公开(公告)号：US20130018112A1

公开(公告)日：2013-01-17

申请号：US13395710

申请日：2010-09-14

Applicant: Wim Albert Wilfried Irene Thielemans ,  Rebecca Davies

Inventor： Wim Albert Wilfried Irene Thielemans ,  Rebecca Davies

IPC: C08B15/00 ,  E04B1/74 ,  C09D101/00 ,  B01F17/32 ,  C09K3/00 ,  C12N11/12 ,  A61K8/72 ,  B01J31/02 ,  H01B1/24 ,  A61K47/38 ,  B82Y30/00

CPC classification number: C08J3/075 ,  B01J13/0091 ,  C08J9/0066 ,  C08J9/0071 ,  C08J9/283 ,  C08J2201/0484 ,  C08J2201/05 ,  C08J2205/026 ,  C08J2301/02

Abstract: A cellulose aerogel comprises a plurality of cellulose nanoparticles. The cellulose nanoparticles preferably comprise at least 50% or 80% cellulose nanocrystals by weight of cellulose nanoparticles, and the cellulose nanoparticle aerogel preferably has a density of from 0.001 to 0.2 g/cm3 or from 0.2 to 1.59 g/cm3 The cellulose nanoparticle aerogel typically has an average pore diameter of less than 100 nmm and the cellulose nanoparticles may comprise anionic and/or cationic surface groups.

Abstract translation: 纤维素气凝胶包含多个纤维素纳米颗粒。 纤维素纳米颗粒优选包含纤维素纳米颗粒重量的至少50％或80％纤维素纳米晶体，纤维素纳米颗粒气凝胶优选具有0.001至0.2g / cm 3或0.2至1.59g / cm 3的密度。纤维素纳米颗粒气凝胶通常 平均孔径小于100nmm，纤维素纳米颗粒可以包含阴离子和/或阳离子表面基团。

公开(公告)号：US20120157672A1

公开(公告)日：2012-06-21

申请号：US13405615

申请日：2012-02-27

Applicant: Naotaka CHINO ,  Miho Kai

Inventor： Naotaka CHINO ,  Miho Kai

IPC: C07H1/06

CPC classification number: C08J9/28 ,  A61K31/715 ,  A61L31/042 ,  A61L31/146 ,  C08J2201/0484 ,  C08J2205/044 ,  C08J2207/10 ,  C08J2305/00

Abstract: A porous structure includes a polysaccharide and having a multitude of pores wherein an average pore size of the pores is not smaller than 40 μm and a ratio of the number of pores having a pore size not smaller than 50 μm to the total number of the pores is not less than 30%. The porous structure improves the solubility of a polysaccharide in water.

Abstract translation: 多孔结构包括多糖并具有多孔，孔的平均孔径不小于40μm，孔径不小于50μm的孔数与孔的总数之比 不低于30％。 多孔结构改善多糖在水中的溶解度。

公开(公告)号：US07893225B2

公开(公告)日：2011-02-22

申请号：US10470349

申请日：2002-01-30

Applicant: Tomoya Sato

Inventor： Tomoya Sato

IPC: C07H5/06 ,  C07H1/00

CPC classification number: C08J9/28 ,  C08B11/12 ,  C08B11/20 ,  C08B15/005 ,  C08B37/00 ,  C08B37/003 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08F28/06 ,  C08F251/00 ,  C08F251/02 ,  C08J2201/0484 ,  C08J2305/00 ,  C08L5/00 ,  C08L51/02 ,  Y10T428/249953

Abstract: A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.

Abstract translation: 制备多糖海绵的方法包括以下步骤：（A）冷冻光反应性多糖溶液，和（B）用光照射冷冻的光反应性多糖溶液以交联光反应性多糖，从而获得多糖海绵。 该方法包括不需要除去溶剂的简化步骤，并且具有容易从其中除去杂质的优点。

公开(公告)号：US20100221301A1

公开(公告)日：2010-09-02

申请号：US12681676

申请日：2008-10-10

Applicant: Catherine Le Visage ,  Didier Letourneur ,  Frederic Chaubet ,  Aude Autissier

Inventor： Catherine Le Visage ,  Didier Letourneur ,  Frederic Chaubet ,  Aude Autissier

IPC: A61F13/00 ,  C07H1/00 ,  C08B37/02 ,  C08B37/12 ,  C08B37/04 ,  C08B37/10 ,  C12N11/10

CPC classification number: A61L27/56 ,  A61L27/20 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/21 ,  A61L2430/02 ,  A61L2430/06 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0039 ,  C08B37/0054 ,  C08B37/0063 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08H1/06 ,  C08J3/24 ,  C08J9/28 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2205/04 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2305/02 ,  C08J2305/08 ,  C08J2305/12 ,  C12N5/0068 ,  C12N11/10 ,  C12N2533/70 ,  Y10T436/147777

Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b). characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).

Abstract translation: 本发明涉及一种用于组织工程的多孔支架的制备方法。 本发明的另一个目的是提供可通过上述方法获得的多孔支架及其在组织工程，细胞培养和细胞递送中的应用。 本发明的方法包括以下步骤：a）制备含有至少一种多糖和一种交联剂的碱性水溶液b）冷冻步骤a）的水溶液c）升华步骤b的冷冻溶液 ）。 其特征在于在步骤a）的溶液中发生多糖的交联之前进行步骤b）。

公开(公告)号：US20060287409A1

公开(公告)日：2006-12-21

申请号：US11157225

申请日：2005-06-21

Applicant: Nafih Mekhilef ,  Ramin Amin-Sanayei

Inventor： Nafih Mekhilef ,  Ramin Amin-Sanayei

IPC: C08J3/28

CPC classification number: C08J9/28 ,  C08J3/28 ,  C08J9/36 ,  C08J2201/0484 ,  C08J2327/16

Abstract: Ionized irradiation can be used to improve the properties of fluoropolymers. In particular, elasticity, strain hardening, and melt strength of a fluoropolymer can be increased by LIP to an order of magnitude by exposure to controlled amounts of radiation; while polymer foams may be thermoformed and crosslinked by irradiation to provide a solvent resistance polymer foams having wide range of densities with good mechanical integrity at elevated temperature

Abstract translation: 电离辐射可用于改善含氟聚合物的性能。 特别地，氟聚合物的弹性，应变硬化和熔体强度可以通过暴露于受控量的辐射而通过LIP增加到一个数量级; 而聚合物泡沫体可以通过辐射热成型和交联，以提供具有宽范围密度的耐溶剂聚合物泡沫体，并且在高温下具有良好的机械完整性

公开(公告)号：US20060057098A1

公开(公告)日：2006-03-16

申请号：US11162597

申请日：2005-09-15

Applicant: Tomoya Sato

Inventor： Tomoya Sato

IPC: A61K31/74 ,  C08G63/91

CPC classification number: A61L31/042 ,  A61K31/738 ,  A61K31/74 ,  A61L27/20 ,  C08B11/12 ,  C08B37/0006 ,  C08B37/0009 ,  C08B37/003 ,  C08B37/0036 ,  C08B37/0039 ,  C08B37/0042 ,  C08B37/0045 ,  C08B37/006 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08J3/075 ,  C08J2201/0484 ,  C08J2305/08 ,  C08L1/286 ,  C08L5/04 ,  C08L5/08 ,  C08L5/10

Abstract: A photoreactive polysaccharide which comprises a polysaccharide bound to a glycidyl ester via a covalent bond, a photocrosslinked-polysaccharide prepared by using the photoreactive polysaccharide, and medical products comprising the photocrosslinked-polysaccharide.

Abstract translation: 包含通过共价键与缩水甘油酯结合的多糖的光反应性多糖，使用所述光反应性多糖制备的光交联多糖和包含所述光交联多糖的医药品。

公开(公告)号：US20030190346A1

公开(公告)日：2003-10-09

申请号：US10115007

申请日：2002-04-04

Applicant: China Textile Institute

Inventor： Jui-Sheng Lee ,  Chun-Yuan Hsu ,  Wei-Hsin Lin

IPC: A61L015/00 ,  C08B037/08

CPC classification number: C08J9/26 ,  A61L15/28 ,  A61L15/425 ,  C08J2201/0484 ,  C08J2305/08 ,  C08L5/08 ,  C08L2203/02 ,  C08L2666/26

Abstract: The present invention relates to a composite sponge wound dressing and method for producing the same. Chitosan and null-Chitin is mixed in a specific ratio for forming the sponge for wound repairing. Particularly, when said ratio is between 0.1-1, the composite sponge wound dressing has a better absorption and tensile strength.

Abstract translation: 复合海绵伤口敷料及其制造方法技术领域本发明涉及复合海绵状伤口敷料及其制造方法。 将壳聚糖和β-甲壳素以特定比例混合以形成用于伤口修复的海绵。 特别地，当所述比例在0.1-1之间时，复合海绵伤口敷料具有更好的吸收和拉伸强度。

公开(公告)号：US20030119157A1

公开(公告)日：2003-06-26

申请号：US10168701

申请日：2002-06-17

Inventor： Seo Young Jeong ,  Eunhee Bae ,  Ick Chan Kwon ,  Kuiwon Choi

IPC: C12N005/00

CPC classification number: C08J9/28 ,  C08B37/003 ,  C08J2201/0484 ,  C08J2305/08 ,  C08L5/08 ,  C12N5/0075 ,  C12N2533/72

Abstract: The present invention relates to macroporous chitosan beads having 5-200 nullm in size of relatively large and uniform pores that are distributed from surface to core region, and a preparation method thereof compring the following steps; by dropping chitosan solution, aqueous chitosan solution or their mixture into the low-temperature of organic solvent or liquid nitrogen; and by regulating pore size by phase separation method via temperature difference. The macroporous chitosan beads of the present invention make cell culture more efficient than the previous substrate, since cell can attach to them efficiently due to their large surface area, it is easy for cell to be injected into them and cell attached to them can exist longer due to their three-dimensional structure, therefore they can be used for a study about production of protein, abtibiotics, anticancer agent, polysaccharide, physiologically active agent, animal hormone, or plant hormone as well as a study about substitution of metabolic organs, cartilage or bone.

Abstract translation: 本发明涉及从表面到核心区域分布的具有相对较大且均匀的孔的尺寸为5-200μm的大孔壳聚糖珠及其制备方法，其包括以下步骤： 通过将壳聚糖溶液，壳聚糖水溶液或其混合物滴加到低温有机溶剂或液氮中; 并通过温度差相分离法调节孔径。 本发明的大孔壳聚糖珠粒使细胞培养物比以前的底物更有效，因为细胞由于其大的表面积而能够有效地附着于它们，因此容易将细胞注射到细胞中，并且附着于细胞的细胞可以存在更长时间 因为它们的三维结构，因此它们可以用于关于蛋白质，抗生素，抗癌剂，多糖，生理活性剂，动物激素或植物激素的生产的研究以及关于代谢器官的替代的研究，软骨 或骨骼。

公开(公告)号：US4753761A

公开(公告)日：1988-06-28

申请号：US102853

申请日：1987-09-30

Applicant: Makoto Suzuki

Inventor： Makoto Suzuki

IPC: A61F2/08 ,  A61F2/68 ,  B25J9/00 ,  B25J9/10 ,  C08J9/28 ,  B05B3/00 ,  B29C35/02

CPC classification number: C08J9/28 ,  A61F2/08 ,  A61F2/68 ,  B25J9/0012 ,  B25J9/1095 ,  A61F2002/0894 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2201/0502

Abstract: An expansible macromolecular material is produced by a method which comprises mixing an aqueous polyvinyl alcohol solution, an acidic aqueous macromolecular electrolyte solution, and a basic aqueous macromolecular electrolyte solution thereby preparing a composite polymer and subjecting this composite polymer to at least one cycle of alternate freezing and defrosting treatments. A macromolecular membrane constituted of said expansible macromolecular material and containing numerous through holes is obtained by mixing, freezing, and defrosting the aforementioned three mixed aqueous solutions under specific conditions.

Abstract translation: 通过包括将聚乙烯醇水溶液，酸性高分子电解质水溶液和碱性高分子电解质水溶液混合从而制备复合聚合物并使该复合聚合物经受至少一个交替冷冻循环的方法制备可膨胀的高分子材料 和除霜治疗。 通过在特定条件下混合，冷冻和除霜上述三种混合水溶液，获得由所述可膨胀大分子材料构成并含有许多通孔的高分子膜。

公开(公告)号：US20240327596A1

公开(公告)日：2024-10-03

申请号：US18524186

申请日：2023-11-30

Applicant: Ocean University of China

Inventor： Hongzhi CUI ,  Ruiqi XU ,  Na WEI ,  Minggang ZHAO ,  Aiping WANG ,  Jun ZHAO

IPC: C08J9/28 ,  B23K26/0622 ,  B23K26/382 ,  B23K26/402 ,  C02F1/14 ,  C08J3/075 ,  C08J3/21 ,  C08J9/36 ,  C08K3/34 ,  C08L5/12 ,  F24S70/16

CPC classification number: C08J9/283 ,  B23K26/0622 ,  B23K26/389 ,  B23K26/402 ,  C02F1/14 ,  C08J3/075 ,  C08J3/212 ,  C08J9/36 ,  C08K3/34 ,  C08L5/12 ,  F24S70/16 ,  C02F2103/08 ,  C08J2201/0484 ,  C08J2205/026 ,  C08J2205/04 ,  C08J2305/12 ,  C08J2429/04 ,  C08K2201/001 ,  C08K2201/011 ,  C08L2203/14 ,  C08L2312/00

Abstract: Disclosed are an aerogel with a hierarchical pore structure formed using a pulsed laser technology, and a preparation method and use thereof. In the preparation method, a nano silicon-containing inorganic material as a freezing element, a biomass polymer as a cross-linking agent, and deionized water as a solvent are mixed and a resulting mixture is left to stand and gelatinized to obtain a hydrogel; the hydrogel is frozen to form ice crystals therein, and the ice crystals are removed by freeze-drying to obtain a micron-nano porous aerogel; the micron-nano porous aerogel is subjected to customized millimeter-scale punching using a pulsed laser to obtain an aerogel with a millimeter-micron-nano hierarchical pore structure.