81C99/009 ,  C25D1/02 ,  Y10T29/49885 ,  Y10T29/4998 ,  Y10T29/49982 ,  Y10T29/49984 ,  Y10T29/49986 ,  Y10T29/49988

Abstract: Side-ported microneedles are produced from a suitably shaped microneedle mould (40). A microneedle mould base (32) is made with a number of microneedle mould recesses (30) in it. One surface of the microneedle mould base (32) is coated with a seed layer (34). The microneedle mould base (32) contains two microneedle mould sheets (24, 26), which are separated to gain access to an internal surface of one of the microneedle mould sheets (24, 26). Side-port forming channels (38) are formed on one of the internal surfaces, intersecting with the recesses (30) within the relevant microneedle mould sheet (24). The two microneedle mould sheets (24, 26) are placed back together and joined together as a unitary microneedle mould (40). The microneedles are formed in the recesses (30) by depositing a microneedle layer (44) therein and on the surface with the seed layer (34). The microneedle layer (44) fails to deposit at side-port forming holes (42) where the side-port forming channels (38) intersect the recesses (30), which result in side-ports (46) in the moulded microneedles (52).

Abstract translation: 由适当形状的微针模具（40）制造侧端微针。 微针模具基座（32）在其中形成有许多微针模具凹槽（30）。 微针模具基座（32）的一个表面涂覆有种子层（34）。 微针模具基座（32）包含两个微针模具片（24,26），它们分开以进入其中一个微针模板（24,26）的内表面。 侧孔形成通道（38）形成在与相关微针模板（24）内的凹部（30）相交的一个内表面上。 将两个微针模具片（24,26）放置在一起并作为整体式微针模具（40）连接在一起。 通过在其中放置微针层（44）并在种子层（34）的表面上，在凹部（30）中形成微针。 该微针层（44）不能沉积在侧孔形成通道（42）处，其中侧孔形成通道（38）与凹槽（30）相交，这导致模制微针（52）中的侧端口（46） ）。

公开(公告)号：US20100280457A1

公开(公告)日：2010-11-04

申请号：US12599394

申请日：2007-10-18

Applicant: Seiji Tokumoto ,  Toshiyuki Matsudo ,  Tetsuji Kuwahara

Inventor： Seiji Tokumoto ,  Toshiyuki Matsudo ,  Tetsuji Kuwahara

IPC: A61M5/00 ,  B05D3/00

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C1/00206

Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).

Abstract translation: 本发明提供了一种涂布微针的方法，通过该方法，安装在微针装置上的微针以可批量生产的方式精确且容易地被涂布。 在该方法中，将具有多个微针（21）的微针装置（22）安装在工作台（23）上，同时具有多个孔（24）的掩模板（25）固定到框架构件（26） ），并且使用刮刀（28）在掩模板（25）上沿箭头A的方向将涂布溶液（27）用涂布溶液填充孔（24）。 在用涂布溶液（27）填充孔（24）之前或之后，将微针（21）插入孔（24）中以涂覆微针（21）。

公开(公告)号：US07763203B2

公开(公告)日：2010-07-27

申请号：US10727124

申请日：2003-12-03

Applicant: Francisco Arias ,  Faiz Feisal Sherman ,  Grover David Owens

Inventor： Francisco Arias ,  Faiz Feisal Sherman ,  Grover David Owens

IPC: B29C35/08

CPC classification number: A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/150984 ,  A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/034

Abstract: A method for manufacturing microneedle structures is disclosed using soft lithography and photolithography, in which micromold structures made of a photoresist material or PDMS are created. The micromold manufacturing occurs quite quickly, using inexpensive materials and processes. Once the molds are available, using moldable materials such as polymers, microneedle arrays can be molded or embossed in relatively fast procedures. In some cases a sacrificial layer is provided between the forming micromold and its substrate layer, for ease of separation. The microneedles themselves can be solid projections, hollow “microtubes,” or shallow “microcups.” Electrodes can be formed on the microneedle arrays, including individual electrodes per hollow microtube.

Abstract translation: 公开了使用软光刻和光刻技术制造微针结构的方法，其中制造由光致抗蚀剂材料或PDMS制成的微型结构。 使用廉价的材料和工艺，微型制造相当快速地发生。 一旦模具可用，使用可模塑材料如聚合物，微针阵列可以以相对较快的程序模制或压花。 在一些情况下，为了易于分离，在成形微胶体与其基底层之间提供牺牲层。 微针本身可以是固体突起，中空“微管”或浅“微杯”。电极可以形成在微针阵列上，包括每个中空微管的单个电极。

公开(公告)号：US20100178810A2

公开(公告)日：2010-07-15

申请号：US12110676

申请日：2008-04-28

Applicant: Arno Aarts ,  Hercules Pereira Neves ,  Chris Van Hoof ,  Eric Beyne ,  Patrick Ruther ,  Robert Puers

Inventor： Arno Aarts ,  Hercules Pereira Neves ,  Chris Van Hoof ,  Eric Beyne ,  Patrick Ruther ,  Robert Puers

IPC: H01R24/00 ,  H01R43/00

CPC classification number: B81C3/008 ,  A61B5/04001 ,  A61B5/0478 ,  A61B2562/125 ,  A61N1/0529 ,  A61N1/0531 ,  B81B2201/055 ,  Y10T29/49222

Abstract: In the present disclosure a device for sensing and/or actuation purposes is presented in which microstructures (20) comprising shafts (2) with different functionality and dimensions can be inserted in a modular way. That way, out-of-plane connectivity, mechanical clamping between the microstructures (20) and a substrate (1) of the device, and electrical connection between electrodes (5) on the microstructures (20) and the substrate (1) can be realized. Connections to external circuitry can be realised. Microfluidic channels (10) in the microstructures (20) can be connected to external equipment. A method to fabricate and assemble the device is provided.

Abstract translation: 在本公开中，提出了用于感测和/或致动目的的装置，其中可以以模块化方式插入包括具有不同功能和尺寸的轴（2）的微结构（20）。 这样，平面外连接，微结构（20）和器件的衬底（1）之间的机械夹紧以及微结构（20）和衬底（1）上的电极（5）之间的电连接可以是 实现了 可以实现与外部电路的连接。 微结构（20）中的微流体通道（10）可以连接到外部设备。 提供了一种制造和组装该装置的方法。

公开(公告)号：US07497980B2

公开(公告)日：2009-03-03

申请号：US10505035

申请日：2003-11-10

Applicant: Yuan Xu ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

Inventor： Yuan Xu ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

IPC: B29C33/42

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/3878 ,  B29C33/42 ,  B29C45/00 ,  B29C2045/0094 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C2201/034

Abstract: A master mould is made by wire cutting a plate in two or more directions to provide a base with an array of master mould needles protruding therefrom. The size and shape of the master mould needles can readily be varied by varying the angles of upward and downward cuts in the two or more directions. The master mould is used to make a secondary mould by hot embossing a secondary mould plate onto the master mould. This forms through-holes in the secondary mould. The secondary mould is plated with a layer of metal, which forms a microneedle array.

Abstract translation: 主模具通过在两个或更多个方向上对板进行线切割来制造，以提供具有从其突出的主模具针阵列的基座。 通过改变在两个或更多个方向上的向上和向下切割的角度，可以容易地改变主模具针的尺寸和形状。 主模具用于通过将二次模板热压在主模上来制造二次模具。 这在二次模具中形成通孔。 二次模具镀有一层金属，形成微针阵列。