公开(公告)号：US08003936B2

公开(公告)日：2011-08-23

申请号：US11869980

申请日：2007-10-10

Applicant: Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

Inventor： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

IPC: H01J49/26

CPC classification number: H01J49/145

Abstract: A system, components thereof, and methods are described for time-of-flight mass spectrometry. A microwave or high-frequency RF energy source is used to ionize a reagent vapor to form reagent ions. The reagent ions enter a chamber and interact with a fluid sample to form product ions. The reagent ions and product ions are directed to a time-of-flight mass spectrometer module for detection and determination of a mass value for the ions. The time-of-flight mass spectrometer module can include an optical system and an ion beam adjuster for focusing, interrupting, or altering a flow of reagent and product ions according to a specified pattern. The time-of-flight mass spectrometer module can include signal processing techniques to collect and analyze an acquired signal, for example, using statistical signal processing, such as maximum likelihood signal processing.

Abstract translation: 描述了用于飞行时间质谱的系统及其组件和方法。 微波或高频RF能量源用于电离试剂蒸气以形成试剂离子。 试剂离子进入室并与流体样品相互作用以形成产物离子。 试剂离子和产物离子被引导到飞行时间质谱仪模块，用于检测和确定离子的质量值。 飞行时间质谱模块可以包括用于根据指定图案聚焦，中断或改变试剂和产物离子流的光学系统和离子束调节器。 飞行时间质谱仪模块可以包括用于收集和分析所获取的信号的信号处理技术，例如使用诸如最大似然信号处理的统计信号处理。

公开(公告)号：US08003935B2

公开(公告)日：2011-08-23

申请号：US11869978

申请日：2007-10-10

Applicant: Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

Inventor： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

IPC: H01J49/26

CPC classification number: H01J49/145

Abstract: A system and methods are described for generating reagent ions and product ions for use in a quadruple mass spectrometry system. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a quadruple mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass values for ion species during spectrometry and faults within the system.

Abstract translation: 描述了用于产生用于四重质谱系统的试剂离子和产物离子的系统和方法。 微波或高频RF能源将试剂蒸气的颗粒电离以形成试剂离子。 试剂离子进入诸如漂移室的室以与流体样品相互作用。 电场引导试剂离子并促进与流体样品的相互作用以形成产物离子。 然后试剂离子和产物离子在电场的影响下离开室，由四重质谱仪模块进行检测。 该系统包括各种控制模块，用于设置系统参数值和分析模块，用于在光谱测定和系统内故障时检测离子物质的质量值。

公开(公告)号：US07982185B2

公开(公告)日：2011-07-19

申请号：US12474379

申请日：2009-05-29

Applicant: Craig Whitehouse ,  Victor Laiko

Inventor： Craig Whitehouse ,  Victor Laiko

IPC: H01J49/26

CPC classification number: H01J49/145 ,  H01J49/045 ,  H01J49/168

Abstract: An Atmospheric Pressure Chemical Ionization (APCI) source interfaced to a mass spectrometer is configured with a corona discharge needle positioned inside the APCI inlet probe assembly. Liquid sample flowing into the APCI inlet probe is nebulized and vaporized prior to passing through the corona discharge region all contained in the APCI inlet probe assembly Ions produced in the corona discharge region are focused toward the APCI probe centerline to maximize ion transmission through the APCI probe exit. External electric fields penetrating into the APCI probe exit end opening providing additional centerline focusing of sample ions exiting the APCI probe. The APCI probe is configured to shield the electric field from the corona discharge region while allowing penetration of an external electric field to focus APCI generated ions into an orifice into vacuum for mass to charge analysis. Ions that exit the APCI probe are directed only by external electric fields and gas flow maximizing ion transmission into a mass to charge analyzer. The new APCI probe can be configured to operate as a stand alone APCI source inlet probe, as a reagent ion gun for ionizing samples introduced on solids or liquid sample probes or through gas inlets in a multiple function ion source or as the APCI portion of a combination Electrospray and APCI multiple function ion source. Sample ions and gas phase reagent ions are generated in the APCI probe from liquid or gas inlet species or mixtures of both.

Abstract translation: 与质谱仪接口的大气压化学电离（APCI）源配置有位于APCI入口探针组件内部的电晕放电针。 流入APCI入口探针的液体样品在通过包含在APCI入口探针组件中的电晕放电区域之前被雾化和蒸发。 在电晕放电区域产生的离子聚焦到APCI探针中心线，以通过APCI探针出口最大化离子传输。 外部电场穿透到APCI探针出口端开口，提供离开APCI探针的样品离子的附加中心线聚焦。 APCI探针被配置为屏蔽来自电晕放电区域的电场，同时允许穿透外部电场以将APCI产生的离子聚焦到孔中以进行质量电荷分析。 离开APCI探头的离子仅由外部电场和气流引导，将离子传输最大化成质量计量分析仪。 新的APCI探针可以配置为作为独立的APCI源入口探针进行操作，作为用于将固体或液体样品探针上引入的样品或通过多功能离子源中的气体入口电离的样品的反应离子枪或作为 组合电喷雾和APCI多功能离子源。 样品离子和气相试剂离子在APCI探针中从液体或气体入口物质或两者的混合物中产生。

公开(公告)号：US07582862B2

公开(公告)日：2009-09-01

申请号：US11873670

申请日：2007-10-17

Applicant: Ralf Hartmer

Inventor： Ralf Hartmer

IPC: H01J49/42 ,  B01D59/44

CPC classification number: H01J49/145 ,  H01J49/0072

Abstract: In mass spectrometric analysis equipment, highly charged analyte fragment ions are obtained by electron transfer dissociation of highly charged analyte ions by radical anions and the dissociation products are then deprotonated with non-radical anions. Both the radical anions for electron transfer dissociation and the non-radical anions for deprotonation are produced in a single ion source from a single substance, or a single mixture of substances by adjusting the electrical operating parameters of the ion source.

Abstract translation: 在质谱分析设备中，高电荷分析物片段离子通过电子转移离子从高分子离子的自由基阴离子离子获得，然后解离产物与非自由基阴离子去质子化。 用于电子转移解离的自由基阴离子和用于去质子化的非自由基阴离子通过调节离子源的电操作参数从单一物质或单一物质混合物在单一离子源中产生。

公开(公告)号：US07462824B2

公开(公告)日：2008-12-09

申请号：US11413733

申请日：2006-04-28

Applicant: Yang Wang

Inventor： Yang Wang

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0463 ,  H01J49/145 ,  H01J49/165 ,  Y10S422/907 ,  Y10T436/24

Abstract: Combined desorption and ionization sources are provided to generate molecular ions form a sample disposed on a substrate surface. A heated gas-jet probe or heated solvent stream probe desorbs sample molecules into the gas phase. The desorbed sample molecules are ionized by reaction between the sample molecule and charged solvent droplets. The charged solvent droplets may be produced by electrospray probe or by a corona discharge. The combined desorption and ionization sources coupled by a vacuum interface to a mass spectrometer, where the sample molecule ions can be analyzed.

Abstract translation: 提供组合解吸和电离源以产生形成设置在基底表面上的样品的分子离子。 加热的气体喷射探针或加热的溶剂流探针将样品分子解吸到气相中。 解吸的样品分子通过样品分子和带电溶剂液滴之间的反应离子化。 带电的溶剂液滴可以通过电喷雾探针或电晕放电产生。 组合的解吸和电离源通过真空界面耦合到质谱仪，其中可以分析样品分子离子。

公开(公告)号：US07429731B1

公开(公告)日：2008-09-30

申请号：US11580876

申请日：2006-10-16

Applicant: Timothy P. Karpetsky

Inventor： Timothy P. Karpetsky

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J49/145 ,  G01N27/624 ,  H01J49/142

Abstract: A system for the stand-off detection of trace amounts of analyte materials such as explosives, chemical warfare agents, toxic industrial chemicals, and the like includes an ion source that is operably connected to an ion collection means and to a sensor. The ion source employs a first gas that is passed through an electrical discharge to produce metastable gas molecules as well as charged particles of various kinds. Ions and other charged particles are removed from the first gas which is then reacted with a second gas having a lower ionization potential to obtain reactant ions of relatively uniform energy. The reactant ions are focused and accelerated into a beam that is directed upon a surface, such as luggage or clothing that is being interrogated, to produce analyte ions which are collected and passed into the sensor that is preferably a differential mobility spectrometer.

Abstract translation: 用于对痕量检测微量分析物质例如爆炸物，化学战剂，有毒工业化学品等的系统包括可操作地连接到离子收集装置和传感器的离子源。 离子源采用通过放电产生亚稳态气体分子以及各种带电粒子的第一气体。 离子和其它带电粒子从第一气体中除去，然后与具有较低电离电位的第二气体反应，以获得相对均匀的能量的反应物离子。 反应物离子被聚焦并加速成被引导到诸如被询问的行李或衣服的表面的波束，以产生分析物离子，所述分析物离子被收集并传递到传感器中，优选地是差动迁移谱仪。

公开(公告)号：US07397025B2

公开(公告)日：2008-07-08

申请号：US11517334

申请日：2006-09-08

Applicant: Takashi Baba ,  Hiroyuki Satake ,  Yasuaki Takada

Inventor： Takashi Baba ,  Hiroyuki Satake ,  Yasuaki Takada

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/145 ,  H01J49/0095 ,  H01J49/063

Abstract: A mass spectrometer having an ion source section capable of creating positive ions and negative ions at high efficiency. The ion source is comprised of an ion source section for creating ions of a sample gas, a mass spectrometric section for conducting mass separation of created ions, linear RF generating multipole electrodes, magnetic fields generation means, a sample gas introduction system, a reaction gas introduction system and an electron source in which the linear RF generating multipole electrodes generate linear RF multipole electric fields. A static magnetic fields is applied in parallel on the center axis where the linear RF multipole electric fields are zero. A sample gas and a reagent gas are introduced into the ion source section. Electrons are injected for creating reaction of the positive ions or negative ions.

Abstract translation: 具有能够以高效率产生正离子和负离子的离子源部的质谱仪。 离子源包括用于产生样品气体的离子的离子源部分，用于导出所产生的离子的质量分离的质谱部分，线性RF产生多极电极，磁场产生装置，样品气体引入系统，反应气体 引入系统和电子源，其中线性RF产生多极电极产生线性RF多极电场。 在线性RF多极电场为零的中心轴上并行施加静态磁场。 样品气体和反应气体被引入离子源部分。 注入电子以产生正离子或负离子的反应。

公开(公告)号：US07368728B2

公开(公告)日：2008-05-06

申请号：US10529256

申请日：2003-09-30

Applicant: Simone Cristoni ,  Luigi P. Rossi Bernardi ,  Pasquale De Blasio

Inventor： Simone Cristoni ,  Luigi P. Rossi Bernardi ,  Pasquale De Blasio

IPC: H01J49/36 ,  H01J49/28 ,  H01J49/26 ,  H01J49/10

CPC classification number: H01J49/145 ,  H01J49/0468 ,  H01J49/16

Abstract: A new ionization source named Surface Activated Chemical Ionization (SACI) has been discovered and used to improve the sensitivity of the mass spectrometer. According to this invention the ionization chamber of a mass spectrometer is heated and contains a physical new surface to improve the ionization process. The analyte neutral molecules that are present in gas phase are ionized on this surface. The surface can be made of various materials and may also chemically modified so to bind different molecules. This new ionization source is able to generate ions with high molecular weight and low charge, an essential new key feature of the invention so to improve sensitivity and reduce noise. The new device can be especially used for the analysis of proteins, peptides and other macromolecules. The new invention overcomes some of the well known and critical limitations of the Electrospray (ESI) and Matrix Assisted Laser Desorption Ionization (MALDI) mass spectrometric techniques.

Abstract translation: 已经发现了一种称为表面活化化学电离（SACI）的新型电离源，用于提高质谱仪的灵敏度。 根据本发明，质谱仪的电离室被加热并包含物理的新表面以改善电离过程。 存在于气相中的分析物中性分子在该表面上离子化。 表面可以由各种材料制成，也可以化学改性以便结合不同的分子。 这种新的电离源能够产生高分子量和低电荷的离子，这是本发明的重要的新的关键特征，从而提高灵敏度并降低噪音。 新装置可以特别用于分析蛋白质，肽和其他大分子。 新发明克服了电喷雾（ESI）和基质辅助激光解吸电离（MALDI）质谱技术的一些众所周知和关键的局限。

公开(公告)号：US20070221835A1

公开(公告)日：2007-09-27

申请号：US11682408

申请日：2007-03-06

Applicant: Daniel Raftery ,  Huanwen Chen ,  Zhengzheng Pan

Inventor： Daniel Raftery ,  Huanwen Chen ,  Zhengzheng Pan

IPC: B01D59/44

CPC classification number: H01J49/0036 ,  G01R33/465 ,  H01J49/145 ,  H01J49/165

Abstract: A method for differentiating complex biological samples, each sample having one or more metabolite species. The method comprises producing a mass spectrum by subjecting the sample to a mass spectrometry analysis, the mass spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting the individual spectral peaks of the mass spectrum to a statistical pattern recognition analysis; identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the mass spectrum; and assigning the sample into a defined sample class.

Abstract translation: 用于区分复杂生物样品的方法，每个样品具有一种或多种代谢物种。 该方法包括通过对样品进行质谱分析来产生质谱，所述质谱包含代表样品中所含的一种或多种代谢物种类的各个光谱峰; 对质谱的各个光谱峰进行统计模式识别分析; 通过分析质谱的各个光谱峰来识别样品中所含的一种或多种代谢物; 并将样本分配到定义的样本类中。

公开(公告)号：US07253406B1

公开(公告)日：2007-08-07

申请号：US11491634

申请日：2006-07-24

Applicant: Edward W Sheehan ,  Ross C Willoughby

Inventor： Edward W Sheehan ,  Ross C Willoughby

IPC: H01J49/00

CPC classification number: H01J49/145

Abstract: An improved ion source for collecting and focusing dispersed gas-phase ions from a reagent source at sub-atmospheric or intermediate pressure, having a remote source of reagent ions separated from a low-field sample ionization region by a barrier, comprised of alternating laminates of metal and insulator, populated with a plurality of openings, wherein DC potentials are applied to each metal laminate necessary for transferring reagent ions from the remote source into the low-field sample ionization region where the reagent ions react with neutral and/or ionic sample forming ionic species. The resulting ionic species are then introduced into the vacuum system of a mass spectrometer or ion mobility spectrometer. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when gas and liquid chromatographic separation techniques are coupled to sub-atmospheric and intermediate pressure photo-ionization, chemical ionization, and thermal-pneumatic ionization sources.

Abstract translation: 一种改进的离子源，用于在亚大气压或中压下从试剂源收集和聚焦分散的气相离子，其具有通过阻挡层从低场样品离子化区域分离出的远程试剂离子源，其包括交替层叠的 金属和绝缘体，其中填充有多个开口，其中DC电位被施加到将试剂离子从远程源传输到低场样品电离区域所需的每个金属层压体上，其中试剂离子与中性和/或离子样品形成 离子物种。 然后将所得的离子物质引入质谱仪或离子迁移谱仪的真空系统中。 本发明的实施例是当气体和液相色谱分离技术与亚大气压和中压光电离，化学电离和热 - 气动电离源耦合时提高质谱的灵敏度的方法和装置。