中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

1604 records (took 0.03 seconds)

    METHOD OF PRODUCING OPTICALLY ACTIVE COMPOUND
    35.
    发明申请
    METHOD OF PRODUCING OPTICALLY ACTIVE COMPOUND 有权
    生产光学活性化合物的方法

    公开(公告)号：US20160250625A1

    公开(公告)日：2016-09-01

    申请号：US14777649

    申请日：2014-06-03

    Applicant: DEXERIALS CORPORATION

    Inventor： Hiroki KANAYA ,  Mamiko NOMURA

    IPC: B01J31/06 ,  C07C201/12 ,  B01J8/02

    CPC classification number: B01J31/062 ,  B01J8/02 ,  B01J31/06 ,  B01J37/00 ,  B01J2208/02 ,  C07B53/00 ,  C07B2200/07 ,  C07C201/12 ,  C07C201/16 ,  C07C205/48 ,  C07C2601/10 ,  C07C2601/14 ,  C07C205/19

    Abstract: An optically active compound production method using a column reactor, a column for column reactor is charged with asymmetric catalyst particles to produce the column reactor, and reaction compound is introduced into column reactor to bring reaction compound into contact with asymmetric catalyst particles, whereby reaction compound is converted to optically active compound. Asymmetric catalyst particles are preferably resin particles that are prepared from a monomer composition containing a proline derivative monomer having unsaturated bond and radical polymerization initiator and serve as catalyst for enamine mechanism reaction. Asymmetric catalyst particles are preferably resin particles prepared by micro-channel method including injecting monomer composition into continuous phase to thereby form droplets of monomer composition in continuous phase and then heating droplets to cause proline derivative monomer having an unsaturated bond to undergo radical polymerization.

    Abstract translation: 使用柱式反应器，塔式反应器塔的旋光化合物制备方法装有不对称催化剂颗粒以制备塔式反应器，并将反应化合物引入塔式反应器以使反应化合物与不对称催化剂颗粒接触，由此反应化合物 转化为光学活性化合物。 不对称催化剂颗粒优选由含有具有不饱和键的脯氨酸衍生物单体和自由基聚合引发剂的单体组合物制备并用作烯胺机理反应的催化剂的树脂颗粒。 不对称催化剂颗粒优选通过微通道法制备的树脂颗粒，包括将单体组合物注入连续相中，从而在连续相中形成单体组合物的液滴，然后加热液滴以使具有不饱和键的脯氨酸衍生物单体进行自由基聚合。

    Methods for the synthesis of activated ethylfumarates and their use as intermediates
    37.
    发明申请
    Methods for the synthesis of activated ethylfumarates and their use as intermediates 审中-公开
    合成活性乙酸富马酸盐的方法及其作为中间体的用途

    公开(公告)号：US20160159753A1

    公开(公告)日：2016-06-09

    申请号：US14949489

    申请日：2015-11-23

    Applicant: MannKind Corporation

    Inventor： Kelly Sullivan Kraft ,  John J. Freeman ,  Paul Serwinski ,  Vincent Pavia ,  Otto Phansteil ,  Navneet Kaur

    IPC: C07D241/08

    CPC classification number: C07D241/08 ,  C07C67/30 ,  C07C67/39 ,  C07C201/12 ,  C07C69/60 ,  C07C205/43

    Abstract: Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphophoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

    Abstract translation: 公开的实施方案涉及用于合成活化的富马酸盐中间体的改进方法及其在化学合成中的用途。 公开的实施方案描述了活化的富马酸酯的合成，包括衍生自活化基团的活化的富马酸酯，包括：4-硝基苯基，二苯基磷酰叠氮化物，新戊酰氯，氯磺酰异氰酸酯，对硝基苯酚，MEF，三氟乙酰基和氯，例如乙基富马酰氯， 的活性酯原位。 另外的实施方案描述了从单分离和未纯化的中间体改进的取代氨基烷基 - 二酮哌嗪的合成，其允许提高产率和反应器生产量。

    Process for the preparation of nitroalcohols
    40.
    发明授权
    Process for the preparation of nitroalcohols 有权
    制备硝基醇的方法

    公开(公告)号：US09212126B2

    公开(公告)日：2015-12-15

    申请号：US14379798

    申请日：2013-02-07

    Applicant: Angus Chemical Company

    Inventor： David W. Moore ,  G. David Green

    IPC: C07C201/12

    CPC classification number: C07C201/12 ,  C07C205/15

    Abstract: A process of preparing a nitroalcohol, e.g., 2-nitro-2-methyl-1-propane, from a nitropolyol, e.g., 2-nitro-2-methyl-1,3-propanediol, the process comprising the step of contacting under hydrogenation conditions the nitropolyol with hydrogen, a hydrogenation catalyst and, optionally, a chelating agent.

    Abstract translation: 一种由硝基多元醇例如2-硝基-2-甲基-1,3-丙二醇制备硝基醇，例如2-硝基-2-甲基-1-丙烷的方法，该方法包括在氢化下接触的步骤 用氢气，硝基多烯醇与氢化催化剂和任选的螯合剂进行反应。

Patent Agency Ranking