公开(公告)号：US3910701A

公开(公告)日：1975-10-07

申请号：US38402673

申请日：1973-07-30

Applicant: HENDERSON GEORGE R ,  GRAFTON DAVID A

Inventor： HENDERSON GEORGE R ,  GRAFTON DAVID A

IPC: G01N21/25 ,  G01N21/47 ,  G01N21/84 ,  G01N33/487 ,  G01N33/16

CPC classification number: G01N21/474 ,  G01N21/255 ,  G01N2021/8466 ,  G01N2201/024 ,  G01N2201/0627

Abstract: A method and apparatus for measuring light reflectance, absorption and/or transmission having a plurality of light emitting diodes (LEDs) arranged to direct light emissions toward a test piece, with the various diodes being selected to emit light of different wavelengths and at least one light-responsive sensor disposed to receive light reflected and/or transmitted by the test piece and originating with each of the light-emitting diodes. Electrical drive circuit means are provided for alternately or sequentially energizing the plurality of LEDs of different wavelengths, such that the reflected or transmitted light received by the sensor is a function of the various wavelengths of the respective LEDs. In one embodiment, the sensor is operative to generate an output signal indicative of the characteristics of the test piece as a function of the different wavelengths of the LEDs which signal is processed to provide a display of the ''''differential'''' light reflectance, transmission and/or absorption characteristics of the workpiece and the wavelengths of the LEDs. In another embodiment, a plurality of LEDs each having a different frequency is operative to generate a range of signals which provide a measurement of reflectance, transmission and/or absorption as a function of the wavelengths of the various LEDs employed. The plurality of LED sources and the sensor may be mounted within a self-contained module which may be detachably connected to an instrument housing containing the drive and output circuitry and display means, such that a number of different source modules may be provided each having LEDs of unique wavelength with the various modules being interchangeable to permit a wide variety of measurement frequencies.

Abstract translation: 一种用于测量光反射率，吸收和/或透射率的方法和装置，其具有多个发光二极管（LED），所述多个发光二极管被布置成将光发射引向测试片，其中选择各种二极管以发射不同波长的光并且至少一个 光响应传感器被设置为接收被测试件反射和/或传输的光并且由每个发光二极管产生。 提供电驱动电路装置用于交替地或顺序地激励不同波长的多个LED，使得由传感器接收的反射或透射的光是各个LED的各种波长的函数。 在一个实施例中，传感器可操作以产生指示测试片的特性的输出信号作为LED的不同波长的函数，该信号被处理以提供“差分”光反射率，透射和/ 或吸收特性和LED的波长。 在另一个实施例中，每个具有不同频率的多个LED可用于产生提供作为所使用的各种LED的波长的函数的反射率，透射和/或吸收的测量的信号范围。 多个LED源和传感器可以安装在独立模块内，该模块可以可拆卸地连接到容纳驱动和输出电路和显示装置的仪器壳体，使得可以提供多个不同的源模块，每个源模块具有LED 独特的波长，各种模块可互换，以允许各种各样的测量频率。

公开(公告)号：US12053774B2

公开(公告)日：2024-08-06

申请号：US17185177

申请日：2021-02-25

Applicant: The General Hospital Corporation

Inventor： Robert Granier ,  Ramin Haghgooie ,  Ken Kotz ,  Anne C. Petrofsky ,  Ronald G. Tompkins

IPC: G01N1/00 ,  B01L3/00 ,  G01N15/01 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/53 ,  G01N21/64 ,  G01N21/78 ,  G01N35/00

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/532 ,  G01N21/6486 ,  G01N21/78 ,  G01N35/00029 ,  G01N35/00871 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2400/0487 ,  G01N15/01 ,  G01N2015/1006 ,  G01N15/12 ,  G01N15/1459 ,  G01N2021/6493 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00881 ,  G01N2201/024 ,  G01N2201/06113 ,  G01N2201/062

Abstract: A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.

公开(公告)号：US20190195768A1

公开(公告)日：2019-06-27

申请号：US16322370

申请日：2017-07-28

Applicant: PCME Limited

Inventor： David Christopher Unitt ,  Trevor Allan Lye ,  Bruce Greetham

IPC: G01N15/10 ,  G01F1/74 ,  G08B17/107

CPC classification number: G01N15/10 ,  G01F1/74 ,  G01N15/0205 ,  G01N21/15 ,  G01N21/53 ,  G01N2015/0096 ,  G01N2015/1075 ,  G01N2021/536 ,  G01N2201/024 ,  G01N2201/12707 ,  G08B17/107

Abstract: A method and apparatus (1) for monitoring particles flowing in a stack are disclosed. The method comprises emitting light from a light source along an optical path for scattering from the particles, rotating a rotatable monitoring assembly (15) mounted in the optical path, and detecting the scattered light using a detector. The rotatable monitoring assembly (15) contains at least two in apertures, and the method further comprises rotating the rotatable monitoring assembly (15) into a plurality of different configurations. In an operation configuration, light passes through the rotatable monitoring assembly (15) and into the stack unimpeded. In a zero-check configuration, the rotatable monitoring assembly (15) blocks the light from reaching the stack. In a span-check configuration, light of varying intensity passes from the light source through the rotatable monitoring assembly (15) into the stack. In a contamination-check configuration, the light is reflected through the rotatable monitoring assembly (15) onto the detector, without entering the stack. In the safety-shutter configuration, the rotatable monitoring assembly (15) protects optical components in the instrument from particles in the stack.

公开(公告)号：US09976996B2

公开(公告)日：2018-05-22

申请号：US15294877

申请日：2016-10-17

Applicant: VUV Analytics, Inc.

Inventor： Dale A. Harrison ,  Anthony T. Hayes ,  Phillip Walsh

IPC: G01N21/00 ,  G01N30/78 ,  G01N21/05 ,  G01N21/33 ,  G01J3/02 ,  G01N30/02 ,  G01N30/74 ,  G01N33/00 ,  G01N21/15 ,  G01N21/03

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.

公开(公告)号：US20180020985A1

公开(公告)日：2018-01-25

申请号：US15520973

申请日：2015-10-22

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： John Wong ,  Ken Kang-Hsin Wang ,  Iulian Loan Iordachita

IPC: A61B5/00

CPC classification number: A61B5/704 ,  A61B5/0064 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0077 ,  A61B5/0079 ,  A61B6/032 ,  A61B2503/40 ,  G01N21/01 ,  G01N21/763 ,  G01N2201/024

Abstract: An optical imaging system for interfacing with a separate examination apparatus and methods of making and using the same are disclosed. The optical imaging system can include an imaging housing including a housing enclosure and a housing receptor plate, a subject support mount, a cart including an extendable arm, an optical arrangement including an optical source, a cantilever mirror system, and the housing enclosure, and a detection optical path providing optical communication between the cantilever mirror system and an optical detector. The subject support mount allows optical illumination via at least one optical port. The extendable arm is affixed to the cart at one end and the optical arrangement at another end. The extendable arm can move from a retracted position to an extended position without contacting the subject support mount or the subject.

公开(公告)号：US09810704B2

公开(公告)日：2017-11-07

申请号：US14183500

申请日：2014-02-18

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Sunny Balwani ,  Michael Chen ,  John K. Frankovich ,  Gary Frenzel ,  Samartha Anekal ,  Adrit Lath ,  Alexander Loo ,  Chinmay Pangarkar ,  Joy Roy ,  Timothy Smith ,  Daniel Young

IPC: C40B30/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  G01N21/27 ,  C12Q1/42 ,  C12Q1/52 ,  G01N33/62 ,  G01N33/68 ,  G01N33/92 ,  B01L9/00 ,  G01N15/00 ,  G01N15/14 ,  G01N15/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20170038401A1

公开(公告)日：2017-02-09

申请号：US15162122

申请日：2016-05-23

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Sunny Balwani ,  Michael Chen ,  John K. Frankovich ,  Gary Frenzel ,  Surekha Gangakhedkar ,  Samartha Anekal ,  Adrit Lath ,  Alexander Loo ,  Chinmay Pangarkar ,  Paul Patel ,  Joy Roy ,  Timothy Smith ,  Daniel Young ,  Ian Gibbons

IPC: G01N35/00 ,  G01N33/68 ,  G01N35/10 ,  C12Q1/52 ,  C12Q1/42 ,  G01N33/92 ,  G01N33/62

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Abstract translation: 提供系统和方法用于样品处理。 可以提供能够接收样品并执行样品制备，样品测定和检测步骤中的一种或多种的装置。 该装置可能能够进行多个测定。 该装置可以包括一个或多个可以执行样品制备，样品测定和检测步骤中的一个或多个的模块。 该装置可以能够使用小体积的样品来执行步骤。

公开(公告)号：US09563061B2

公开(公告)日：2017-02-07

申请号：US14427437

申请日：2013-09-12

Applicant: FORSCHUNGSVERBUND BERLIN E.V.

Inventor： Martin Maiwald ,  Bernd Sumpf

IPC: G02B5/18 ,  G02B27/10 ,  G01J3/44 ,  G01N21/65 ,  G02B27/14 ,  G01J3/427 ,  G02B27/09 ,  G01N21/39

CPC classification number: G02B27/1006 ,  G01J3/427 ,  G01J3/44 ,  G01J2003/4424 ,  G01N21/65 ,  G01N2021/399 ,  G01N2201/0221 ,  G01N2201/024 ,  G02B27/09 ,  G02B27/1086 ,  G02B27/141

Abstract: A device (122) is described having an arrangement of optical elements comprising excitation light sources (101, 115) for generating individual light beams (102, 116) having different wavelengths for exciting a sample in such a way that light scattered back from the sample as a result of the excitation is made available to a Raman spectroscopic analysis. The device (122) has deflection devices (103, 117) associated with the individual light beams (102, 116) for deflecting the individual light beams (102, 116) onto a common light path, wherein the common light path has a same optical system (109) for focusing the light beams (102, 116).

Abstract translation: 描述了一种装置（122），其具有包括激发光源（101,115）的光学元件的布置，用于产生具有不同波长的单个光束（102,116），以使样品激发，使得从样品散射回来的光 作为激发的结果可用于拉曼光谱分析。 所述装置（122）具有与各个光束（102,116）相关联的偏转装置（103,117），用于将各个光束（102,116）偏转到公共光路上，其中公共光路具有相同的光 系统（109），用于聚焦光束（102,116）。

公开(公告)号：US20160377640A1

公开(公告)日：2016-12-29

申请号：US15161547

申请日：2016-05-23

Applicant: Theranos, Inc.

Inventor： Sunny Balwani ,  Daniel Young ,  Samartha Anekal ,  Elizabeth A. Holmes

IPC: G01N35/04 ,  G01N15/14 ,  G01N21/27 ,  G01N35/00 ,  G01N35/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20160377531A1

公开(公告)日：2016-12-29

申请号：US15259312

申请日：2016-09-08

Applicant: VUV Analytics, Inc.

Inventor： Dale A. Harrison ,  Anthony T. Hayes ,  Phillip Walsh, JR.

IPC: G01N21/33 ,  G01N30/74

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.