公开(公告)号：US3887473A

公开(公告)日：1975-06-03

申请号：US42030573

申请日：1973-11-29

Applicant: BERGISHAGEN & ASSOCIATES

Inventor： STERNBERG STANLEY P ,  YOUNG JAMES E ,  LENNINGTON JOHN W

IPC: G01N21/31 ,  G01N21/35 ,  G01N21/26

CPC classification number: G01N21/3504 ,  G01N21/314 ,  G01N2201/1215

Abstract: A dual path analyzer and a single path analyzer are disclosed, each for determining the concentration of one or more gaseous components in a mixture of gases. The preferred analyzer is a single path instrument which includes a source of infrared energy, a detector for the energy, a sample cell for the gas mixture positioned between the source and detector, and a filter wheel having a plurality of filters and a source blocking device positioned between the sample cell and detector for sequentially interposing the filters and the source blocking device between the source and the detector. Means are provided for amplifying the output signal of the detector and for processing the signal to provide a direct readout display which indicates the concentration of the gaseous components being analyzed. The processing electronics preferably include provision for calibrating the analyzer with clean ambient air, for compensating for background levels of radiation, and for correcting the displayed output signal for the effects of absorption band interferences between two or more gases in the gas mixture. The structure of the dual path analyzer includes a source of infrared energy, a detector for the energy, a sample cell for the gas mixture, a cell for a reference gas, and optical path means between the source and detector for sequentially directing the source energy through the sample cell, the reference cell, and through neither cell. Processing electronics similar to the single path instrument can be incorporated to compensate for background radiation and absorption band interferences.

公开(公告)号：US09091676B2

公开(公告)日：2015-07-28

申请号：US13156295

申请日：2011-06-08

Applicant: Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

IPC: G01N33/49 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/153 ,  A61B5/00 ,  G01N21/31 ,  G01N21/35

CPC classification number: G01N33/491 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150801 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/7275 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0437 ,  A61B2560/0443 ,  A61B2562/0238 ,  A61B2562/08 ,  G01N21/35 ,  G01N2021/3174 ,  G01N2201/1215 ,  G01N2201/1293 ,  G06F19/00

Abstract: Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.

Abstract translation: 提供了用于分析流体样品的多个组分的系统和方法。 在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。 在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。 在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。 在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分 的样品分离后。

公开(公告)号：US09046481B2

公开(公告)日：2015-06-02

申请号：US14279369

申请日：2014-05-16

Applicant: Sick AG

Inventor： Julian Edler ,  Thomas Beyer ,  Rolf Disch

IPC: G01N21/00 ,  G01N21/17 ,  G01N21/31 ,  G01N21/39 ,  G01N21/3504 ,  G01J3/433 ,  G01N21/27 ,  G01N21/3554

CPC classification number: G01N21/39 ,  G01J3/433 ,  G01J3/4338 ,  G01N21/274 ,  G01N21/3504 ,  G01N21/3554 ,  G01N2021/399 ,  G01N2201/0691 ,  G01N2201/1211 ,  G01N2201/1215 ,  G01N2201/1218

Abstract: A method of determining a concentration of a gas in a sample and/or the composition of a gas using a spectrometer comprises transmitting of radiation whose wavelength substantially continuously runs through a wavelength range, wherein the continuous running through of the wavelength range is overlaid by a wavelength modulation; measuring of an absorption signal as a function of the wavelength of the radiation; converting of the absorption signal into first and second derivative signals; deriving of a first and a second measured gas concentration value from the first and the second derivative signals, respectively; and determining of the concentration and/or the composition of the gas from at least the first measured gas concentration value, wherein the wavelength modulation is adapted in response to a change of a state variable of the gas such that a ratio between the first and the second measured gas concentration values is kept substantially constant.

Abstract translation: 使用光谱仪确定样品中的气体浓度和/或气体组成的方法包括传输其波长基本上连续穿过波长范围的辐射，其中波长范围的连续穿过被覆盖在 波长调制; 测量作为辐射波长的函数的吸收信号; 将吸收信号转换为第一和第二导数信号; 分别从第一和第二导数信号得出第一和第二测量气体浓度值; 以及从至少第一测量的气体浓度值确定气体的浓度和/或组成，其中响应于气体的状态变量的改变而适配波长调制，使得第一和第 第二测量气体浓度值保持基本恒定。

公开(公告)号：US08879053B2

公开(公告)日：2014-11-04

申请号：US13456259

申请日：2012-04-26

Applicant: Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  William Soltmann

Inventor： Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  William Soltmann

IPC: G01N21/00 ,  G01K13/00 ,  G06E3/00 ,  G01N21/27 ,  G01N21/17

CPC classification number: G01N21/17 ,  G01K13/00 ,  G01N21/274 ,  G01N2201/1211 ,  G01N2201/1214 ,  G01N2201/1215 ,  G06E3/001

Abstract: The output of optical computing devices containing an integrated computational element can be corrected when an interferent substance or condition is present. The devices may comprise an optional electromagnetic radiation source; a sample detection unit comprising an integrated computational element and a detector configured to receive electromagnetic radiation that has optically interacted with the integrated computational element and produce a sample signal associated therewith; an interferent monitor located proximal to the sample detection unit, the interferent monitor being configured to produce an interferent signal associated with an interferent substance; and a signal processing unit operable to convert the interferent signal into an interferent input form suitable for being computationally combined with the sample signal, the signal processing unit being further operable to computationally combine the sample signal and the interferent input form to determine a characteristic of a sample in real-time or near real-time.

Abstract translation: 当存在干扰物质或条件时，可以校正包含集成计算元件的光学计算装置的输出。 这些装置可以包括可选的电磁辐射源; 样本检测单元，包括集成的计算元件和被配置为接收与所述集成的计算元件光学相互作用并产生与其相关联的采样信号的电磁辐射的检测器; 位于样本检测单元附近的干扰物监测器，所述干扰物监测器被配置为产生与干扰物质相关的干扰信号; 信号处理单元，可操作以将干扰信号转换成适于与采样信号进行计算组合的干扰输入形式，所述信号处理单元进一步可操作以计算地组合采样信号和干扰输入形式，以确定 实时或近实时采样。

公开(公告)号：US20130287061A1

公开(公告)日：2013-10-31

申请号：US13456259

申请日：2012-04-26

Applicant: Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  Bill Soltmann

Inventor： Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  Bill Soltmann

IPC: G01N21/17 ,  G01K13/00

CPC classification number: G01N21/17 ,  G01K13/00 ,  G01N21/274 ,  G01N2201/1211 ,  G01N2201/1214 ,  G01N2201/1215 ,  G06E3/001

Abstract: The output of optical computing devices containing an integrated computational element can be corrected when an interferent substance or condition is present. The devices may comprise an optional electromagnetic radiation source; a sample detection unit comprising an integrated computational element and a detector configured to receive electromagnetic radiation that has optically interacted with the integrated computational element and produce a sample signal associated therewith; an interferent monitor located proximal to the sample detection unit, the interferent monitor being configured to produce an interferent signal associated with an interferent substance; and a signal processing unit operable to convert the interferent signal into an interferent input form suitable for being computationally combined with the sample signal, the signal processing unit being further operable to computationally combine the sample signal and the interferent input form to determine a characteristic of a sample in real-time or near real-time.

Abstract translation: 当存在干扰物质或条件时，可以校正包含集成计算元件的光学计算装置的输出。 这些装置可以包括可选的电磁辐射源; 样本检测单元，包括集成的计算元件和被配置为接收与所述集成的计算元件光学相互作用并产生与其相关联的采样信号的电磁辐射的检测器; 位于样本检测单元附近的干扰物监测器，所述干扰物监测器被配置为产生与干扰物质相关的干扰信号; 信号处理单元，可操作以将干扰信号转换成适合于与采样信号进行计算组合的干扰输入形式，所述信号处理单元还可操作以计算地组合采样信号和干扰输入形式，以确定 实时或近实时采样。

公开(公告)号：US08152900B2

公开(公告)日：2012-04-10

申请号：US12911666

申请日：2010-10-25

Applicant: Xin Zhou ,  Xiang Liu ,  Alfred Feitisch ,  Gregory M. Sanger

Inventor： Xin Zhou ,  Xiang Liu ,  Alfred Feitisch ,  Gregory M. Sanger

IPC: B01D59/26

CPC classification number: G01N21/3504 ,  G01N2021/3545 ,  G01N2021/399 ,  G01N2201/1215

Abstract: A differential absorption spectrum for a reactive gas in a gas mixture can be generated for sample absorption data by subtracting background absorption data set from the sample absorption data. The background absorption data can be characteristic of absorption characteristics of the background composition in a laser light scan range that includes a target wavelength. The differential absorption spectrum can be converted to a measured concentration of the reactive gas using calibration data. A determination can be made whether the background composition has substantially changed relative to the background absorption data, and new background absorption data can be used if the background composition has substantially changed. Related systems, apparatus, methods, and/or articles are also described.

Abstract translation: 可以通过从样品吸收数据中减去设置的背景吸收数据，为样品吸收数据产生气体混合物中的反应气体的差分吸收光谱。 背景吸收数据可以是包括目标波长的激光扫描范围中背景组合物的吸收特性的特征。 使用校准数据可以将差示吸收光谱转换为测量的反应气体浓度。 可以确定背景组合物是否相对于背景吸收数据基本上改变，并且如果背景组合物已经基本上改变，则可以使用新的背景吸收数据。 还描述了相关系统，装置，方法和/或制品。

公开(公告)号：US07835005B2

公开(公告)日：2010-11-16

申请号：US12112436

申请日：2008-04-30

Applicant: Dirk Appel ,  Gaston E. Marzoratti ,  Shrikrishna H. Nabar ,  Robert F. Mouradian

Inventor： Dirk Appel ,  Gaston E. Marzoratti ,  Shrikrishna H. Nabar ,  Robert F. Mouradian

IPC: G01N21/00

CPC classification number: G01N21/3504 ,  G01N21/031 ,  G01N21/274 ,  G01N2021/3133 ,  G01N2021/3174 ,  G01N2201/1215

Abstract: A gas analyzer system includes an optical source, an optical filter assembly, a controller, and an analyzer. The optical source generates an optical signal. The optical filter assembly includes different optical filters in which to filter the optical signal. During operation, the controller selects sequential application of each of the different optical filters in a path of the optical signal to modulate the optical signal using different frequency bands of optical energy. The modulated optical signal passes through an unknown sample. Based on absorption of the optical signal by the sample gas at different frequencies, the optical analyzer detects which types of multiple different gases are present in the sample.

Abstract translation: 气体分析仪系统包括光源，光学滤光器组件，控制器和分析器。 光源产生光信号。 滤光器组件包括不同的滤光器，用于滤光光信号。 在操作期间，控制器选择在光信号的路径中的每个不同滤光器的顺序应用，以使用不同的光能频带调制光信号。 经调制的光信号通过未知样品。 基于不同频率的样品气体对光信号的吸收，光学分析仪检测样品中存在哪种类型的多种不同气体。

公开(公告)号：US20100211328A1

公开(公告)日：2010-08-19

申请号：US12656444

申请日：2010-01-29

Applicant: Christian Eggeling ,  Kaupo Palo ,  Nicolas Fay ,  Maciej Hoffman-Wecker ,  Pierre Ilouga

Inventor： Christian Eggeling ,  Kaupo Palo ,  Nicolas Fay ,  Maciej Hoffman-Wecker ,  Pierre Ilouga

IPC: G01N21/62 ,  G06F19/00

CPC classification number: G01N21/6445 ,  G01N2201/1215

Abstract: The invention provides a method for identifying the impacts of interfering effects on experimental data. In particular, a method is described for identifying the impacts of unwanted auto-fluorescence, fluorescence quenching, and deterioration of a fluorescent sample under study on the collected experimental data. The data are analyzed whether or not said data fulfill certain criteria with respect to a threshold which is indicative for said interfering effect.

Abstract translation: 本发明提供了一种识别干扰效应对实验数据的影响的方法。 特别地，描述了一种用于识别不期望的自动荧光，荧光猝灭和正在研究的荧光样品的劣化对所收集的实验数据的影响的方法。 分析数据是否所述数据是否符合指示所述干扰效应的阈值的某些标准。

公开(公告)号：US07684931B2

公开(公告)日：2010-03-23

申请号：US11243001

申请日：2005-10-04

Applicant: Anthony T. Pierry ,  David R. Rich

Inventor： Anthony T. Pierry ,  David R. Rich

IPC: G01N33/00

CPC classification number: A61B5/087 ,  A61B5/0205 ,  A61B5/083 ,  A61B2562/226 ,  G01N21/05 ,  G01N21/3504 ,  G01N33/497 ,  G01N2021/0118 ,  G01N2021/0193 ,  G01N2201/1215

Abstract: A method and apparatus for interfacing a plurality of gas measurement systems, including a mainstream and a sidestream gas measurement system, to a host system via an interface unit. The present invention also pertains to a sidestream gas measurement system that output signals emulating the signals output by a mainstream gas measurement system or portion thereof, so that the sidestream gas measurement system can seamlessly communicate with a host system configured to communicate with a mainstream gas measurement system or a portion thereof.

Abstract translation: 一种用于经由接口单元将多个气体测量系统（包括主流和侧流气体测量系统）连接到主机系统的方法和装置。 本发明还涉及一种侧流气体测量系统，其输出模拟由主流气体测量系统或其一部分输出的信号的信号，使得侧流气体测量系统可以与被配置为与主流气体测量通信的主机系统无缝地通信 系统或其一部分。

公开(公告)号：US20090213380A1

公开(公告)日：2009-08-27

申请号：US12112436

申请日：2008-04-30

Applicant: Dirk Appel ,  Gaston E. Marzoratti ,  Shrikrishna H. Nabar ,  Robert F. Mouradian

Inventor： Dirk Appel ,  Gaston E. Marzoratti ,  Shrikrishna H. Nabar ,  Robert F. Mouradian

IPC: G01N21/00

CPC classification number: G01N21/3504 ,  G01N21/031 ,  G01N21/274 ,  G01N2021/3133 ,  G01N2021/3174 ,  G01N2201/1215

Abstract: A gas analyzer system includes an optical source, an optical filter assembly, a controller, and an analyzer. The optical source generates an optical signal. The optical filter assembly includes different optical filters in which to filter the optical signal. During operation, the controller selects sequential application of each of the different optical filters in a path of the optical signal to modulate the optical signal using different frequency bands of optical energy. The modulated optical signal passes through an unknown sample. Based on absorption of the optical signal by the sample gas at different frequencies, the optical analyzer detects which types of multiple different gases are present in the sample.

Abstract translation: 气体分析仪系统包括光源，光学滤光器组件，控制器和分析器。 光源产生光信号。 滤光器组件包括不同的滤光器，用于滤光光信号。 在操作期间，控制器选择在光信号的路径中的每个不同滤光器的顺序应用，以使用不同的光能频带调制光信号。 经调制的光信号通过未知样品。 基于不同频率的样品气体对光学信号的吸收，光学分析仪检测样品中存在哪种类型的多种不同的气体。